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The results of arterial blood gas analysis, including pH value, base excess (BE), concentrations of electrolyte, and lactate (Lac) were documented before intravenous infusion (T0) and 5\u00a0min after the surgery (T1). Additional metrics included tumor necrosis factor-\u03b1 (TNF-\u03b1) and interleukin-6 (IL-6) and were quantified before intravenous infusion and at 30\u00a0min post-surgery. The quality of recovery-15 questionnaire (QoR-15) scores were documented preoperatively (D0) and on the first (D1) and third (D3) days, postoperatively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There was no significant interaction effect between the two factors of BRS and PEEP (<jats:italic>p<\/jats:italic>\u2009=\u20090.659). After the infusion of BRS, the pH level increased significantly at T2 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Using PEEP during operation can increase PaO2 in patients with obesity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The level of pH value is increased, and the concentrations of inflammatory factors are reduced due to the combination of BRS and PEEP (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Compared with group C, group BP exhibited an augmentation in QoR-15 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and the recovery time of group BP was significantly shortened (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>BRS combined with PEEP has been demonstrated to improve acid\u2013base balance, reduce the inflammatory response, shorten the recovery time, and substantially enhance the quality of early postoperative recovery.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11695-024-07631-5","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:51:01Z","timestamp":1735174261000},"page":"239-248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Sodium Bicarbonate Ringer\u2019s Solution Combined with Positive End-Expiratory Pressure on the Internal Environment of Patients Undergoing Bariatric Surgery: A Randomized 2\u2009\u00d7\u20092 Factorial Design Pilot"],"prefix":"10.1007","volume":"35","author":[{"given":"Xinyue","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengru","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"issue":"7","key":"7631_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s40273-014-0243-x","volume":"33","author":"A Hruby","year":"2015","unstructured":"Hruby A, Hu FB. 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This study was conducted in accordance with the Consolidated Standards of Reporting Trials Checklist. This manuscript adheres to the applicable EQUATOR guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent was obtained from all individual participants included in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article is licenced under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence and indicate if changes were made. The images or other third-party material in this article are included in the article\u2019s Creative Commons licence unless indicated otherwise in a credit line to the material. If material is not included in the article\u2019s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit .","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Open Access"}}]}}