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Data on the indications, surgical technique, and outcomes of RYGB reversal remain scarce.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We identified 48 cases of RYGB reversals with complete 90-day follow-up within a multi-centric international retrospective database of elective secondary bariatric surgery. The operations were performed between 2010 and 2024 in high-volume referral centers in Europe and USA. Data were collected on body weight, associated diseases, and on surgical outcomes up to 1-year postoperatively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Patients were mainly female (81.3%) with a median age of 50 years (IQR 39\u201356). RYGB reversal was performed 7 years (median) after primary RYGB in patients with a BMI of 23.9 kg\/m<jats:sup>2<\/jats:sup> (IQR 20\u201327). Half of the patients underwent at least 1 bariatric revision before the reversal. Main indications for reversal were dumping syndrome (33.3%), excessive weight loss (29.2%), marginal ulcer (14.6%), malabsorption (12.5%), and abdominal pain (10.4%). Rate of conversion to open surgery was 8.3%, and the postoperative complications during the first year reached 50%, including 31.3% Clavien-Dindo grade I\u2013II, 16.7% grade III\u2013IV complications, and one death. At 1 year, the mean BMI of the cohort increased by 18% to 28.25 kg\/m<jats:sup>2<\/jats:sup>; only 1 patient reached pre-RYGB BMI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Although RYGB is a theoretically reversible procedure, normal anatomy is re-established only in selected cases which are refractory to medical therapy and often also to revisional bariatric surgery. RYGB reversals entail high morbidity, while the extent of recurrent weight gain at 1-year post-reversal seems to allow patients to remain below the threshold of severe obesity.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11695-024-07650-2","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T22:18:37Z","timestamp":1737065917000},"page":"471-480","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Reversal of Roux-en-Y Gastric Bypass: A Multi-Centric Analysis of Indications, Techniques, and Surgical 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The Swiss Cantonal Ethics Committees of Zurich, Vaud and Northwest- and Central Switzerland approved the\u00a0creation and analysis of the Global Benchmarks in Secondary Bariatric Surgery database (BASEC-Nr. 2019\u201302145).\u00a0Centers from the European Union complied with the General Data Protection Regulation (EU Regulation 2016\/679).\u00a0The Austrian co-authors additionally applied guidelines of the Austrian Data Protection Law (\u00d6sterreichisches\u00a0Datenschutzgesetz, DSG 2000). The co-authors from the United Kingdom complied with the NHS Health Research\u00a0Agency decision making tool for data handling. Co-authors from the United States complied with the Health\u00a0Insurance Portability and Accountability Act of 1996 (HIPAA).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Only fully anonymized data without any patient identifiers (such as date of birth, date of operation, date of follow-up, name, social security number, address of patient) were transferred for data analysis, derived from patients who consented for further use of their health-related data for research purposes.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"Prof. Bueter and Prof. Peterli report consulting fees from Johnson & Johnson and Medtronic, outside the submitted work. Dr. Dillemans reports consulting fees from Medtronic and Johnson & Johnson, outside the submitted work. Prof. Lannoo reports a non-restricted grant from Medtronic, outside the submitted work. Prof Pring and Dr Slater are also employed by Streamline Clinics Ltd, outside the scope of this work. The other authors have no commercial associations to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}