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A systematic review was performed using MEDLINE, Embase, Emcare, and CINAHL databases for studies that reported on GORD outcomes following RYGB\u00a0for obesity (January 2000\u2013November 2023). Fourteen studies with 28,027 patients underwent RYGB, with pooled analysis demonstrating a 47% (95% CI 34.0\u201359.0;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264 0.005) improvement in GORD symptoms and 4.5% (95% CI 1.7\u20137.2;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264 0.005) with worsening\/new onset GORD. Postoperative DeMeester score improved by 16.49 points (95% CI 0.2\u201332.7;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u00a00.005) and 79.4% (95% CI 68.7\u201390.1;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009= 0.01) completely discontinued proton-pump inhibitor therapy during the follow-up period. RYGB surgery may potentially improve GORD symptoms in patients with obesity, with an overall low incidence of de novo GORD.\n                  <\/jats:p>","DOI":"10.1007\/s11695-025-07865-x","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T07:56:35Z","timestamp":1745481395000},"page":"2321-2332","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gastro-Oesophageal Reflux Disease Outcomes Following Roux-en-Y Gastric Bypass Surgery in Patients with Obesity: A Systematic Review and Meta-analysis"],"prefix":"10.1007","volume":"35","author":[{"given":"Narek","family":"Sargsyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iihan","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Namgoong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibek","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matyas","family":"Fehervari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Fadel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"7865_CR1","doi-asserted-by":"publisher","first-page":"17034","DOI":"10.1038\/nrdp.2017.34","volume":"3","author":"P Gonz\u00e1lez-Muniesa","year":"2017","unstructured":"Gonz\u00e1lez-Muniesa P, M\u00e1rtinez-Gonz\u00e1lez MA, Hu FB, Despr\u00e9s JP, Matsuzawa Y, Loos RJF, Moreno LA, Bray GA, Martinez JA. 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