{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:53:09Z","timestamp":1785163989395,"version":"3.55.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["OBES SURG"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11695-025-08327-0","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:45:50Z","timestamp":1763142350000},"page":"4989-4999","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Roux-en-Y Gastric Bypass Improves Insulin Response and Secretion of GLP-1 and PYY in Response to Postprandial Acute Exercise"],"prefix":"10.1007","volume":"35","author":[{"given":"Saulo","family":"Gil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor Hisashi","family":"Murai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner S.","family":"Dantas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto Abujabra","family":"Merege-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Erwig","family":"Leit\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Ferreira","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisson Padilha de","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Benatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto de","family":"Cleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aur\u00e9lio","family":"Santo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Kirwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Gualano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamilton","family":"Roschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"8327_CR1","doi-asserted-by":"crossref","unstructured":"Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007;357(8):753\u201361.","DOI":"10.1056\/NEJMoa066603"},{"key":"8327_CR2","doi-asserted-by":"crossref","unstructured":"Reges O, Greenland P, Dicker D, et al. Association of bariatric surgery using laparoscopic banding, Roux-en-Y gastric bypass, or laparoscopic sleeve gastrectomy vs usual care obesity management with all-cause mortality. JAMA. 2018;319(3):279\u201390.","DOI":"10.1001\/jama.2017.20513"},{"key":"8327_CR3","doi-asserted-by":"crossref","unstructured":"Martinou E, Stefanova I, Iosif E, et al. Neurohormonal changes in the gut-brain axis and underlying neuroendocrine mechanisms following bariatric surgery. Int J Mol Sci. 2022;19;23(6):3339.","DOI":"10.3390\/ijms23063339"},{"key":"8327_CR4","doi-asserted-by":"crossref","unstructured":"Nguyen KT, Korner J. The sum of many parts: potential mechanisms for improvement in glucose homeostasis after bariatric surgery. Curr Diab Rep. 2014;14(5):481.\u00a0","DOI":"10.1007\/s11892-014-0481-5"},{"key":"8327_CR5","doi-asserted-by":"crossref","unstructured":"Holst JJ, Madsbad S. Mechanisms of surgical control of type 2 diabetes: GLP-1 is key factor. Surg Obes Relat Dis: Off J Am Soc Bariatric Surg. 2016;12(6):1236\u201342.","DOI":"10.1016\/j.soard.2016.02.033"},{"key":"8327_CR6","doi-asserted-by":"crossref","unstructured":"le Roux CW, Aylwin SJ, Batterham RL, et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg. 2006;243(1):108\u201314.","DOI":"10.1097\/01.sla.0000183349.16877.84"},{"key":"8327_CR7","doi-asserted-by":"crossref","unstructured":"Dalmas E, Rouault C, Abdennour M, et al. Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction. Am J Clin Nutr. 2011;94(2):450\u20138.","DOI":"10.3945\/ajcn.111.013771"},{"key":"8327_CR8","doi-asserted-by":"crossref","unstructured":"Illan-Gomez F, Gonzalvez-Ortega M, Orea-Soler I, et al. Obesity and inflammation: change in adiponectin, C-reactive protein, tumour necrosis factor-alpha and interleukin-6 after bariatric surgery. Obes Surg. 2012;22(6):950\u20135.","DOI":"10.1007\/s11695-012-0643-y"},{"key":"8327_CR9","doi-asserted-by":"crossref","unstructured":"Gualano B, Kirwan JP, Roschel H. Exercise is key to sustaining metabolic gains after bariatric surgery. Exerc Sport Sci Rev. 2021;49(3):197\u2013204.","DOI":"10.1249\/JES.0000000000000253"},{"key":"8327_CR10","doi-asserted-by":"crossref","unstructured":"Cartee GD. Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise. Am J Physiol Endocrinol Metab. 2015;309(12):E949\u201359.\u00a0","DOI":"10.1152\/ajpendo.00416.2015"},{"key":"8327_CR11","doi-asserted-by":"crossref","unstructured":"Black LE, Swan PD, Alvar BA. Effects of intensity and volume on insulin sensitivity during acute bouts of resistance training. J Strength Cond Res. 2010;24(4):1109\u201316.","DOI":"10.1519\/JSC.0b013e3181cbab6d"},{"key":"8327_CR12","doi-asserted-by":"crossref","unstructured":"Gleeson M, Bishop NC, Stensel DJ, et al. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011;11(9):607\u201315.\u00a0","DOI":"10.1038\/nri3041"},{"key":"8327_CR13","doi-asserted-by":"crossref","unstructured":"Dantas WS, Neves WD, Gil S, et al. Exercise-induced anti-inflammatory effects in overweight\/obese women with polycystic ovary syndrome. Cytokine. 2019;120:66\u201370.","DOI":"10.1016\/j.cyto.2019.04.006"},{"key":"8327_CR14","doi-asserted-by":"crossref","unstructured":"Heden TD, Liu Y, Park Y, et al. Acute aerobic exercise differentially alters acylated ghrelin and perceived fullness in normal-weight and obese individuals. J Appl Physiol. 2013;115(5):680\u20137.","DOI":"10.1152\/japplphysiol.00515.2013"},{"key":"8327_CR15","doi-asserted-by":"crossref","unstructured":"Ringleb M, Javelle F, Haunhorst S, et al. Beyond muscles: Investigating immunoregulatory myokines in acute resistance exercise - a systematic review and meta-analysis. Faseb J. 2024;38(7):e23596.\u00a0","DOI":"10.1096\/fj.202301619R"},{"key":"8327_CR16","doi-asserted-by":"crossref","unstructured":"Martins C, Morgan LM, Bloom SR, et al. Effects of exercise on gut peptides, energy intake and appetite. J Endocrinol. 2007;193(2):251\u20138.\u00a0","DOI":"10.1677\/JOE-06-0030"},{"key":"8327_CR17","doi-asserted-by":"crossref","unstructured":"Halliday TM, White MH, Hild AK, et al. Appetite and energy intake regulation in response to acute exercise. Med Sci Sports Exerc. 2021;53(10):2173\u201381.","DOI":"10.1249\/MSS.0000000000002678"},{"key":"8327_CR18","doi-asserted-by":"crossref","unstructured":"Schubert MM, Sabapathy S, Leveritt M, et al. Acute exercise and hormones related to appetite regulation: a meta-analysis. Sports Med. 2014;44(3):387\u2013403.","DOI":"10.1007\/s40279-013-0120-3"},{"key":"8327_CR19","doi-asserted-by":"crossref","unstructured":"McCarthy SF, Tucker JAL, Hazell TJ. Exercise-induced appetite suppression: an update on potential mechanisms. Physiol Rep. 2024;12(16):e70022.","DOI":"10.14814\/phy2.70022"},{"key":"8327_CR20","doi-asserted-by":"crossref","unstructured":"Unick JL, Otto AD, Goodpaster BH, et al. Acute effect of walking on energy intake in overweight\/obese women. Appetite. 2010;55(3):413\u20139.","DOI":"10.1016\/j.appet.2010.07.012"},{"key":"8327_CR21","doi-asserted-by":"crossref","unstructured":"Heiston EM, Eichner NZM, Gilbertson NM, et al. Two weeks of exercise training intensity on appetite regulation in obese adults with prediabetes. J Appl Physiol. 2019;126(3):746\u201354.\u00a0","DOI":"10.1152\/japplphysiol.00655.2018"},{"key":"8327_CR22","doi-asserted-by":"crossref","unstructured":"Bornath DPD, McKie GL, McCarthy SF, et al. Interleukin-6 is not involved in appetite regulation following moderate-intensity exercise in males with normal weight and obesity. Obesity (Silver Spring). 2023;31(9):2315\u201324.","DOI":"10.1002\/oby.23841"},{"key":"8327_CR23","doi-asserted-by":"crossref","unstructured":"Asri S, Rahmani-Nia F, Saidie P, et al. Acute effect of exercise on appetite-related factors in males with obesity: a pilot study. Physiol Rep. 2024;12(24):e70167.","DOI":"10.14814\/phy2.70167"},{"key":"8327_CR24","doi-asserted-by":"crossref","unstructured":"Khodabandeh S, Rahmani-Nia F, Mirzaei B, et al. The effects of acute aerobic exercise on appetite-regulating parameters and energy intake in males with obesity. Health Sci Rep. 2024;7(9):e70067.","DOI":"10.1002\/hsr2.70067"},{"key":"8327_CR25","doi-asserted-by":"crossref","unstructured":"Gil S, Kirwan JP, Murai IH, et al. A randomized clinical trial on the effects of exercise on muscle remodelling following bariatric surgery. J Cachexia Sarcopenia Muscle. 2021;12(6):1440\u20131455","DOI":"10.1002\/jcsm.12815"},{"key":"8327_CR26","doi-asserted-by":"crossref","unstructured":"Gil S, Pecanha T, Dantas WS, et al. Exercise enhances the effect of bariatric surgery in markers of cardiac autonomic function. Obes Surg. 2021;31(3):1381\u20131386.","DOI":"10.1007\/s11695-020-05053-7"},{"key":"8327_CR27","doi-asserted-by":"crossref","unstructured":"Dantas WS, Gil S, Murai IH, et al. Reversal of improved endothelial function after bariatric surgery is mitigated by exercise training. J Am Coll Cardiol. 2018;72(18):2278\u20139.","DOI":"10.1016\/j.jacc.2018.07.094"},{"key":"8327_CR28","doi-asserted-by":"crossref","unstructured":"Dantas WS, Roschel H, Murai IH, et al. Exercise-induced increases in insulin sensitivity after bariatric surgery are mediated by muscle extracellular matrix remodeling. Diabetes. 2020;69(8):1675\u201391.","DOI":"10.2337\/db19-1180"},{"key":"8327_CR29","doi-asserted-by":"crossref","unstructured":"Murai IH, Roschel H, Dantas WS, et al. Exercise mitigates bone loss in women with severe obesity after roux-en-y gastric bypass: a randomized controlled trial. J Clin Endocrinol Metab. 2019;104(10):4639\u201350.","DOI":"10.1210\/jc.2019-00074"},{"key":"8327_CR30","unstructured":"Merege-Filho CAA, Gil SS, Kirwan JP, et al. Exercise modifies hypothalamic connectivity and brain functional networks in women after bariatric surgery: a randomized clinical trial. Int J Obes (Lond). 2023;47(3):165\u2013174."},{"key":"8327_CR31","doi-asserted-by":"crossref","unstructured":"Morales-Marroquin E, Kohl HW, 3rd, Knell G, et al. Resistance training in post-metabolic and bariatric surgery patients: a systematic review. Obes Surg. 2020;30(10):4071\u201380.","DOI":"10.1007\/s11695-020-04837-1"},{"key":"8327_CR32","doi-asserted-by":"crossref","unstructured":"Shimano T, Kraemer WJ, Spiering BA, et al. Relationship between the number of repetitions and selected percentages of one repetition maximum in free weight exercises in trained and untrained men. J Strength Cond Res. 2006;20(4):819\u201323.","DOI":"10.1519\/00124278-200611000-00015"},{"key":"8327_CR33","doi-asserted-by":"crossref","unstructured":"Lansley KE, Dimenna FJ, Bailey SJ, et al. A \u201cnew\u201d method to normalise exercise intensity. Int J Sports Med. 2011;32(7):535\u201341.","DOI":"10.1055\/s-0031-1273754"},{"key":"8327_CR34","doi-asserted-by":"crossref","unstructured":"Dantas WS, Marcondes JA, Shinjo SK, et al. GLUT4 translocation is not impaired after acute exercise in skeletal muscle of women with obesity and polycystic ovary syndrome. Obesity (Silver Spring). 2015;23(11):2207\u201315.","DOI":"10.1002\/oby.21217"},{"key":"8327_CR35","doi-asserted-by":"crossref","unstructured":"Astley C, Gil S, Clemente G, et al. Poor physical activity levels and cardiorespiratory fitness among patients with childhood-onset takayasu arteritis in remission: a cross-sectional, multicenter study. Pediatr Rheumatol Online J. 2021;19(1):39.\u00a0","DOI":"10.1186\/s12969-021-00519-z"},{"key":"8327_CR36","doi-asserted-by":"crossref","unstructured":"Gil S, Pecanha T, Dantas WS, et al. Exercise enhances the effect of bariatric surgery in markers of cardiac autonomic function. Obes Surg. 2021;31(3):1381\u20136.","DOI":"10.1007\/s11695-020-05053-7"},{"key":"8327_CR37","unstructured":"Brown L, Weir J. ASEP procedures recommendation I: accurate assessment of muscular strength and power. J Exerc Physiol. 2001;4(3):1\u201321."},{"key":"8327_CR38","doi-asserted-by":"crossref","unstructured":"Bacchetti P, McCulloch CE, Segal MR. Simple, defensible sample sizes based on cost efficiency. Biometrics. 2008;64(2):577\u201385; discussion 86\u201394.\u00a0","DOI":"10.1111\/j.1541-0420.2008.01004_1.x"},{"key":"8327_CR39","doi-asserted-by":"crossref","unstructured":"Bacchetti P. Current sample size conventions: flaws, harms, and alternatives. BMC Med. 2010;8:17.","DOI":"10.1186\/1741-7015-8-17"},{"key":"8327_CR40","unstructured":"Cohen, J. Statistical Power Analysis for the Behavioral Sciences (2nd ed.). Hillsdale, NJ: Lawrence Erlbaum Associates, Routledge, 1988."},{"key":"8327_CR41","doi-asserted-by":"crossref","unstructured":"Leonetti F, Capoccia D, Coccia F, et al. Obesity, type 2 diabetes mellitus, and other comorbidities: a prospective cohort study of laparoscopic sleeve gastrectomy vs medical treatment. Arch Surg. 2012;147(8):694\u2013700.\u00a0","DOI":"10.1001\/archsurg.2012.222"},{"key":"8327_CR42","doi-asserted-by":"crossref","unstructured":"Schauer PR, Bhatt DL, Kirwan JP, et al. Bariatric surgery versus intensive medical therapy for diabetes - 5-year outcomes. N Engl J Med. 2017;376(7):641\u201351.","DOI":"10.1056\/NEJMoa1600869"},{"key":"8327_CR43","doi-asserted-by":"crossref","unstructured":"Schiavon CA, Bersch-Ferreira AC, Santucci EV, et al. Effects of Bariatric Surgery in Obese Patients With Hypertension: The GATEWAY Randomized Trial (Gastric Bypass to Treat Obese Patients With Steady Hypertension). Circulation. 2018;137(11):1132\u20131142.","DOI":"10.1161\/CIRCULATIONAHA.117.032130"},{"key":"8327_CR44","doi-asserted-by":"crossref","unstructured":"Larraufie P, Roberts GP, McGavigan AK, et al. Important role of the GLP-1 axis for glucose homeostasis after bariatric surgery. Cell Rep. 2019;26(6):1399\u2013408 e6.","DOI":"10.1016\/j.celrep.2019.01.047"},{"key":"8327_CR45","doi-asserted-by":"crossref","unstructured":"Drucker DJ. The cardiovascular biology of glucagon-like peptide-1. Cell Metab. 2016;24(1):15\u201330.","DOI":"10.1016\/j.cmet.2016.06.009"},{"key":"8327_CR46","doi-asserted-by":"crossref","unstructured":"Gribble FM, Reimann F. Enteroendocrine cells: chemosensors in the intestinal epithelium. Annu Rev Physiol. 2016;78:277\u201399.","DOI":"10.1146\/annurev-physiol-021115-105439"},{"key":"8327_CR47","doi-asserted-by":"crossref","unstructured":"Smits MM, Holst JJ. Endogenous glucagon-like peptide (GLP)-1 as alternative for GLP-1 receptor agonists: Could this work and how? Diabetes\/Metab Res Rev. 2023;39(8):e3699.","DOI":"10.1002\/dmrr.3699"},{"key":"8327_CR48","doi-asserted-by":"crossref","unstructured":"King A, Miller EM. Glucagon-Like peptide 1 receptor agonists have the potential to revolutionize the attainment of target a1c levels in type 2 diabetes-so why is their uptake so low?. Clin Diabetes. 2023;41(2):226\u2013238.","DOI":"10.2337\/cd22-0027"},{"key":"8327_CR49","doi-asserted-by":"crossref","unstructured":"da Silva LS, Germano DB, Fonseca FAH, et al. Persistence of a proinflammatory status after treatment of the acute myocardial infarction. Geriatr Gerontol Int. 2023;23(9):700\u20137.","DOI":"10.1111\/ggi.14649"},{"key":"8327_CR50","doi-asserted-by":"crossref","unstructured":"Ahlborg B, Ahlborg G. Exercise leukocytosis with and without beta-adrenergic blockade. Acta Med Scand. 1970;187(4):241\u20136.","DOI":"10.1111\/j.0954-6820.1970.tb02938.x"},{"key":"8327_CR51","doi-asserted-by":"crossref","unstructured":"Connolly PH, Caiozzo VJ, Zaldivar F, et al. Effects of exercise on gene expression in human peripheral blood mononuclear cells. J Appl Physiol. 2004;97(4):1461\u20139.","DOI":"10.1152\/japplphysiol.00316.2004"},{"key":"8327_CR52","unstructured":"Edwards AJ, Bacon TH, Elms CA, et al. Changes in the populations of lymphoid cells in human peripheral blood following physical exercise. Clin Exp Immunol. 1984;58(2):420\u20137.\u00a0"},{"key":"8327_CR53","doi-asserted-by":"crossref","unstructured":"Kendall A, Hoffman-Goetz L, Houston M, et al. Exercise and blood lymphocyte subset responses: intensity, duration, and subject fitness effects. J Appl Physiol. 1990;69(1):251\u201360.","DOI":"10.1152\/jappl.1990.69.1.251"},{"key":"8327_CR54","doi-asserted-by":"crossref","unstructured":"Bullo M, Garcia-Lorda P, Megias I, et al. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obes Res. 2003;11(4):525\u201331.","DOI":"10.1038\/oby.2003.74"},{"key":"8327_CR55","unstructured":"Mabrouk R, Ghareeb H, Shehab A, et al. Serum visfatin, resistin and IL-18 in A group of Egyptian obese diabetic and non diabetic individuals. Egypt J Immunol. 2013;20(1):1\u201311.\u00a0"},{"key":"8327_CR56","doi-asserted-by":"crossref","unstructured":"Christiansen T, Bruun JM, Paulsen SK, et al. Acute exercise increases circulating inflammatory markers in overweight and obese compared with lean subjects. Eur J Appl Physiol. 2013;113(6):1635\u201342.","DOI":"10.1007\/s00421-013-2592-0"},{"key":"8327_CR57","unstructured":"Perandini LA, Sales-de-Oliveira D, Mello S, et al. Inflammatory cytokine kinetics to single bouts of acute moderate and intense aerobic exercise in women with active and inactive systemic lupus erythematosus. Exerc Immunol Rev. 2015;21:174\u201385."},{"key":"8327_CR58","doi-asserted-by":"crossref","unstructured":"Dorneles GP, Haddad DO, Fagundes VO, et al. High intensity interval exercise decreases IL-8 and enhances the immunomodulatory cytokine interleukin-10 in lean and overweight-obese individuals. Cytokine. 2016;77:1\u20139.\u00a0","DOI":"10.1016\/j.cyto.2015.10.003"},{"key":"8327_CR59","unstructured":"Fischer CP. Interleukin-6 in acute exercise and training: what is the biological relevance? Exerc Immunol Rev. 2006;12:6\u201333."}],"container-title":["Obesity Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-025-08327-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11695-025-08327-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-025-08327-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:53:09Z","timestamp":1766415189000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11695-025-08327-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":59,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["8327"],"URL":"https:\/\/doi.org\/10.1007\/s11695-025-08327-0","relation":{},"ISSN":["0960-8923","1708-0428"],"issn-type":[{"value":"0960-8923","type":"print"},{"value":"1708-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]},"assertion":[{"value":"30 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}