{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T01:50:23Z","timestamp":1769651423142,"version":"3.49.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["OBES SURG"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Very Long Chain Acyl-CoA Dehydrogenase Deficiency (VLCADD) is a rare inherited disorder of mitochondrial fatty acid \u03b2-oxidation that predisposes patients to metabolic crises, rhabdomyolysis, and cardiomyopathy. Surgical stress, fasting, and anaesthesia may precipitate metabolic decompensation. We present the case of a 65-year-old female with late-onset VLCADD, multiple comorbidities, and chronic kidney disease (CKD) stage 3 who underwent laparoscopic sleeve gastrectomy. Despite perioperative glucose infusion, normothermia, and careful anaesthetic planning, she developed postoperative rhabdomyolysis. This case highlights perioperative challenges in VLCADD, provides practical strategies for anaesthetic and nutritional management, and, to our knowledge, represents the first report of bariatric surgery in a patient with VLCADD. Long-term follow-up demonstrated sustained weight loss, improved cardiometabolic profile, and stable muscle and renal function.<\/jats:p>","DOI":"10.1007\/s11695-025-08347-w","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T14:24:19Z","timestamp":1764944659000},"page":"341-344","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Management of a Patient With Very Long Chain Acyl-CoA Dehydrogenase Deficiency Undergoing Laparoscopic Sleeve Gastrectomy: First Report of Bariatric Surgery in VLCADD"],"prefix":"10.1007","volume":"36","author":[{"given":"Mirza Anwar","family":"Baig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bennedict","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"8347_CR1","unstructured":"Leslie ND. GeneReviews: VLCADD. 2023 update."},{"key":"8347_CR2","doi-asserted-by":"crossref","unstructured":"Yuasa H et al. Anesthesia management in a patient with VLCAD deficiency. JA Clin Rep. 2020. Sep 16;6:72","DOI":"10.1186\/s40981-020-00379-8"},{"key":"8347_CR3","unstructured":"Tanaka A et al. Anesthetic management and neuromonitoring in a patient with VLCADD. 2024."},{"key":"8347_CR4","doi-asserted-by":"crossref","unstructured":"Peixoto C et al. Perioperative anesthetic management of VLCADD. Trends Anaesth Crit Care. 2023. Apr;70(4):231-234.","DOI":"10.1016\/j.redare.2021.12.005"},{"key":"8347_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-025-01625-5","volume":"24","author":"M Kumar","year":"2025","unstructured":"Kumar M, Nigam V, Kumar S, et al. Regulation of metabolic pathways genes and the effects of very low-calorie diet on insulin resistance and fatty acid profiles in obese patients undergoing bariatric surgery. J Diabetes Metab Disord. 2025;24:114. https:\/\/doi.org\/10.1007\/s40200-025-01625-5.","journal-title":"J Diabetes Metab Disord"},{"key":"8347_CR6","doi-asserted-by":"crossref","unstructured":"Van Calcar SC et al. Nutrition management guideline for VLCADD. Mol Genet Metab. 2020. Sep-Oct;131(1-2):23-37","DOI":"10.1016\/j.ymgme.2020.10.001"},{"key":"8347_CR7","unstructured":"Bariatric N Guidelines. 2025."},{"key":"8347_CR8","unstructured":"Metabolic Support UK. VLCAD condition overview."}],"container-title":["Obesity Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-025-08347-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11695-025-08347-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-025-08347-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:04:24Z","timestamp":1769609064000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11695-025-08347-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["8347"],"URL":"https:\/\/doi.org\/10.1007\/s11695-025-08347-w","relation":{},"ISSN":["0960-8923","1708-0428"],"issn-type":[{"value":"0960-8923","type":"print"},{"value":"1708-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,5]]},"assertion":[{"value":"30 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}