{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T14:45:29Z","timestamp":1772635529681,"version":"3.50.1"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Fifth Affiliated Hospital of Sun Yat-sen University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["OBES SURG"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s11695-025-08437-9","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T10:51:20Z","timestamp":1766055080000},"page":"590-601","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of Lactobacillus Johnsonii in Gastroesophageal Reflux Disease in Obese Mice Following Sleeve Gastrectomy"],"prefix":"10.1007","volume":"36","author":[{"given":"Xiongwei","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Decheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiantao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qixuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiqiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"8437_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3810\/pgm.2003.12.1544","volume":"114","author":"GA Bray","year":"2003","unstructured":"Bray GA. Evaluation of obesity. Who are the obese? Postgrad Med. 2003;114:19\u201327.","journal-title":"Postgrad Med"},{"key":"8437_CR2","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1001\/jama.2020.14775","volume":"324","author":"BC Brajcich","year":"2020","unstructured":"Brajcich BC, Hungness ES. Sleeve gastrectomy. JAMA. 2020;324:908.","journal-title":"JAMA"},{"key":"8437_CR3","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1001\/jamasurg.2022.2229","volume":"157","author":"P Salminen","year":"2022","unstructured":"Salminen P, Gr\u00f6nroos S, Helmi\u00f6 M, Hurme S, Juuti A, Juusela R, et al. Effect of laparoscopic sleeve gastrectomy vs Roux-en-Y gastric bypass on weight loss, comorbidities, and reflux at 10 years in adult patients with obesity: the SLEEVEPASS randomized clinical trial. JAMA Surg. 2022;157:656\u201366.","journal-title":"JAMA Surg"},{"key":"8437_CR4","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1001\/jama.2017.20897","volume":"319","author":"R Peterli","year":"2018","unstructured":"Peterli R, W\u00f6lnerhanssen BK, Peters T, Vetter D, Kr\u00f6ll D, Borb\u00e9ly Y, et al. Effect of laparoscopic sleeve gastrectomy vs laparoscopic Roux-en-Y gastric bypass on weight loss in patients with morbid obesity: the SM-BOSS randomized clinical trial. JAMA. 2018;319:255\u201365.","journal-title":"JAMA"},{"key":"8437_CR5","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/SLA.0000000000003275","volume":"271","author":"KTD Yeung","year":"2020","unstructured":"Yeung KTD, Penney N, Ashrafian L, Darzi A, Ashrafian H. Does sleeve gastrectomy expose the distal esophagus to severe reflux? A systematic review and meta-analysis. Ann Surg. 2020;271:257\u201365.","journal-title":"Ann Surg"},{"issue":"8","key":"8437_CR6","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.3390\/jpm13081243","volume":"13","author":"P Znamirowski","year":"2023","unstructured":"Znamirowski P, Ko\u0142oma\u0144ska M, Mazurkiewicz R, Tymchyshyn O, Nawacki \u0141. GERD as a complication of laparoscopic sleeve gastrectomy for the treatment of obesity: A systematic review and Meta-Analysis. J Personalized Med. 2023;13(8):1243.","journal-title":"J Personalized Med."},{"key":"8437_CR7","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1007\/s11695-012-0612-5","volume":"22","author":"WV Petersen","year":"2012","unstructured":"Petersen WV, Schneider JH. Functional importance of laparoscopic sleeve gastrectomy for the lower esophageal sphincter in patients with morbid obesity. Obes Surg. 2012;22:949.","journal-title":"Obes Surg"},{"key":"8437_CR8","doi-asserted-by":"publisher","first-page":"e407","DOI":"10.1097\/SLA.0000000000004637","volume":"276","author":"Y Johari","year":"2022","unstructured":"Johari Y, Lim G, Wickremasinghe A, Yue H, Seah J, Ooi G, et al. Pathophysiological mechanisms of Gastro-esophageal reflux after sleeve gastrectomy. Ann Surg. 2022;276:e407\u201316.","journal-title":"Ann Surg"},{"key":"8437_CR9","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/nyas.14467","volume":"1482","author":"E Felinska","year":"2020","unstructured":"Felinska E, Billeter A, Nickel F, Contin P, Berlth F, Chand B, et al. Do we understand the pathophysiology of GERD after sleeve gastrectomy? Ann N Y Acad Sci. 2020;1482:26\u201335.","journal-title":"Ann N Y Acad Sci"},{"key":"8437_CR10","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1038\/s41467-019-09964-7","volume":"10","author":"GB Saffouri","year":"2019","unstructured":"Saffouri GB, Shields-Cutler RR, Chen J, Yang Y, Lekatz HR, Hale VL, et al. Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders. Nat Commun. 2019;10:2012.","journal-title":"Nat Commun"},{"key":"8437_CR11","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.csbj.2023.12.026","volume":"23","author":"A Barchi","year":"2024","unstructured":"Barchi A, Massimino L, Mandarino FV, Vespa E, Sinagra E, Almolla O, et al. Microbiota profiling in esophageal diseases: novel insights into molecular staining and clinical outcomes. Comput Struct Biotechnol J. 2024;23:626\u201337.","journal-title":"Comput Struct Biotechnol J"},{"key":"8437_CR12","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/jgh3.12045","volume":"2","author":"PC Revaiah","year":"2018","unstructured":"Revaiah PC, Kochhar R, Rana SV, Berry N, Ashat M, Dhaka N, et al. Risk of small intestinal bacterial overgrowth in patients receiving proton pump inhibitors versus proton pump inhibitors plus prokinetics. JGH Open. 2018;2:47\u201353.","journal-title":"JGH Open"},{"key":"8437_CR13","doi-asserted-by":"publisher","first-page":"1267192","DOI":"10.3389\/fcimb.2023.1267192","volume":"13","author":"X Ye","year":"2023","unstructured":"Ye X, Yu F, Zhou J, Zhao C, Wu J, Ni X. Analysis of the gut microbiota in children with gastroesophageal reflux disease using metagenomics and metabolomics. Front Cell Infect Microbiol. 2023;13:1267192.","journal-title":"Front Cell Infect Microbiol"},{"issue":"7","key":"8437_CR14","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.3390\/jcm9072162","volume":"9","author":"J Zhou","year":"2020","unstructured":"Zhou J, Shrestha P, Qiu Z, Harman DG, Teoh WC, Al-Sohaily S, et al. Distinct microbiota dysbiosis in patients with Non-Erosive reflux disease and esophageal adenocarcinoma. J Clin Med. 2020;9(7):2162.","journal-title":"J Clin Med."},{"key":"8437_CR15","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1097\/01.sla.0000118751.95179.c6","volume":"239","author":"MM Abdel-Latif","year":"2004","unstructured":"Abdel-Latif MM, O\u2019Riordan J, Windle HJ, Carton E, Ravi N, Kelleher D, et al. <article-title update=\"added\">NF-\u03baB activation in esophageal adenocarcinoma: relationship to Barrett\u2019s metaplasia, survival, and response to neoadjuvant chemoradiotherapy. Ann Surg. 2004;239:491\u2013500.","journal-title":"Ann Surg"},{"key":"8437_CR16","first-page":"2929","volume":"58","author":"KT Wilson","year":"1998","unstructured":"Wilson KT, Fu S, Ramanujam KS, Meltzer SJ. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in barrett\u2019s esophagus and associated adenocarcinomas. Cancer Res. 1998;58:2929\u201334.","journal-title":"Cancer Res"},{"key":"8437_CR17","doi-asserted-by":"publisher","first-page":"G32","DOI":"10.1152\/ajpgi.2001.280.1.G32","volume":"280","author":"YP Fan","year":"2001","unstructured":"Fan YP, Chakder S, Gao F, Rattan S. Inducible and neuronal nitric oxide synthase involvement in lipopolysaccharide-induced sphincteric dysfunction. Am J Physiol Gastrointest Liver Physiol. 2001;280:G32\u201342.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"8437_CR18","first-page":"990","volume":"96","author":"CD Morris","year":"2001","unstructured":"Morris CD, Armstrong GR, Bigley G, Green H, Attwood SE. Cyclooxygenase-2 expression in the barrett\u2019s metaplasia-dysplasia-adenocarcinoma sequence. Am J Gastroenterol. 2001;96:990\u20136.","journal-title":"Am J Gastroenterol"},{"key":"8437_CR19","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cmet.2015.07.009","volume":"22","author":"V Tremaroli","year":"2015","unstructured":"Tremaroli V, Karlsson F, Werling M, St\u00e5hlman M, Kovatcheva-Datchary P, Olbers T, et al. Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation. Cell Metab. 2015;22:228\u201338.","journal-title":"Cell Metab"},{"key":"8437_CR20","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1007\/s11695-019-03863-y","volume":"29","author":"J Luijten","year":"2019","unstructured":"Luijten J, Vugts G, Nieuwenhuijzen GAP, Luyer MDP. The importance of the microbiome in bariatric surgery: a systematic review. Obes Surg. 2019;29:2338\u201349.","journal-title":"Obes Surg"},{"key":"8437_CR21","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1530\/EJE-17-0403","volume":"178","author":"Y Guo","year":"2018","unstructured":"Guo Y, Huang ZP, Liu CQ, Qi L, Sheng Y, Zou DJ. Modulation of the gut microbiome: a systematic review of the effect of bariatric surgery. Eur J Endocrinol. 2018;178:43\u201356.","journal-title":"Eur J Endocrinol"},{"issue":"9","key":"8437_CR22","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.3390\/microorganisms11092353","volume":"11","author":"DI Tedjo","year":"2023","unstructured":"Tedjo DI, Wilbrink JA, Boekhorst J, Timmerman HM, Nienhuijs SW, Stronkhorst A, et al. Impact of sleeve gastrectomy on fecal microbiota in individuals with morbid obesity. Microorganisms. 2023;11(9):2353.","journal-title":"Microorganisms."},{"key":"8437_CR23","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1002\/bjs.11654","volume":"107","author":"T Ikeda","year":"2020","unstructured":"Ikeda T, Aida M, Yoshida Y, Matsumoto S, Tanaka M, Nakayama J, et al. Alteration in faecal bile acids, gut microbial composition and diversity after laparoscopic sleeve gastrectomy. Br J Surg. 2020;107:1673\u201385.","journal-title":"Br J Surg"},{"key":"8437_CR24","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1007\/s11695-020-04494-4","volume":"30","author":"G Chen","year":"2020","unstructured":"Chen G, Zhuang J, Cui Q, Jiang S, Tao W, Chen W, et al. Two bariatric surgical procedures differentially alter the intestinal microbiota in obesity patients. Obes Surg. 2020;30:2345\u201361.","journal-title":"Obes Surg"},{"key":"8437_CR25","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","volume":"11","author":"C Hill","year":"2014","unstructured":"Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Reviews Gastroenterol Hepatol. 2014;11:506\u201314.","journal-title":"Nat Reviews Gastroenterol Hepatol"},{"key":"8437_CR26","doi-asserted-by":"publisher","first-page":"127","DOI":"10.4161\/gmic.2.3.16174","volume":"2","author":"ME Sanders","year":"2011","unstructured":"Sanders ME, Heimbach JT, Pot B, Tancredi DJ, Lenoir-Wijnkoop I, L\u00e4hteenm\u00e4ki-Uutela A, et al. Health claims substantiation for probiotic and prebiotic products. Gut Microbes. 2011;2:127\u201333.","journal-title":"Gut Microbes"},{"key":"8437_CR27","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1111\/apt.14539","volume":"47","author":"APS Hungin","year":"2018","unstructured":"Hungin APS, Mitchell CR, Whorwell P, Mulligan C, Cole O, Agr\u00e9us L, et al. Systematic review: probiotics in the management of lower gastrointestinal symptoms - an updated evidence-based international consensus. Aliment Pharmacol Ther. 2018;47:1054\u201370.","journal-title":"Aliment Pharmacol Ther"},{"key":"8437_CR28","doi-asserted-by":"crossref","unstructured":"Cheng J, Ouwehand AC. Gastroesophageal reflux disease and probiotics: A systematic review. Nutrients. 2020;12(1):132.","DOI":"10.3390\/nu12010132"},{"key":"8437_CR29","doi-asserted-by":"publisher","first-page":"6817","DOI":"10.1007\/s00253-014-5752-1","volume":"98","author":"J Xin","year":"2014","unstructured":"Xin J, Zeng D, Wang H, Ni X, Yi D, Pan K, et al. Preventing non-alcoholic fatty liver disease through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment in obese mice. Appl Microbiol Biotechnol. 2014;98:6817\u201329.","journal-title":"Appl Microbiol Biotechnol"},{"key":"8437_CR30","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/S0168-8278(02)00142-3","volume":"37","author":"M Chiva","year":"2002","unstructured":"Chiva M, Soriano G, Rochat I, Peralta C, Rochat F, Llovet T, et al. Effect of Lactobacillus johnsonii La1 and antioxidants on intestinal flora and bacterial translocation in rats with experimental cirrhosis. J Hepatol. 2002;37:456\u201362.","journal-title":"J Hepatol"},{"key":"8437_CR31","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.10125","volume":"8","author":"J Xin","year":"2020","unstructured":"Xin J, Zeng D, Wang H, Sun N, Khalique A, Zhao Y, et al. Lactobacillus johnsonii BS15 improves intestinal environment against fluoride-induced memory impairment in mice-a study based on the gut-brain axis hypothesis. PeerJ. 2020;8:e10125.","journal-title":"PeerJ"},{"key":"8437_CR32","doi-asserted-by":"publisher","first-page":"3931","DOI":"10.1002\/fsn3.2989","volume":"10","author":"S Han","year":"2022","unstructured":"Han S, Zheng H, Han F, Zhang X, Zhang G, Ma S, et al. Lactobacillus johnsonii 6084 alleviated sepsis-induced organ injury by modulating gut microbiota. Food Sci Nutr. 2022;10:3931\u201341.","journal-title":"Food Sci Nutr"},{"key":"8437_CR33","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2145843","volume":"14","author":"DJ Jia","year":"2022","unstructured":"Jia DJ, Wang QW, Hu YY, He JM, Ge QW, Qi YD, et al. Lactobacillus johnsonii alleviates colitis by TLR1\/2-STAT3 mediated CD206(+) macrophages(IL-10) activation. Gut Microbes. 2022;14:2145843.","journal-title":"Gut Microbes"},{"key":"8437_CR34","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/mbo3.252","volume":"4","author":"Y Aiba","year":"2015","unstructured":"Aiba Y, Nakano Y, Koga Y, Takahashi K, Komatsu Y. A highly acid-resistant novel strain of Lactobacillus johnsonii 1088 has antibacterial activity, including that against Helicobacter pylori, and inhibits gastrin-mediated acid production in mice. Microbiologyopen. 2015;4:465\u201374.","journal-title":"Microbiologyopen"},{"key":"8437_CR35","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s40168-023-01655-2","volume":"11","author":"Y Wen","year":"2023","unstructured":"Wen Y, Yang L, Wang Z, Liu X, Gao M, Zhang Y, et al. Blocked conversion of Lactobacillus johnsonii derived acetate to butyrate mediates copper-induced epithelial barrier damage in a pig model. Microbiome. 2023;11:218.","journal-title":"Microbiome"},{"key":"8437_CR36","doi-asserted-by":"crossref","unstructured":"Vieth M, Mastracci L, Vakil N, Dent J, Wernersson B, Baldycheva I et al. Epithelial Thickness is a Marker of Gastroesophageal Reflux Disease. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 2016;14:1544-51.e1.","DOI":"10.1016\/j.cgh.2016.06.018"},{"key":"8437_CR37","doi-asserted-by":"publisher","first-page":"e0238852","DOI":"10.1371\/journal.pone.0238852","volume":"15","author":"L Hu","year":"2020","unstructured":"Hu L, Zhang C, Yang K, Li M, Shaker A. Human esophageal myofibroblasts increase squamous epithelial thickness via paracrine mechanisms in an in vitro model of gastroesophageal reflux disease. PLoS One. 2020;15:e0238852.","journal-title":"PLoS One"},{"key":"8437_CR38","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1093\/carcin\/bgs241","volume":"33","author":"E McAdam","year":"2012","unstructured":"McAdam E, Haboubi HN, Forrester G, Eltahir Z, Spencer-Harty S, Davies C, et al. Inducible nitric oxide synthase (iNOS) and nitric oxide (NO) are important mediators of reflux-induced cell signalling in esophageal cells. Carcinogenesis. 2012;33:2035\u201343.","journal-title":"Carcinogenesis"},{"key":"8437_CR39","doi-asserted-by":"crossref","unstructured":"Jiang B, Zhao S, Tao Z, Wen J, Yang Y, Zheng Y et al. Controlled bile acid exposure to oesophageal mucosa causes up-regulation of nuclear \u03b3-H2AX possibly via iNOS induction. Biosci Rep. 2016;36(4):e00357.","DOI":"10.1042\/BSR20160124"},{"key":"8437_CR40","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/mc.20382","volume":"47","author":"NM Vaninetti","year":"2008","unstructured":"Vaninetti NM, Geldenhuys L, Porter GA, Risch H, Hainaut P, Guernsey DL, et al. Inducible nitric oxide synthase, Nitrotyrosine and p53 mutations in the molecular pathogenesis of barrett\u2019s esophagus and esophageal adenocarcinoma. Mol Carcinog. 2008;47:275\u201385.","journal-title":"Mol Carcinog"},{"key":"8437_CR41","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3346\/jkms.2005.20.1.56","volume":"20","author":"JD Bae","year":"2005","unstructured":"Bae JD, Jung KH, Ahn WS, Bae SH, Jang TJ. Expression of inducible nitric oxide synthase is increased in rat barrett\u2019s esophagus induced by duodenal contents reflux. J Korean Med Sci. 2005;20:56\u201360.","journal-title":"J Korean Med Sci"},{"key":"8437_CR42","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1136\/jim-2020-001691","volume":"69","author":"NR Im","year":"2021","unstructured":"Im NR, Kim B, Jung KY, Kim TH, Baek SK. Non-surgical animal model of gastroesophageal reflux disease by overeating induced in mice. J Invest Medicine: Official Publication Am Federation Clin Res. 2021;69:1208\u201314.","journal-title":"J Invest Medicine: Official Publication Am Federation Clin Res"},{"key":"8437_CR43","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/1751-2980.12692","volume":"20","author":"Y Yu","year":"2019","unstructured":"Yu Y, Gao F, Chen X, Zheng S, Zhang J. Changes in the distal esophageal microbiota in Chinese patients with reflux esophagitis. J Dig Dis. 2019;20:18\u201324.","journal-title":"J Dig Dis"},{"key":"8437_CR44","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12103","volume":"25","author":"L Crouzet","year":"2013","unstructured":"Crouzet L, Gaultier E, Del\u2019Homme C, Cartier C, Delmas E, Dapoigny M, et al. The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota. Neurogastroenterol Motil. 2013;25:e272-82.","journal-title":"Neurogastroenterol Motil"},{"key":"8437_CR45","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1053\/j.gastro.2009.07.055","volume":"137","author":"RF Souza","year":"2009","unstructured":"Souza RF, Huo X, Mittal V, Schuler CM, Carmack SW, Zhang HY, et al. Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury. Gastroenterology. 2009;137:1776\u201384.","journal-title":"Gastroenterology"},{"key":"8437_CR46","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1053\/j.gastro.2019.04.013","volume":"157","author":"NS M\u00fcnch","year":"2019","unstructured":"M\u00fcnch NS, Fang HY, Ingermann J, Maurer HC, Anand A, Kellner V, et al. High-fat diet accelerates carcinogenesis in a mouse model of Barrett\u2019s esophagus via interleukin 8 and alterations to the gut microbiome. Gastroenterology. 2019;157:492\u2013506.e2.","journal-title":"Gastroenterology"},{"key":"8437_CR47","doi-asserted-by":"crossref","unstructured":"Markowiak-Kope\u0107 P, \u015ali\u017cewska K. The effect of probiotics on the production of Short-Chain fatty acids by human intestinal Microbiome. Nutrients. 2020;12(4):1107.","DOI":"10.3390\/nu12041107"},{"key":"8437_CR48","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/s41575-022-00631-9","volume":"19","author":"PD Cani","year":"2022","unstructured":"Cani PD, Depommier C, Derrien M, Everard A, de Vos WM. Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms. Nature reviews Gastroenterology & hepatology. 2022;19:625\u201337.","journal-title":"Nature reviews Gastroenterology & hepatology"},{"key":"8437_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2016.17","volume":"5","author":"R Corr\u00eaa-Oliveira","year":"2016","unstructured":"Corr\u00eaa-Oliveira R, Fachi JL, Vieira A, Sato FT, Vinolo MA. Regulation of immune cell function by short-chain fatty acids. Clinical & translational immunology. 2016;5:e73.","journal-title":"Clinical & translational immunology"},{"key":"8437_CR50","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","volume":"165","author":"A Koh","year":"2016","unstructured":"Koh A, De Vadder F, Kovatcheva-Datchary P, B\u00e4ckhed F. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell. 2016;165:1332\u201345.","journal-title":"Cell"},{"key":"8437_CR51","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","volume":"10","author":"D Parada Venegas","year":"2019","unstructured":"Parada Venegas D, De la Fuente MK, Landskron G, Gonz\u00e1lez MJ, Quera R, Dijkstra G, et al. Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Front Immunol. 2019;10:277.","journal-title":"Front Immunol"},{"key":"8437_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-022-00495-3","volume":"23","author":"X Yue","year":"2022","unstructured":"Yue X, Wen S, Long-Kun D, Man Y, Chang S, Min Z, et al. Three important short-chain fatty acids (SCFAs) attenuate the inflammatory response induced by 5-FU and maintain the integrity of intestinal mucosal tight junction. BMC Immunol. 2022;23:19.","journal-title":"BMC Immunol"},{"key":"8437_CR53","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jaci.2022.11.007","volume":"151","author":"JK Tan","year":"2023","unstructured":"Tan JK, Macia L, Mackay CR. Dietary fiber and SCFAs in the regulation of mucosal immunity. J Allergy Clin Immunol. 2023;151:361\u201370.","journal-title":"J Allergy Clin Immunol"},{"key":"8437_CR54","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.gtc.2016.09.004","volume":"46","author":"S Smolinska","year":"2017","unstructured":"Smolinska S, Groeger D, O\u2019Mahony L. Biology of the microbiome 1: interactions with the host immune response. Gastroenterol Clin North Am. 2017;46:19\u201335.","journal-title":"Gastroenterol Clin North Am"},{"key":"8437_CR55","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s00403-018-1865-1","volume":"310","author":"A Krejner","year":"2018","unstructured":"Krejner A, Bruhs A, Mrowietz U, Wehkamp U, Schwarz T, Schwarz A. Decreased expression of G-protein-coupled receptors GPR43 and GPR109a in psoriatic skin can be restored by topical application of sodium butyrate. Arch Dermatol Res. 2018;310:751\u20138.","journal-title":"Arch Dermatol Res"},{"key":"8437_CR56","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1111\/all.15069","volume":"77","author":"MTA Kleuskens","year":"2022","unstructured":"Kleuskens MTA, Haasnoot ML, Herpers BM, Ampting M, Bredenoord AJ, Garssen J, et al. Butyrate and propionate restore interleukin 13-compromised esophageal epithelial barrier function. Allergy. 2022;77:1510\u201321.","journal-title":"Allergy"},{"key":"8437_CR57","doi-asserted-by":"crossref","unstructured":"Lu H, Xu X, Fu D, Gu Y, Fan R, Yi H et al. Butyrate-producing Eubacterium rectale suppresses lymphomagenesis by alleviating the TNF-induced TLR4\/MyD88\/NF-\u03baB axis. Cell host & microbe. 2022;30:1139-50.e7.","DOI":"10.1016\/j.chom.2022.07.003"},{"key":"8437_CR58","doi-asserted-by":"publisher","first-page":"2826","DOI":"10.3748\/wjg.v13.i20.2826","volume":"13","author":"S Tedelind","year":"2007","unstructured":"Tedelind S, Westberg F, Kjerrulf M, Vidal A. Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease. World J Gastroenterol. 2007;13:2826\u201332.","journal-title":"World J Gastroenterol"},{"key":"8437_CR59","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.clnesp.2022.09.015","volume":"52","author":"Z Martin","year":"2022","unstructured":"Martin Z, Spry G, Hoult J, Maimone IR, Tang X, Crichton M, et al. What is the efficacy of dietary, nutraceutical, and probiotic interventions for the management of gastroesophageal reflux disease symptoms? A systematic literature review and meta-analysis. Clin Nutr ESPEN. 2022;52:340\u201352.","journal-title":"Clin Nutr ESPEN"},{"key":"8437_CR60","first-page":"1378","volume":"12","author":"DN Sgouras","year":"2005","unstructured":"Sgouras DN, Panayotopoulou EG, Martinez-Gonzalez B, Petraki K, Michopoulos S, Mentis A. Lactobacillus johnsonii La1 attenuates Helicobacter pylori-associated gastritis and reduces levels of proinflammatory chemokines in C57BL\/6 mice. Clin Diagn Lab Immunol. 2005;12:1378\u201386.","journal-title":"Clin Diagn Lab Immunol"},{"key":"8437_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.micpath.2019.04.020","volume":"132","author":"Y Wang","year":"2019","unstructured":"Wang Y, Li A, Liu J, Mehmood K, Wangdui B, Shi H, et al. L. pseudomesenteroides and L. johnsonii isolated from yaks in Tibet modulate gut microbiota in mice to ameliorate enteroinvasive Escherichia coli-induced diarrhea. Microb Pathog. 2019;132:1\u20139.","journal-title":"Microb Pathog"},{"key":"8437_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.104856","volume":"154","author":"Y Hu","year":"2021","unstructured":"Hu Y, Zhao M, Lu Z, Lv F, Zhao H, Bie X. L. johnsonii, L. plantarum, and L. rhamnosus alleviated Enterohaemorrhagic Escherichia coli-induced diarrhoea in mice by regulating gut microbiota. Microb Pathog. 2021;154:104856.","journal-title":"Microb Pathog"}],"updated-by":[{"DOI":"10.1007\/s11695-026-08517-4","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000}}],"container-title":["Obesity Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-025-08437-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11695-025-08437-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-025-08437-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:02:07Z","timestamp":1772611327000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11695-025-08437-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["8437"],"URL":"https:\/\/doi.org\/10.1007\/s11695-025-08437-9","relation":{},"ISSN":["0960-8923","1708-0428"],"issn-type":[{"value":"0960-8923","type":"print"},{"value":"1708-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]},"assertion":[{"value":"21 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11695-026-08517-4","URL":"https:\/\/doi.org\/10.1007\/s11695-026-08517-4","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All applicable institutional and\/or national guidelines for the care and use of animals were followed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}