{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T18:02:07Z","timestamp":1780164127163,"version":"3.54.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Talent Construction Fund Research Project of Jiangsu Province Geriatric Hospital","award":["IR2021101"],"award-info":[{"award-number":["IR2021101"]}]},{"name":"Research Incubation Startup Fund of Jiangsu Province Geriatric Hospital","award":["FHQD202501"],"award-info":[{"award-number":["FHQD202501"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["OBES SURG"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s11695-026-08523-6","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:28:27Z","timestamp":1775100507000},"page":"2110-2122","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Pain-informed Predictive Model and Mediation Analysis for Postoperative Nausea after Metabolic Bariatric Surgery: Insights from the PAIN OUT Registry"],"prefix":"10.1007","volume":"36","author":[{"given":"Hongxu","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengchi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiahao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanning","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"8523_CR1","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/aas.12884","volume":"61","author":"TA Halliday","year":"2017","unstructured":"Halliday TA, Sundqvist J, Hultin M, et al. Post-operative nausea and vomiting in bariatric surgery patients: an observational study. Acta Anaesthesiol Scand. 2017;61:471\u20139.","journal-title":"Acta Anaesthesiol Scand"},{"key":"8523_CR2","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1213\/ANE.0000000000004833","volume":"131","author":"TJ Gan","year":"2020","unstructured":"Gan TJ, Belani KG, Bergese S, et al. Fourth consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2020;131:411\u201348.","journal-title":"Anesth Analg"},{"key":"8523_CR3","doi-asserted-by":"publisher","first-page":"9217","DOI":"10.1007\/s00464-023-10483-2","volume":"37","author":"X Ding","year":"2023","unstructured":"Ding X, Che J, Xu S, et al. A nomogram to predict postoperative nausea and vomiting in the ward following laparoscopic bariatric surgery. Surg Endosc. 2023;37:9217\u201327.","journal-title":"Surg Endosc"},{"key":"8523_CR4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.bja.2023.04.004","volume":"131","author":"D Benhamou","year":"2023","unstructured":"Benhamou D. Postoperative nausea and vomiting: is the big little problem becoming a smaller little problem? Br J Anaesth. 2023;131:22\u20135.","journal-title":"Br J Anaesth"},{"key":"8523_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e12430","volume":"8","author":"Y Qian","year":"2022","unstructured":"Qian Y, Zhu JK, Hou BL, et al. Risk factors of postoperative nausea and vomiting following ambulatory surgery: a retrospective case-control study. Heliyon. 2022;8:e12430.","journal-title":"Heliyon"},{"key":"8523_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-021-01172-9","volume":"21","author":"RM Elsaid","year":"2021","unstructured":"Elsaid RM, Namrouti AS, Samara AM, et al. Assessment of pain and postoperative nausea and vomiting and their association in the early postoperative period: an observational study from Palestine. BMC Surg. 2021;21:177.","journal-title":"BMC Surg"},{"key":"8523_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1102017","volume":"14","author":"Y Song","year":"2023","unstructured":"Song Y, Zhu J, Dong Z, et al. Incidence and risk factors of postoperative nausea and vomiting following laparoscopic sleeve gastrectomy and its relationship with Helicobacterpylori: a propensity score matching analysis. Front Endocrinol. 2023;14:1102017.","journal-title":"Front Endocrinol"},{"key":"8523_CR8","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/ejp.571","volume":"19","author":"R Zaslansky","year":"2015","unstructured":"Zaslansky R, Rothaug J, Chapman CR, et al. PAIN OUT: the making of an international acute pain registry. Eur J Pain. 2015;19:490\u2013502.","journal-title":"Eur J Pain"},{"key":"8523_CR9","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","volume":"61","author":"E von Elm","year":"2008","unstructured":"von Elm E, Altman DG, Egger M, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61:344\u20139.","journal-title":"J Clin Epidemiol"},{"key":"8523_CR10","doi-asserted-by":"publisher","first-page":"e071018","DOI":"10.1136\/bmj-2022-071018","volume":"380","author":"TPA Debray","year":"2023","unstructured":"Debray TPA, Collins GS, Riley RD, et al. Transparent reporting of multivariable prediction models developed or validated using clustered data: TRIPOD-cluster checklist. BMJ. 2023;380:e071018.","journal-title":"BMJ"},{"key":"8523_CR11","doi-asserted-by":"publisher","first-page":"51","DOI":"10.7326\/M18-1376","volume":"170","author":"RF Wolff","year":"2019","unstructured":"Wolff RF, Moons KGM, Riley RD, et al. PROBAST: a tool to assess the risk of bias and applicability of prediction model studies. Ann Intern Med. 2019;170:51\u20138.","journal-title":"Ann Intern Med"},{"key":"8523_CR12","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000005818","author":"JS Khan","year":"2025","unstructured":"Khan JS, Mulazzani F, Devereaux PJ, et al. Pain as a driver of myocardial injury in hip fracture patients: a HIP fracture accelerated surgical treatment and care track (HIP ATTACK) trial secondary analysis. Anesthesiology. 2025. https:\/\/doi.org\/10.1097\/aln.0000000000005818.","journal-title":"Anesthesiology"},{"key":"8523_CR13","doi-asserted-by":"publisher","first-page":"m4284","DOI":"10.1136\/bmj.m4284","volume":"371","author":"H Nowak","year":"2020","unstructured":"Nowak H, Zech N, Asmussen S, et al. Effect of therapeutic suggestions during general anaesthesia on postoperative pain and opioid use: multicentre randomised controlled trial. BMJ. 2020;371:m4284.","journal-title":"BMJ"},{"key":"8523_CR14","doi-asserted-by":"publisher","first-page":"e0249258","DOI":"10.1371\/journal.pone.0249258","volume":"16","author":"J Bogie","year":"2021","unstructured":"Bogie J, Fleming M, Cullen B, et al. Using graphic modelling to identify modifiable mediators of the association between area-based deprivation at birth and offspring unemployment. PLoS One. 2021;16:e0249258.","journal-title":"PLoS One"},{"key":"8523_CR15","doi-asserted-by":"publisher","first-page":"268","DOI":"10.7326\/M16-2607","volume":"167","author":"TJ VanderWeele","year":"2017","unstructured":"VanderWeele TJ, Ding P. Sensitivity analysis in observational research: introducing the E-value. Ann Intern Med. 2017;167:268\u201374.","journal-title":"Ann Intern Med"},{"key":"8523_CR16","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1136\/amiajnl-2012-000872","volume":"19","author":"P Sarin","year":"2012","unstructured":"Sarin P, Urman RD, Ohno-Machado L. An improved model for predicting postoperative nausea and vomiting in ambulatory surgery patients using physician-modifiable risk factors. J Am Med Inform Assoc. 2012;19:995\u20131002.","journal-title":"J Am Med Inform Assoc"},{"key":"8523_CR17","doi-asserted-by":"publisher","DOI":"10.1111\/aas.70000","volume":"69","author":"TXM Tran","year":"2025","unstructured":"Tran TXM, Wetterslev M, N\u00f8rskov AK, et al. Intraoperative opioid administrations, rescue doses in the post-anaesthesia care unit and clinician-perceived factors for dose adjustments in adults: a Danish nationwide survey. Acta Anaesthesiol Scand. 2025;69:e70000.","journal-title":"Acta Anaesthesiol Scand"},{"key":"8523_CR18","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1016\/j.bja.2024.08.009","volume":"133","author":"M Carron","year":"2024","unstructured":"Carron M, Tamburini E, Linassi F, et al. Efficacy of nonopioid analgesics and adjuvants in multimodal analgesia for reducing postoperative opioid consumption and complications in obesity: a systematic review and network meta-analysis. Br J Anaesth. 2024;133:1234\u201349.","journal-title":"Br J Anaesth"},{"key":"8523_CR19","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1007\/s11695-019-03720-y","volume":"29","author":"SH Emile","year":"2019","unstructured":"Emile SH, Abdel-Razik MA, Elbahrawy K, et al. Impact of ultrasound-guided transversus abdominis plane block on postoperative pain and early outcome after laparoscopic bariatric surgery: a randomized double-blinded controlled trial. Obes Surg. 2019;29:1534\u201341.","journal-title":"Obes Surg"},{"key":"8523_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.934866","volume":"9","author":"Y Gao","year":"2022","unstructured":"Gao Y, Liu L, Cui Y, et al. Postoperative analgesia efficacy of erector spinae plane block in adult abdominal surgery: a systematic review and meta-analysis of randomized trials. Front Med Lausanne. 2022;9:934866.","journal-title":"Front Med Lausanne"},{"key":"8523_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-023-02123-y","volume":"23","author":"X Ding","year":"2023","unstructured":"Ding X, Zhu X, Zhao C, et al. Use of sugammadex is associated with reduced incidence and severity of postoperative nausea and vomiting in adult patients with obesity undergoing laparoscopic bariatric surgery: a post-hoc analysis. BMC Anesthesiol. 2023;23:163.","journal-title":"BMC Anesthesiol"},{"key":"8523_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2253-13-39","volume":"13","author":"RG Hahn","year":"2013","unstructured":"Hahn RG, Ljunggren S. Preoperative insulin resistance reduces complications after hip replacement surgery in non-diabetic patients. BMC Anesthesiol. 2013;13:39.","journal-title":"BMC Anesthesiol"},{"key":"8523_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12051835","author":"X Gu","year":"2023","unstructured":"Gu X, Zhang Y, Wei W, et al. Effects of preoperative anxiety on postoperative outcomes and sleep quality in patients undergoing laparoscopic gynecological surgery. J Clin Med. 2023. https:\/\/doi.org\/10.3390\/jcm12051835.","journal-title":"J Clin Med"},{"key":"8523_CR24","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1111\/anae.16081","volume":"78","author":"TR Grigio","year":"2023","unstructured":"Grigio TR, Timmerman H, Martins JVB, et al. Olanzapine as an add-on, pre-operative anti-emetic drug for postoperative nausea or vomiting: a randomised controlled trial. Anaesthesia. 2023;78:1206\u201314.","journal-title":"Anaesthesia"},{"key":"8523_CR25","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.bja.2023.11.045","volume":"132","author":"E Au","year":"2024","unstructured":"Au E, Zhao K, Belley-C\u00f4t\u00e9 E, et al. The effect of perioperative benzodiazepine administration on postoperative nausea and vomiting: a systematic review and meta-analysis of randomised controlled trials. Br J Anaesth. 2024;132:469\u201382.","journal-title":"Br J Anaesth"},{"key":"8523_CR26","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/EJA.0000000000000979","volume":"36","author":"R Laufenberg-Feldmann","year":"2019","unstructured":"Laufenberg-Feldmann R, M\u00fcller M, Ferner M, et al. Is \u201canxiety sensitivity\u201d predictive of postoperative nausea and vomiting? A prospective observational study. Eur J Anaesthesiol. 2019;36:369\u201374.","journal-title":"Eur J Anaesthesiol"},{"key":"8523_CR27","doi-asserted-by":"crossref","unstructured":"Herndon CM, Jackson KC, Hallin PA 2nd. Management of opioid-induced gastrointestinal effects in patients receiving palliative care. Pharmacotherapy. 2002;22(2):240\u201350.","DOI":"10.1592\/phco.22.3.240.33552"},{"key":"8523_CR28","doi-asserted-by":"publisher","first-page":"6043","DOI":"10.2174\/138161212803582540","volume":"18","author":"F Coluzzi","year":"2012","unstructured":"Coluzzi F, Rocco A, Mandatori I, et al. Non-analgesic effects of opioids: opioid-induced nausea and vomiting: mechanisms and strategies for their limitation. Curr Pharm Des. 2012;18:6043\u201352.","journal-title":"Curr Pharm Des"}],"container-title":["Obesity Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-026-08523-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11695-026-08523-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-026-08523-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T17:58:16Z","timestamp":1780163896000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11695-026-08523-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["8523"],"URL":"https:\/\/doi.org\/10.1007\/s11695-026-08523-6","relation":{},"ISSN":["0960-8923","1708-0428"],"issn-type":[{"value":"0960-8923","type":"print"},{"value":"1708-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]},"assertion":[{"value":"3 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}