{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T19:52:19Z","timestamp":1781639539422,"version":"3.54.5"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006183","name":"Faculdade De Medicina De S\u00e3o Jos\u00e9 Do Rio Preto","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006183","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["OBES SURG"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metabolic Bariatric Surgery (MBS), an effective intervention for severe obesity, elevates the risk of cholelithiasis (CL) due to rapid weight loss and altered biliary metabolism. Ursodeoxycholic acid (UDCA) is increasingly investigated as a prophylactic strategy to mitigate this complication. This scoping review aimed to map and compare UDCA dosage, duration, and initiation timing protocols for CL prevention after MBS. A review was conducted across PubMed\/MEDLINE, Web of Science, and Scopus, selecting 10 articles published between 2014 and 2023. The analyzed literature consistently indicates that UDCA prophylaxis significantly reduced CL incidence from 25 to 40% in control groups to 1.4\u201310.8% in treated groups. Studies commonly reported dosages of 500\u2013600\u00a0mg\/day for 6 months postoperatively were common, with early initiation being crucial. Efficacy is evident for both Sleeve Gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB), with CL relative risks between 0.13 and 0.36. The evidence demonstrates UDCA safety, efficacy, and cost-effectiveness. Collectively, the literature supports UDCA as an effective and safe prophylactic measure against post-MBS cholelithiasis. The identified heterogeneity in protocols underscores the need for standardization to optimize clinical application.<\/jats:p>","DOI":"10.1007\/s11695-026-08544-1","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:11:50Z","timestamp":1772165510000},"page":"1890-1898","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Udca Dosage, Duration, and Initiation Timing for Post-metabolic Bariatric Surgery Scholelithiasis Prevention: A Scoping Review"],"prefix":"10.1007","volume":"36","author":[{"given":"Matheus Querino","family":"da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikaell Alexandre Gouvea","family":"Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Daniel","family":"de Souza Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"8544_CR1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s11605-022-05567-8","volume":"27","author":"F Amorim-Cruz","year":"2023","unstructured":"Amorim-Cruz F, Santos-Sousa H, Ribeiro M, Nogueiro J, Pereira A, Resende F, et al. Risk and prophylactic management of gallstone disease in bariatric surgery: a systematic review and A bayesian meta-analysis. J Gastrointest Surg. 2023;27:433\u201348. https:\/\/doi.org\/10.1007\/s11605-022-05567-8.","journal-title":"J Gastrointest Surg"},{"key":"8544_CR2","doi-asserted-by":"publisher","first-page":"559064","DOI":"10.3389\/fsurg.2020.559064","volume":"7","author":"MA Aldriweesh","year":"2020","unstructured":"Aldriweesh MA, Aljahdali GL, Shafaay EA, Alangari DZ, Alhamied NA, Alradhi HA, et al. The incidence and risk factors of cholelithiasis development after bariatric surgery in Saudi arabia: A Two-Center retrospective cohort study. Front Surg. 2020;7:559064. https:\/\/doi.org\/10.3389\/fsurg.2020.559064.","journal-title":"Front Surg"},{"key":"8544_CR3","unstructured":"Vural A, Goksu K, Kahraman AN, Boy FN, Anil BS, Fersahoglu MM. Increased gallstone formation after sleeve gastrectomy and the preventive role of ursodeoxycholic acid."},{"key":"8544_CR4","doi-asserted-by":"publisher","unstructured":"Buyuker F, Sermet M, Ozsoy MS, Tosun S, Ekinci \u00d6, Baysal H, et al. The effect of ursodeoxycholic acid in dissolving gallstones formed after laparoscopic sleeve gastrectomy: retrospective cohort study. Langenbecks Arch Surg Springer Sci Bus Media Deutschland GmbH. 2025;410. https:\/\/doi.org\/10.1007\/s00423-025-03656-1.","DOI":"10.1007\/s00423-025-03656-1"},{"key":"8544_CR5","doi-asserted-by":"publisher","unstructured":"Komorniak N, Pawlus J, Gawe\u0142 K, Hawry\u0142kowicz V, Stachowska E, Cholelithiasis. Gut microbiota and bile acids after bariatric Surgery-Can cholelithiasis be prevented by modulating the microbiota? Literature Rev Nutrients. 2024;16. https:\/\/doi.org\/10.3390\/nu16152551.","DOI":"10.3390\/nu16152551"},{"key":"8544_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12944-023-01774-7","volume":"22","author":"Y Dai","year":"2023","unstructured":"Dai Y, Luo B, Li W. Incidence and risk factors for cholelithiasis after bariatric surgery: a systematic review and meta-analysis. Lipids Health Dis. 2023;22:5. https:\/\/doi.org\/10.1186\/s12944-023-01774-7.","journal-title":"Lipids Health Dis"},{"key":"8544_CR7","doi-asserted-by":"publisher","first-page":"e40549","DOI":"10.7759\/cureus.40549","volume":"15","author":"RA Altalhi","year":"2023","unstructured":"Altalhi RA, Alsaqqa RM, Alasmari RM, Aljuaid A, Althobaiti L, Mahfouz MEM. The incidence of cholelithiasis after bariatric surgery in Saudi Arabia and its associated risk factors. Cureus. 2023;15:e40549. https:\/\/doi.org\/10.7759\/cureus.40549.","journal-title":"Cureus"},{"key":"8544_CR8","doi-asserted-by":"publisher","first-page":"1506780","DOI":"10.3389\/fsurg.2025.1506780","volume":"12","author":"S Chen","year":"2025","unstructured":"Chen S, Zheng Y, Cai J, Wu Y, Chen X. Gallstones after bariatric surgery: mechanisms and prophylaxis. Front Surg. 2025;12:1506780. https:\/\/doi.org\/10.3389\/fsurg.2025.1506780.","journal-title":"Front Surg"},{"key":"8544_CR9","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1007\/s11695-023-06581-8","volume":"33","author":"MSS Guman","year":"2023","unstructured":"Guman MSS, Haal S, Acherman YIZ, van de Laar AWL, Nieuwdorp M, Voermans RP, et al. Ursodeoxycholic acid use after bariatric surgery: effects on metabolic and inflammatory blood markers. Obes Surg. 2023;33:1773\u201381. https:\/\/doi.org\/10.1007\/s11695-023-06581-8.","journal-title":"Obes Surg"},{"key":"8544_CR10","doi-asserted-by":"publisher","first-page":"6396","DOI":"10.1007\/s00464-021-08980-3","volume":"36","author":"MA Salman","year":"2022","unstructured":"Salman MA, Salman A, Mohamed US, Hussein AM, Ameen MA, Omar HSE, et al. Ursodeoxycholic acid for the prevention of gall stones after laparoscopic sleeve gastrectomy: a prospective controlled study. Surg Endosc. 2022;36:6396\u2013402. https:\/\/doi.org\/10.1007\/s00464-021-08980-3.","journal-title":"Surg Endosc"},{"key":"8544_CR11","doi-asserted-by":"publisher","unstructured":"Stokes CS, Gluud LL, Casper M, Lammert F. Ursodeoxycholic acid and diets higher in fat prevent gallbladder stones during weight loss: A meta-analysis of randomized controlled trials. Clinical gastroenterology and hepatology. W.B. 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