{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:02:50Z","timestamp":1776265370493,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Natural Science Foundation of Shanghai"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["OBES SURG"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s11695-026-08547-y","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T23:15:56Z","timestamp":1772320556000},"page":"1607-1620","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut Microbiota and Bile Acid Profiles as Predictors of PCOS Remission: Findings from a Sleeve Gastrectomy Treatment Study"],"prefix":"10.1007","volume":"36","author":[{"given":"Shaoqian","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingxia","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aibo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiayang","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengmin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqiong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiqiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"issue":"10","key":"8547_CR1","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1210\/clinem\/dgad463","volume":"108","author":"HJ Teede","year":"2023","unstructured":"Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, et al. Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2023;108(10):2447\u201369. PubMed PMID: 37580314. Pubmed Central PMCID: PMC10505534. Epub 2023\/08\/15. eng.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"8547_CR2","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s42000-020-00219-5","volume":"19","author":"C Fu","year":"2020","unstructured":"Fu C, Minjie C, Weichun Z, Huihuang Y, Guishan C, Qingxia H, et al. Efficacy of sex hormone-binding globulin on predicting metabolic syndrome in newly diagnosed and untreated patients with polycystic ovary syndrome. Horm (Athens). 2020;19(3):439\u201345. PubMed PMID: 32562143. Epub 2020\/06\/21. eng.","journal-title":"Horm (Athens)"},{"issue":"5","key":"8547_CR3","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/nrendo.2018.24","volume":"14","author":"HF Escobar-Morreale","year":"2018","unstructured":"Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14(5):270\u201384. PubMed PMID: 29569621. Epub 2018\/03\/24. eng.","journal-title":"Nat Rev Endocrinol"},{"key":"8547_CR4","doi-asserted-by":"publisher","first-page":"117955811987404","DOI":"10.1177\/1179558119874042","volume":"13","author":"TM Barber","year":"2019","unstructured":"Barber TM, Hanson P, Weickert MO, Franks S. Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies. Clin Med Insights Reprod Health. 2019;13:1179558119874042. PubMed PMID: 31523137. Pubmed Central PMCID: PMC6734597. Epub 2019\/09\/17. eng.","journal-title":"Clin Med Insights Reprod Health"},{"issue":"4","key":"8547_CR5","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.fertnstert.2016.12.029","volume":"107","author":"P Liang","year":"2017","unstructured":"Liang P, Xi L, Shi J, Li W, Zhao S, Deng Y, et al. Prevalence of polycystic ovary syndrome in Chinese obese women of reproductive age with or without metabolic syndrome. Fertil Steril. 2017;107(4):1048\u201354. PubMed PMID: 28238496. Epub 2017\/02\/28. eng.","journal-title":"Fertil Steril"},{"issue":"6","key":"8547_CR6","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1159\/000479371","volume":"88","author":"L Ib\u00e1\u00f1ez","year":"2017","unstructured":"Ib\u00e1\u00f1ez L, Oberfield SE, Witchel S, Auchus RJ, Chang RJ, Codner E, et al. An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence. Horm Res Paediatr. 2017;88(6):371\u201395. PubMed PMID: 29156452. Epub 2017\/11\/21. eng.","journal-title":"Horm Res Paediatr"},{"issue":"4","key":"8547_CR7","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1210\/jc.2018-00241","volume":"103","author":"KA Martin","year":"2018","unstructured":"Martin KA, Anderson RR, Chang RJ, Ehrmann DA, Lobo RA, Murad MH, et al. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103(4):1233\u201357. PubMed PMID: 29522147. Epub 2018\/03\/10. eng.","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"8547_CR8","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1210\/jc.2013-2350","volume":"98","author":"RS Legro","year":"2013","unstructured":"Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2013;98(12):4565\u201392. PubMed PMID: 24151290. Pubmed Central PMCID: PMC5399492. Epub 2013\/10\/24. eng.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"8547_CR9","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/ijo.2009.213","volume":"34","author":"JG Christian","year":"2010","unstructured":"Christian JG, Tsai AG, Bessesen DH. Interpreting weight losses from lifestyle modification trials: using categorical data. Int J Obes (Lond). 2010;34(1):207\u20139. PubMed PMID: 19823184. Pubmed Central PMCID: PMC2897147. Epub 2009\/10\/14. eng.","journal-title":"Int J Obes (Lond)"},{"issue":"4","key":"8547_CR10","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1093\/humupd\/dmx012","volume":"23","author":"HF Escobar-Morreale","year":"2017","unstructured":"Escobar-Morreale HF, Santacruz E, Luque-Ram\u00edrez M, Botella Carretero JI. Prevalence of \u2018obesity-associated gonadal dysfunction\u2019 in severely obese men and women and its resolution after bariatric surgery: a systematic review and meta-analysis. Hum Reprod Update. 2017;23(4):390\u2013408. PubMed PMID: 28486593. Epub 2017\/05\/10. eng.","journal-title":"Hum Reprod Update"},{"issue":"7418","key":"8547_CR11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature11450","volume":"490","author":"J Qin","year":"2012","unstructured":"Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012;490(7418):55\u201360. PubMed PMID: 23023125. Epub 2012\/10\/02. eng.","journal-title":"Nature"},{"issue":"7516","key":"8547_CR12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature13568","volume":"513","author":"N Qin","year":"2014","unstructured":"Qin N, Yang F, Li A, Prifti E, Chen Y, Shao L, et al. Alterations of the human gut microbiome in liver cirrhosis. Nature. 2014;513(7516):59\u201364. PubMed PMID: 25079328. Epub 2014\/08\/01. eng.","journal-title":"Nature"},{"issue":"7","key":"8547_CR13","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/nm.4358","volume":"23","author":"R Liu","year":"2017","unstructured":"Liu R, Hong J, Xu X, Feng Q, Zhang D, Gu Y, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat Med. 2017;23(7):859\u201368. PubMed PMID: 28628112. Epub 2017\/06\/20. eng.","journal-title":"Nat Med"},{"issue":"1","key":"8547_CR14","doi-asserted-by":"publisher","first-page":"2462261","DOI":"10.1080\/19490976.2025.2462261","volume":"17","author":"S Zhao","year":"2025","unstructured":"Zhao S, Lin H, Li W, Xu X, Wu Q, Wang Z, et al. Post sleeve gastrectomy-enriched gut commensal Clostridia promotes secondary bile acid increase and weight loss. Gut Microbes. 2025;17(1):2462261. PubMed PMID: 39915243. Pubmed Central PMCID: PMC11810084. Epub 2025\/02\/07. eng.","journal-title":"Gut Microbes"},{"issue":"4","key":"8547_CR15","doi-asserted-by":"publisher","first-page":"e13417","DOI":"10.1111\/eci.13417","volume":"51","author":"G Mammadova","year":"2021","unstructured":"Mammadova G, Ozkul C, Yilmaz Isikhan S, Acikgoz A, Yildiz BO. Characterization of gut microbiota in polycystic ovary syndrome: Findings from a lean population. Eur J Clin Invest. 2021;51(4):e13417. PubMed PMID: 32991745. Epub 2020\/09\/30. eng.","journal-title":"Eur J Clin Invest"},{"issue":"1","key":"8547_CR16","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13048-021-00799-9","volume":"14","author":"F He","year":"2021","unstructured":"He F, Li Y. The gut microbial composition in polycystic ovary syndrome with insulin resistance: findings from a normal-weight population. J Ovarian Res. 2021;14(1):50. PubMed PMID: 33773586. Pubmed Central PMCID: PMC8005233. Epub 2021\/03\/29. eng.","journal-title":"J Ovarian Res"},{"issue":"6","key":"8547_CR17","doi-asserted-by":"publisher","first-page":"e2134","DOI":"10.1210\/clinem\/dgz263","volume":"105","author":"B Jobira","year":"2020","unstructured":"Jobira B, Frank DN, Pyle L, Silveira LJ, Kelsey MM, Garcia-Reyes Y, et al. Obese Adolescents With PCOS Have Altered Biodiversity and Relative Abundance in Gastrointestinal Microbiota. J Clin Endocrinol Metab. 2020;105(6):e2134. 44. PubMed PMID: 31970418. Pubmed Central PMCID: PMC7147870. Epub 2020\/01\/24. eng.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"8547_CR18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.tem.2017.11.002","volume":"29","author":"A Molinaro","year":"2018","unstructured":"Molinaro A, Wahlstr\u00f6m A, Marschall HU. Role of Bile Acids in Metabolic Control. Trends Endocrinol Metab. 2018;29(1):31\u201341. PubMed PMID: 29195686. Epub 2017\/12\/03. eng.","journal-title":"Trends Endocrinol Metab"},{"issue":"8","key":"8547_CR19","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/s41591-019-0509-0","volume":"25","author":"X Qi","year":"2019","unstructured":"Qi X, Yun C, Sun L, Xia J, Wu Q, Wang Y, et al. Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med. 2019;25(8):1225\u201333. PubMed PMID: 31332392. Pubmed Central PMCID: PMC7376369. Epub 2019\/07\/25. eng.","journal-title":"Nat Med"},{"key":"8547_CR20","doi-asserted-by":"crossref","unstructured":"Revised. 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41\u2009\u2013\u20097","DOI":"10.1093\/humrep\/deh098"},{"issue":"9","key":"8547_CR21","doi-asserted-by":"publisher","first-page":"e3619","DOI":"10.1210\/clinem\/dgab297","volume":"106","author":"J Hong","year":"2021","unstructured":"Hong J, Bo T, Xi L, Xu X, He N, Zhan Y, et al. Reversal of Functional Brain Activity Related to Gut Microbiome and Hormones After VSG Surgery in Patients With Obesity. J Clin Endocrinol Metab. 2021;106(9):e3619\u201333. PubMed PMID: 33950216. Pubmed Central PMCID: PMC8372652. Epub 2021\/05\/06. eng.","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"8547_CR22","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1016\/S0895-4356(96)00236-3","volume":"49","author":"P Peduzzi","year":"1996","unstructured":"Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol. 1996;49(12):1373\u20139. PubMed PMID: 8970487. Epub 1996\/12\/01. eng.","journal-title":"J Clin Epidemiol"},{"key":"8547_CR23","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780198524847.001.0001","volume-title":"Analysis of Longitudinal Data","author":"PJ Diggle","year":"2002","unstructured":"Diggle PJ, Heagerty PJ, Liang KY, Zeger SL. Analysis of Longitudinal Data. Oxford, UK: Oxford University Press; 2002."},{"issue":"8","key":"8547_CR24","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1016\/j.soard.2021.04.009","volume":"17","author":"Z Tian","year":"2021","unstructured":"Tian Z, Zhang YC, Wang Y, Chang XH, Zhu HL, Zhao Y. Effects of bariatric surgery on patients with obesity and polycystic ovary syndrome: a meta-analysis. Surg Obes Relat Dis. 2021;17(8):1399\u2013408. PubMed PMID: 34006495. Epub 2021\/05\/20. eng.","journal-title":"Surg Obes Relat Dis"},{"issue":"12","key":"8547_CR25","doi-asserted-by":"publisher","first-page":"6364","DOI":"10.1210\/jc.2005-1490","volume":"90","author":"HF Escobar-Morreale","year":"2005","unstructured":"Escobar-Morreale HF, Botella-Carretero JI, Alvarez-Blasco F, Sancho J, San Mill\u00e1n JL. The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery. J Clin Endocrinol Metab. 2005;90(12):6364\u20139. PubMed PMID: 16189250. Epub 2005\/09\/29. eng.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"8547_CR26","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s11695-021-05820-0","volume":"32","author":"T Tatarchuk","year":"2022","unstructured":"Tatarchuk T, Todurov I, Anagnostis P, Tutchenko T, Pedachenko N, Glamazda M, et al. The Effect of Gastric Sleeve Resection on Menstrual Pattern and Ovulation in Premenopausal Women with Classes III-IV Obesity. Obes Surg. 2022;32(3):599\u2013606. PubMed PMID: 34817794. Epub 2021\/11\/25. eng.","journal-title":"Obes Surg"},{"issue":"8","key":"8547_CR27","doi-asserted-by":"publisher","first-page":"e3217","DOI":"10.1210\/clinem\/dgac294","volume":"107","author":"L Hu","year":"2022","unstructured":"Hu L, Ma L, Xia X, Ying T, Zhou M, Zou S, et al. Efficacy of Bariatric Surgery in the Treatment of Women With Obesity and Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2022;107(8):e3217\u201329. PubMed PMID: 35554540. Pubmed Central PMCID: PMC9282367. Epub 2022\/05\/14. eng.","journal-title":"J Clin Endocrinol Metab"},{"key":"8547_CR28","doi-asserted-by":"publisher","first-page":"101886","DOI":"10.1016\/j.redox.2021.101886","volume":"41","author":"T Li","year":"2021","unstructured":"Li T, Zhang T, Gao H, Liu R, Gu M, Yang Y, et al. Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction. Redox Biol. 2021;41(0):101886.","journal-title":"Redox Biol"},{"issue":"1","key":"8547_CR29","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/s12916-023-02975-8","volume":"21","author":"P Li","year":"2023","unstructured":"Li P, Shuai P, Shen S, Zheng H, Sun P, Zhang R, et al. Perturbations in gut microbiota composition in patients with polycystic ovary syndrome: a systematic review and meta-analysis. BMC Med. 2023;21(1):302. PubMed PMID: 37559119. Pubmed Central PMCID: PMC10413517. Epub 2023\/08\/10. eng.","journal-title":"BMC Med"},{"issue":"5","key":"8547_CR30","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1080\/19490976.2020.1737307","volume":"11","author":"C Depommier","year":"2020","unstructured":"Depommier C, Van Hul M, Everard A, Delzenne NM, De Vos WM, Cani PD. Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice. Gut Microbes. 2020;11(5):1231\u201345. PubMed PMID: 32167023. Pubmed Central PMCID: PMC7524283. Epub 2020\/03\/14. eng.","journal-title":"Gut Microbes"},{"issue":"1","key":"8547_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/JME-16-0054","volume":"58","author":"S Zhao","year":"2017","unstructured":"Zhao S, Liu W, Wang J, Shi J, Sun Y, Wang W, et al. Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice. J Mol Endocrinol. 2017;58(1):1\u201314. PubMed PMID: 27821438. Epub 2016\/11\/09. eng.","journal-title":"J Mol Endocrinol"},{"issue":"1","key":"8547_CR32","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","volume":"24","author":"A Wahlstr\u00f6m","year":"2016","unstructured":"Wahlstr\u00f6m A, Sayin SI, Marschall HU, B\u00e4ckhed F. Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism. Cell Metab. 2016;24(1):41\u201350. PubMed PMID: 27320064. Epub 2016\/06\/21. eng.","journal-title":"Cell Metab"},{"issue":"6","key":"8547_CR33","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1093\/ajcn\/nqac252","volume":"116","author":"YY Wu","year":"2022","unstructured":"Wu YY, Gou W, Yan Y, Liu CY, Yang Y, Chen D, et al. Gut microbiota and acylcarnitine metabolites connect the beneficial association between equol and adiposity in adults: a prospective cohort study. Am J Clin Nutr. 2022;116(6):1831\u201341. PubMed PMID: 36095141. Epub 2022\/09\/13. eng.","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"8547_CR34","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","volume":"47","author":"JM Ridlon","year":"2006","unstructured":"Ridlon JM, Kang DJ, Hylemon PB. Bile salt biotransformations by human intestinal bacteria. J Lipid Res. 2006;47(2):241\u201359. PubMed PMID: 16299351. Epub 2005\/11\/22. eng.","journal-title":"J Lipid Res"},{"key":"8547_CR35","doi-asserted-by":"publisher","first-page":"108238","DOI":"10.1016\/j.pharmthera.2022.108238","volume":"237","author":"J Cai","year":"2022","unstructured":"Cai J, Rimal B, Jiang C, Chiang JYL, Patterson AD. Bile acid metabolism and signaling, the microbiota, and metabolic disease. Pharmacol Ther. 2022;237:108238. PubMed PMID: 35792223. Epub 2022\/07\/07. eng.","journal-title":"Pharmacol Ther"},{"issue":"5","key":"8547_CR36","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1210\/clinem\/dgae399","volume":"110","author":"ECE Meessen","year":"2025","unstructured":"Meessen ECE, Majait S, Ay \u00dc, Olde Damink SW, Romijn JA, Holst JJ, et al. Glycodeoxycholic Acid Inhibits Primary Bile Acid Synthesis With Minor Effects on Glucose and Lipid Homeostasis in Humans. J Clin Endocrinol Metab. 2025;110(5):1468\u201377. PubMed PMID: 38864544. Pubmed Central PMCID: PMC12012696. Epub 2024\/06\/12. eng.","journal-title":"J Clin Endocrinol Metab"},{"key":"8547_CR37","doi-asserted-by":"publisher","unstructured":"Yang X, Wu R, Qi D, Fu L, Song T, Wang Y et al. Profile of Bile Acid Metabolomics in the Follicular Fluid of PCOS Patients. Metabolites. 2021;11(12):845. https:\/\/doi.org\/10.3390\/metabo11120845","DOI":"10.3390\/metabo11120845"},{"key":"8547_CR38","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jsbmb.2019.03.005","volume":"189","author":"B Zhang","year":"2019","unstructured":"Zhang B, Shen S, Gu T, Hong T, Liu J, Sun J, et al. Increased circulating conjugated primary bile acids are associated with hyperandrogenism in women with polycystic ovary syndrome. J Steroid Biochem Mol Biol. 2019;189:171\u20135. PubMed PMID: 30849463. Epub 2019\/03\/09. eng.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"8","key":"8547_CR39","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/nrendo.2014.60","volume":"10","author":"F Kuipers","year":"2014","unstructured":"Kuipers F, Bloks VW, Groen AK. Beyond intestinal soap\u2013bile acids in metabolic control. Nat Rev Endocrinol. 2014;10(8):488\u201398. PubMed PMID: 24821328. Epub 2014\/05\/14. eng.","journal-title":"Nat Rev Endocrinol"},{"key":"8547_CR40","doi-asserted-by":"publisher","first-page":"853501","DOI":"10.1155\/2011\/853501","volume":"2011","author":"X Chen","year":"2011","unstructured":"Chen X, Lou G, Meng Z, Huang W. TGR5: a novel target for weight maintenance and glucose metabolism. Exp Diabetes Res. 2011;2011:853501. PubMed PMID: 21754919. Pubmed Central PMCID: PMC3132465. Epub 2011\/07\/15. eng.","journal-title":"Exp Diabetes Res"},{"issue":"6","key":"8547_CR41","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1016\/j.jhep.2014.12.034","volume":"62","author":"M Mueller","year":"2015","unstructured":"Mueller M, Thorell A, Claudel T, Jha P, Koefeler H, Lackner C, et al. Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity. J Hepatol. 2015;62(6):1398\u2013404. PubMed PMID: 25617503. Pubmed Central PMCID: PMC4451470. Epub 2015\/01\/27. eng.","journal-title":"J Hepatol"},{"key":"8547_CR42","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.3389\/fmicb.2018.02849","volume":"9","author":"LJ Palmieri","year":"2018","unstructured":"Palmieri LJ, Rainteau D, Sokol H, Beaugerie L, Dior M, Coffin B, et al. Inhibitory Effect of Ursodeoxycholic Acid on Clostridium difficile Germination Is Insufficient to Prevent Colitis: A Study in Hamsters and Humans. Front Microbiol. 2018;9:2849. PubMed PMID: 30524414. Pubmed Central PMCID: PMC6262072. Epub 2018\/12\/14. eng.","journal-title":"Front Microbiol"},{"issue":"4","key":"8547_CR43","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1136\/gutjnl-2015-310904","volume":"66","author":"T Duparc","year":"2017","unstructured":"Duparc T, Plovier H, Marrachelli VG, Van Hul M, Essaghir A, St\u00e5hlman M, et al. Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism. Gut. 2017;66(4):620\u201332. PubMed PMID: 27196572. Pubmed Central PMCID: PMC5529962. Epub 2016\/05\/20. eng.","journal-title":"Gut"},{"issue":"3","key":"8547_CR44","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/liv.13562","volume":"38","author":"M Mueller","year":"2018","unstructured":"Mueller M, Castro RE, Thorell A, Marschall HU, Auer N, Herac M, et al. Ursodeoxycholic acid: Effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients. Liver Int. 2018;38(3):523\u201331. PubMed PMID: 28853202. Pubmed Central PMCID: PMC5836915. Epub 2017\/08\/31. eng.","journal-title":"Liver Int"}],"updated-by":[{"DOI":"10.1007\/s11695-026-08572-x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000}}],"container-title":["Obesity Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-026-08547-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11695-026-08547-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-026-08547-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:03:15Z","timestamp":1776261795000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11695-026-08547-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["8547"],"URL":"https:\/\/doi.org\/10.1007\/s11695-026-08547-y","relation":{},"ISSN":["0960-8923","1708-0428"],"issn-type":[{"value":"0960-8923","type":"print"},{"value":"1708-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"assertion":[{"value":"5 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11695-026-08572-x","URL":"https:\/\/doi.org\/10.1007\/s11695-026-08572-x","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}