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While metabolic bariatric surgery provides durable weight loss and metabolic improvement, optimal anthropometric and body composition targets for hyperglycemia remission remain undefined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective cohort study of women undergoing sleeve gastrectomy (SG) in Melbourne, Australia (2019\u20132022). Anthropometric, biochemical, and dual-energy X-ray absorptiometry (DXA) derived body composition data were collected at baseline and 12 months post-surgery. The primary outcome was change in body composition. Secondary outcomes included percentage total body weight loss (%TBWL), fat-mass loss, and central adiposity thresholds associated with hyperglycemia remission, defined as HbA1c\u2009&lt;\u20096.0% or fasting glucose\u2009&lt;\u20096.0 mmol\/L without medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 50 patients recruited, 39 completed the study. Marked reductions in fat mass and central adiposity were observed. All seven participants with T2D achieved hyperglycemia remission; five discontinued hypoglycemic therapy. Among those with prediabetes\/T2D (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914), 93% achieved hyperglycemia remission. ROC analyses identified candidate thresholds associated with remission, including\u2009\u2265\u200921.9% TBWL (AUC 0.85), \u2265\u200975.8% fat-mass contribution to weight loss (AUC 0.85), postoperative waist circumference\u2009\u2264\u2009107\u00a0cm (AUC 0.93), and waist-to-height ratio\u2009\u2264\u20090.72 (AUC 0.85). Logistic regression combining %TBWL and WHtR yielded an AUC of 1.00; however, this likely reflects overfitting given the very small remission subgroup.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Total weight loss and reductions in central adiposity were strongly associated with hyperglycemia remission after SG in women. Achieving 20\u201325% TBWL, \u2265\u200975% fat-mass contribution to weight loss, and postoperative waist circumference\u2009&lt;\u2009107\u00a0cm may represent candidate treatment targets, but require validation in larger independent cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11695-026-08570-z","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:10:39Z","timestamp":1773241839000},"page":"1727-1735","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is All Weight Loss Equal Following Sleeve Gastrectomy? 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PS reports grants from NHMRC. Eli Lilly, Novo Nordisk for lectures and advisory boards, medical equipment.WB reports grants from Johnson and Johnson, Medtronic, GORE, Applied Medical, Novo Nordisc, NHMRC, Myerton and the Australian Commonwealth Government. Personal fees from Johnson and Johnson, GORE, Novo Nordisc, Pfizer, Medtronic, Lily and Merck. Sharpe and Dohme for lectures and advisory boards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}