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Secondary outcomes included risk factors for POB, thromboembolic events (TEE), and mortality. In this mixed cohort study, consecutive patients undergoing RYGB between 2020 and 2025 were divided according to systematic TXA use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 678 patients, 347 (51.2%) received TXA. This group\u2019s mean age was 37 years and their mean BMI 40.4\u00a0kg\/m\u00b2. POB occurred in 21 patients (3.1%). TXA significantly reduced POB risk (OR 4.25;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Being of male sex increased POB risk (OR 2.59;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031). No differences in TEE or mortality were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TXA reduced POB risk by 70\u201378%. It was also noted that male sex was an independent risk factor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11695-026-08658-6","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T14:45:55Z","timestamp":1776350755000},"page":"2511-2517","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prophylactic Tranexamic Acid as Prevention for Early Postoperative Bleeding after Roux-en-Y Gastric Bypass"],"prefix":"10.1007","volume":"36","author":[{"given":"Jo\u00e3o Victor","family":"Vecchi Ferri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Scardua Cocicov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor","family":"Mamoru Haida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Alfredo","family":"Sadowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner","family":"Herbert Sobottka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Rodrigues Alves Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Caetano","family":"Dallegrave Marchesini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Coutinho Teixeira de Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"8658_CR1","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1097\/00000658-200010000-00007","volume":"232","author":"PR Schauer","year":"2000","unstructured":"Schauer PR, Ikramuddin S, Gourash W. 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