{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:32:50Z","timestamp":1793111570138,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["OBES SURG"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s11695-026-08898-6","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:58:03Z","timestamp":1786607883000},"page":"5670-5677","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimized Amoxicillin Dosing is Associated with Higher Helicobacter pylori Eradication in Metabolic and Bariatric Surgery Candidates: A Retrospective Cohort Study"],"prefix":"10.1007","volume":"36","author":[{"given":"Oscar","family":"Laudanno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Ahumar\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Thom\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Gollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"8898_CR1","doi-asserted-by":"publisher","first-page":"5341","DOI":"10.1007\/s12325-025-03352-y","volume":"42","author":"V Singh","year":"2025","unstructured":"Singh V, Sun J, Cheng S, et al. Obesity as a chronic disease: a narrative review of evolving definitions, management strategies, and cardiometabolic prioritization. Adv Ther. 2025;42:5341\u201364.","journal-title":"Adv Ther"},{"key":"8898_CR2","doi-asserted-by":"publisher","first-page":"100375","DOI":"10.1016\/j.metop.2025.100375","volume":"27","author":"SK Ahmed","year":"2025","unstructured":"Ahmed SK, Mohammed RA, Obesity. Prevalence, causes, consequences, management, preventive strategies and future research directions. Metab Open. 2025;27:100375.","journal-title":"Metab Open"},{"key":"8898_CR3","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1002\/phar.2769","volume":"43","author":"L Meng","year":"2023","unstructured":"Meng L, Mui E, Ha DR, et al. Comprehensive guidance for antibiotic dosing in obese adults: 2022 update. Pharmacotherapy. 2023;43:226\u201346.","journal-title":"Pharmacotherapy"},{"key":"8898_CR4","doi-asserted-by":"publisher","first-page":"3790","DOI":"10.1007\/s11695-024-07505-w","volume":"34","author":"O Laudanno","year":"2024","unstructured":"Laudanno O, Ahumar\u00e1n G, Thom\u00e9 M, et al. Relationship between obesity severity and Helicobacter pylori eradication in patients undergoing bariatric and metabolic surgery: a post hoc analysis. Obes Surg. 2024;34:3790\u20135.","journal-title":"Obes Surg"},{"key":"8898_CR5","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1001\/jama.2020.12567","volume":"324","author":"DE Arterburn","year":"2020","unstructured":"Arterburn DE, Telem DA, Kushner RF, et al. Benefits and risks of bariatric surgery in adults: a review. JAMA. 2020;324:879\u201387.","journal-title":"JAMA"},{"key":"8898_CR6","doi-asserted-by":"publisher","first-page":"e071027","DOI":"10.1136\/bmj-2022-071027","volume":"383","author":"AP Courcoulas","year":"2023","unstructured":"Courcoulas AP, Daigle CR, Arterburn DE. Long term outcomes of metabolic\/bariatric surgery in adults. BMJ. 2023;383:e071027.","journal-title":"BMJ"},{"key":"8898_CR7","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/j.soard.2022.08.013","volume":"18","author":"D Eisenberg","year":"2022","unstructured":"Eisenberg D, Shikora SA, Aarts E, et al. 2022 American Society for Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO): indications for metabolic and bariatric surgery. Surg Obes Relat Dis. 2022;18:1345\u201356.","journal-title":"Surg Obes Relat Dis"},{"key":"8898_CR8","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1007\/s00464-020-07555-y","volume":"34","author":"N Di Lorenzo","year":"2020","unstructured":"Di Lorenzo N, Antoniou SA, Batterham RL, et al. Clinical practice guidelines of the European Association for Endoscopic Surgery (EAES) on bariatric surgery: update 2020 endorsed by IFSO-EC, EASO and ESPCOP. Surg Endosc. 2020;34:2332\u201358.","journal-title":"Surg Endosc"},{"key":"8898_CR9","doi-asserted-by":"publisher","first-page":"95","DOI":"10.47196\/diab.v49i3.206","volume":"49","author":"MA Ackermann","year":"2015","unstructured":"Ackermann MA, Alva O, \u00c1lvarez G, et al. Consenso argentino de cirug\u00eda metab\u00f3lica. Rev Soc Argent Diabetes. 2015;49:95\u2013110.","journal-title":"Rev Soc Argent Diabetes"},{"key":"8898_CR10","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.gie.2014.09.044","volume":"81","author":"JA Evans","year":"2015","unstructured":"Evans JA, Muthusamy VR, Acosta RD, et al. The role of endoscopy in the bariatric surgery patient. Gastrointest Endosc. 2015;81:1063\u201372.","journal-title":"Gastrointest Endosc"},{"key":"8898_CR11","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1007\/s11695-023-06567-6","volume":"33","author":"SG Doukas","year":"2023","unstructured":"Doukas SG, Doukas PG, Vageli DP, et al. Gastric cancer after bariatric bypass surgery. Do they relate? (a systematic review). Obes Surg. 2023;33:1876\u201388.","journal-title":"Obes Surg"},{"key":"8898_CR12","doi-asserted-by":"publisher","first-page":"299","DOI":"10.52787\/agl.v54i4.456","volume":"54","author":"O Laudanno","year":"2024","unstructured":"Laudanno O, Riquelme A, Medel-Jara P. Prevenci\u00f3n del c\u00e1ncer g\u00e1strico: Contexto y experiencia latinoamericana. Acta Gastroenterol Latinoam. 2024;54:299\u2013309.","journal-title":"Acta Gastroenterol Latinoam"},{"key":"8898_CR13","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/ases.12052","volume":"6","author":"C-C Wu","year":"2013","unstructured":"Wu C-C, Lee W-J, Ser K-H, et al. Gastric cancer after mini-gastric bypass surgery: a case report and literature review. Asian J Endosc Surg. 2013;6:303\u20136.","journal-title":"Asian J Endosc Surg"},{"key":"8898_CR14","first-page":"327745","volume":"gutjnl-2022","author":"P Malfertheiner","year":"2022","unstructured":"Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI\/Florence consensus report. Gut. 2022;gutjnl-2022:327745.","journal-title":"Gut"},{"key":"8898_CR15","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.14309\/ajg.0000000000002968","volume":"119","author":"WD Chey","year":"2024","unstructured":"Chey WD, Howden CW, Moss SF, et al. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. Off J Am Coll Gastroenterol ACG. 2024;119:1730.","journal-title":"Off J Am Coll Gastroenterol ACG"},{"key":"8898_CR16","first-page":"884","volume":"84","author":"O Laudanno","year":"2024","unstructured":"Laudanno O, Ahumaran G, Thome M, et al. [Argentinean registry on the management of Helicobacter pylori infection: effectiveness and safety of first line treatment]. Med B Aires. 2024;84:884\u201392.","journal-title":"Med B Aires"},{"key":"8898_CR17","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3748\/wjg.v20.i3.647","volume":"20","author":"M Carabotti","year":"2014","unstructured":"Carabotti M, D\u2019Ercole C, Iossa A, et al. Helicobacter pylori infection in obesity and its clinical outcome after bariatric surgery. World J Gastroenterol WJG. 2014;20:647\u201353.","journal-title":"World J Gastroenterol WJG"},{"key":"8898_CR18","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1007\/s11695-008-9477-z","volume":"18","author":"M Abdullahi","year":"2008","unstructured":"Abdullahi M, Annibale B, Capoccia D, et al. The eradication of Helicobacter pylori is affected by body mass index (BMI). Obes Surg. 2008;18:1450\u20134.","journal-title":"Obes Surg"},{"key":"8898_CR19","doi-asserted-by":"publisher","first-page":"40","DOI":"10.52787\/KSMH4439","volume":"50","author":"O Laudanno","year":"2020","unstructured":"Laudanno O, Ahumar\u00e1n G, Thom\u00e9 M, Gollo P, Khoury M, Thom\u00e9 M. Erradicaci\u00f3n del Helicobacter pylori en pacientes obesos pre-cirug\u00eda bari\u00e1trica. Acta Gastroenterol Latinoam. 2020;50:40\u20134.","journal-title":"Acta Gastroenterol Latinoam"},{"key":"8898_CR20","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1080\/17425255.2018.1440287","volume":"14","author":"C Smit","year":"2018","unstructured":"Smit C, De Hoogd S, Br\u00fcggemann RJM, et al. Obesity and drug pharmacology: a review of the influence of obesity on pharmacokinetic and pharmacodynamic parameters. Expert Opin Drug Metab Toxicol. 2018;14:275\u201385.","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"8898_CR21","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/S0140-6736(09)60743-1","volume":"375","author":"ME Falagas","year":"2010","unstructured":"Falagas ME, Karageorgopoulos DE. Adjustment of dosing of antimicrobial agents for bodyweight in adults. Lancet. 2010;375:248\u201351.","journal-title":"Lancet"},{"key":"8898_CR22","doi-asserted-by":"publisher","first-page":"189","DOI":"10.18773\/austprescr.2017.053","volume":"40","author":"M Barras","year":"2017","unstructured":"Barras M, Legg A. Drug dosing in obese adults. Aust Prescr. 2017;40:189\u201393.","journal-title":"Aust Prescr"},{"key":"8898_CR23","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01719-23","volume":"68","author":"A Castro-Balado","year":"2024","unstructured":"Castro-Balado A, Varela-Rey I, Mejuto B, et al. Updated antimicrobial dosing recommendations for obese patients. Antimicrob Agents Chemother. 2024;68:e01719-23.","journal-title":"Antimicrob Agents Chemother"},{"key":"8898_CR24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.47892\/rgp.2024.444.1797","volume":"44","author":"RW Otero","year":"2024","unstructured":"Otero RW, Riquelme A, Remes-Troche JM, et al. [An update of the Helicobacter pylori treatment: a Latin American Gastric Cancer, Helicobacter and Microbiota Study Group review]. Rev Gastroenterol Peru Organo Soc Gastroenterol Peru. 2024;44:359\u201373.","journal-title":"Rev Gastroenterol Peru Organo Soc Gastroenterol Peru"},{"key":"8898_CR25","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s00428-025-04042-4","volume":"487","author":"C Mayer","year":"2025","unstructured":"Mayer C, Hillel D, Barshack I, et al. Coccoid Helicobacter pylori in patients with obesity: an immunohistochemical study. Virchows Arch. 2025;487:681\u20136.","journal-title":"Virchows Arch"},{"key":"8898_CR26","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.gastrohep.2015.04.009","volume":"39","author":"M Sarem","year":"2016","unstructured":"Sarem M, Corti R. [Role of Helicobacter pylori coccoid forms in infection and recrudescence]. Gastroenterol Hepatol. 2016;39:28\u201335.","journal-title":"Gastroenterol Hepatol"},{"key":"8898_CR27","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12788","volume":"26","author":"H Eto","year":"2021","unstructured":"Eto H, Suzuki S, Kusano C, et al. Impact of body size on first-line Helicobacter pylori eradication success using vonoprazan and amoxicillin dual therapy. Helicobacter. 2021;26:e12788.","journal-title":"Helicobacter"},{"key":"8898_CR28","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1053\/j.gastro.2022.05.055","volume":"163","author":"WD Chey","year":"2022","unstructured":"Chey WD, M\u00e9graud F, Laine L, et al. Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial. Gastroenterology. 2022;163:608\u201319.","journal-title":"Gastroenterology"},{"key":"8898_CR29","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/ygh2.494","volume":"3","author":"JY Kao","year":"2021","unstructured":"Kao JY, Almenoff JS, Portenier DD, et al. Helicobacter pylori eradication by low-dose rifabutin triple therapy (RHB-105) is unaffected by high body mass index. GastroHep. 2021;3:426\u201334.","journal-title":"GastroHep"},{"key":"8898_CR30","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s11695-023-06549-8","volume":"34","author":"CR Maria","year":"2024","unstructured":"Maria CR, Rodriguez CM, Ines P, et al. Bismuth-based therapy: the new therapy for obese patients undergoing gastric bypass surgery? Obes Surg. 2024;34:123\u20137.","journal-title":"Obes Surg"},{"key":"8898_CR31","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1111\/bcp.14739","volume":"87","author":"ALPPDP Soares","year":"2021","unstructured":"Soares ALPPDP, Montanha MC, Alcantara CDS, et al. Pharmacokinetics of amoxicillin in obese and nonobese subjects. Br J Clin Pharmacol. 2021;87:3227\u201333.","journal-title":"Br J Clin Pharmacol"},{"key":"8898_CR32","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1093\/eurheartj\/ehv319","volume":"36","author":"G Habib","year":"2015","unstructured":"Habib G, Lancellotti P, Antunes MJ, et al. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 2015;36:3075\u2013128.","journal-title":"Eur Heart J"},{"key":"8898_CR33","doi-asserted-by":"publisher","first-page":"105011","DOI":"10.1016\/j.idnow.2024.105011","volume":"55","author":"V Le Moing","year":"2025","unstructured":"Le Moing V, Bonnet \u00c9, Cattoir V, et al. Antibiotic therapy and prophylaxis of infective endocarditis - A SPILF-AEPEI position statement on the ESC 2023 guidelines. Infect Dis Now. 2025;55:105011.","journal-title":"Infect Dis Now"},{"key":"8898_CR34","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1177\/0300060518769543","volume":"46","author":"T Pintar","year":"2018","unstructured":"Pintar T, Kaliterna N, Carli T. The need for a patient-tailored Helicobacter pylori eradication protocol prior to bariatric surgery. J Int Med Res. 2018;46:2696\u2013707.","journal-title":"J Int Med Res"},{"key":"8898_CR35","first-page":"345","volume":"113","author":"O Laudanno","year":"2021","unstructured":"Laudanno O, Ahumar\u00e1n G, Gollo P, et al. Tailored Helicobacter pylori eradication therapy in obese patients undergoing bariatric surgery. Rev Esp Enferm Dig. 2021;113:345\u20137.","journal-title":"Rev Esp Enferm Dig"},{"key":"8898_CR36","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1089\/mdr.2015.0361","volume":"23","author":"G Zerbetto De Palma","year":"2017","unstructured":"Zerbetto De Palma G, Mendiondo N, Wonaga A, et al. Occurrence of mutations in the antimicrobial target genes related to levofloxacin, clarithromycin, and amoxicillin resistance in Helicobacter pylori isolates from Buenos Aires City. Microb Drug Resist. 2017;23:351\u20138.","journal-title":"Microb Drug Resist"},{"key":"8898_CR37","doi-asserted-by":"publisher","first-page":"S-928","DOI":"10.1016\/S0016-5085(25)03069-0","volume":"169","author":"G Latorre","year":"2025","unstructured":"Latorre G, Norwood DA, Venezian FM, et al. Study of antimicrobial resistance in Helicobacter pylori based on molecular tests by next generation sequencing in Latin American countries. Gastroenterology. 2025;169:S-928\u2013S-928.","journal-title":"Gastroenterology"},{"key":"8898_CR38","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1007\/s11605-023-05619-7","volume":"27","author":"A Beran","year":"2023","unstructured":"Beran A, Shaear M, Al-Mudares S, et al. Predictors of marginal ulcer after gastric bypass: a systematic review and meta-analysis. J Gastrointest Surg. 2023;27:1066\u201377.","journal-title":"J Gastrointest Surg"},{"key":"8898_CR39","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1017\/S0029665118000149","volume":"77","author":"N Steenackers","year":"2018","unstructured":"Steenackers N, Van der Schueren B, Mertens A, et al. Iron deficiency after bariatric surgery: what is the real problem? Proc Nutr Soc. 2018;77:445\u201355.","journal-title":"Proc Nutr Soc"},{"key":"8898_CR40","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1002\/pds.3461","volume":"22","author":"C Longo","year":"2013","unstructured":"Longo C, Bartlett G, Macgibbon B, et al. The effect of obesity on antibiotic treatment failure: a historical cohort study. Pharmacoepidemiol Drug Saf. 2013;22:970\u20136.","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"8898_CR41","doi-asserted-by":"publisher","first-page":"ofab212","DOI":"10.1093\/ofid\/ofab212","volume":"8","author":"NA Pinner","year":"2021","unstructured":"Pinner NA, Tapley NG, Barber KE, et al. Effect of obesity on clinical failure of patients treated with \u03b2-Lactams. Open Forum Infect Dis. 2021;8:ofab212.","journal-title":"Open Forum Infect Dis"},{"key":"8898_CR42","first-page":"1","volume":"13","author":"X Zhao","year":"2022","unstructured":"Zhao X, Zhang Z, Lu F, Xiong M, Jiang L, Tang K, et al. Effects of CYP2C19 genetic polymorphisms on the cure rates of H. pylori in patients treated with the proton pump inhibitors: an updated meta-analysis. Front Pharmacol. 2022;13:1\u201322.","journal-title":"Front Pharmacol"}],"container-title":["Obesity Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-026-08898-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11695-026-08898-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-026-08898-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:36:03Z","timestamp":1793108163000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11695-026-08898-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["8898"],"URL":"https:\/\/doi.org\/10.1007\/s11695-026-08898-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8752699\/v1","asserted-by":"object"}]},"ISSN":["0960-8923","1708-0428"],"issn-type":[{"value":"0960-8923","type":"print"},{"value":"1708-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"31 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}