{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:12:36Z","timestamp":1789578756278,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Robotic Surg"],"DOI":"10.1007\/s11701-025-02816-1","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:45:07Z","timestamp":1758707107000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety and diagnostic yield of robotic-assisted stereotactic biopsy for pediatric brainstem lesions: a systematic review and single-arm meta-analysis"],"prefix":"10.1007","volume":"19","author":[{"given":"Jianqiang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"2816_CR1","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s11910-023-01317-8","volume":"23","author":"C Cacciotti","year":"2023","unstructured":"Cacciotti C, Wright KD (2023) Advances in treatment of diffuse midline gliomas. Curr Neurol Neurosci Rep 23:849\u2013856. https:\/\/doi.org\/10.1007\/s11910-023-01317-8","journal-title":"Curr Neurol Neurosci Rep"},{"key":"2816_CR2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41572-024-00516-y","volume":"10","author":"M Weller","year":"2024","unstructured":"Weller M, Wen PY, Chang SM et al (2024) Glioma. Nat Rev Dis Primers 10:33. https:\/\/doi.org\/10.1038\/s41572-024-00516-y","journal-title":"Nat Rev Dis Primers"},{"key":"2816_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1504440","author":"SR Sheikh","year":"2024","unstructured":"Sheikh SR, Recinos VMR, Thompson EM et al (2024) The role of brainstem biopsy and targeted therapies in pediatric diffuse midline glioma\/diffuse intrinsic pontine glioma. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2024.1504440","journal-title":"Front Oncol"},{"key":"2816_CR4","doi-asserted-by":"publisher","first-page":"S176","DOI":"10.4103\/2152-7806.110677","volume":"4","author":"JD Waters","year":"2013","unstructured":"Waters JD, Gonda DD, Reddy H et al (2013) Diagnostic yield of stereotactic needle-biopsies of sub-cubic centimeter intracranial lesions. Surg Neurol Int 4:S176. https:\/\/doi.org\/10.4103\/2152-7806.110677","journal-title":"Surg Neurol Int"},{"key":"2816_CR5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.clineuro.2014.12.011","volume":"130","author":"LL Furlanetti","year":"2015","unstructured":"Furlanetti LL, Monaco BA, Cordeiro JG et al (2015) Frame-based stereotactic neurosurgery in children under the age of seven: Freiburg University\u2019s experience from 99 consecutive cases. Clin Neurol Neurosurg 130:42\u201347. https:\/\/doi.org\/10.1016\/j.clineuro.2014.12.011","journal-title":"Clin Neurol Neurosurg"},{"key":"2816_CR6","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3171\/2014.9.JNS14107","volume":"122","author":"M Lefranc","year":"2015","unstructured":"Lefranc M, Capel C, Pruvot-Occean A-S et al (2015) Frameless robotic stereotactic biopsies: a consecutive series of 100 cases. J Neurosurg 122:342\u2013352. https:\/\/doi.org\/10.3171\/2014.9.JNS14107","journal-title":"J Neurosurg"},{"key":"2816_CR7","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s00381-018-3821-y","volume":"34","author":"HJ Marcus","year":"2018","unstructured":"Marcus HJ, Vakharia VN, Ourselin S et al (2018) Robot-assisted stereotactic brain biopsy: systematic review and bibliometric analysis. Childs Nerv Syst 34:1299\u20131309. https:\/\/doi.org\/10.1007\/s00381-018-3821-y","journal-title":"Childs Nerv Syst"},{"key":"2816_CR8","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.neuchi.2016.07.005","volume":"62","author":"HA Coca","year":"2016","unstructured":"Coca HA, Cebula H, Benmekhbi M et al (2016) Diffuse intrinsic pontine gliomas in children: interest of robotic frameless assisted biopsy. A technical note. Neurochirurgie 62:327\u2013331. https:\/\/doi.org\/10.1016\/j.neuchi.2016.07.005","journal-title":"Neurochirurgie"},{"key":"2816_CR9","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s11701-018-0899-x","volume":"13","author":"W Dawes","year":"2019","unstructured":"Dawes W, Marcus HJ, Tisdall M, Aquilina K (2019) Robot-assisted stereotactic brainstem biopsy in children: prospective cohort study. J Robot Surg 13:575\u2013579. https:\/\/doi.org\/10.1007\/s11701-018-0899-x","journal-title":"J Robot Surg"},{"key":"2816_CR10","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s11060-022-03952-6","volume":"157","author":"I Peciu-Florianu","year":"2022","unstructured":"Peciu-Florianu I, Legrand V, Monfilliette-Djelad A et al (2022) Frameless robot-assisted stereotactic biopsies for lesions of the brainstem-a series of 103 consecutive biopsies. J Neurooncol 157:109\u2013119. https:\/\/doi.org\/10.1007\/s11060-022-03952-6","journal-title":"J Neurooncol"},{"key":"2816_CR11","doi-asserted-by":"publisher","first-page":"E7","DOI":"10.3171\/2017.2.FOCUS16579","volume":"42","author":"A De Benedictis","year":"2017","unstructured":"De Benedictis A, Trezza A, Carai A et al (2017) Robot-assisted procedures in pediatric neurosurgery. Neurosurg Focus 42:E7. https:\/\/doi.org\/10.3171\/2017.2.FOCUS16579","journal-title":"Neurosurg Focus"},{"key":"2816_CR12","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.wneu.2017.02.088","volume":"101","author":"A Carai","year":"2017","unstructured":"Carai A, Mastronuzzi A, De Benedictis A et al (2017) Robot-assisted stereotactic biopsy of diffuse intrinsic pontine glioma: a single-center experience. World Neurosurg 101:584\u2013588. https:\/\/doi.org\/10.1016\/j.wneu.2017.02.088","journal-title":"World Neurosurg"},{"key":"2816_CR13","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s11060-023-04475-4","volume":"165","author":"AB Khan","year":"2023","unstructured":"Khan AB, Dang HQ, Gopakumar S et al (2023) Clinical outcomes of stereotactic biopsy on children with pontine diffuse midline glioma. J Neurooncol 165:353\u2013360. https:\/\/doi.org\/10.1007\/s11060-023-04475-4","journal-title":"J Neurooncol"},{"key":"2816_CR14","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.neuchi.2010.05.006","volume":"56","author":"C Haegelen","year":"2010","unstructured":"Haegelen C, Touzet G, Reyns N et al (2010) Stereotactic robot-guided biopsies of brain stem lesions: experience with 15 cases. Neurochirurgie 56:363\u2013367. https:\/\/doi.org\/10.1016\/j.neuchi.2010.05.006","journal-title":"Neurochirurgie"},{"key":"2816_CR15","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3171\/2020.7.PEDS20373","volume":"27","author":"M Gupta","year":"2021","unstructured":"Gupta M, Chan TM, Santiago-Dieppa DR et al (2021) Robot-assisted stereotactic biopsy of pediatric brainstem and thalamic lesions. J Neurosurg Pediatr 27:317\u2013324. https:\/\/doi.org\/10.3171\/2020.7.PEDS20373","journal-title":"J Neurosurg Pediatr"},{"key":"2816_CR16","doi-asserted-by":"publisher","first-page":"e84","DOI":"10.1016\/j.wneu.2023.05.108","volume":"177","author":"A Fr\u00fch","year":"2023","unstructured":"Fr\u00fch A, Schaumann A, Cohrs G et al (2023) Biopsies of caudal brainstem tumors in pediatric patients-a single-center retrospective case series. World Neurosurg 177:e84\u2013e93. https:\/\/doi.org\/10.1016\/j.wneu.2023.05.108","journal-title":"World Neurosurg"},{"key":"2816_CR17","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s11060-022-04122-4","volume":"160","author":"M Wang","year":"2022","unstructured":"Wang M, Zhang Y, Shi W et al (2022) Frameless robot-assisted stereotactic biopsy: an effective and minimally invasive technique for pediatric diffuse intrinsic pontine gliomas. J Neurooncol 160:107\u2013114. https:\/\/doi.org\/10.1007\/s11060-022-04122-4","journal-title":"J Neurooncol"},{"key":"2816_CR18","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1007\/s00381-024-06349-0","volume":"40","author":"P Spennato","year":"2024","unstructured":"Spennato P, Di Costanzo M, Mirone G et al (2024) Image-guided biopsy of intracranial lesions in children, with a small robotic device: a case series. Childs Nerv Syst 40:1681\u20131688. https:\/\/doi.org\/10.1007\/s00381-024-06349-0","journal-title":"Childs Nerv Syst"},{"key":"2816_CR19","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1007\/s00381-023-06102-z","volume":"39","author":"A Di Rita","year":"2023","unstructured":"Di Rita A, Lenge M, Mantovani G et al (2023) Robot-assisted transcerebellar stereotactic approach to the posterior fossa in pediatric patients: a technical note. Childs Nerv Syst 39:2493\u20132497. https:\/\/doi.org\/10.1007\/s00381-023-06102-z","journal-title":"Childs Nerv Syst"},{"key":"2816_CR20","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.jocn.2017.06.028","volume":"44","author":"J Quick-Weller","year":"2017","unstructured":"Quick-Weller J, Tritt S, Behmanesh B et al (2017) Biopsies of pediatric brainstem lesions display low morbidity but strong impact on further treatment decisions. J Clin Neurosci 44:254\u2013259. https:\/\/doi.org\/10.1016\/j.jocn.2017.06.028","journal-title":"J Clin Neurosci"},{"key":"2816_CR21","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ejca.2022.10.014","volume":"178","author":"T Mueller","year":"2023","unstructured":"Mueller T, Laternser S, Guerreiro St\u00fccklin AS et al (2023) Real-time drug testing of paediatric diffuse midline glioma to support clinical decision making: the Zurich DIPG\/DMG centre experience. Eur J Cancer 178:171\u2013179. https:\/\/doi.org\/10.1016\/j.ejca.2022.10.014","journal-title":"Eur J Cancer"},{"key":"2816_CR22","doi-asserted-by":"publisher","first-page":"E12","DOI":"10.3171\/2021.10.FOCUS21359","volume":"52","author":"K Machetanz","year":"2022","unstructured":"Machetanz K, Grimm F, Wang S et al (2022) Rediscovery of the transcerebellar approach: improving the risk-benefit ratio in robot-assisted brainstem biopsies. Neurosurg Focus 52:E12. https:\/\/doi.org\/10.3171\/2021.10.FOCUS21359","journal-title":"Neurosurg Focus"},{"key":"2816_CR23","doi-asserted-by":"publisher","first-page":"g7647","DOI":"10.1136\/bmj.g7647","volume":"350","author":"L Shamseer","year":"2015","unstructured":"Shamseer L, Moher D, Clarke M et al (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 350:g7647. https:\/\/doi.org\/10.1136\/bmj.g7647","journal-title":"BMJ"},{"key":"2816_CR24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.wneu.2022.10.071","volume":"169","author":"VM Lu","year":"2023","unstructured":"Lu VM, Koester SW, Di L, Elarjani T, Luther EM, Eichberg DG, Morell AA, Graffeo CS, Bin-Alamer O, Abou-Al-Shaar H, Komotar RJ (2023) Frameless robotic-assisted biopsy of pediatric brainstem lesions: a systematic review and meta-analysis of efficacy and safety. World Neurosurg 169:87-93.e1. https:\/\/doi.org\/10.1016\/j.wneu.2022.10.071","journal-title":"World Neurosurg"},{"key":"2816_CR25","doi-asserted-by":"publisher","first-page":"4558","DOI":"10.3390\/curroncol29070360","volume":"29","author":"Y Hirano","year":"2022","unstructured":"Hirano Y, Shinya Y, Aono T et al (2022) The role of stereotactic frame-based biopsy for brainstem tumors in the era of molecular-based diagnosis and treatment decisions. Curr Oncol 29:4558\u20134565. https:\/\/doi.org\/10.3390\/curroncol29070360","journal-title":"Curr Oncol"},{"key":"2816_CR26","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00381-023-06208-4","volume":"40","author":"AY Fu","year":"2024","unstructured":"Fu AY, Kavia J, Yadava Y et al (2024) Biopsy of diffuse midline glioma is safe and impacts targeted therapy: a systematic review and meta-analysis. Childs Nerv Syst 40:625\u2013634. https:\/\/doi.org\/10.1007\/s00381-023-06208-4","journal-title":"Childs Nerv Syst"},{"key":"2816_CR27","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/0090-3019(95)00156-5","volume":"43","author":"J Steck","year":"1995","unstructured":"Steck J, Friedman WA (1995) Stereotactic biopsy of brainstem mass lesions. Surg Neurol 43:563\u2013567. https:\/\/doi.org\/10.1016\/0090-3019(95)00156-5","journal-title":"Surg Neurol"},{"key":"2816_CR28","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s003810050379","volume":"15","author":"M Cartmill","year":"1999","unstructured":"Cartmill M, Punt J (1999) Diffuse brain stem glioma. A review of stereotactic biopsies. Childs Nerv Syst 15:235\u2013237. https:\/\/doi.org\/10.1007\/s003810050379","journal-title":"Childs Nerv Syst"},{"key":"2816_CR29","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1097\/00019052-200112000-00006","volume":"14","author":"JS Guillamo","year":"2001","unstructured":"Guillamo JS, Doz F, Delattre JY (2001) Brain stem gliomas. Curr Opin Neurol 14:711\u2013715. https:\/\/doi.org\/10.1097\/00019052-200112000-00006","journal-title":"Curr Opin Neurol"},{"key":"2816_CR30","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1007\/s00381-013-2101-0","volume":"29","author":"TA Cage","year":"2013","unstructured":"Cage TA, Samagh SP, Mueller S et al (2013) Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children. Childs Nerv Syst 29:1313\u20131319. https:\/\/doi.org\/10.1007\/s00381-013-2101-0","journal-title":"Childs Nerv Syst"},{"key":"2816_CR31","doi-asserted-by":"publisher","first-page":"552","DOI":"10.3171\/2020.4.PEDS2092","volume":"26","author":"DS Hersh","year":"2020","unstructured":"Hersh DS, Kumar R, Moore KA et al (2020) Safety and efficacy of brainstem biopsy in children and young adults. J Neurosurg Pediatr 26:552\u2013562. https:\/\/doi.org\/10.3171\/2020.4.PEDS2092","journal-title":"J Neurosurg Pediatr"},{"key":"2816_CR32","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1093\/neuonc\/noy070","volume":"20","author":"N Gupta","year":"2018","unstructured":"Gupta N, Goumnerova LC, Manley P et al (2018) Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma. Neuro Oncol 20:1547\u20131555. https:\/\/doi.org\/10.1093\/neuonc\/noy070","journal-title":"Neuro Oncol"},{"key":"2816_CR33","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1002\/pbc.25224","volume":"62","author":"ZJ Wang","year":"2015","unstructured":"Wang ZJ, Rao L, Bhambhani K et al (2015) Diffuse intrinsic pontine glioma biopsy: a single institution experience. Pediatr Blood Cancer 62:163\u2013165. https:\/\/doi.org\/10.1002\/pbc.25224","journal-title":"Pediatr Blood Cancer"},{"key":"2816_CR34","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1159\/000098831","volume":"43","author":"PF Recinos","year":"2007","unstructured":"Recinos PF, Sciubba DM, Jallo GI (2007) Brainstem tumors: where are we today? Pediatr Neurosurg 43:192\u2013201. https:\/\/doi.org\/10.1159\/000098831","journal-title":"Pediatr Neurosurg"},{"key":"2816_CR35","doi-asserted-by":"publisher","DOI":"10.25259\/SNI_187_2024","author":"L Ts","year":"2024","unstructured":"Ts L, Ar P, Bn N et al (2024) Computed tomography-guided frame-based stereotactic brain biopsy of non-enhancing lesions using indirect evidence of target selection, technical consideration, and early clinical experience. Surg Neurol Int. https:\/\/doi.org\/10.25259\/SNI_187_2024","journal-title":"Surg Neurol Int"},{"key":"2816_CR36","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1824-7288-36-40","volume":"36","author":"E Commodari","year":"2010","unstructured":"Commodari E (2010) Children staying in hospital: a research on psychological stress of caregivers. Ital J Pediatr 36:40. https:\/\/doi.org\/10.1186\/1824-7288-36-40","journal-title":"Ital J Pediatr"}],"container-title":["Journal of Robotic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11701-025-02816-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11701-025-02816-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11701-025-02816-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T01:22:20Z","timestamp":1767489740000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11701-025-02816-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,24]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2816"],"URL":"https:\/\/doi.org\/10.1007\/s11701-025-02816-1","relation":{},"ISSN":["1863-2491"],"issn-type":[{"value":"1863-2491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,24]]},"assertion":[{"value":"28 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"629"}}