{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:46:30Z","timestamp":1793166390111,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s11739-016-1573-9","type":"journal-article","created":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T13:20:38Z","timestamp":1480080038000},"page":"319-326","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Utility of FVC\/DLCO ratio to stratify the risk of mortality in unselected subjects with pulmonary hypertension"],"prefix":"10.1007","volume":"12","author":[{"given":"Lacedonia","family":"Donato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carpagnano","family":"Giovanna Elisiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galgano","family":"Giuseppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schino","family":"Pietro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Correale","family":"Michele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9610-7408","authenticated-orcid":false,"given":"Natale Daniele","family":"Brunetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ventura","family":"Valentina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di Biase","family":"Matteo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foschino Barbaro","family":"Maria Pia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,25]]},"reference":[{"key":"1573_CR1","doi-asserted-by":"crossref","unstructured":"Gali\u00e8 N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M (2015) ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Respir J (pii ERJ-01032-2015)","DOI":"10.1183\/13993003.01032-2015"},{"key":"1573_CR2","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1378\/chest.13-1422","volume":"145","author":"AS Iyer","year":"2014","unstructured":"Iyer AS, Wells JM, Vishin S, Bhatt SP, Wille KM, Dransfield MT (2014) CT scan-measured pulmonary artery to aorta ratio and echocardiography for detecting pulmonary hypertension in severe COPD. Chest 145:824\u2013832","journal-title":"Chest"},{"key":"1573_CR3","doi-asserted-by":"crossref","first-page":"e78001","DOI":"10.1371\/journal.pone.0078001","volume":"8","author":"N Sivova","year":"2013","unstructured":"Sivova N, Launay D, W\u00e9meau-Stervinou L, De Groote P, Remy-Jardin M, Denis G, Lambert M, Lamblin N, Morell-Dubois S, Fertin M, Lefevre G, Sobanski V, Le Rouzic O, Hatron PY, Wallaert B, Hachulla E, Perez T (2013) Relevance of partitioning DLCO to detect pulmonary hypertension in systemic sclerosis. PLoS One 8:e78001","journal-title":"PLoS One"},{"key":"1573_CR4","doi-asserted-by":"crossref","unstructured":"Sidhu B, Hashemi N, Rashidian A, Sharma S, Gill N, Mills P, Balasubramanian V (2015) Utility of pulmonary function testing in detection of pulmonary arterial hypertension. A58. Clinical evaluation of pulmonary hypertension. p A1875 (First published online 17 Feb 2015)","DOI":"10.1164\/ajrccm-conference.2012.185.1_MeetingAbstracts.A1875"},{"key":"1573_CR5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.semarthrit.2014.03.002","volume":"44","author":"VM Hsu","year":"2014","unstructured":"Hsu VM, Chung L, Hummers LK, Wigley F, Simms R, Bolster M, Silver R, Fischer A, Hinchcliff ME, Varga J, Goldberg AZ, Derk CT, Schiopu E, Khanna D, Shapiro LS, Domsic RT, Medsger T, Mayes MD, Furst D, Csuka ME, Molitor JA, Alkassab F, Steen VD (2014) Development of pulmonary hypertension in a high-risk population with systemic sclerosis in the pulmonary hypertension assessment and recognition of outcomes in scleroderma (PHAROS) cohort study. Semin Arthr Rheum 44:55\u201362","journal-title":"Semin Arthr Rheum"},{"key":"1573_CR6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1378\/chest.07-1771","volume":"134","author":"Plummer Al","year":"2008","unstructured":"Al Plummer (2008) The carbon monoxide diffusing capacity: clinical implications, coding, and documentation. Chest 134:663\u2013667","journal-title":"Chest"},{"key":"1573_CR7","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0735-1097(02)02964-9","volume":"41","author":"XG Sun","year":"2003","unstructured":"Sun XG, Hansen JE, Oudiz RJ, Wasserman K (2003) Pulmonary function in primary pulmonary hypertension. J Am Coll Cardiol 41:1028\u20131035","journal-title":"J Am Coll Cardiol"},{"key":"1573_CR8","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1136\/annrheumdis-2013-203301","volume":"73","author":"JG Coghlan","year":"2014","unstructured":"Coghlan JG, Denton CP, Gr\u00fcnig E, Bonderman D, Distler O, Khanna D, M\u00fcller-Ladner U, Pope JE, Vonk MC, Doelberg M, Chadha-Boreham H, Heinzl H, Rosenberg DM, McLaughlin VV, Seibold JR, DETECT study group (2014) Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Ann Rheum Dis 73:1340\u20131349","journal-title":"Ann Rheum Dis"},{"key":"1573_CR9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.healun.2009.07.005","volume":"29","author":"S Chandra","year":"2010","unstructured":"Chandra S, Shah SJ, Thenappan T, Archer SL, Rich S, Gomberg-Maitland M (2010) Carbon monoxide diffusing capacity and mortality in pulmonary arterial hypertension. J Heart Lung Transplant 29:181\u2013187","journal-title":"J Heart Lung Transplant"},{"key":"1573_CR10","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jchf.2015.12.016","volume":"4","author":"MM Hoeper","year":"2016","unstructured":"Hoeper MM, Meyer K, Rademacher J, Fuge J, Welte T, Olsson KM (2016) Diffusion capacity and mortality in patients with pulmonary hypertension due to heart failure with preserved ejection fraction. JACC Heart Fail 4:441\u2013449","journal-title":"JACC Heart Fail"},{"key":"1573_CR11","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1164\/ajrccm.163.5.2101039","volume":"163","author":"RA Pauwels","year":"2001","unstructured":"Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS (2001) Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. NHLBI\/WHO Global Initiative for Chronic Obstructive Lung Disease [GOLD] Workshop summary. Am J Resp Crit Care Med 163:1256\u20131276","journal-title":"Am J Resp Crit Care Med"},{"key":"1573_CR12","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1183\/09031936.05.00035205","volume":"26","author":"R Pellegrino","year":"2005","unstructured":"Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, Coates A, van der Grinten CPM, Gustafsson P, Hankinson J, Jensen R, Johnson DC, MacIntyre M, McKay R, Miller MR, Navajas D, Pedersen OF, Wanger J (2005) Interpretative strategies for lung function tests. Eur Respir J 26:948\u2013968","journal-title":"Eur Respir J"},{"key":"1573_CR13","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1183\/09031936.05.00034905","volume":"26","author":"N Macintyre","year":"2005","unstructured":"Macintyre N, Crapo RO, Viegi G, Johnson DC, van der Grinten CP, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, Gustafsson P, Hankinson J, Jensen R, McKay R, Miller MR, Navajas D, Pedersen OF, Pellegrino R, Wanger J (2005) Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J 26:720\u2013735","journal-title":"Eur Respir J"},{"key":"1573_CR14","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1016\/j.jacc.2006.07.061","volume":"48","author":"MM Hoeper","year":"2006","unstructured":"Hoeper MM, Lee SH, Voswinckel R, Palazzini M, Jais X, Marinelli A, Barst RJ, Ghofrani HA, Jing Z, Opitz C, Seyfarth H, Halank M, McLaughlin V, Oudiz RJ, Ewert R, Wilkens H, Kluge S, Bremer H, Baroke E, Rubin LJ (2006) Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers. J Am Coll Cardiol 48:2546\u20132552","journal-title":"J Am Coll Cardiol"},{"key":"1573_CR15","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1164\/rccm.200510-1668OC","volume":"173","author":"M Humbert","year":"2006","unstructured":"Humbert M, Sitbon O, Chaouat A, Bertocchi M, Habib G, Gressin V, Yaici A, Weitzenblum E, Cordier JF, Chabot F, Dromer C, Pison C, Reynaud-Gaubert M, Haloun A, Laurent M, Hachulla E, Simonneau G (2006) Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med 173:1023\u20131030","journal-title":"Am J Respir Crit Care Med"},{"key":"1573_CR16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1378\/chest.10-1166","volume":"140","author":"LM Brown","year":"2011","unstructured":"Brown LM, Chen H, Halpern S, Taichman D, McGoon MD, Farber HW, Frost AE, Liou TG, Turner M, Feldkircher K, Miller DP, Elliott CG (2011) Delay in recognition of pulmonary arterial hypertension: factors identified from the REVEAL registry. Chest 140:19\u201326","journal-title":"Chest"},{"key":"1573_CR17","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0140-6736(08)60919-8","volume":"371","author":"N Gali\u00e8","year":"2008","unstructured":"Gali\u00e8 N, Rubin LJ, Hoeper MM, Jansa P, Al-Hiti H, Meyer GMB, Chiossig E, Kusic-Pajic A, Simonneau G (2008) Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. Lancet 371:2093\u20132100","journal-title":"Lancet"},{"key":"1573_CR18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0272-5231(21)00199-4","volume":"4","author":"B Meyrick","year":"1983","unstructured":"Meyrick B, Reid L (1983) Pulmonary hypertension. Anatomic and physiologic correlates. Clin Chest Med 4:199\u2013217","journal-title":"Clin Chest Med"},{"key":"1573_CR19","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0735-1097(02)02964-9","volume":"41","author":"XG Sun","year":"2003","unstructured":"Sun XG, Hansen JE, Oudiz RJ, Wasserman K (2003) Pulmonary function in primary pulmonary hypertension. J Am Coll Cardiol 41:1028\u20131035","journal-title":"J Am Coll Cardiol"},{"key":"1573_CR20","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/art.1780350709","volume":"35","author":"VD Steen","year":"1992","unstructured":"Steen VD, Graham G, Conte C, Owens G, Medsger TA Jr (1992) Isolated diffusing capacity reduction in systemic sclerosis. Arthr Rheum 35:765\u2013770","journal-title":"Arthr Rheum"},{"key":"1573_CR21","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1378\/chest.06-2485","volume":"131","author":"SD Nathan","year":"2007","unstructured":"Nathan SD, Shlobin OA, Ahmad S, Urbanek S, Barnett SD (2007) Pulmonary hypertension and pulmonary function testing in idiopathic pulmonary fibrosis. Chest 131:657\u2013663","journal-title":"Chest"},{"key":"1573_CR22","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1378\/chest.127.5.1531","volume":"127","author":"G Thabut","year":"2005","unstructured":"Thabut G, Dauriat G, Stern JB, Logeart D, Levy A, Marrash-Chahla R, Mal H (2005) Pulmonary hemodynamics in advanced COPD candidates for lung volume reduction surgery or lung transplantation. Chest 127:1531\u20131536","journal-title":"Chest"},{"key":"1573_CR23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1164\/rccm.200401-006OC","volume":"172","author":"A Chaouat","year":"2005","unstructured":"Chaouat A, Bugnet AS, Kadaoui N, Schott R, Enache I, Ducolon\u00e9 A, Ehrhart M, Kessler R, Weitzenblum E (2005) Severe pulmonary hypertension in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 172:189\u2013194","journal-title":"Am J Respir Crit Care Med"},{"key":"1573_CR24","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1378\/chest.127.5.1480","volume":"127","author":"E Weitzenblum","year":"2005","unstructured":"Weitzenblum E, Chaouat A (2005) Severe pulmonary hypertension in COPD: is it a distinct disease? Chest 127:1480\u20131482","journal-title":"Chest"},{"key":"1573_CR25","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1164\/rccm.2107027","volume":"166","author":"SM Scharf","year":"2002","unstructured":"Scharf SM, Iqbal M, Keller C, Criner G, Lee S, Fessler HE (2002) Hemodynamic characterization of patients with severe emphysema. Am J Respir Crit Care Med 166:314\u2013322","journal-title":"Am J Respir Crit Care Med"},{"key":"1573_CR26","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1378\/chest.107.5.1193","volume":"107","author":"M Oswald-Mammosser","year":"1995","unstructured":"Oswald-Mammosser M, Weitzenblum E, Quoix E, Moser G, Chaouat A, Carpentier C, Kessler R (1995) Prognostic factors in COPD patients receiving long-term oxygen therapy: importance of pulmonary artery pressure. Chest 107:1193\u20131198","journal-title":"Chest"},{"key":"1573_CR27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.7326\/0003-4819-115-5-343","volume":"115","author":"GE D\u2019Alonzo","year":"1991","unstructured":"D\u2019Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM, Kernis JT (1991) Survival in patients with primary pulmonary hypertension: results from a national prospective registry. Ann Intern Med 115:343\u2013349","journal-title":"Ann Intern Med"},{"key":"1573_CR28","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1161\/CIRCULATIONAHA.104.503540","volume":"114","author":"VV McLaughlin","year":"2006","unstructured":"McLaughlin VV, McGoon MD (2006) Pulmonary arterial hypertension. Circulation 114:1417\u20131431","journal-title":"Circulation"},{"key":"1573_CR29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.healun.2009.07.005","volume":"29","author":"S Chandra","year":"2010","unstructured":"Chandra S, Shah SJ, Thenappan T, Archer SL, Rich S, Gomberg-Maitland M (2010) Carbon monoxide diffusing capacity and mortality in pulmonary arterial hypertension. J Heart Lung Transplant 29:181\u2013187","journal-title":"J Heart Lung Transplant"},{"key":"1573_CR30","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s11739-013-0900-7","volume":"9","author":"C Marini","year":"2014","unstructured":"Marini C, Formichi B, Bauleo C, Michelassi C, Pancani R, Prediletto R, Miniati M, Catapano G, Monti S, Mannucci F, Tavoni A, D\u2019Ascanio A, Pastormerlo LE, Giannoni A, Giuntini C (2014) Improved survival in limited scleroderma-related pulmonary artery hypertension. Intern Emerg Med 9:385\u2013396","journal-title":"Intern Emerg Med"},{"key":"1573_CR31","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s11739-016-1446-2","volume":"11","author":"C Marini","year":"2016","unstructured":"Marini C, Formichi B, Bauleo C, Michelassi C, Air\u00f2 E, Rossi G, Giuntini C (2016) Survival protection by bodyweight in isolated scleroderma-related pulmonary artery hypertension. Intern Emerg Med 11:941\u2013952","journal-title":"Intern Emerg Med"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-016-1573-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11739-016-1573-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-016-1573-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T21:36:44Z","timestamp":1749764204000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11739-016-1573-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,25]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["1573"],"URL":"https:\/\/doi.org\/10.1007\/s11739-016-1573-9","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,25]]}}}