{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:39:00Z","timestamp":1792787940947,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T00:00:00Z","timestamp":1489622400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s11739-017-1650-8","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T02:52:20Z","timestamp":1489632740000},"page":"679-687","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The efficacy and safety of high-dose statins in acute phase of ischemic stroke and transient ischemic attack: a systematic review"],"prefix":"10.1007","volume":"12","author":[{"given":"Jing-xue","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Er-qiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,16]]},"reference":[{"key":"1650_CR1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1474-4422(09)70025-0","volume":"8","author":"VL Feigin","year":"2009","unstructured":"Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V (2009) Worldwide stroke incidence and early case fatality reported in 56 population- based studies: a systematic review. Lancet Neurol 8:355\u2013369","journal-title":"Lancet Neurol"},{"key":"1650_CR2","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1161\/STR.0000000000000046","volume":"45","author":"JF Meschia","year":"2014","unstructured":"Meschia JF, Bushnell C, Boden-Albala B et al (2014) Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke 45:3754\u20133832","journal-title":"Stroke"},{"key":"1650_CR3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.5853\/jos.2015.17.3.282","volume":"17","author":"KS Hong","year":"2015","unstructured":"Hong KS, Lee JS (2015) Statins in acute ischemic stroke: a systematic review. J Stroke 17:282\u2013301","journal-title":"J Stroke"},{"key":"1650_CR4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/biof.1157","volume":"40","author":"A Blum","year":"2014","unstructured":"Blum A (2014) HMG-CoA reductase inhibitors (statins), inflammation, and endothelial progenitor cells\u2014new mechanistic insights of atherosclerosis. BioFactors 40:295\u2013302","journal-title":"BioFactors"},{"key":"1650_CR5","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/1073858406297121","volume":"13","author":"M Cimino","year":"2007","unstructured":"Cimino M, Gelosa P, Gianella A, Nobili E, Tremoli E, Sironi L (2007) Statins: multiple mechanisms of action in the ischemic brain. Neuroscientist 13:208\u2013213","journal-title":"Neuroscientist"},{"key":"1650_CR6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.20996\/1819-6446-2012-8-1-4-16","volume":"8","author":"VV Yakusevich","year":"2012","unstructured":"Yakusevich VV, Malygin AYu, Lychenko SV, Petrochenko AS, Kabanov AV (2012) The efficacy of high-dose simvastatin in acute period of ischemic stroke. Rational Pharmacother Cardiol 8:4\u201316","journal-title":"Rational Pharmacother Cardiol"},{"key":"1650_CR7","doi-asserted-by":"crossref","first-page":"e3186","DOI":"10.1097\/MD.0000000000003186","volume":"95","author":"A Tuttolomondo","year":"2016","unstructured":"Tuttolomondo A, Di Raimondo D, Pecoraro R, Maida C, Arnao V, Della Corte V, Simonetta I, Corpora F, Di Bona D, Maugeri R, Iacopino DG, Pinto A (2016) Early high-dosage atorvastatin treatment improved serum immune-inflammatory markers and functional outcome in acute ischemic strokes classified as large artery atherosclerotic stroke: a randomized trial. Medicine 95:e3186","journal-title":"Medicine"},{"key":"1650_CR8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.5853\/jos.2015.01578","volume":"18","author":"JH Heo","year":"2016","unstructured":"Heo JH, Song D, Nam HS, Kim EY, Kim YD, Lee KY, Lee KJ, Yoo J, Kim YN, Lee BC, Yoon BW, Kim JS, Investigators EUREKA (2016) Effect and safety of rosuvastatin in acute ischemic stroke. J Stroke 18:87\u201395","journal-title":"J Stroke"},{"key":"1650_CR9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/WNF.0b013e3182206c2f","volume":"34","author":"A Muscari","year":"2011","unstructured":"Muscari A, Puddu GM, Santoro N, Serafini C, Cenni A, Rossi V, Zoli M (2011) The atorvastatin during ischemic stroke study: a pilot randomized controlled trial. Clin Neuropharmacol 34:141\u2013147","journal-title":"Clin Neuropharmacol"},{"key":"1650_CR10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.atherosclerosis.2015.08.043","volume":"243","author":"K Tziomalos","year":"2015","unstructured":"Tziomalos K, Giampatzis V, Bouziana SD, Spanou M, Kostaki S, Papadopoulou M, Angelopoulou SM, Konstantara F, Savopoulos C, Hatzitolios AI (2015) Comparative effects of more versus less aggressive treatment with statins on the long-term outcome of patients with acute ischemic stroke. Atherosclerosis 243:65\u201370","journal-title":"Atherosclerosis"},{"key":"1650_CR11","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","volume":"339","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339:b2535","journal-title":"BMJ"},{"key":"1650_CR12","unstructured":"Higgins JPT, Green S (2011) Cochrane handbook for systematic reviews of interventions version 5.1.0 updated March 2011. The Cochrane Collaboration 2011. http:\/\/www.cochrane-handbook.org . Accessed 06 June 2016"},{"key":"1650_CR13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1747-4949.2011.00653.x","volume":"7","author":"C Beer","year":"2012","unstructured":"Beer C, Blacker D, Bynevelt M, Hankey GJ, Puddey IB (2012) A randomized placebo controlled trial of early treatment of acute ischemic stroke with atorvastatin and irbesartan. Int J Stroke 7:104\u2013111","journal-title":"Int J Stroke"},{"key":"1650_CR14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1468-1331.2007.02015.x","volume":"15","author":"J Montaner","year":"2008","unstructured":"Montaner J, Chac\u00f3n P, Krupinski J, Rubio F, Mill\u00e1n M, Molina CA, Hereu P, Quintana M, Alvarez-Sab\u00edn J (2008) Simvastatin in the acute phase of ischemic stroke: a safety and efficacy pilot trial. Eur J Neurol 15:82\u201390","journal-title":"Eur J Neurol"},{"key":"1650_CR15","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S1474-4422(07)70250-8","volume":"6","author":"J Kennedy","year":"2007","unstructured":"Kennedy J, Hill MD, Ryckborst KJ, Eliasziw M, Demchuk AM, Buchan AM, Investigators FASTER (2007) Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial. Lancet Neurol 6:961\u2013969","journal-title":"Lancet Neurol"},{"key":"1650_CR16","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1161\/01.ATV.17.11.3294","volume":"17","author":"DJ Schneider","year":"1997","unstructured":"Schneider DJ, Ricci MA, Taatjes DJ et al (1997) Changes in arterial expression of fibrinolytic system proteins inatherogenesis. Arterioscler Thromb Vasc Biol 17:3294\u20133301","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1650_CR17","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1161\/STROKEAHA.109.557330","volume":"40","author":"LB Goldstein","year":"2009","unstructured":"Goldstein LB, Amarenco P, Zivin J et al (2009) Statin treatment and stroke outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. Stroke 40:3526\u20133531","journal-title":"Stroke"},{"key":"1650_CR18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2377-10-47","volume":"10","author":"A Arboix","year":"2010","unstructured":"Arboix A, Garc\u00eda-Eroles L, Oliveres M, Targa C, Balcells M, Massons J (2010) Pretreatment with statins improves early outcome in patients with first-ever ischaemic stroke: a pleiotropic effect of statins or a beneficial effect of hypercholesterolemia? BMC Neurol 10:47","journal-title":"BMC Neurol"},{"key":"1650_CR19","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2174\/138161209787315729","volume":"15","author":"VG Athyros","year":"2009","unstructured":"Athyros VG, Kakafika AI, Tziomalos K, Karagiannis A, Mikhailidis DP (2009) Pleiotropic effects of statins\u2014clinical evidence. Curr Pharm Des 15:479\u2013489","journal-title":"Curr Pharm Des"},{"key":"1650_CR20","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jacc.2006.04.070","volume":"48","author":"CP Cannon","year":"2006","unstructured":"Cannon CP, Steinberg BA, Murphy SA, Mega JL, Braunwald E (2006) Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy. J Am Coll Cardiol 48:438\u2013445","journal-title":"J Am Coll Cardiol"},{"key":"1650_CR21","doi-asserted-by":"crossref","first-page":"561","DOI":"10.33588\/rn.4811.2009069","volume":"48","author":"J Fern\u00e1ndezde Bobadilla","year":"2009","unstructured":"Fern\u00e1ndezde Bobadilla J, Moreno R, Fern\u00e1ndez C, Mart\u00ednez A, S\u00e1nchez-Maestre C, Ezpeleta-Echevarri D (2009) Effect of intensive treatment with atorvastatin versus standard doses of statins on the risk of stroke. A meta-analysis from five randomized trials including 25,709 patients. Revue Neurol 48:561\u2013565","journal-title":"Revue Neurol"},{"key":"1650_CR22","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1503\/cmaj.070675","volume":"178","author":"K Josan","year":"2008","unstructured":"Josan K, Majumdar SR, McAlister FA (2008) The efficacy and safety of intensive statin therapy: a meta-analysis of randomized trials. Can Med Assoc J 178:576\u2013584","journal-title":"Can Med Assoc J"},{"key":"1650_CR23","doi-asserted-by":"crossref","first-page":"e111247","DOI":"10.1371\/journal.pone.0111247","volume":"9","author":"FM Vries de","year":"2014","unstructured":"de Vries FM, Kolthof J, Postma MJ, Denig P, Hak E (2014) Efficacy of standard and intensive statin treatment for the secondary prevention of cardiovascular and cerebrovascular events in diabetes patients: a meta-analysis. PLoS One 9:e111247","journal-title":"PLoS One"},{"key":"1650_CR24","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/ane.12540","volume":"134","author":"AK Pandit","year":"2016","unstructured":"Pandit AK, Kumar P, Kumar A, Chakravarty K, Misra S, Prasad K (2016) High-dose statin therapy and risk of intracerebral hemorrhage: a meta-analysis. Acta Neurol Scand 134:22\u201328","journal-title":"Acta Neurol Scand"},{"key":"1650_CR25","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.STR.20.7.864","volume":"20","author":"T Brott","year":"1989","unstructured":"Brott T, Adams HP Jr, Olinger CP, Walker M (1989) Measurement of acute cerebral infarction: a clinical examination scale. Stroke 20:864\u2013870","journal-title":"Stroke"},{"key":"1650_CR26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12883-015-0367-4","volume":"15","author":"J Kang","year":"2015","unstructured":"Kang J, Kim N, Park TH, Bang OY, Lee JS, Lee J, Han MK, Park SH, Gorelick PB, Bae HJ (2015) Early statin use in ischemic stroke patients treated with recanalization therapy: retrospective observational study. BMC Neurol 15:122","journal-title":"BMC Neurol"},{"key":"1650_CR27","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(04)15690-0","volume":"363","author":"R Collins","year":"2004","unstructured":"Collins R, Armitage J, Parish S, Sleight P, Peto R, Heart Protection Study Collaborative Group (2004) Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions. Lancet 363:757\u2013767","journal-title":"Lancet"},{"key":"1650_CR28","doi-asserted-by":"crossref","unstructured":"Cholesterol Treatment Trialists\u2019 (CTT) Collaboration, Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, Bhala N, Peto R, Barnes EH, Keech A, Simes J, Collins R (2010) Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 376: 1670\u20131681","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"1650_CR29","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1212\/WNL.0000000000002606","volume":"86","author":"JF Scheitz","year":"2016","unstructured":"Scheitz JF, MacIsaac RL, Abdul-Rahim AH, Siegerink B, Bath PM, Endres M, Lees KR, Nolte CH, VISTA collaboration (2016) Statins and risk of poststroke hemorrhagic complications. Neurology 86:1590\u20131596","journal-title":"Neurology"},{"key":"1650_CR30","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1161\/STROKEAHA.112.655894","volume":"43","author":"JS McKinney","year":"2012","unstructured":"McKinney JS, Kostis WJ (2012) Statin therapy and the risk of intracerebral hemorrhage: a meta-analysis of 31 randomized controlled trials. Stroke 43:2149\u20132156","journal-title":"Stroke"},{"key":"1650_CR31","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/ijs.12539","volume":"A100","author":"S \u00c5sberg","year":"2015","unstructured":"\u00c5sberg S, Eriksson M (2015) Statin therapy and the risk of intracerebral haemorrhage: a nationwide observational study. Int J Stroke Suppl A100:46\u201349","journal-title":"Int J Stroke Suppl"},{"key":"1650_CR32","doi-asserted-by":"crossref","unstructured":"Fukuma K (2015) Early statin intervention can reduce the early neurological deterioration and recurrence in acute lacunar stroke. Stroke 46:TP65","DOI":"10.1161\/str.46.suppl_1.tp65"},{"key":"1650_CR33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10557-013-6493-6","volume":"28","author":"Y Ueno","year":"2014","unstructured":"Ueno Y, Yamashiro K, Tanaka Y (2014) Rationale and design of the EPISTEME trial: efficacy of post-stroke intensive rosuvastatin treatment for aortogenic embolic stroke. Cardiovasc Drugs Ther 28:79\u201385","journal-title":"Cardiovasc Drugs Ther"},{"key":"1650_CR34","first-page":"1014","volume":"60","author":"J Kurzepa","year":"2008","unstructured":"Kurzepa J, Bielewicz J, Bartosik-Psujek H, Szczepa\u0144ska-Szerej A, Stelmasiak Z (2008) Simvastatin inhibits the increase in serum tau protein levels in the acute phase of ischemic stroke. Pharmacol Rep 60:1014\u20131018","journal-title":"Pharmacol Rep"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11739-017-1650-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-017-1650-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-017-1650-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T18:53:37Z","timestamp":1750100017000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11739-017-1650-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,16]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["1650"],"URL":"https:\/\/doi.org\/10.1007\/s11739-017-1650-8","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727425126.793538026","asserted-by":"object"}]},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,16]]}}}