{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:16:09Z","timestamp":1767906969112,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T00:00:00Z","timestamp":1544140800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s11739-018-1990-z","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T10:48:12Z","timestamp":1544179692000},"page":"459-466","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Prognostic value of sepsis-induced coagulation abnormalities: an early assessment in the emergency department"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7805-7619","authenticated-orcid":false,"given":"Francesca","family":"Innocenti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Gori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betti","family":"Giusti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Tozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Donnini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Meo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Giacomelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Ralli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Sereni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Sticchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Zari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Caldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Tassinari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Zanobetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Marcucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Pini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,7]]},"reference":[{"issue":"2","key":"1990_CR1","doi-asserted-by":"publisher","first-page":"R82","DOI":"10.1186\/cc2459","volume":"8","author":"GT Kinasewitz","year":"2004","unstructured":"Kinasewitz GT, Yan SB, Basson B, Comp P, Russell JA, Cariou A, Um SL, Utterback B, Laterre PF, Dhainaut JF (2004) Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]. Crit Care 8(2):R82\u2013R90. \n                    https:\/\/doi.org\/10.1186\/cc2459","journal-title":"Crit Care"},{"issue":"2","key":"1990_CR2","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/j.1365-2141.2006.06281.x","volume":"135","author":"PW Collins","year":"2006","unstructured":"Collins PW, Macchiavello LI, Lewis SJ, Macartney NJ, Saayman AG, Luddington R, Baglin T, Findlay GP (2006) Global tests of haemostasis in critically ill patients with severe sepsis syndrome compared to controls. Br J Haematol 135(2):220\u2013227. \n                    https:\/\/doi.org\/10.1111\/j.1365-2141.2006.06281.x","journal-title":"Br J Haematol"},{"issue":"1","key":"1990_CR3","doi-asserted-by":"publisher","first-page":"R13","DOI":"10.1186\/cc13190","volume":"18","author":"K Koyama","year":"2014","unstructured":"Koyama K, Madoiwa S, Nunomiya S, Koinuma T, Wada M, Sakata A, Ohmori T, Mimuro J, Sakata Y (2014) Combination of thrombin-antithrombin complex, plasminogen activator inhibitor-1, and protein C activity for early identification of severe coagulopathy in initial phase of sepsis: a prospective observational study. Crit Care 18(1):R13. \n                    https:\/\/doi.org\/10.1186\/cc13190","journal-title":"Crit Care"},{"key":"1990_CR4","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","volume":"149","author":"M Levi","year":"2017","unstructured":"Levi M, van der Poll T (2017) Coagulation and sepsis. Thromb Res 149:38\u201344. \n                    https:\/\/doi.org\/10.1016\/j.thromres.2016.11.007","journal-title":"Thromb Res"},{"issue":"2","key":"1990_CR5","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1097\/01.CCM.0000196832.27501.B2","volume":"34","author":"MW Angstwurm","year":"2006","unstructured":"Angstwurm MW, Dempfle CE, Spannagl M (2006) New disseminated intravascular coagulation score: a useful tool to predict mortality in comparison with Acute Physiology and Chronic Health Evaluation II and Logistic Organ Dysfunction scores. Crit Care Med 34(2):314\u2013320 (00003246-200602000-00005 [pii])","journal-title":"Crit Care Med"},{"issue":"10","key":"1990_CR6","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.ejim.2015.10.024","volume":"26","author":"M Schwameis","year":"2015","unstructured":"Schwameis M, Steiner MM, Schoergenhofer C, Lagler H, Buchtele N, Jilma-Stohlawetz P, Boehm T, Jilma B (2015) D-dimer and histamine in early stage bacteremia: a prospective controlled cohort study. Eur J Intern Med 26(10):782\u2013786. \n                    https:\/\/doi.org\/10.1016\/j.ejim.2015.10.024","journal-title":"Eur J Intern Med"},{"issue":"2","key":"1990_CR7","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1097\/mbc.0000000000000572","volume":"28","author":"B Adamik","year":"2017","unstructured":"Adamik B, Gozdzik W, Jakubczyk D, Welna M, Kubler A (2017) Coagulation abnormalities identified by thromboelastometry in patients with severe sepsis: the relationship to endotoxemia and mortality. Blood Coagul Fibrinolysis 28(2):163\u2013170. \n                    https:\/\/doi.org\/10.1097\/mbc.0000000000000572","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"4","key":"1990_CR8","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1097\/MEJ.0000000000000075","volume":"21","author":"F Innocenti","year":"2014","unstructured":"Innocenti F, Bianchi S, Guerrini E, Vicidomini S, Conti A, Zanobetti M, Pini R (2014) Prognostic scores for early stratification of septic patients admitted to an emergency department-high dependency unit. Eur J Emerg Med 21(4):254\u2013259. \n                    https:\/\/doi.org\/10.1097\/mej.0000000000000075","journal-title":"Eur J Emerg Med"},{"issue":"4","key":"1990_CR9","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","volume":"31","author":"MM Levy","year":"2003","unstructured":"Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G (2003) 2001 SCCM\/ESICM\/ACCP\/ATS\/SIS international sepsis definitions conference. Crit Care Med 31(4):1250\u20131256. \n                    https:\/\/doi.org\/10.1097\/01.ccm.0000050454.01978.3b","journal-title":"Crit Care Med"},{"issue":"12","key":"1990_CR10","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1097\/01.CCM.0000147769.07699.E3","volume":"32","author":"K Bakhtiari","year":"2004","unstructured":"Bakhtiari K, Meijers JC, de Jonge E, Levi M (2004) Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med 32(12):2416\u20132421 (00003246-200412000-00008 [pii])","journal-title":"Crit Care Med"},{"issue":"6","key":"1990_CR11","first-page":"488","volume":"23","author":"A Oberholzer","year":"2005","unstructured":"Oberholzer A, Souza SM, Tschoeke SK, Oberholzer C, Abouhamze A, Pribble JP, Moldawer LL (2005) Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis. Shock 23(6):488\u2013493 (00024382-200506000-00002 [pii])","journal-title":"Shock"},{"issue":"5","key":"1990_CR12","doi-asserted-by":"publisher","first-page":"R182","DOI":"10.1186\/cc9290","volume":"14","author":"NI Shapiro","year":"2010","unstructured":"Shapiro NI, Schuetz P, Yano K, Sorasaki M, Parikh SM, Jones AE, Trzeciak S, Ngo L, Aird WC (2010) The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care 14(5):R182. \n                    https:\/\/doi.org\/10.1186\/cc9290","journal-title":"Crit Care"},{"key":"1990_CR13","doi-asserted-by":"publisher","DOI":"10.1159\/000487818","author":"KR Genga","year":"2018","unstructured":"Genga KR, Shimada T, Boyd JH, Walley KR, Russell JA (2018) The understanding and management of organism toxicity in septic shock. J Innate Immun. \n                    https:\/\/doi.org\/10.1159\/000487818","journal-title":"J Innate Immun"},{"issue":"1","key":"1990_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1055\/s-0034-1398376","volume":"41","author":"M Levi","year":"2015","unstructured":"Levi M, Poll T (2015) Coagulation in patients with severe sepsis. Semin Thromb Hemost 41(1):9\u201315. \n                    https:\/\/doi.org\/10.1055\/s-0034-1398376","journal-title":"Semin Thromb Hemost"},{"issue":"2","key":"1990_CR15","doi-asserted-by":"publisher","first-page":"R68","DOI":"10.1186\/cc12609","volume":"17","author":"A Couto-Alves","year":"2013","unstructured":"Couto-Alves A, Wright VJ, Perumal K, Binder A, Carrol ED, Emonts M, de Groot R, Hazelzet J, Kuijpers T, Nadel S, Zenz W, Ramnarayan P, Levin M, Coin L, Inwald DP (2013) A new scoring system derived from base excess and platelet count at presentation predicts mortality in paediatric meningococcal sepsis. Crit Care 17(2):R68. \n                    https:\/\/doi.org\/10.1186\/cc12609","journal-title":"Crit Care"},{"issue":"7","key":"1990_CR16","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1111\/aas.12918","volume":"61","author":"S Benediktsson","year":"2017","unstructured":"Benediktsson S, Frigyesi A, Kander T (2017) Routine coagulation tests on ICU admission are associated with mortality in sepsis: an observational study. Acta Anaesthesiol Scand 61(7):790\u2013796. \n                    https:\/\/doi.org\/10.1111\/aas.12918","journal-title":"Acta Anaesthesiol Scand"},{"issue":"9","key":"1990_CR17","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1016\/j.ajem.2016.06.015","volume":"34","author":"JY Wang","year":"2016","unstructured":"Wang JY, Chen YX, Guo SB, Mei X, Yang P (2016) Predictive performance of quick Sepsis-related Organ Failure Assessment for mortality and ICU admission in patients with infection at the ED. Am J Emerg Med 34(9):1788\u20131793. \n                    https:\/\/doi.org\/10.1016\/j.ajem.2016.06.015","journal-title":"Am J Emerg Med"},{"issue":"14","key":"1990_CR18","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1001\/jama.286.14.1754","volume":"286","author":"FL Ferreira","year":"2001","unstructured":"Ferreira FL, Bota DP, Bross A, Melot C, Vincent JL (2001) Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 286(14):1754\u20131758 (jce00056 [pii])","journal-title":"JAMA"},{"issue":"5","key":"1990_CR19","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1097\/CCM.0b013e31819def97","volume":"37","author":"AE Jones","year":"2009","unstructured":"Jones AE, Trzeciak S, Kline JA (2009) The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation. Crit Care Med 37(5):1649\u20131654. \n                    https:\/\/doi.org\/10.1097\/ccm.0b013e31819def97","journal-title":"Crit Care Med"},{"key":"1990_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-017-1629-5","author":"F Innocenti","year":"2017","unstructured":"Innocenti F, Tozzi C, Donnini C, De VE, Conti A, Zanobetti M, Pini R (2017) SOFA score in septic patients: incremental prognostic value over age, comorbidities, and parameters of sepsis severity. Intern Emerg Med. \n                    https:\/\/doi.org\/10.1007\/s11739-017-1629-5","journal-title":"Intern Emerg Med"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-018-1990-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11739-018-1990-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-018-1990-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T19:10:18Z","timestamp":1575659418000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11739-018-1990-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,7]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["1990"],"URL":"https:\/\/doi.org\/10.1007\/s11739-018-1990-z","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,7]]},"assertion":[{"value":"5 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in compliance with the Declaration of Helsinki at the Careggi University Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of human and animal rights"}},{"value":"The study protocol was approved by the local Ethics Committee, and all subjects provided oral.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}