{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:44:09Z","timestamp":1756385049402,"version":"3.37.3"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s11739-019-02219-9","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T20:26:27Z","timestamp":1572467187000},"page":"437-441","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The doctor who stared at schistocytes: an intriguing case of suspected thrombotic microangiopathic anemia"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1016-7432","authenticated-orcid":false,"given":"Filippo","family":"Pieralli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Milia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Fruttuoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Bandini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Mercatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Nozzoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Luise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Sammicheli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Moggi Pignone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"2219_CR1","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1056\/NEJM199108083250604","volume":"325","author":"GA Rock","year":"1991","unstructured":"Rock GA, Shumak KH, Buskard NA et al (1991) Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. N Engl J Med 325:393\u2013397. https:\/\/doi.org\/10.1056\/NEJM199108083250604","journal-title":"N Engl J Med"},{"key":"2219_CR2","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/00005792-196603000-00003","volume":"45","author":"EL Amorosi","year":"1966","unstructured":"Amorosi EL, Ultmann JE (1966) Thrombotic thrombocytopenic purpura: report of 16 cases and review of the literature. Medicine. 45:139\u2013160","journal-title":"Medicine."},{"issue":"7","key":"2219_CR3","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1056\/NEJMra1312353","volume":"371","author":"JN George","year":"2014","unstructured":"George JN, Nester CM (2014) Syndromes of thrombotic microangiopathy. N Engl J Med 371(7):654\u2013666. https:\/\/doi.org\/10.1056\/NEJMra1312353","journal-title":"N Engl J Med"},{"key":"2219_CR4","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1182\/blood-2016-10-709857","volume":"129","author":"BS Joly","year":"2017","unstructured":"Joly BS, Coppo P, Veyradier A (2017) Thrombotic thrombocytopenic purpura. Blood 129:2836\u20132846. https:\/\/doi.org\/10.1182\/blood-2016-10-709857","journal-title":"Blood"},{"key":"2219_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s41100-016-0088-1","volume":"3","author":"Y Yoshida","year":"2017","unstructured":"Yoshida Y, Kato H, Nangaku M (2017) Atypical hemolytic uremic syndrome. Ren Replace Ther 3:5. https:\/\/doi.org\/10.1186\/s41100-016-0088-1","journal-title":"Ren Replace Ther"},{"issue":"19","key":"2219_CR6","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3238\/arztebl.2018.0327","volume":"115","author":"M Bommer","year":"2018","unstructured":"Bommer M, W\u00f6lfle-Guter M, Bohl S, Kuchenbauer F (2018) The Differential Diagnosis and treatment of thrombotic microangiopathies. Deutsches Arzteblatt Int 115(19):327\u2013334. https:\/\/doi.org\/10.3238\/arztebl.2018.0327","journal-title":"Deutsches Arzteblatt Int"},{"issue":"10","key":"2219_CR7","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1182\/bloodadvances.2017005124","volume":"1","author":"EE Page","year":"2017","unstructured":"Page EE, Kremer Hovinga JA, Terrell DR, Vesely SK, George JN (2017) Thrombotic thrombocytopenic purpura: diagnostic criteria, clinical features, and long-term outcomes from 1995 through 2015. Blood Adv 1(10):590\u2013600. https:\/\/doi.org\/10.1182\/bloodadvances.2017005124","journal-title":"Blood Adv"},{"key":"2219_CR8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/jca.21470","volume":"31","author":"J Schwartz","year":"2016","unstructured":"Schwartz J, Padmanabhan A, Aqui N et al (2016) Guidelines on the use of therapeutic apheresis in clinical practice\u2013evidence-based approach from the writing committee of the american society for apheresis: the seventh special issue. J Clin Apheresis 31:149\u2013338. https:\/\/doi.org\/10.1002\/jca.21470","journal-title":"J Clin Apheresis"},{"key":"2219_CR9","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1751-553X.2011.01380.x","volume":"34","author":"G Zini","year":"2012","unstructured":"Zini G, D\u2019onofrio G, Briggs C et al (2012) ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes. Int J Lab Hematol 34:107\u2013116. https:\/\/doi.org\/10.1111\/j.1751-553X.2011.01380.x","journal-title":"Int J Lab Hematol"},{"issue":"21","key":"2219_CR10","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1182\/blood.V124.21.231.231","volume":"124","author":"PK Bendapudi","year":"2014","unstructured":"Bendapudi PK, Li A, Hamdan A et al (2014) Derivation and prospective validation of a predictive score for the rapid diagnosis of thrombotic thrombocytopenic purpura: the plasmic score. Blood 124(21):231\u2013237","journal-title":"Blood"},{"key":"2219_CR11","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.1365-2257.2006.00755.x","volume":"28","author":"E Andr\u00e8s","year":"2006","unstructured":"Andr\u00e8s E, Affenberger S, Zimmer J et al (2006) Current hematological findings in cobalamin deficiency. a study of 201 consecutive patients with documented cobalamin deficiency. Clin Lab Haematol 28:50\u201356. https:\/\/doi.org\/10.1111\/j.1365-2257.2006.00755.x","journal-title":"Clin Lab Haematol"},{"issue":"11","key":"2219_CR12","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1093\/qjmed\/hct142","volume":"106","author":"N No\u00ebl","year":"2013","unstructured":"No\u00ebl N, Maign\u00e9 G, Tertian G et al (2013) Haemolysis and schistocytosis in the emergency department: consider pseudothrombotic microangiopathy related to vitamin B12 deficiency. QJM 106(11):1017\u20131022. https:\/\/doi.org\/10.1093\/qjmed\/hct142","journal-title":"QJM"},{"key":"2219_CR13","doi-asserted-by":"publisher","first-page":"9410727","DOI":"10.1155\/2017\/9410727","volume":"2017","author":"F Yousaf","year":"2017","unstructured":"Yousaf F, Spinowitz B, Charytan C, Galler M (2017) Pernicious anemia associated cobalamin deficiency and thrombotic microangiopathy: case report and review of the literature. Case Rep Med 2017:9410727. https:\/\/doi.org\/10.1155\/2017\/9410727","journal-title":"Case Rep Med"},{"key":"2219_CR14","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.transci.2018.01.003","volume":"57","author":"PN Tran","year":"2018","unstructured":"Tran PN, Tran MH (2018) Cobalamin deficiency presenting with thrombotic microangiopathy (TMA) features: a systematic review. Transfus Apher Sci 57:102\u2013106. https:\/\/doi.org\/10.1016\/j.transci.2018.01.003","journal-title":"Transfus Apher Sci"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-019-02219-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11739-019-02219-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-019-02219-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T05:07:36Z","timestamp":1615439256000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11739-019-02219-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,30]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["2219"],"URL":"https:\/\/doi.org\/10.1007\/s11739-019-02219-9","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"type":"print","value":"1828-0447"},{"type":"electronic","value":"1970-9366"}],"subject":[],"published":{"date-parts":[[2019,10,30]]},"assertion":[{"value":"25 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of human and animal rights"}},{"value":"None.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}