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We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70\u00a0years, range 25\u201397; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was\u2009&gt;\u200950\u00a0mU\/ml, gamma-glutamyl transpeptidase (GGT)\u2009&gt;\u200950\u00a0mU\/ml, or total bilirubin\u2009&gt;\u20091.1\u00a0mg\/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and\/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>\u2009&lt;\u2009200 was associated with greater mortality and need for intensive care (HR 2.34, 95% CI 1.07\u20135.11,<jats:italic>p<\/jats:italic>\u2009=\u20090.033). To conclude, a high prevalence of altered liver function tests was noticed in Italian patients with COVID-19, and this was associated with worse outcomes when developing severe acute respiratory distress syndrome.<\/jats:p>","DOI":"10.1007\/s11739-020-02425-w","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T09:03:43Z","timestamp":1594371823000},"page":"1399-1407","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy"],"prefix":"10.1007","volume":"15","author":[{"given":"Marco Vincenzo","family":"Lenti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Borrelli de 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