{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:05:06Z","timestamp":1791925506687,"version":"4.3.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s11739-020-02485-y","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T15:34:47Z","timestamp":1599752087000},"page":"1533-1544","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cause-specific death in hospitalized individuals infected with SARS-CoV-2: more than just acute respiratory failure or thromboembolic events"],"prefix":"10.1007","volume":"15","author":[{"given":"Marta","family":"Cobos-Siles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Cubero-Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Arroyo-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Rey-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hern\u00e1ndez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derly Judith","family":"Vargas-Parra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Gonz\u00e1lez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Cazorla-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Gabella-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1s","family":"Ru\u00edz-Albi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Angel","family":"Berezo-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas Fernando","family":"Garc\u00eda-Cruces-M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Pablo","family":"Miramontes-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0151-5420","authenticated-orcid":false,"given":"Luis","family":"Corral-Gudino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"2485_CR1","unstructured":"Coronavirus Update (Live): 2,646,247 Cases and 184,352 Deaths from COVID-19 Virus Pandemic\u2014Worldometer. https:\/\/www.worldometers.info\/coronavirus\/. Accessed 23 Apr 2020"},{"key":"2485_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30195-X","author":"D Baud","year":"2020","unstructured":"Baud D, Qi X, Nielsen-Saines K et al (2020) Real estimates of mortality following COVID-19 infection. Lancet Infect Dis. https:\/\/doi.org\/10.1016\/S1473-3099(20)30195-X","journal-title":"Lancet Infect Dis"},{"key":"2485_CR3","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","volume":"382","author":"W-J Guan","year":"2020","unstructured":"Guan W-J, Ni Z-Y, Hu Y et al (2020) Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 382:1708\u20131720. https:\/\/doi.org\/10.1056\/NEJMoa2002032","journal-title":"N Engl J Med"},{"key":"2485_CR4","doi-asserted-by":"publisher","first-page":"m1198","DOI":"10.1136\/bmj.m1198","volume":"368","author":"RE Jordan","year":"2020","unstructured":"Jordan RE, Adab P, Cheng KK (2020) Covid-19: risk factors for severe disease and death. BMJ 368:m1198. https:\/\/doi.org\/10.1136\/bmj.m1198","journal-title":"BMJ"},{"key":"2485_CR5","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1001\/jama.2020.2648","volume":"323","author":"Z Wu","year":"2020","unstructured":"Wu Z, McGoogan JM (2020) Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA 323:1239\u20131242. https:\/\/doi.org\/10.1001\/jama.2020.2648","journal-title":"JAMA"},{"key":"2485_CR6","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1001\/jama.2020.5394","volume":"323","author":"G Grasselli","year":"2020","unstructured":"Grasselli G, Zangrillo A, Zanella A et al (2020) Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy. JAMA 323:1574\u20131581. https:\/\/doi.org\/10.1001\/jama.2020.5394","journal-title":"JAMA"},{"key":"2485_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.017","author":"J Yang","year":"2020","unstructured":"Yang J, Zheng Y, Gou X et al (2020) Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis. Int J Infect Dis. https:\/\/doi.org\/10.1016\/j.ijid.2020.03.017","journal-title":"Int J Infect Dis"},{"key":"2485_CR8","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1001\/jama.2020.1585","volume":"323","author":"D Wang","year":"2020","unstructured":"Wang D, Hu B, Hu C et al (2020) Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 323:1061\u20131069. https:\/\/doi.org\/10.1001\/jama.2020.1585","journal-title":"JAMA"},{"key":"2485_CR9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4344","author":"E Livingston","year":"2020","unstructured":"Livingston E, Bucher K (2020) Coronavirus disease 2019 (COVID-19) in Italy. JAMA. https:\/\/doi.org\/10.1001\/jama.2020.4344","journal-title":"JAMA"},{"key":"2485_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2020.04.043","author":"PR Martins-Filho","year":"2020","unstructured":"Martins-Filho PR, Tavares CSS, Santos VS (2020) Factors associated with mortality in patients with COVID-19. A quantitative evidence synthesis of clinical and laboratory data. Euron J Int Med. https:\/\/doi.org\/10.1016\/j.ejim.2020.04.043","journal-title":"Euron J Int Med"},{"key":"2485_CR11","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","volume":"395","author":"P Mehta","year":"2020","unstructured":"Mehta P, McAuley DF, Brown M et al (2020) COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 395:1033\u20131034. https:\/\/doi.org\/10.1016\/S0140-6736(20)30628-0","journal-title":"Lancet"},{"key":"2485_CR12","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/S0140-6736(16)32381-9","volume":"389","author":"V Kontis","year":"2017","unstructured":"Kontis V, Bennett JE, Mathers CD et al (2017) Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble. Lancet 389:1323\u20131335. https:\/\/doi.org\/10.1016\/S0140-6736(16)32381-9","journal-title":"Lancet"},{"key":"2485_CR13","unstructured":"Clinical management of severe acute respiratory infection when COVID-19 is suspected. https:\/\/www.who.int\/publications-detail\/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected. Accessed 2 Apr 2020"},{"key":"2485_CR14","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1001\/jama.2012.5669","volume":"307","author":"ARDS Definition Task Force","year":"2012","unstructured":"Definition Task Force ARDS, Ranieri VM, Rubenfeld GD et al (2012) Acute respiratory distress syndrome: the Berlin definition. JAMA 307:2526\u20132533. https:\/\/doi.org\/10.1001\/jama.2012.5669","journal-title":"JAMA"},{"key":"2485_CR15","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s11547-020-01200-3","volume":"125","author":"A Borghesi","year":"2020","unstructured":"Borghesi A, Maroldi R (2020) COVID-19 outbreak in Italy: experimental chest X-ray scoring system for quantifying and monitoring disease progression. Radiol Med 125:509\u2013513. https:\/\/doi.org\/10.1007\/s11547-020-01200-3","journal-title":"Radiol Med"},{"key":"2485_CR16","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1503\/cmaj.050051","volume":"173","author":"K Rockwood","year":"2005","unstructured":"Rockwood K, Song X, MacKnight C et al (2005) A global clinical measure of fitness and frailty in elderly people. CMAJ 173:489\u2013495. https:\/\/doi.org\/10.1503\/cmaj.050051","journal-title":"CMAJ"},{"key":"2485_CR17","first-page":"61","volume":"14","author":"FI Mahoney","year":"1965","unstructured":"Mahoney FI, Barthel DW (1965) Functional evaluation: the barthel index. Md State Med J 14:61\u201365","journal-title":"Md State Med J"},{"key":"2485_CR18","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0994","author":"C Wu","year":"2020","unstructured":"Wu C, Chen X, Cai Y et al (2020) Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. https:\/\/doi.org\/10.1001\/jamainternmed.2020.0994","journal-title":"JAMA Intern Med"},{"key":"2485_CR19","unstructured":"Before their time\u2014Would most covid-19 victims have died soon, without the virus? (Graphic detail) The Economist. https:\/\/www.economist.com\/graphic-detail\/2020\/05\/02\/would-most-covid-19-victims-have-died-soon-without-the-virus?utm_campaign=coronavirus-special-edition&utm_medium=newsletter&utm_source=salesforce-marketing-cloud&utm_term=2020-05-02&utm_content=article-link-2, https:\/\/www.msn.com\/es-es\/?cobrand=acer17win10.msn.com&ocid=ACERDHP17&pc=ACTE. Accessed 2 May 2020"},{"key":"2485_CR20","doi-asserted-by":"publisher","DOI":"10.12788\/jhm.3452","author":"CJ Wang","year":"2020","unstructured":"Wang CJ, Bair H, Yeh C-C (2020) How to prevent and manage hospital-based infections during coronavirus outbreaks: five lessons from Taiwan. J Hosp Med. https:\/\/doi.org\/10.12788\/jhm.3452","journal-title":"J Hosp Med"},{"key":"2485_CR21","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.1782","author":"RO Bonow","year":"2020","unstructured":"Bonow RO, Hernandez AF, Turakhia M (2020) Hydroxychloroquine, coronavirus disease 2019, and QT prolongation. JAMA Cardiol. https:\/\/doi.org\/10.1001\/jamacardio.2020.1782","journal-title":"JAMA Cardiol"},{"key":"2485_CR22","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.medcli.2018.05.011","volume":"151","author":"JB Soriano","year":"2018","unstructured":"Soriano JB, Rojas-Rueda D, Alonso J et al (2018) The burden of disease in Spain: results from the global burden of disease 2016. Med Clin (Barc) 151:171\u2013190. https:\/\/doi.org\/10.1016\/j.medcli.2018.05.011","journal-title":"Med Clin (Barc)"},{"key":"2485_CR23","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcaa145","author":"S Donnelly","year":"2020","unstructured":"Donnelly S (2020) The elderly & COVID-19: cocooning or culling: -the choice is ours. QJM. https:\/\/doi.org\/10.1093\/qjmed\/hcaa145","journal-title":"QJM"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-020-02485-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-020-02485-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-020-02485-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T22:39:30Z","timestamp":1631227170000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11739-020-02485-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,10]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["2485"],"URL":"https:\/\/doi.org\/10.1007\/s11739-020-02485-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-39922\/v1","asserted-by":"object"}]},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,10]]},"assertion":[{"value":"1 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures perfomed in human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of human and animal rights"}},{"value":"Our study is a retrospective cohort. Due to the nature of the retrospective chart review, the hospital ethics committee waived the need for informed consent from individual patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}