{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:30:25Z","timestamp":1785778225642,"version":"3.56.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s11739-020-02576-w","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T19:02:32Z","timestamp":1609527752000},"page":"1061-1070","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Predictors of post-traumatic complication of mild brain injury in anticoagulated patients: DOACs are\u00a0safer than VKAs"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7085-3621","authenticated-orcid":false,"given":"Alessandro","family":"Cipriano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naria","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Pecori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bionda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Frassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Lami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Leoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Manca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Del Prato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Santini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Ghiadoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,1]]},"reference":[{"key":"2576_CR1","unstructured":"American College of Surgeons' Committee on Trauma (2018) Head trauma: advanced trauma life support, student course manual, 10th edn, pp 109\u2013111"},{"key":"2576_CR2","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1089\/neu.2015.4070","volume":"33","author":"H Losoi","year":"2016","unstructured":"Losoi H, Silverberg ND, Waljas M et al (2016) Recovery from mild traumatic brain injury in previously healthy adults. J Neurotrauma 33:766\u2013776","journal-title":"J Neurotrauma"},{"key":"2576_CR3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/16501960410023822","volume":"36","author":"J Borg","year":"2004","unstructured":"Borg J, Holm L, Cassidy JD et al (2004) Diagnostic procedures in mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. J Rehabil Med 36:61\u201375","journal-title":"J Rehabil Med"},{"key":"2576_CR4","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1001\/archsurg.2010.313","volume":"146","author":"LA Dossett","year":"2011","unstructured":"Dossett LA, Riesel JN, Griffin MR, Cotton BA (2011) Prevalence and implications of preinjury warfarin use: an analysis of the National Trauma Databank. Arch Surg 146:565\u2013570","journal-title":"Arch Surg"},{"key":"2576_CR5","first-page":"519","volume":"63","author":"FM Pieracci","year":"2007","unstructured":"Pieracci FM, Eachempati SR, Shou J et al (2007) Use of long-term anticoagulation is associated with traumatic intracranial hemorrhage and subsequent mortality in elderly patients hospitalized after falls: analysis of the New York State Administrative Database. J Trauma 63:519\u2013524","journal-title":"J Trauma"},{"key":"2576_CR6","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s11739-017-1628-6","volume":"12","author":"D Prisco","year":"2017","unstructured":"Prisco D, Ageno W, Becattini C et al (2017) Italian intersociety consensus on DOAC use in internal medicine. Intern Emerg Med 12:387\u2013406","journal-title":"Intern Emerg Med"},{"key":"2576_CR7","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1016\/j.ajem.2013.04.035","volume":"31","author":"DK Nishijima","year":"2013","unstructured":"Nishijima DK, Shahlaie K, Sarkar K et al (2013) Risk of unfavorable long-term outcome in older adults with traumatic intracranial hemorrhage and anticoagulant or antiplatelet use. Am J Emerg Med 31:1244\u20131247","journal-title":"Am J Emerg Med"},{"issue":"544\u2013549","key":"2576_CR8","first-page":"e541","volume":"208","author":"CE Collins","year":"2014","unstructured":"Collins CE, Witkowski ER, Flahive JM et al (2014) Effect of preinjury warfarin use on outcomes after head trauma in Medicare beneficiaries. Am J Surg 208(544\u2013549):e541","journal-title":"Am J Surg"},{"key":"2576_CR9","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1046\/j.1468-1331.2002.00407.x","volume":"9","author":"PE Vos","year":"2002","unstructured":"Vos PE, Battistin L, Birbamer G et al (2002) EFNS guideline on mild traumatic brain injury: report of an EFNS task force. Eur J Neurol 9:207\u2013219","journal-title":"Eur J Neurol"},{"key":"2576_CR10","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1136\/archdischild-2014-306797","volume":"100","author":"T Davis","year":"2015","unstructured":"Davis T, Ings A, National Institute of H. Care E (2015) Head injury: triage, assessment investigation and early management of head injury in children, young people and adults (NICE guideline CG 176). Arch Dis Child Educ Pract Ed 100:97\u2013100","journal-title":"Arch Dis Child Educ Pract Ed"},{"key":"2576_CR11","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1111\/jth.13139","volume":"13","author":"C Chai-Adisaksopha","year":"2015","unstructured":"Chai-Adisaksopha C, Hillis C, Isayama T et al (2015) Mortality outcomes in patients receiving direct oral anticoagulants: a systematic review and meta-analysis of randomized controlled trials. J Thromb Haemost 13:2012\u20132020","journal-title":"J Thromb Haemost"},{"key":"2576_CR12","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1161\/CIRCULATIONAHA.112.115410","volume":"126","author":"F Dentali","year":"2012","unstructured":"Dentali F, Riva N, Crowther M et al (2012) Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature. Circulation 126:2381\u20132391","journal-title":"Circulation"},{"key":"2576_CR13","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.annemergmed.2018.07.020","volume":"73","author":"GW Fuller","year":"2019","unstructured":"Fuller GW, Evans R, Preston L et al (2019) Should adults with mild head injury who are receiving direct oral anticoagulants undergo computed tomography scanning? A Systematic Review. Ann Emerg Med 73:66\u201375","journal-title":"Ann Emerg Med"},{"issue":"9","key":"2576_CR14","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/j.ajem.2018.12.003","volume":"37","author":"MB Spinola","year":"2018","unstructured":"Spinola MB, Riccardi A, Minuto P et al (2018) Hemorrhagic risk and intracranial complications in patients with minor head injury (MHI) taking different oral anticoagulants. Am J Emerg Med 37(9):1677\u20131680","journal-title":"Am J Emerg Med"},{"key":"2576_CR15","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13049-018-0487-0","volume":"26","author":"O Prexl","year":"2018","unstructured":"Prexl O, Bruckbauer M, Voelckel W et al (2018) The impact of direct oral anticoagulants in traumatic brain injury patients greater than 60-years-old. Scand J Trauma Resusc Emerg Med 26:20","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"2576_CR16","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.surg.2018.05.060","volume":"164","author":"M Batey","year":"2018","unstructured":"Batey M, Hecht J, Callahan C, Wahl W (2018) Direct oral anticoagulants do not worsen traumatic brain injury after low-level falls in the elderly. Surgery 164:814\u2013819","journal-title":"Surgery"},{"issue":"6","key":"2576_CR17","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.jemermed.2019.09.007","volume":"57","author":"G Turcato","year":"2019","unstructured":"Turcato G, Zannoni M, Zaboli A et al (2019) Direct oral anticoagulant treatment and mild traumatic brain injury: risk of early and delayed bleeding and the severity of injuries compared with vitamin K antagonists. J Emerg Med 57(6):817\u2013824","journal-title":"J Emerg Med"},{"key":"2576_CR18","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1007\/s11739-018-1806-1","volume":"13","author":"A Cipriano","year":"2018","unstructured":"Cipriano A, Pecori A, Bionda AE et al (2018) Intracranial hemorrhage in anticoagulated patients with mild traumatic brain injury: significant differences between direct oral anticoagulants and vitamin K antagonists. Intern Emerg Med 13:1077\u20131087","journal-title":"Intern Emerg Med"},{"key":"2576_CR19","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1212\/WNL.0000000000003886","volume":"88","author":"D Wilson","year":"2017","unstructured":"Wilson D, Seiffge DJ, Traenka C et al (2017) Outcome of intracerebral hemorrhage associated with different oral anticoagulants. Neurology 88:1693\u20131700","journal-title":"Neurology"},{"key":"2576_CR20","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1097\/TA.0000000000001995","volume":"85","author":"M Zeeshan","year":"2018","unstructured":"Zeeshan M, Jehan F, O\u2019Keeffe T et al (2018) The novel oral anticoagulants (NOACs) have worse outcomes compared with warfarin in patients with intracranial hemorrhage after TBI. J Trauma Acute Care Surg 85:915\u2013920","journal-title":"J Trauma Acute Care Surg"},{"key":"2576_CR21","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jemermed.2014.08.016","volume":"48","author":"KN Alrajhi","year":"2015","unstructured":"Alrajhi KN, Perry JJ, Forster AJ (2015) Intracranial bleeds after minor and minimal head injury in patients on warfarin. J Emerg Med 48:137\u2013142","journal-title":"J Emerg Med"},{"key":"2576_CR22","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s11739-017-1680-2","volume":"13","author":"M Akhter","year":"2018","unstructured":"Akhter M, Morotti A, Cohen AS et al (2018) Timing of INR reversal using fresh-frozen plasma in warfarin-associated intracerebral hemorrhage. Intern Emerg Med 13:557\u2013565","journal-title":"Intern Emerg Med"},{"key":"2576_CR23","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.annemergmed.2011.12.003","volume":"59","author":"VG Menditto","year":"2012","unstructured":"Menditto VG, Lucci M, Polonara S et al (2012) Management of minor head injury in patients receiving oral anticoagulant therapy: a prospective study of a 24-hour observation protocol. Ann Emerg Med 59:451\u2013455","journal-title":"Ann Emerg Med"},{"key":"2576_CR24","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.jemermed.2013.08.107","volume":"46","author":"B Cohn","year":"2014","unstructured":"Cohn B, Keim SM, Sanders AB (2014) Can anticoagulated patients be discharged home safely from the emergency department after minor head injury? J Emerg Med 46:410\u2013417","journal-title":"J Emerg Med"},{"issue":"460\u2013468","key":"2576_CR25","first-page":"e461","volume":"59","author":"DK Nishijima","year":"2012","unstructured":"Nishijima DK, Offerman SR, Ballard DW et al (2012) Immediate and delayed traumatic intracranial hemorrhage in patients with head trauma and preinjury warfarin or clopidogrel use. Ann Emerg Med 59(460\u2013468):e461-467","journal-title":"Ann Emerg Med"},{"key":"2576_CR26","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/978-1-62703-059-5_23","volume":"930","author":"H Abdi","year":"2013","unstructured":"Abdi H, Williams LJ (2013) Partial least squares methods: partial least squares correlation and partial least square regression. Methods Mol Biol 930:549\u2013579","journal-title":"Methods Mol Biol"},{"key":"2576_CR27","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1538-7836.2009.03678.x","volume":"8","author":"S Schulman","year":"2010","unstructured":"Schulman S, Angeras U, Bergqvist D et al (2010) Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients. J Thromb Haemost 8:202\u2013204","journal-title":"J Thromb Haemost"},{"key":"2576_CR28","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1067\/mem.2001.116796","volume":"38","author":"IG Stiell","year":"2001","unstructured":"Stiell IG, Lesiuk H, Wells GA et al (2001) The Canadian CT Head Rule Study for patients with minor head injury: rationale, objectives, and methodology for phase I (derivation). Ann Emerg Med 38:160\u2013169","journal-title":"Ann Emerg Med"},{"key":"2576_CR29","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1227\/00006123-199009000-00014","volume":"27","author":"DH Williams","year":"1990","unstructured":"Williams DH, Levin HS, Eisenberg HM (1990) Mild head injury classification. Neurosurgery 27:422\u2013428","journal-title":"Neurosurgery"},{"key":"2576_CR30","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1089\/neu.2016.4618","volume":"34","author":"S Dikmen","year":"2017","unstructured":"Dikmen S, Machamer J, Temkin N (2017) Mild traumatic brain injury: longitudinal study of cognition, functional status and post-traumatic symptoms. J Neurotrauma 34:1524\u20131530","journal-title":"J Neurotrauma"},{"key":"2576_CR31","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fneur.2020.00112","volume":"11","author":"N Garza","year":"2020","unstructured":"Garza N, Toussi A, Wilson M et al (2020) The increasing age of tbi patients at a single level 1 trauma center and the discordance between GCS and ct rotterdam scores in the elderly. Front Neurol 11:112","journal-title":"Front Neurol"},{"key":"2576_CR32","doi-asserted-by":"publisher","first-page":"e129","DOI":"10.1016\/j.wneu.2019.04.060","volume":"128","author":"EJ Bobeff","year":"2019","unstructured":"Bobeff EJ, Fortuniak J, Bryszewski B et al (2019) Mortality after traumatic brain injury in elderly patients: a new scoring system. World Neurosurg 128:e129\u2013e147","journal-title":"World Neurosurg"},{"key":"2576_CR33","doi-asserted-by":"publisher","first-page":"e014324","DOI":"10.1136\/bmjopen-2016-014324","volume":"7","author":"S Mason","year":"2017","unstructured":"Mason S, Kuczawski M, Teare MD et al (2017) AHEAD Study: an observational study of the management of anticoagulated patients who suffer head injury. BMJ Open 7:e014324","journal-title":"BMJ Open"},{"key":"2576_CR34","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","volume":"383","author":"CT Ruff","year":"2014","unstructured":"Ruff CT, Giugliano RP, Braunwald E et al (2014) Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet 383:955\u2013962","journal-title":"Lancet"},{"key":"2576_CR35","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1056\/NEJMoa0905561","volume":"361","author":"SJ Connolly","year":"2009","unstructured":"Connolly SJ, Ezekowitz MD, Yusuf S et al (2009) Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361:1139\u20131151","journal-title":"N Engl J Med"},{"key":"2576_CR36","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1056\/NEJMoa1107039","volume":"365","author":"CB Granger","year":"2011","unstructured":"Granger CB, Alexander JH, McMurray JJ et al (2011) Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 365:981\u2013992","journal-title":"N Engl J Med"},{"key":"2576_CR37","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1056\/NEJMoa1310907","volume":"369","author":"RP Giugliano","year":"2013","unstructured":"Giugliano RP, Ruff CT, Braunwald E et al (2013) Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 369:2093\u20132104","journal-title":"N Engl J Med"},{"key":"2576_CR38","doi-asserted-by":"publisher","first-page":"3126","DOI":"10.1007\/s00415-019-09536-1","volume":"266","author":"DJ Seiffge","year":"2019","unstructured":"Seiffge DJ, Goeldlin MB, Tatlisumak T et al (2019) Meta-analysis of haematoma volume, haematoma expansion and mortality in intracerebral haemorrhage associated with oral anticoagulant use. J Neurol 266:3126\u20133135","journal-title":"J Neurol"},{"key":"2576_CR39","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/HPC.0000000000000139","volume":"17","author":"A Conti","year":"2018","unstructured":"Conti A, Molesti D, Bianchi S et al (2018) Role of hypertension and other clinical variables in prognostication of patients presenting to the emergency department with major bleeding events. Crit Pathw Cardiol 17:139\u2013146","journal-title":"Crit Pathw Cardiol"},{"issue":"7","key":"2576_CR40","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1590\/0004-282x20200008","volume":"78","author":"JBC Andrade","year":"2020","unstructured":"Andrade JBC, Mohr JP, Lima FO et al (2020) Predictors of hemorrhagic transformation after acute ischemic stroke based on the experts\u2019 opinion. Arq Neuropsiquiatr 78(7):390\u2013396","journal-title":"Arq Neuropsiquiatr"},{"key":"2576_CR41","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1212\/01.WNL.0000138428.40673.83","volume":"63","author":"JJ Flibotte","year":"2004","unstructured":"Flibotte JJ, Hagan N, O\u2019Donnell J et al (2004) Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage. Neurology 63:1059\u20131064","journal-title":"Neurology"},{"key":"2576_CR42","doi-asserted-by":"publisher","first-page":"104292","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.07.008","volume":"28","author":"Y Kato","year":"2019","unstructured":"Kato Y, Hayashi T, Suzuki K et al (2019) Resumption of direct oral anticoagulants in patients with acute spontaneous intracerebral hemorrhage. J Stroke Cerebrovasc Dis 28:104292","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2576_CR43","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ejim.2020.01.010","volume":"75","author":"M Bjork","year":"2020","unstructured":"Bjork M, Melin EO, Frisk T, Thunander M (2020) Admission glucose level was associated with increased short-term mortality and length-of-stay irrespective of diagnosis treating medical specialty or concomitant laboratory values. Eur J Intern Med 75:71\u201378","journal-title":"Eur J Intern Med"},{"key":"2576_CR44","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1177\/1479164119871540","volume":"16","author":"V Ritsinger","year":"2019","unstructured":"Ritsinger V, Jensen J, Ohm D et al (2019) Elevated admission glucose is common and associated with high short-term complication burden after acute myocardial infarction: insights from the VALIDATE-SWEDEHEART study. Diab Vasc Dis Res 16:582\u2013584","journal-title":"Diab Vasc Dis Res"},{"key":"2576_CR45","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s00592-018-1139-6","volume":"55","author":"F Wang","year":"2018","unstructured":"Wang F, Jiang B, Kanesan L et al (2018) Higher admission fasting plasma glucose levels are associated with a poorer short-term neurologic outcome in acute ischemic stroke patients with good collateral circulation. Acta Diabetol 55:703\u2013714","journal-title":"Acta Diabetol"},{"key":"2576_CR46","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1097\/01.TA.0000051601.60556.FC","volume":"54","author":"FD Reynolds","year":"2003","unstructured":"Reynolds FD, Dietz PA, Higgins D, Whitaker TS (2003) Time to deterioration of the elderly anticoagulated minor head injury patient who presents without evidence of neurologic abnormality. J Trauma 54:492\u2013496","journal-title":"J Trauma"},{"key":"2576_CR47","first-page":"895","volume":"68","author":"A Kaen","year":"2010","unstructured":"Kaen A, Jimenez-Roldan L, Arrese I et al (2010) The value of sequential computed tomography scanning in anticoagulated patients suffering from minor head injury. J Trauma 68:895\u2013898","journal-title":"J Trauma"},{"key":"2576_CR48","first-page":"1600","volume":"71","author":"KA Peck","year":"2011","unstructured":"Peck KA, Sise CB, Shackford SR et al (2011) Delayed intracranial hemorrhage after blunt trauma: are patients on preinjury anticoagulants and prescription antiplatelet agents at risk? J Trauma 71:1600\u20131604","journal-title":"J Trauma"},{"key":"2576_CR49","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ajem.2015.09.009","volume":"34","author":"BL Lim","year":"2016","unstructured":"Lim BL, Manauis C, Asinas-Tan ML (2016) Outcomes of warfarinized patients with minor head injury and normal initial CT scan. Am J Emerg Med 34:75\u201378","journal-title":"Am J Emerg Med"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-020-02576-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-020-02576-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-020-02576-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T02:18:23Z","timestamp":1650248303000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11739-020-02576-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["2576"],"URL":"https:\/\/doi.org\/10.1007\/s11739-020-02576-w","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,1]]},"assertion":[{"value":"24 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of human and animal rights"}},{"value":"All the patients in the study signed an informed consent and cannot be identified in the text or images.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}