{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:54:28Z","timestamp":1780613668146,"version":"3.54.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s11739-020-02593-9","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T07:03:03Z","timestamp":1609830183000},"page":"1289-1295","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of FilmArray ME panel for the rapid diagnosis of meningitis\u2013encephalitis in emergency departments"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1181-7396","authenticated-orcid":false,"given":"Javier","family":"Ena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raisa Goretti","family":"Afonso-Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Bou-Collado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Dolores","family":"Reyes-Jara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roser","family":"Navarro-Soler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"de Haedo-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Martinez-Peinado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Gomez-Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Arjona-Zaragozi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"2593_CR1","doi-asserted-by":"publisher","first-page":"449","DOI":"10.5694\/mja17.01073","volume":"209","author":"MH Beaman","year":"2018","unstructured":"Beaman MH (2018) Community-acquired acute meningitis and encephalitis: a narrative review. Med J Aust 209:449\u2013454","journal-title":"Med J Aust"},{"key":"2593_CR2","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1055\/s-0035-1564686","volume":"35","author":"MB Richie","year":"2015","unstructured":"Richie MB, Josephson SA (2015) A Practical approach to meningitis and encephalitis. Semin Neurol 35:611\u2013620","journal-title":"Semin Neurol"},{"key":"2593_CR3","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1056\/NEJMoa010399","volume":"345","author":"R Hasbun","year":"2001","unstructured":"Hasbun R, Abrahams J, Jekel J, Quagliarello VJ (2001) Computed tomography of the head before lumbar puncture in adults with suspected meningitis. N Engl J Med 345:1727\u20131733","journal-title":"N Engl J Med"},{"key":"2593_CR4","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s12916-019-1387-5","volume":"17","author":"L Sigfrid","year":"2019","unstructured":"Sigfrid L, Perfect C, Rojek A, Longuere KS, Lipworth S, Harriss E et al (2019) A systematic review of clinical guidelines on the management of acute, community-acquired CNS infections. BMC Med 17:170","journal-title":"BMC Med"},{"key":"2593_CR5","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1093\/cid\/cit458","volume":"57","author":"A Venkatesan","year":"2013","unstructured":"Venkatesan A, Tunkel AR, Bloch KC, Lauring AS, Sejvar J, Bitnun A et al (2013) Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis 57:1114\u20131128","journal-title":"Clin Infect Dis"},{"key":"2593_CR6","first-page":"85","volume":"32","author":"F Cobo","year":"2019","unstructured":"Cobo F, Borrego J, Rodr\u00edguez-Granger J, Puertas A, Sampedro A, Navarro-Mar\u00ed JM (2019) Detection of bacterial pathogens in sterile fluids with the FilmArray Meningitis\/Encephalitis identification system. Rev Esp Quimioter 32:85\u201386","journal-title":"Rev Esp Quimioter"},{"key":"2593_CR7","first-page":"246","volume":"32","author":"L L\u00f3pez-Amor","year":"2019","unstructured":"L\u00f3pez-Amor L, Escudero D, Fern\u00e1ndez J, Mart\u00edn-Iglesias L, Vi\u00f1a L, Fern\u00e1ndez-Su\u00e1rez J et al (2019) Meningitis\/encephalitis diagnosis in ICU using Multiplex PCR system: is it time of change? Rev Esp Quimioter 32:246\u2013253","journal-title":"Rev Esp Quimioter"},{"issue":"9","key":"2593_CR8","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1161\/01.STR.0000027437.22450.BD","volume":"33","author":"JT Wilson","year":"2002","unstructured":"Wilson JT, Hareendran A, Grant M, Baird T, Schulz UG, Muir KW, Bone I (2002) Improving the assessment of outcomes in stroke: use of a structured interview to assign grades on the modified Rankin Scale. Stroke 33(9):2243\u20132246","journal-title":"Stroke"},{"key":"2593_CR9","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.jmii.2019.04.005","volume":"52","author":"SH Lee","year":"2019","unstructured":"Lee SH, Chen SY, Chien JY, Lee TF, Chen JM, Hsueh PR (2019) Usefulness of the FilmArray meningitis\/encephalitis (M\/E) panel for the diagnosis of infectious meningitis and encephalitis in Taiwan. J Microbiol Immunol Infect 52:760\u2013768","journal-title":"J Microbiol Immunol Infect"},{"key":"2593_CR10","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.diagmicrobio.2016.05.020","volume":"86","author":"K Messacar","year":"2016","unstructured":"Messacar K, Breazeale G, Robinson CC, Dominguez SR (2016) Potential clinical impact of the film array meningitis encephalitis panel in children with suspected central nervous system infections. Diagn Microbiol Infect Dis 86:118\u2013120","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2593_CR11","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3389\/fneur.2019.00281","volume":"10","author":"S Radmard","year":"2019","unstructured":"Radmard S, Reid S, Ciryam P, Boubour A, Ho N, Zucker J et al (2019) Clinical utilization of the FilmArray meningitis\/encephalitis (ME) multiplex polymerase chain reaction (PCR) assay. Front Neurol 10:281","journal-title":"Front Neurol"},{"key":"2593_CR12","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1093\/cid\/ciy077","volume":"67","author":"R Patel","year":"2018","unstructured":"Patel R, Fang FC (2018) Diagnostic stewardship: opportunity for a laboratory-infectious diseases partnership. Clin Infect Dis 67:799\u2013801","journal-title":"Clin Infect Dis"},{"key":"2593_CR13","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1128\/JCM.00730-16","volume":"54","author":"AL Leber","year":"2016","unstructured":"Leber AL, Everhart K, Balada-Llasat JM, Cullison J, Daly J, Holt S et al (2016) Multicenter evaluation of BioFire FilmArray meningitis\/encephalitis panel for detection of bacteria, viruses, and yeast in cerebrospinal fluid specimens. J Clin Microbiol 54:2251\u20132261","journal-title":"J Clin Microbiol"},{"key":"2593_CR14","doi-asserted-by":"publisher","first-page":"e01927","DOI":"10.1128\/JCM.01927-17","volume":"56","author":"RM Liesman","year":"2018","unstructured":"Liesman RM, Strasburg AP, Heitman AK, Theel ES, Patel R, Binnicker MJ (2018) Evaluation of a commercial multiplex molecular panel for diagnosis of infectious meningitis and encephalitis. J Clin Microbiol 56:e01927-e2017","journal-title":"J Clin Microbiol"},{"key":"2593_CR15","doi-asserted-by":"publisher","first-page":"ofw245","DOI":"10.1093\/ofid\/ofw245","volume":"4","author":"CA Gomez","year":"2016","unstructured":"Gomez CA, Pinsky BA, Liu A, Banaei N (2016) Delayed Diagnosis of tuberculous meningitis misdiagnosed as herpes simplex virus-1 encephalitis with the filmarray syndromic polymerase chain reaction panel. Open Forum Infect Dis 4:ofw245","journal-title":"Open Forum Infect Dis"},{"issue":"3","key":"2593_CR16","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.cmi.2019.11.016","volume":"26","author":"GS Tansarli","year":"2020","unstructured":"Tansarli GS, Chapin KC (2020) Diagnostic test accuracy of the BioFire\u00ae FilmArray\u00ae meningitis\/encephalitis panel: a systematic review and meta-analysis. Clin Microbiol Infect 26(3):281\u2013290. https:\/\/doi.org\/10.1016\/j.cmi.2019.11.016","journal-title":"Clin Microbiol Infect"},{"key":"2593_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.17161\/kjm.v12i1.11695","volume":"12","author":"K Dack","year":"2019","unstructured":"Dack K, Pankow S, Ablah E, Zackula R, Assi M (2019) Contribution of the BioFire(\u00ae) FilmArray(\u00ae) meningitis\/encephalitis panel: assessing antimicrobial duration and length of stay. Kans J Med 12:1\u20133","journal-title":"Kans J Med"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-020-02593-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-020-02593-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-020-02593-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T09:28:25Z","timestamp":1659086905000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11739-020-02593-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,5]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["2593"],"URL":"https:\/\/doi.org\/10.1007\/s11739-020-02593-9","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,5]]},"assertion":[{"value":"1 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Research Commission of our center.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of Human and animal right"}},{"value":"As it was a retrospective study, the informed consent of the patients was not requested. The treatment of personal data was governed by organic law 15\/1999 and Royal Decree 1720\/2007 for its protection.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}