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Gastrointestinal (GI) bleeding from SB accounts for the majority of SBCE indications. We aimed to assess, in a \u201creal-world\u201d prospective study, the diagnostic yield of SBCE in a cohort of consecutive patients with obscure gastrointestinal bleeding (OGIB)<jats:italic>.<\/jats:italic> Secondary end point was to assess the frequency of adverse events and the role of SBCE in determining the diagnostic work-up and clinical outcome. From 2016 to 2018, all patients referred for SBCE examination were enrolled. Indication for SBCE was re-assessed by 2 dedicated gastroenterologists. Inclusion criteria: (1) age\u2009\u2265\u200918 and\u2009\u2264\u200985\u00a0years; (2) diagnosis of OGIB; 3) non-diagnostic standard bidirectional endoscopy; (4) informed consent. Exclusion criteria: (1) deglutition impairment; (2) SBCE contraindications; (3) pregnancy. The cohort included 50 patients [males 18 (36%), age 68 (27\u201383)]. SBCE indication: patients with ongoing overt OGIB (Group A) (<jats:italic>n<\/jats:italic>\u2009=\u200911; 22%), previous overt OGIB (Group B) (<jats:italic>n<\/jats:italic>\u2009=\u200914; 28%), occult bleeding (with Iron Deficiency Anaemia) (Group C) (<jats:italic>n<\/jats:italic>\u2009=\u200925; 50%). SBCE detected clinically relevant lesions in 46 (92%) cases. Clinically relevant lesions were more frequent in Group C (24\/25; 96%), followed by Group A (10\/11; 91%) and Group B (12\/14; 85.5%). After SBCE, treatment was medical (60%); endoscopic (14%), surgical (36%) or conservative (18%). Clinical follow-up showed complete resolution in 63.2%, partial\/absent resolution in 18.4% of cases. In a prospective study, the high diagnostic yield of SBCE supports its role as first-line investigation in patients with OGIB. However, this achievement requires an accurate and timely assessment by dedicated gastroenterologists.<\/jats:p>","DOI":"10.1007\/s11739-021-02791-z","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T05:02:16Z","timestamp":1624770136000},"page":"349-358","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic yield of small bowel capsule endoscopy in obscure gastrointestinal bleeding: a real-world prospective study"],"prefix":"10.1007","volume":"17","author":[{"given":"Samanta","family":"Romeo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetto","family":"Neri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelangela","family":"Mossa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Riccioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Scucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Sena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Potenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelina","family":"Petruzziello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Biancone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,27]]},"reference":[{"key":"2791_CR1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1053\/j.gastro.2016.12.032","volume":"152","author":"RA Enns","year":"2017","unstructured":"Enns RA, Hookey L, Armstrong D, Bernstein CN, Heitman SJ, Teshima C, Leontiadis GI, Tse F, Sadowski D (2017) Clinical practice guidelines for the use of video capsule endoscopy. 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