{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:42:12Z","timestamp":1780630932791,"version":"3.54.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012990","name":"Universit\u00e0 degli Studi di Siena","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012990","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Purpose of the present paper is to point out the design, development and deployment of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric and adult patients with Beh\u00e7et\u2019s disease (BD). The Registry is a clinical physician-driven non-population- and electronic-based instrument implemented for the retrospective and prospective collection of real-life data about demographics, clinical, therapeutic, laboratory, instrumental and socioeconomic information from BD patients; the Registry is based on the Research Electronic Data Capture (REDCap) tool, which is thought to collect standardised information for clinical real-life research, and has been realised to change over time according to future scientific acquisitions and potentially communicate with other existing and future Registries dedicated to BD. Starting from January 31st, 2021, to February 7th, 2022, 110 centres from 23 countries in 4 continents have been involved. Fifty-four of these have already obtained the approval from their local Ethics Committees. Currently, the platform counts 290 users (111 Principal Investigators, 175 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry collects baseline and follow-up data using 5993 fields organised into 16 instruments, including patient\u2019s demographics, history, clinical manifestations and symptoms, trigger\/risk factors, therapies and healthcare access. The development of the AIDA International Registry for BD patients will facilitate the collection of standardised data leading to real-world evidence, enabling international multicentre collaborative research through data sharing, international consultation, dissemination of knowledge, inclusion of patients and families, and ultimately optimisation of scientific efforts and implementation of standardised care.<\/jats:p><jats:p><jats:italic>Trial registration<\/jats:italic> NCT05200715 in 21\/01\/2022.<\/jats:p>","DOI":"10.1007\/s11739-022-03038-1","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T02:03:46Z","timestamp":1657764226000},"page":"1977-1986","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Development and implementation of the AIDA International Registry for patients with Beh\u00e7et\u2019s disease"],"prefix":"10.1007","volume":"17","clinical-trial-number":[{"clinical-trial-number":"nct05200715","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Antonio","family":"Vitale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Della Casa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaafar","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim A.","family":"Almaghlouth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lopalco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Guerriero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Govoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros P.","family":"Sfikakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Giacomelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Ciccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Monti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Ruscitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Piga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lomater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahman","family":"Tufan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Opris-Belinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Emmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Hern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Domenico","family":"Sebastiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bartoloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurullah","family":"Akko\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcl Soysal","family":"G\u00fcnd\u00fcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cattalini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulen","family":"Hatemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Parronchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Del Giudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukran","family":"Erten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Insalaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Li Gobbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Maggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Shahram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Caggiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Tharwat","family":"Hegazy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazi Nur","family":"Asfina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Morrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro L.","family":"Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Dammacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ruffilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Arida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Navarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"Pantano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Cavagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Conforti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Cauli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Maria","family":"Marucco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamit","family":"Kucuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra","family":"Ionescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Mattioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Karka\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Canofari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Sota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Hatem","family":"Laymouna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma. A.","family":"Bedaiwi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Colella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Ayres M.","family":"Giardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Albano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lo Monaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E.","family":"Fragoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riza Can","family":"Kardas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Berlengiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"La Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Rigante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wi\u0119sik-Szewczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micol","family":"Frassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gentileschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Marco","family":"Tosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia Ambiel","family":"Dagostin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman Abdel-Monem Ahmed","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tarsia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Alessio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Cimaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Giani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Gaggiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florenzo","family":"Iannone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Cipriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Mourabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Spedicato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Barneschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Aragona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Balistreri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Frediani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Fabiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-1275","authenticated-orcid":false,"given":"Luca","family":"Cantarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Autoinflammatory Diseases Alliance (AIDA) Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"3038_CR1","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.5272\/jimab.2016222.1166","volume":"22","author":"M Deliverska","year":"2016","unstructured":"Deliverska M (2016) Patient registries for rare diseases. J IMAB Annu Proc Sci Pap 22:1166\u20131168. https:\/\/doi.org\/10.5272\/jimab.2016222.1166","journal-title":"J IMAB Annu Proc Sci Pap"},{"key":"3038_CR2","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s13023-018-0836-0","volume":"13","author":"MC Jansen-van der Weide","year":"2018","unstructured":"Jansen-van der Weide MC, Gaasterland CMW, Roes KCB, Pontes C, Vives R, Sancho A et al (2018) Rare disease registries: potential applications towards impact on development of new drug treatments. Orphanet J Rare Dis 13:154. https:\/\/doi.org\/10.1186\/s13023-018-0836-0","journal-title":"Orphanet J Rare Dis"},{"key":"3038_CR3","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3109\/09273948.2012.723112","volume":"20","author":"M Khairallah","year":"2012","unstructured":"Khairallah M, Accorinti M, Muccioli C, Kahloun R, Kempen JH (2012) Epidemiology of Beh\u00e7et disease. Ocul Immunol Inflamm 20:324\u2013335. https:\/\/doi.org\/10.3109\/09273948.2012.723112","journal-title":"Ocul Immunol Inflamm"},{"key":"3038_CR4","first-page":"51","volume":"35","author":"WY Madanat","year":"2017","unstructured":"Madanat WY, Alawneh KM, Smadi MM, Saadeh SS, Omari MM, Bani Hani AB et al (2017) The prevalence of Beh\u00e7et\u2019s disease in the north of Jordan: a hospital-based epidemiological survey. Clin Exp Rheumatol 35:51\u201354","journal-title":"Clin Exp Rheumatol"},{"key":"3038_CR5","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1046\/j.1365-4362.2003.01893.x","volume":"42","author":"G Azizlerli","year":"2003","unstructured":"Azizlerli G, K\u00f6se AA, Sarica R, G\u00fcl A, Tutkun IT, Kula\u00e7 M et al (2003) Prevalence of Beh\u00e7et\u2019s disease in Istanbul, Turkey. Int J Dermatol 42:803\u2013806. https:\/\/doi.org\/10.1046\/j.1365-4362.2003.01893.x","journal-title":"Int J Dermatol"},{"key":"3038_CR6","first-page":"1078","volume":"335","author":"International Study Group for Beh\u00e7et\u2019s Disease","year":"1990","unstructured":"International Study Group for Beh\u00e7et\u2019s Disease (1990) Criteria for diagnosis of Behcet\u2019s disease. Lancet 335:1078\u20131080","journal-title":"Lancet"},{"key":"3038_CR7","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/jdv.12107","volume":"28","author":"International team for the revision of the international criteria for Beh\u00e7et's disease (ITR-ICBD)","year":"2014","unstructured":"International team for the revision of the international criteria for Beh\u00e7et\u2019s disease (ITR-ICBD) (2014) The International Criteria for Beh\u00e7et\u2019s Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol 28:338\u2013347. https:\/\/doi.org\/10.1111\/jdv.12107","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"3038_CR8","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1136\/annrheumdis-2015-208491","volume":"75","author":"I Kon\u00e9-Paut","year":"2016","unstructured":"Kon\u00e9-Paut I, Shahram F, Darce-Bello M, Cantarini L, Cimaz R, Gattorno M et al (2016) Consensus classification criteria for paediatric Beh\u00e7et\u2019s disease from a prospective observational cohort: PEDBD. Ann Rheum Dis 75:958\u2013964. https:\/\/doi.org\/10.1136\/annrheumdis-2015-208491","journal-title":"Ann Rheum Dis"},{"key":"3038_CR9","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","volume":"42","author":"PA Harris","year":"2009","unstructured":"Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG (2009) Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 42:377\u2013381. https:\/\/doi.org\/10.1016\/j.jbi.2008.08.010","journal-title":"J Biomed Inform"},{"key":"3038_CR10","unstructured":"EUR-Lex-32016R0679-EN-EUR-Lex. Cited 2021 Aug 18. Available from: https:\/\/eur-lex.europa.eu\/eli\/reg\/2016\/679\/oj"},{"issue":"8","key":"3038_CR11","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.3390\/ijerph15081644","volume":"15","author":"Y Kodra","year":"2018","unstructured":"Kodra Y, Weinbach J, Posada-de-la-Paz M, Coi A, Lemonnier SL, Van Enckevort D et al (2018) Recommendations for improving the Quality of Rare Disease Registries. Int J Environ Res Public Health 15(8):1644. https:\/\/doi.org\/10.3390\/ijerph15081644","journal-title":"Int J Environ Res Public Health"},{"key":"3038_CR12","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1093\/rheumatology\/keg453","volume":"43","author":"G Lawton","year":"2004","unstructured":"Lawton G, Bhakta BB, Chamberlain MA, Tennant A (2004) The Beh\u00e7et\u2019s disease activity index. Rheumatology 43:73\u201378. https:\/\/doi.org\/10.1093\/rheumatology\/keg453","journal-title":"Rheumatology"},{"key":"3038_CR13","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001192","volume":"6","author":"M Piga","year":"2020","unstructured":"Piga M, Floris A, Espinosa G, Serpa Pinto L, Kougkas N et al (2020) Development and preliminary validation of the Beh\u00e7et\u2019s syndrome Overall Damage Index (BODI). RMD Open 6:e001192. https:\/\/doi.org\/10.1136\/rmdopen-2020-001192","journal-title":"RMD Open"},{"key":"3038_CR14","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ajo.2005.03.057","volume":"140","author":"DA Jabs","year":"2005","unstructured":"Jabs DA, Nussenblatt RB, Rosenbaum JT, Standardization of Uveitis Nomenclature (SUN) Working Group (2005) Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol 140:509\u2013516. https:\/\/doi.org\/10.1016\/j.ajo.2005.03.057","journal-title":"Am J Ophthalmol"},{"key":"3038_CR15","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/s0161-6420(85)34001-0","volume":"92","author":"RB Nussenblatt","year":"1985","unstructured":"Nussenblatt RB, Palestine AG, Chan C-C, Roberge F (1985) Standardization of vitreal inflammatory activity in intermediate and posterior uveitis. Ophthalmology 92:467\u2013471. https:\/\/doi.org\/10.1016\/s0161-6420(85)34001-0","journal-title":"Ophthalmology"},{"key":"3038_CR16","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.ophtha.2010.08.027","volume":"118","author":"HN Sen","year":"2011","unstructured":"Sen HN, Sangave AA, Goldstein DA, Suhler EB, Cunningham D, Vitale S et al (2011) A standardized grading system for scleritis. Ophthalmology 118:768\u2013771. https:\/\/doi.org\/10.1016\/j.ophtha.2010.08.027","journal-title":"Ophthalmology"},{"key":"3038_CR17","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1442-9071.1991.tb00663.x","volume":"19","author":"P McCluskey","year":"1991","unstructured":"McCluskey P, Wakefield D (1991) Prediction of response to treatment in patients with scleritis using a standardised scoring system. Aust NZ J Ophthalmol 19:211\u2013215. https:\/\/doi.org\/10.1111\/j.1442-9071.1991.tb00663.x","journal-title":"Aust NZ J Ophthalmol"},{"key":"3038_CR18","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s10792-008-9263-x","volume":"30","author":"I Tugal-Tutkun","year":"2010","unstructured":"Tugal-Tutkun I, Herbort CP, Khairallah M, Angiography Scoring for Uveitis Working Group (ASUWOG) (2010) Scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading of posterior segment inflammation (dual fluorescein and ICG angiographic scoring system for uveitis). Int Ophthalmol 30:539\u2013552. https:\/\/doi.org\/10.1007\/s10792-008-9263-x","journal-title":"Int Ophthalmol"},{"key":"3038_CR19","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1001\/archopht.1993.01090060119035","volume":"111","author":"LT Chylack Jr","year":"1993","unstructured":"Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL et al (1993) The lens opacities classification system III. Arch Ophthalmol 111:831\u2013836. https:\/\/doi.org\/10.1001\/archopht.1993.01090060119035","journal-title":"Arch Ophthalmol"},{"key":"3038_CR20","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ajo.2021.03.061","volume":"228","author":"Standardization of Uveitis Nomenclature (SUN) Working Group","year":"2021","unstructured":"Standardization of Uveitis Nomenclature (SUN) Working Group (2021) Development of classification criteria for the uveitides. Am J Ophthalmol 228:96\u2013105. https:\/\/doi.org\/10.1016\/j.ajo.2021.03.061","journal-title":"Am J Ophthalmol"},{"key":"3038_CR21","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.bulcan.2019.06.017","volume":"107","author":"A H\u00e9laine","year":"2020","unstructured":"H\u00e9laine A, Podevin M (2020) The role of patients\u2019 associations. Bull Cancer (Paris) 107:381\u2013384. https:\/\/doi.org\/10.1016\/j.bulcan.2019.06.017","journal-title":"Bull Cancer (Paris)"},{"key":"3038_CR22","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1002\/ajmg.a.38413","volume":"176","author":"L Kempf","year":"2018","unstructured":"Kempf L, Goldsmith JC, Temple R (2018) Challenges of developing and conducting clinical trials in rare disorders. Am J Med Genet A 176:773\u2013783. https:\/\/doi.org\/10.1002\/ajmg.a.38413","journal-title":"Am J Med Genet A"},{"key":"3038_CR23","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3109\/09273948.2015.1094095","volume":"25","author":"M Accorinti","year":"2017","unstructured":"Accorinti M, Pesci FR, Pirraglia MP, Abicca I, Pivetti-Pezzi P (2017) Ocular Beh\u00e7et\u2019s disease: changing patterns over time, complications and long-term visual prognosis. Ocul Immunol Inflamm 25:29\u201336. https:\/\/doi.org\/10.3109\/09273948.2015.1094095","journal-title":"Ocul Immunol Inflamm"},{"key":"3038_CR24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3109\/09273948.2014.918154","volume":"23","author":"YR Chung","year":"2015","unstructured":"Chung YR, Lee ES, Kim MH, Lew HM, Song JH (2015) Changes in ocular manifestations of Beh\u00e7et disease in Korean patients over time: a single-center experience in the 1990s and 2000s. Ocul Immunol Inflamm 23:157\u2013161. https:\/\/doi.org\/10.3109\/09273948.2014.918154","journal-title":"Ocul Immunol Inflamm"},{"key":"3038_CR25","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/bjd.12661","volume":"170","author":"DY Kim","year":"2014","unstructured":"Kim DY, Choi MJ, Cho S, Kim DW, Bang D (2014) Changing clinical expression of Beh\u00e7et disease in Korea during three decades (1983\u20132012): chronological analysis of 3674 hospital-based patients. Br J Dermatol 170:458\u2013461. https:\/\/doi.org\/10.1111\/bjd.12661","journal-title":"Br J Dermatol"},{"key":"3038_CR26","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s11739-020-02319-x","volume":"15","author":"C Marvisi","year":"2020","unstructured":"Marvisi C (2020) The geographic and clinical clusters of Beh\u00e7et\u2019s syndrome. Intern Emerg Med 15:933\u2013934. https:\/\/doi.org\/10.1007\/s11739-020-02319-x","journal-title":"Intern Emerg Med"},{"key":"3038_CR27","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s11739-019-02248-4","volume":"15","author":"J Sota","year":"2020","unstructured":"Sota J, Rigante D, Emmi G, Lopalco G, Orlando I, Tosi GM et al (2020) Beh\u00e7et\u2019s syndrome in Italy: a detailed retrospective analysis of 396 cases seen in 3 tertiary referral clinics. Intern Emerg Med 15:1031\u20131039. https:\/\/doi.org\/10.1007\/s11739-019-02248-4","journal-title":"Intern Emerg Med"},{"key":"3038_CR28","first-page":"2393","volume":"29","author":"R Tunc","year":"2002","unstructured":"Tunc R, Keyman E, Melikoglu M, Fresko I, Yazici H (2002) Target organ associations in Turkish patients with Beh\u00e7et\u2019s disease: a cross sectional study by exploratory factor analysis. J Rheumatol 29:2393\u20132396","journal-title":"J Rheumatol"},{"key":"3038_CR29","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.ophtha.2003.07.018","volume":"111","author":"A Yoshida","year":"2004","unstructured":"Yoshida A, Kawashima H, Motoyama Y, Shibui H, Kaburaki T, Shimizu K et al (2004) Comparison of patients with Beh\u00e7et\u2019s disease in the 1980s and 1990s. Ophthalmology 111:810\u2013815. https:\/\/doi.org\/10.1016\/j.ophtha.2003.07.018","journal-title":"Ophthalmology"},{"key":"3038_CR30","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.berh.2018.08.010","volume":"32","author":"N Akko\u00e7","year":"2018","unstructured":"Akko\u00e7 N (2018) Update on the epidemiology, risk factors and disease outcomes of Beh\u00e7et\u2019s disease. Best Pract Res Clin Rheumatol 32:261\u2013270. https:\/\/doi.org\/10.1016\/j.berh.2018.08.010","journal-title":"Best Pract Res Clin Rheumatol"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-022-03038-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-022-03038-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-022-03038-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T13:43:59Z","timestamp":1664459039000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11739-022-03038-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,14]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["3038"],"URL":"https:\/\/doi.org\/10.1007\/s11739-022-03038-1","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,14]]},"assertion":[{"value":"18 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Azienda Ospedaliero-Universitaria Senese, Siena, Italy (Ref. N. 14951), June 2019.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study or from their legal guardians.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}