{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:31:01Z","timestamp":1785306661628,"version":"3.55.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the National Key Research and Development Program of China","award":["2018YFC1312903"],"award-info":[{"award-number":["2018YFC1312903"]}]},{"name":"the Beijing Municipal Administration of Hospitals Incubating Program","award":["PX2020021"],"award-info":[{"award-number":["PX2020021"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s11739-022-03059-w","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T10:02:40Z","timestamp":1660989760000},"page":"1987-1996","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Aspartate aminotransferase to alanine aminotransferase ratio and clinical outcomes after acute ischemic stroke: the CNSR-III registry"],"prefix":"10.1007","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8039-709X","authenticated-orcid":false,"given":"Qin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5776-0241","authenticated-orcid":false,"given":"Xiaofan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingting","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-2877","authenticated-orcid":false,"given":"Anxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4918-0845","authenticated-orcid":false,"given":"Xia","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"key":"3059_CR1","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","volume":"20","author":"GBDS Collaborators","year":"2021","unstructured":"Collaborators GBDS (2021) Global, regional, and national burden of stroke and its risk factors, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 20:795\u2013820","journal-title":"Lancet Neurol"},{"key":"3059_CR2","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1161\/STROKEAHA.120.028992","volume":"51","author":"C Flach","year":"2020","unstructured":"Flach C, Muruet W, Wolfe CDA, Bhalla A, Douiri A (2020) Risk and secondary prevention of stroke recurrence: a population-base cohort study. Stroke 51:2435\u20132444","journal-title":"Stroke"},{"issue":"1935\u20131944","key":"3059_CR3","volume":"135","author":"W Goessling","year":"1944","unstructured":"Goessling W, Massaro JM, Vasan RS, D\u2019Agostino RB Sr, Ellison RC (1944) Fox CS (2008) Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease. Gastroenterology 135(1935\u20131944):e1931","journal-title":"Gastroenterology"},{"key":"3059_CR4","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3748\/wjg.v21.i3.711","volume":"21","author":"S Sookoian","year":"2015","unstructured":"Sookoian S, Pirola CJ (2015) Liver enzymes, metabolomics and genome-wide association studies: from systems biology to the personalized medicine. World J Gastroenterol 21:711\u2013725","journal-title":"World J Gastroenterol"},{"key":"3059_CR5","doi-asserted-by":"publisher","first-page":"4857917","DOI":"10.1155\/2016\/4857917","volume":"2016","author":"M Yokoyama","year":"2016","unstructured":"Yokoyama M, Watanabe T, Otaki Y, Takahashi H, Arimoto T, Shishido T, Miyamoto T, Konta T, Shibata Y, Daimon M, Ueno Y, Kato T, Kayama T, Kubota I (2016) Association of the aspartate aminotransferase to alanine aminotransferase ratio with BNP level and cardiovascular mortality in the general population: the Yamagata study 10-year follow-up. Dis Markers 2016:4857917","journal-title":"Dis Markers"},{"key":"3059_CR6","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s12944-018-0920-4","volume":"17","author":"Y Liu","year":"2018","unstructured":"Liu Y, Zhao P, Cheng M, Yu L, Cheng Z, Fan L, Chen C (2018) AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population: a secondary analysis based on a cross-sectional study. Lipids Health Dis 17:275","journal-title":"Lipids Health Dis"},{"key":"3059_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154874","volume":"124","author":"M Li","year":"2021","unstructured":"Li M, Zhao Z, Qin G, Chen L, Lu J, Huo Y, Chen L, Zeng T, Xu M, Chen Y, Wang T, Wang S, Xu Y, Shi L, Tang X, Su Q, Yu X, Yan L, Wan Q, Chen G, Gao Z, Wang G, Shen F, Luo Z, Zhang Y, Liu C, Wang Y, Hu R, Ye Z, Wu S, Deng H, Yang T, Li Q, Qin Y, Mu Y, Zhao J, Ning G, Bi Y, Xu Y, Wang W (2021) Non-alcoholic fatty liver disease, metabolic goal achievement with incident cardiovascular disease and eGFR-based chronic kidney disease in patients with prediabetes and diabetes. Metabolism 124:154874","journal-title":"Metabolism"},{"key":"3059_CR8","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3390\/diagnostics11010098","volume":"11","author":"S Ballestri","year":"2021","unstructured":"Ballestri S, Mantovani A, Baldelli E, Lugari S, Maurantonio M, Nascimbeni F, Marrazzo A, Romagnoli D, Targher G, Lonardo A (2021) Liver fibrosis biomarkers accurately exclude advanced fibrosis and are associated with higher cardiovascular risk scores in patients with NAFLD or viral chronic liver disease. Diagnostics (Basel) 11:98","journal-title":"Diagnostics (Basel)"},{"key":"3059_CR9","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1136\/gutjnl-2020-320622","volume":"69","author":"G Targher","year":"2020","unstructured":"Targher G, Byrne CD, Tilg H (2020) NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications. Gut 69:1691\u20131705","journal-title":"Gut"},{"key":"3059_CR10","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1016\/S0140-6736(14)61838-9","volume":"384","author":"R Williams","year":"2014","unstructured":"Williams R, Aspinall R, Bellis M, Camps-Walsh G, Cramp M, Dhawan A, Ferguson J, Forton D, Foster G, Gilmore I, Hickman M, Hudson M, Kelly D, Langford A, Lombard M, Longworth L, Martin N, Moriarty K, Newsome P, O\u2019Grady J, Pryke R, Rutter H, Ryder S, Sheron N, Smith T (2014) Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis. Lancet 384:1953\u20131997","journal-title":"Lancet"},{"key":"3059_CR11","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1136\/gut.2010.216077","volume":"59","author":"S McPherson","year":"2010","unstructured":"McPherson S, Stewart SF, Henderson E, Burt AD, Day CP (2010) Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease. Gut 59:1265\u20131269","journal-title":"Gut"},{"key":"3059_CR12","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1080\/01616412.2020.1796403","volume":"42","author":"Y Wang","year":"2020","unstructured":"Wang Y, Qiu K, Song Q, Cheng Y, Liu J, Liu M (2020) AST to ALT ratio and risk of hemorrhagic transformation in patients with acute ischemic stroke. Neurol Res 42:980\u2013986","journal-title":"Neurol Res"},{"key":"3059_CR13","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.2147\/NDT.S139316","volume":"13","author":"F Gao","year":"2017","unstructured":"Gao F, Chen C, Lu J, Zheng J, Ma XC, Yuan XY, Huo K, Han JF (2017) De Ritis ratio (AST\/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke. Neuropsychiatr Dis Treat 13:1551\u20131557","journal-title":"Neuropsychiatr Dis Treat"},{"key":"3059_CR14","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1002\/hep.510300604","volume":"30","author":"P Angulo","year":"1999","unstructured":"Angulo P, Keach JC, Batts KP, Lindor KD (1999) Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 30:1356\u20131362","journal-title":"Hepatology"},{"key":"3059_CR15","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018869","volume":"10","author":"HH Liu","year":"2021","unstructured":"Liu HH, Cao YX, Jin JL, Hua Q, Li YF, Guo YL, Zhu CG, Wu NQ, Gao RL, Li JJ (2021) Liver fibrosis scoring systems as novel tools for predicting cardiovascular outcomes in patients following elective percutaneous coronary intervention. J Am Heart Assoc 10:e018869","journal-title":"J Am Heart Assoc"},{"key":"3059_CR16","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1136\/svn-2019-000242","volume":"4","author":"Y Wang","year":"2019","unstructured":"Wang Y, Jing J, Meng X, Pan Y, Wang Y, Zhao X, Lin J, Li W, Jiang Y, Li Z, Zhang X, Yang X, Ji R, Wang C, Wang Z, Han X, Wu S, Jia Z, Chen Y, Li H (2019) The Third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics. Stroke Vasc Neurol 4:158\u2013164","journal-title":"Stroke Vasc Neurol"},{"key":"3059_CR17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","volume":"24","author":"HP Adams Jr","year":"1993","unstructured":"Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd (1993) Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24:35\u201341","journal-title":"Stroke"},{"key":"3059_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157517","volume":"11","author":"MT Long","year":"2016","unstructured":"Long MT, Pedley A, Massaro JM, Hoffmann U, Fox CS (2016) The association between non-invasive hepatic fibrosis markers and cardiometabolic risk factors in the Framingham Heart Study. PLoS ONE 11:e0157517","journal-title":"PLoS ONE"},{"key":"3059_CR19","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s12882-020-01840-7","volume":"21","author":"X Feng","year":"2020","unstructured":"Feng X, Wen Y, Peng FF, Wang N, Zhan X, Wu X (2020) Association between aminotransferase\/alanine aminotransferase ratio and cardiovascular disease mortality in patients on peritoneal dialysis: a multi-center retrospective study. BMC Nephrol 21:209","journal-title":"BMC Nephrol"},{"key":"3059_CR20","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3390\/jcm7120474","volume":"7","author":"M Steininger","year":"2018","unstructured":"Steininger M, Winter MP, Reiberger T, Koller L, El-Hamid F, Forster S, Schnaubelt S, Hengstenberg C, Distelmaier K, Goliasch G, Wojta J, Toma A, Niessner A, Sulzgruber P (2018) De-Ritis ratio improves long-term risk prediction after acute myocardial infarction. J Clin Med 7:474","journal-title":"J Clin Med"},{"key":"3059_CR21","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-033532","volume":"10","author":"V Katzke","year":"2020","unstructured":"Katzke V, Johnson T, Sookthai D, Husing A, Kuhn T, Kaaks R (2020) Circulating liver enzymes and risks of chronic diseases and mortality in the prospective EPIC-Heidelberg case-cohort study. BMJ Open 10:e033532","journal-title":"BMJ Open"},{"key":"3059_CR22","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.amjcard.2020.10.036","volume":"139","author":"D Maeda","year":"2021","unstructured":"Maeda D, Sakane K, Kanzaki Y, Okuno T, Nomura H, Hourai R, Akamatsu K, Tsuda K, Ito T, Sohmiya K, Hoshiga M (2021) Relation of aspartate aminotransferase to alanine aminotransferase ratio to nutritional status and prognosis in patients with acute heart failure. Am J Cardiol 139:64\u201370","journal-title":"Am J Cardiol"},{"key":"3059_CR23","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.jhep.2014.11.024","volume":"62","author":"M Lazo","year":"2015","unstructured":"Lazo M, Rubin J, Clark JM, Coresh J, Schneider AL, Ndumele C, Hoogeveen RC, Ballantyne CM, Selvin E (2015) The association of liver enzymes with biomarkers of subclinical myocardial damage and structural heart disease. J Hepatol 62:841\u2013847","journal-title":"J Hepatol"},{"key":"3059_CR24","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1161\/CIRCRESAHA.121.319059","volume":"128","author":"Z Chen","year":"2021","unstructured":"Chen Z, Liu J, Zhou F, Li H, Zhang XJ, She ZG, Lu Z, Cai J, Li H (2021) Nonalcoholic fatty liver disease: an emerging driver of cardiac arrhythmia. Circ Res 128:1747\u20131765","journal-title":"Circ Res"},{"key":"3059_CR25","doi-asserted-by":"publisher","first-page":"567","DOI":"10.3390\/cells9030567","volume":"9","author":"H El Hadi","year":"2020","unstructured":"El Hadi H, Di Vincenzo A, Vettor R, Rossato M (2020) Relationship between heart disease and liver disease: a two-way street. Cells 9:567","journal-title":"Cells"},{"key":"3059_CR26","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1161\/STROKEAHA.120.030433","volume":"52","author":"J Xu","year":"2021","unstructured":"Xu J, Dai L, Zhang Y, Wang A, Li H, Wang Y, Meng X, Wu S, Wang Y (2021) Severity of nonalcoholic fatty liver disease and risk of future ischemic stroke events. Stroke 52:103\u2013110","journal-title":"Stroke"},{"issue":"2138\u20132147","key":"3059_CR27","volume":"19","author":"H Lee","year":"2021","unstructured":"Lee H, Lee YH, Kim SU, Kim HC (2021) Metabolic dysfunction-associated fatty liver disease and incident cardiovascular disease risk: a nationwide cohort study. Clin Gastroenterol Hepatol 19(2138\u20132147):e2110","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2324\u20132331","key":"3059_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.12.026","volume":"18","author":"F Baratta","year":"2020","unstructured":"Baratta F, Pastori D, Angelico F, Balla A, Paganini AM, Cocomello N, Ferro D, Violi F, Sanyal AJ, Del Ben M (2020) Nonalcoholic fatty liver disease and fibrosis associated with increased risk of cardiovascular events in a prospective study. Clin Gastroenterol Hepatol 18(2324\u20132331):e2324","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3059_CR29","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004821","volume":"95","author":"G Zoppini","year":"2016","unstructured":"Zoppini G, Cacciatori V, Negri C, Stoico V, Lippi G, Targher G, Bonora E (2016) The aspartate aminotransferase-to-alanine aminotransferase ratio predicts all-cause and cardiovascular mortality in patients with type 2 diabetes. Medicine (Baltimore) 95:e4821","journal-title":"Medicine (Baltimore)"},{"key":"3059_CR30","doi-asserted-by":"publisher","first-page":"175628642110372","DOI":"10.1177\/17562864211037239","volume":"14","author":"S Fandler-Hofler","year":"2021","unstructured":"Fandler-Hofler S, Stauber RE, Kneihsl M, Wunsch G, Haidegger M, Poltrum B, Pichler A, Deutschmann H, Enzinger C, Fickert P, Gattringer T (2021) Non-invasive markers of liver fibrosis and outcome in large vessel occlusion stroke. Ther Adv Neurol Disord 14:17562864211037240","journal-title":"Ther Adv Neurol Disord"},{"key":"3059_CR31","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1159\/000510436","volume":"49","author":"M Baik","year":"2020","unstructured":"Baik M, Nam HS, Heo JH, Park HJ, Kim BK, Park JY, Kim DY, Ahn SH, Han KH, Lee HS, Kim SU, Kim YD (2020) Advanced liver fibrosis predicts unfavorable long-term prognosis in first-ever ischemic stroke or transient ischemic attack. Cerebrovasc Dis 49:474\u2013480","journal-title":"Cerebrovasc Dis"},{"key":"3059_CR32","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.jhep.2012.11.021","volume":"58","author":"MV Machado","year":"2013","unstructured":"Machado MV, Cortez-Pinto H (2013) Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal. J Hepatol 58:1007\u20131019","journal-title":"J Hepatol"},{"key":"3059_CR33","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1002\/hep.27368","volume":"61","author":"M Ekstedt","year":"2015","unstructured":"Ekstedt M, Hagstrom H, Nasr P, Fredrikson M, Stal P, Kechagias S, Hultcrantz R (2015) Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up. Hepatology 61:1547\u20131554","journal-title":"Hepatology"},{"key":"3059_CR34","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1016\/j.dld.2019.01.017","volume":"51","author":"A De Vincentis","year":"2019","unstructured":"De Vincentis A, Costanzo L, Vespasiani-Gentilucci U, Picardi A, Bandinelli S, Ferrucci L, Antonelli Incalzi R, Pedone C (2019) Association between non-invasive liver fibrosis scores and occurrence of health adverse outcomes in older people. Dig Liver Dis 51:1330\u20131336","journal-title":"Dig Liver Dis"},{"key":"3059_CR35","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/ajg.2016.453","volume":"112","author":"S McPherson","year":"2017","unstructured":"McPherson S, Hardy T, Dufour JF, Petta S, Romero-Gomez M, Allison M, Oliveira CP, Francque S, Van Gaal L, Schattenberg JM, Tiniakos D, Burt A, Bugianesi E, Ratziu V, Day CP, Anstee QM (2017) Age as a confounding factor for the accurate non-invasive diagnosis of advanced NAFLD fibrosis. Am J Gastroenterol 112:740\u2013751","journal-title":"Am J Gastroenterol"},{"key":"3059_CR36","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.jacl.2017.04.115","volume":"11","author":"SM Abdeldyem","year":"2017","unstructured":"Abdeldyem SM, Goda T, Khodeir SA, Abou Saif S, Abd-Elsalam S (2017) Nonalcoholic fatty liver disease in patients with acute ischemic stroke is associated with more severe stroke and worse outcome. J Clin Lipidol 11:915\u2013919","journal-title":"J Clin Lipidol"},{"key":"3059_CR37","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/ene.12904","volume":"23","author":"G Tan","year":"2016","unstructured":"Tan G, Lei C, Hao Z, Chen Y, Yuan R, Liu M (2016) Liver function may play an uneven role in haemorrhagic transformation for stroke subtypes after acute ischaemic stroke. Eur J Neurol 23:597\u2013604","journal-title":"Eur J Neurol"},{"key":"3059_CR38","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s12975-019-00763-2","volume":"11","author":"MJ Haley","year":"2020","unstructured":"Haley MJ, White CS, Roberts D, O\u2019Toole K, Cunningham CJ, Rivers-Auty J, O\u2019Boyle C, Lane C, Heaney O, Allan SM, Lawrence CB (2020) Stroke induces prolonged changes in lipid metabolism, the liver and body composition in mice. Transl Stroke Res 11:837\u2013850","journal-title":"Transl Stroke Res"},{"key":"3059_CR39","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1002\/ana.25286","volume":"84","author":"A da Silva-Candal","year":"2018","unstructured":"da Silva-Candal A, Perez-Diaz A, Santamaria M, Correa-Paz C, Rodriguez-Yanez M, Arda A, Perez-Mato M, Iglesias-Rey R, Brea J, Azuaje J, Sotelo E, Sobrino T, Loza MI, Castillo J, Campos F (2018) Clinical validation of blood\/brain glutamate grabbing in acute ischemic stroke. Ann Neurol 84:260\u2013273","journal-title":"Ann Neurol"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-022-03059-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-022-03059-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-022-03059-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T13:48:06Z","timestamp":1664459286000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11739-022-03059-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,20]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["3059"],"URL":"https:\/\/doi.org\/10.1007\/s11739-022-03059-w","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,20]]},"assertion":[{"value":"11 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the ethics committees of Beijing Tiantan Hospital and all other research centres according to the principles expressed in the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of human and animal rights"}},{"value":"Written informed consent was obtained from all patients or legally authorized representatives before entering into the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}