{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:29:21Z","timestamp":1781576961793,"version":"3.54.5"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s11739-023-03192-0","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T08:30:31Z","timestamp":1674549031000},"page":"467-475","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Vascular health in subjects with rheumatoid arthritis: assessment of endothelial function indices and serum biomarkers of vascular damage"],"prefix":"10.1007","volume":"18","author":[{"given":"Mario","family":"Daidone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Del Cuore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Casuccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Di Chiara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Guggino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Di Raimondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Puleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Ferrante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Scaglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6440-7318","authenticated-orcid":false,"given":"Antonino","family":"Tuttolomondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"issue":"9","key":"3192_CR1","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1016\/j.amjcard.2011.06.054","volume":"108","author":"R Micha","year":"2011","unstructured":"Micha R, Imamura F, Wyler von Ballmoos M, Solomon DH, Hernan MA, Ridker PM et al (2011) Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease. Am J Cardiol 108(9):1362\u20131370","journal-title":"Am J Cardiol"},{"key":"3192_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S1462399405009154","volume":"7","author":"RJ Stevens","year":"2005","unstructured":"Stevens RJ, Douglas KMJ, Saratzis AN, Kitas GD (2005) Inflammation and atherosclerosis in rheumatoid arthritis. Expert Rev Mol Med 7:1\u201324. https:\/\/doi.org\/10.1017\/S1462399405009154","journal-title":"Expert Rev Mol Med"},{"issue":"Suppl 5","key":"3192_CR3","doi-asserted-by":"publisher","first-page":"v3","DOI":"10.1093\/rheumatology\/kes113","volume":"51","author":"E Choy","year":"2012","unstructured":"Choy E (2012) Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatol Oxf Engl 51(Suppl 5):v3-11. https:\/\/doi.org\/10.1093\/rheumatology\/kes113","journal-title":"Rheumatol Oxf Engl"},{"key":"3192_CR4","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1136\/annrheumdis-2013-203617","volume":"73","author":"GA Karpouzas","year":"2014","unstructured":"Karpouzas GA, Malpeso J, Choi T-Y, Li D, Munoz S, Budoff MJ (2014) Prevalence, extent and composition of coronary plaque in patients with rheumatoid arthritis without symptoms or prior diagnosis of coronary artery disease. Ann Rheum Dis 73:1797\u20131804. https:\/\/doi.org\/10.1136\/annrheumdis-2013-203617","journal-title":"Ann Rheum Dis"},{"key":"3192_CR5","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.3899\/jrheum.090188","volume":"36","author":"KP Liang","year":"2009","unstructured":"Liang KP, Maradit-Kremers H, Crowson CS, Snyder MR, Therneau TM, Roger VL, Gabriel SE (2009) Autoantibodies and the risk of cardiovascular events. J Rheumatol 36:2462\u20132469. https:\/\/doi.org\/10.3899\/jrheum.090188","journal-title":"J Rheumatol"},{"key":"3192_CR6","doi-asserted-by":"publisher","first-page":"422","DOI":"10.3109\/03009742.2011.585350","volume":"40","author":"G Hjeltnes","year":"2011","unstructured":"Hjeltnes G, Hollan I, F\u00f8rre \u00d8, Wiik A, Mikkelsen K, Agewall S (2011) Anti-CCP and RF IgM: predictors of impaired endothelial function in rheumatoid arthritis patients. Scand J Rheumatol 40:422\u2013427. https:\/\/doi.org\/10.3109\/03009742.2011.585350","journal-title":"Scand J Rheumatol"},{"key":"3192_CR7","first-page":"10","volume":"818037","author":"D Spasovski","year":"2013","unstructured":"Spasovski D, Latifi A, Osmani B et al (2013) Determination of the diagnostic values of asymmetric dimethylarginine as an indicator for evaluation of the endothelial dysfunction in patients with rheumatoid arthritis. Arthritis 818037:10","journal-title":"Arthritis"},{"key":"3192_CR8","first-page":"28","volume":"801896","author":"G Favero","year":"2014","unstructured":"Favero G, Paganelli C, Buffoli B, Rodella LF, Rezzani R (2014) Endothelium and its alterations in cardiovascular diseases: life style intervention. BioMedResearch Int 801896:28","journal-title":"BioMedResearch Int"},{"issue":"17","key":"3192_CR9","doi-asserted-by":"publisher","first-page":"9114","DOI":"10.1073\/pnas.93.17.9114","volume":"93","author":"BV Khan","year":"1996","unstructured":"Khan BV, Harrison DG, Olbrych MT, Alexander RW, Medford RM (1996) Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Proceed Nat Acad Sci USA 93(17):9114\u20139119","journal-title":"Proceed Nat Acad Sci USA"},{"issue":"4","key":"3192_CR10","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1152\/physrev.00047.2003","volume":"84","author":"R Stocker","year":"2004","unstructured":"Stocker R, Keaney JF Jr (2004) Role of oxidative modifications in atherosclerosis. Physiol Rev 84(4):1381\u20131478","journal-title":"Physiol Rev"},{"issue":"Suppl 2","key":"3192_CR11","doi-asserted-by":"publisher","first-page":"S314","DOI":"10.2337\/dc09-S330","volume":"32","author":"D Versari","year":"2009","unstructured":"Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S (2009) Endothelial dysfunction as a target for prevention of cardiovascular disease. Diabetes Care 32(Suppl 2):S314-321. https:\/\/doi.org\/10.2337\/dc09-S330","journal-title":"Diabetes Care"},{"key":"3192_CR12","doi-asserted-by":"crossref","unstructured":"MacDonald IJ, Liu SC, Su CM, et al. (2018) Implications of angiogenesis involvement in arthritis. Int J Mol Sci 19(7):2012","DOI":"10.3390\/ijms19072012"},{"key":"3192_CR13","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1007\/s00134-009-1413-8","volume":"35","author":"L Su","year":"2009","unstructured":"Su L, Zhai R, Sheu CC et al (2009) Genetic variants in the angiopoietin-2 gene are associated with increased risk of ARDS. Intensive Care Med 35:1024\u20131030","journal-title":"Intensive Care Med"},{"key":"3192_CR14","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.canlet.2017.01.013","volume":"391","author":"LH Wang","year":"2017","unstructured":"Wang LH, Tsai HC, Cheng YC et al (2017) CTGF promotes osteosarcoma angiogenesis by regulating MiR-543\/angiopoietin 2 signaling. Cancer Lett 391:28\u201337","journal-title":"Cancer Lett"},{"key":"3192_CR15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.canlet.2012.08.018","volume":"328","author":"E Fagiani","year":"2013","unstructured":"Fagiani E, Christofori G (2013) Angiopoietins in angiogenesis. Cancer Lett 328:18\u201326","journal-title":"Cancer Lett"},{"key":"3192_CR16","doi-asserted-by":"publisher","first-page":"3854","DOI":"10.1016\/j.semarthrit.2008.03.006","volume":"39","author":"OD Ortega-Hernandez","year":"2009","unstructured":"Ortega-Hernandez OD, Bassi N, Shoenfeld Y et al (2009) The long pentraxin 3 and its role in autoimmunity. Semin Arthritis Rheum 39:3854","journal-title":"Semin Arthritis Rheum"},{"key":"3192_CR17","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1172\/JCI200523273","volume":"115","author":"G Xu","year":"2005","unstructured":"Xu G, Nie H, Li N, Zheng W, Zhang D, Feng G, Ni L, Xu R, Hong J, Zhang JZ (2005) Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. J Clin Invest 115:1060\u20131067","journal-title":"J Clin Invest"},{"key":"3192_CR18","doi-asserted-by":"publisher","first-page":"E0119709","DOI":"10.1371\/journal.pone.0119709","volume":"10","author":"D Pilling","year":"2015","unstructured":"Pilling D, Cox N, Vakil V et al (2015) The long pentraxin PTX3 promotes fibrocyte differentiation. PLoS ONE 10:E0119709","journal-title":"PLoS ONE"},{"key":"3192_CR19","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes279","author":"J Kay","year":"2012","unstructured":"Kay J, Upchurch KS (2012) ACR\/EULAR 2010 rheumatoid arthritis classification criteria. Rheumatol Oxf Engl. https:\/\/doi.org\/10.1093\/rheumatology\/kes279","journal-title":"Rheumatol Oxf Engl"},{"key":"3192_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107","author":"MLV Prevoo","year":"1995","unstructured":"Prevoo MLV, Hof MA, Kuper HHV, Leeuwen MAV, de Putte LB, Van Riel PL (1995) Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. https:\/\/doi.org\/10.1002\/art.1780380107","journal-title":"Arthritis Rheum"},{"key":"3192_CR21","doi-asserted-by":"crossref","unstructured":"Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatric Res 12(3):189\u2013198","DOI":"10.1016\/0022-3956(75)90026-6"},{"issue":"Supplement 2","key":"3192_CR22","doi-asserted-by":"publisher","first-page":"S314","DOI":"10.2337\/dc09-S330","volume":"32","author":"D Versari","year":"2009","unstructured":"Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S (2009) Endothelial dysfunction as a target for prevention of cardio- vascular disease. Diabetes Care 32(Supplement 2):S314\u2013S321","journal-title":"Diabetes Care"},{"key":"3192_CR23","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/978-1-4613-1241-3_8","volume":"80","author":"M Lotz","year":"1995","unstructured":"Lotz M (1995) Interleukin-6: a comprehensive review. Cancer Treat- Ment Res 80:209\u2013233","journal-title":"Cancer Treat- Ment Res"},{"issue":"1","key":"3192_CR24","first-page":"601","volume":"272","author":"JF Schmedtje Jr","year":"1997","unstructured":"Schmedtje JF Jr, Ji Y-S, Liu W-L, DuBois RN, Runge MS (1997) Hypoxia induces cyclooxygenase-2 via the NF-\u03baB P65 transcription factor in human vascular endothelial cells. J BiologicalChem 272(1):601\u2013608","journal-title":"J BiologicalChem"},{"key":"3192_CR25","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1093\/rheumatology\/23.2.92","volume":"23","author":"P Prior","year":"1984","unstructured":"Prior P, Symmons DPM, Scott DL, Brown R, Hawkins CF (1984) Cause of death in rheumatoid arthritis. Rheumatology 23:92\u201399. https:\/\/doi.org\/10.1093\/rheumatology\/23.2.92","journal-title":"Rheumatology"},{"key":"3192_CR26","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1093\/rheumatology\/kem169","volume":"46","author":"VF Panoulas","year":"2007","unstructured":"Panoulas VF, Douglas KMJ, Milionis HJ, Stavropoulos-Kalinglou A, Nightingale P, Kita MD, Tselios AL, Metsios GS, Elisaf MS, Kitas GD (2007) Prevalence and associations of hypertension and its control in patients with rheumatoid arthritis. Rheumatol Oxf Engl 46:1477\u20131482. https:\/\/doi.org\/10.1093\/rheumatology\/kem169","journal-title":"Rheumatol Oxf Engl"},{"key":"3192_CR27","first-page":"841","volume":"13","author":"T Pincus","year":"1986","unstructured":"Pincus T, Callahan LF (1986) Taking mortality in rheumatoid arthritis seriously-predictive markers. Socioecon Status Comorb J Rheumatol 13:841\u2013845","journal-title":"Socioecon Status Comorb J Rheumatol"},{"key":"3192_CR28","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1146\/annurev.immunol.23.021704.115756","volume":"23","author":"C Garlanda","year":"2005","unstructured":"Garlanda C, Bottazzi B, Bastone A, Mantovani A (2005) Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition and female fertility. Annu Rev Immunol 23:337\u2013366","journal-title":"Annu Rev Immunol"},{"key":"3192_CR29","doi-asserted-by":"publisher","first-page":"119128","DOI":"10.3109\/08916934.2011.611549","volume":"45","author":"P Cieslik","year":"2012","unstructured":"Cieslik P, Hrycek A (2012) Long Pentraxin 3 (PTX3) in the light of its structure, mechanism of action and clinical implications. Autoimmunity 45:119128","journal-title":"Autoimmunity"},{"key":"3192_CR30","doi-asserted-by":"publisher","first-page":"38","DOI":"10.2174\/138161211795049750","volume":"17","author":"C Garlanda","year":"2011","unstructured":"Garlanda C, Bottazzi B, Moalli F, Deban L, Molla F, Latini R et al (2011) Pentraxins and atherosclerosis: the role of PTX3. Curr Pharm Des 17:38\u201346","journal-title":"Curr Pharm Des"},{"key":"3192_CR31","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s10238-007-0118-y","volume":"7","author":"A Bosutti","year":"2007","unstructured":"Bosutti A, Grassi G, Zanetti M, Aleksova A, Zecchin M, Sinagra G, Biolo G, Guarnieri G (2007) Relation between the plasma levels of LDL-cholesterol and the expression of the early marker of inflammation long pentraxin PTX3 and the stress response gene P66ShcA in pacemaker-implanted patients. Clin Exp Med 7:16\u201323","journal-title":"Clin Exp Med"},{"key":"3192_CR32","doi-asserted-by":"publisher","first-page":"378385","DOI":"10.1002\/acr.20094","volume":"62","author":"I Hollan","year":"2010","unstructured":"Hollan I, Bottazzi B, Cuccovillo I et al (2010) Increased levels of serum pentraxin 3, a novel cardiovascular biomarker, in patients with inflammatory rheumatic disease. Arthritis Care Res (Hoboken) 62:378385","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"3192_CR33","doi-asserted-by":"publisher","first-page":"926931","DOI":"10.1177\/1352458512457845","volume":"19","author":"H Wang","year":"2013","unstructured":"Wang H, Wang K, Wang C et al (2013) Increased plasma levels of pentraxin 3 in patients with multiple sclerosis and neuromyelitis optica. Mult Scler 19:926931","journal-title":"Mult Scler"},{"key":"3192_CR34","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1046\/j.1365-2249.2000.01110.x","volume":"119","author":"MM Luchetti","year":"2000","unstructured":"Luchetti MM, Piccinini G, Mantovani A, Peri G, Matteucci C, Pomponio G, Fratini M, Fraticelli P, Sambo P, Di Loreto C, Doni A, Introna M, Gabrielli A (2000) Expression and production of the long pentraxin PTX3 in rheumatoid arthritis (RA). Clin Exp Immunol 119:196\u2013202","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"3192_CR35","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/art.21574","volume":"54","author":"HE Barksby","year":"2006","unstructured":"Barksby HE, Hui W, Wappler I, Peters HH, Milner JM, Richards CD et al (2006) Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes: implications for cartilage destruction and repair. Arthritis Rheum 54(2):540\u2013545","journal-title":"Arthritis Rheum"},{"issue":"10","key":"3192_CR36","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1002\/1529-0131(199810)41:10<1760::AID-ART8>3.0.CO;2-M","volume":"41","author":"TE Cawston","year":"1998","unstructured":"Cawston TE, Curry VA, Summers CA, Clark IM, Riley GP, LifePF, et al (1998) The role of Oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint. Arthritis Rheum 41(10):1760\u20131771","journal-title":"Arthritis Rheum"},{"issue":"1","key":"3192_CR37","doi-asserted-by":"publisher","first-page":"R57","DOI":"10.1186\/ar1460","volume":"7","author":"W Hui","year":"2005","unstructured":"Hui W, Cawston TE, Richards CD, Rowan AD (2005) A model for inflammatory arthritis highlights a role for Oncostatin M in proinflammatory cytokine-induced bone destruction via RANK\/RANKL. Arthritis Res Ther 7(1):R57-64","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"3192_CR38","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1016\/S0002-9440(10)64330-1","volume":"162","author":"AD Rowan","year":"2003","unstructured":"Rowan AD, Hui W, Cawston TE, Richards CD (2003) Adenoviral gene transfer of interleukin-1 in combination with Oncostatin M induces significant joint damage in a murine model. Am J Pathol 162(6):1975\u20131984","journal-title":"Am J Pathol"},{"key":"3192_CR39","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.humpath.2003.11.010","volume":"35","author":"K Takahara","year":"2004","unstructured":"Takahara K, Iioka T, Furukawa K, Uchida T, Nakashima M, Tsukazaki T, Shindo H (2004) Autocrine\/paracrine role of the angiopoietin-1 and -2\/Tie2 system in cell proliferation and chemotaxis of cultured fibroblastic synoviocytes in rheumatoid arthritis. Hum Pathol 35:150\u2013158. https:\/\/doi.org\/10.1016\/j.humpath.2003.11.010","journal-title":"Hum Pathol"},{"key":"3192_CR40","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.neures.2009.04.007","volume":"64","author":"X Chen","year":"2009","unstructured":"Chen X, Fu W, Tung CE, Ward NL (2009) Angiopoietin-1 induces neurite outgrowth of PC12 cells in a tie2-independent, beta1-integrin-dependent manner. Neurosci Res 64:348\u2013354","journal-title":"Neurosci Res"},{"key":"3192_CR41","doi-asserted-by":"publisher","first-page":"5050","DOI":"10.1182\/blood-2011-03-343293","volume":"118","author":"A Scholz","year":"2011","unstructured":"Scholz A et al (2011) Angiopoietin-2 promotes myeloid cell infiltration in a beta(2)- integrin-dependent manner. Blood 118:5050\u20135059","journal-title":"Blood"},{"key":"3192_CR42","doi-asserted-by":"publisher","first-page":"203127","DOI":"10.1126\/scitranslmed.3006666","volume":"5","author":"J Lee","year":"2013","unstructured":"Lee J et al (2013) Angiopoietin-1 guides directional angiogenesis through integrin Avb5 signaling for recovery of ischemic retinopathy. Sci Transl Med 5:203127","journal-title":"Sci Transl Med"},{"key":"3192_CR43","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1172\/JCI58832","volume":"122","author":"M Felcht","year":"2012","unstructured":"Felcht M et al (2012) Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. J Clin Invest 122:1991\u20132005","journal-title":"J Clin Invest"},{"key":"3192_CR44","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1124\/jpet.105.086553","volume":"314","author":"F Roviezzo","year":"2005","unstructured":"Roviezzo F, Tsigkos S, Kotanidou A, Bucci M, Brancaleone V, Cirino G, Papapetropoulos A (2005) Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage. J Pharmacol Exp Ther 314:738\u2013744. https:\/\/doi.org\/10.1124\/jpet.105.086553","journal-title":"J Pharmacol Exp Ther"},{"key":"3192_CR45","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1182\/blood-2004-09-3531","volume":"105","author":"C Lemieux","year":"2005","unstructured":"Lemieux C, Maliba R, Favier J, Th\u00e9or\u00eat J-F, Merhi Y, Sirois MG (2005) Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses. Blood 105:1523\u20131530. https:\/\/doi.org\/10.1182\/blood-2004-09-3531","journal-title":"Blood"},{"key":"3192_CR46","first-page":"761","volume":"31","author":"R Lopez-Mejias","year":"2013","unstructured":"Lopez-Mejias R, Corrales A, Genre F et al (2013) Angiopoietin-2 serum levels correlate with severity, early onset and cardiovascular disease in patients with rheumatoid arthritis. ClinExpRheumatol 31:761\u2013766","journal-title":"ClinExpRheumatol"},{"key":"3192_CR47","first-page":"225","volume":"13","author":"R Patarca","year":"1993","unstructured":"Patarca R, Saavedra RA, Cantor H (1993) Molecular and cellular basis of genetic resistance to bacterial infection: the role of the early T lymphocyte activation-1\/osteopontin gene. Crit Rev Immunol 13:225\u2013246","journal-title":"Crit Rev Immunol"},{"key":"3192_CR48","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1177\/10454411000110030101","volume":"11","author":"J Sodek","year":"2000","unstructured":"Sodek J, Ganss B, McKee MD (2000) Osteopontin. Crit Rev Oral Biol Med 11:279\u2013303","journal-title":"Crit Rev Oral Biol Med"},{"key":"3192_CR49","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1172\/JCI12980","volume":"107","author":"DT Denhardt","year":"2001","unstructured":"Denhardt DT, Noda M, O\u2019Regan AW, Pavlin D, Berman JS (2001) Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 107:1055\u20131061","journal-title":"J Clin Invest"},{"key":"3192_CR50","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s10067-013-2375-3","volume":"33","author":"HI Ji","year":"2014","unstructured":"Ji HI, Lee SH, Song R et al (2014) Serum level of osteopontin as an inflammatory marker does not indicate disease activity or responsiveness to therapeutic treatments in patients with rheumatoid arthritis. Clin Rheumatol 33:397\u2013402","journal-title":"Clin Rheumatol"},{"key":"3192_CR51","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1093\/eurheartj\/ehl254","volume":"27","author":"S Laurent","year":"2006","unstructured":"Laurent S et al (2006) Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 27:2588\u20132605","journal-title":"Eur Heart J"},{"key":"3192_CR52","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0021-9150(03)00298-3","volume":"170","author":"R Ohmori","year":"2003","unstructured":"Ohmori R et al (2003) Plasma osteopontin levels are associated with the presence and extent of coronary artery disease. Atherosclerosis 170:333\u2013337","journal-title":"Atherosclerosis"},{"key":"3192_CR53","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1161\/01.ATV.0000194157.26665.e6","volume":"26","author":"R Kato","year":"2006","unstructured":"Kato R et al (2006) High plasma levels of osteopontin in patients with restenosis after percutaneous coronary intervention. Arterioscler Thromb Vasc Biol 26:E1-2","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-023-03192-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-023-03192-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-023-03192-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T13:54:24Z","timestamp":1678888464000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11739-023-03192-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,24]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["3192"],"URL":"https:\/\/doi.org\/10.1007\/s11739-023-03192-0","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,24]]},"assertion":[{"value":"16 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors do not have any competing interest. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the Ethics Committee of the Policlinico \u201cP. Giaccone\u201d University Hospital of Palermo.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All enrolled patients gave written informed consent for enrollment and publication of data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and consent for publication"}}]}}