{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:30:48Z","timestamp":1782761448137,"version":"3.54.5"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Nutrition Clinical Research Foundation of China Foundation","award":["No. Z-2017-24-2110"],"award-info":[{"award-number":["No. Z-2017-24-2110"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This is a literature review describes Crohn\u2019s disease (CD) concomitant with breast cancer and summarizes possible common pathogenic mechanisms shared by the two diseases involving the IL-17 and NF-\u03baB signaling pathways. Inflammatory cytokines including TNF-\u03b1 and Th17 cells in CD patients can induce activation of the ERK1\/2, NF-\u03baB and Bcl-2 pathways. Hub genes are involved in the generation of cancer stem cells (CSCs) and are related to inflammatory mediators, including CXCL8, IL1-\u03b2 and PTGS2, which promote inflammation and breast cancer growth, metastasis, and development. CD activity is highly associated with altered intestinal microbiota processes, including secretion of complex glucose polysaccharides by Ruminococcus gnavus colonies; furthermore, \u03b3-proteobacteria and Clostridium are associated with CD recurrence and active CD, while Ruminococcaceae, Faecococcus and Vibrio desulfuris are associated with CD remission. Intestinal microbiota disorder promotes breast cancer occurrence and development. Bacteroides fragilis can produce toxins that induce breast epithelial hyperplasia and breast cancer growth and metastasis. Gut microbiota regulation can also improve chemotherapy and immunotherapy efficacy in breast cancer treatment. Intestinal inflammation can affects the brain through the brain\u2013gut axis, which activates the hypothalamic\u2012pituitary\u2012adrenal (HPA) axis to induce anxiety and depression in patients; these effects can inhibit the antitumor immune responses of the immune system and promote breast cancer occurrence in patients with CD. There are few studies on the treatment of patients with CD concomitant with breast cancer, but published studies show three main strategies: new biological agents combined with breast cancer treatment methods, intestinal fecal bacteria transplantation, and dietary treatment.<\/jats:p>","DOI":"10.1007\/s11739-023-03281-0","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T16:02:14Z","timestamp":1683129734000},"page":"1303-1316","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Crohn\u2019s disease and breast cancer: a literature review of the mechanisms and treatment"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8350-5850","authenticated-orcid":false,"given":"Sisi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"issue":"10080","key":"3281_CR1","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","volume":"389","author":"J Torres","year":"2017","unstructured":"Torres J, Mehandru S, Colombel JF, Peyrin-Biroulet L (2017) Crohn\u2019s disease. Lancet 389(10080):1741\u20131755. https:\/\/doi.org\/10.1016\/S0140-6736(16)31711-1","journal-title":"Lancet"},{"issue":"4","key":"3281_CR2","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ajg.2018.27","volume":"113","author":"GR Lichtenstein","year":"2018","unstructured":"Lichtenstein GR, Loftus EV, Isaacs KL, Regueiro MD, Gerson LB, Sands BE (2018) ACG clinical guideline: management of Crohn\u2019s disease in adults. Am J Gastroenterol 113(4):481\u2013517. https:\/\/doi.org\/10.1038\/ajg.2018.27. (Published correction appears in Am J Gastroenterol. 2018 Jul;113(7):1101)","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"3281_CR3","first-page":"217","volume":"85","author":"CM Mansfield","year":"1993","unstructured":"Mansfield CM (1993) A review of the etiology of breast cancer. J Natl Med Assoc 85(3):217\u2013221","journal-title":"J Natl Med Assoc"},{"issue":"5","key":"3281_CR4","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1002\/cam4.1427","volume":"7","author":"F Bravi","year":"2018","unstructured":"Bravi F, Decarli A, Russo AG (2018) Risk factors for breast cancer in a cohort of mammographic screening program: a nested case-control study within the FRiCaM study. Cancer Med 7(5):2145\u20132152. https:\/\/doi.org\/10.1002\/cam4.1427","journal-title":"Cancer Med"},{"issue":"12","key":"3281_CR5","doi-asserted-by":"publisher","first-page":"524","DOI":"10.3390\/cancers10120524","volume":"10","author":"J Kotsopoulos","year":"2018","unstructured":"Kotsopoulos J (2018) BRCA mutations and breast cancer prevention. Cancers (Basel) 10(12):524. https:\/\/doi.org\/10.3390\/cancers10120524. (Published 2018 Dec 19)","journal-title":"Cancers (Basel)"},{"key":"3281_CR6","first-page":"369","volume":"30","author":"A Mehrgou","year":"2016","unstructured":"Mehrgou A, Akouchekian M (2016) The importance of BRCA1 and BRCA2 genes mutations in breast cancer development. Med J Islam Repub Iran 30:369 (Published 2016 May 15)","journal-title":"Med J Islam Repub Iran"},{"key":"3281_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.acc.2015.05.001","volume":"71","author":"MJ Duffy","year":"2015","unstructured":"Duffy MJ, Walsh S, McDermott EW, Crown J (2015) Biomarkers in breast cancer: where are we and where are we going? Adv Clin Chem 71:1\u201323. https:\/\/doi.org\/10.1016\/bs.acc.2015.05.001","journal-title":"Adv Clin Chem"},{"issue":"1","key":"3281_CR8","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1186\/s13256-021-03224-3","volume":"15","author":"M Al-Arsan Al-Yaseen","year":"2021","unstructured":"Al-Arsan Al-Yaseen M, Haydar SA, Alali M, Saifo M (2021) Gestational breast cancer in a patient with Crohn\u2019s disease: two case reports. J Med Case Rep 15(1):633. https:\/\/doi.org\/10.1186\/s13256-021-03224-3. (Published 2021 Dec 27)","journal-title":"J Med Case Rep"},{"issue":"1","key":"3281_CR9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.dld.2005.07.006","volume":"38","author":"G Riegler","year":"2006","unstructured":"Riegler G, Caserta L, Castiglione F et al (2006) Increased risk of breast cancer in first-degree relatives of Crohn\u2019s disease patients. An IG-IBD study. Dig Liver Dis 38(1):18\u201323. https:\/\/doi.org\/10.1016\/j.dld.2005.07.006","journal-title":"Dig Liver Dis"},{"issue":"2\u20133","key":"3281_CR10","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1159\/000179361","volume":"78","author":"H Gutmann","year":"2008","unstructured":"Gutmann H, Hruz P, Zimmermann C et al (2008) Breast cancer resistance protein and P-glycoprotein expression in patients with newly diagnosed and therapy-refractory ulcerative colitis compared with healthy controls. Digestion 78(2\u20133):154\u2013162. https:\/\/doi.org\/10.1159\/000179361","journal-title":"Digestion"},{"issue":"3","key":"3281_CR11","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/ibd.20030","volume":"13","author":"G Englund","year":"2007","unstructured":"Englund G, Jacobson A, Rorsman F, Artursson P, Kindmark A, R\u00f6nnblom A (2007) Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1). Inflamm Bowel Dis 13(3):291\u2013297. https:\/\/doi.org\/10.1002\/ibd.20030","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"3281_CR12","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1093\/ecco-jcc\/jjw193","volume":"11","author":"\u00d8 Hovde","year":"2017","unstructured":"Hovde \u00d8, H\u00f8ivik ML, Henriksen M, Solberg IC, Sm\u00e5stuen MC, Moum BA (2017) Malignancies in patients with inflammatory bowel disease: results from 20 years of follow-up in the IBSEN study. J Crohns Colitis 11(5):571\u2013577. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjw193. (Published correction appears in J Crohns Colitis. 2016 Dec 30)","journal-title":"J Crohns Colitis"},{"issue":"3","key":"3281_CR13","first-page":"194","volume":"50","author":"N Hamajima","year":"2003","unstructured":"Hamajima N, Yuasa H (2003) Genetic polymorphisms related to interleukin-1 beta production and disease risk. Nihon Koshu Eisei Zasshi 50(3):194\u2013207","journal-title":"Nihon Koshu Eisei Zasshi"},{"issue":"9010","key":"3281_CR14","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1016\/s0140-6736(96)90734-5","volume":"347","author":"J Satsangi","year":"1996","unstructured":"Satsangi J, Welsh KI, Bunce M et al (1996) Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease. Lancet 347(9010):1212\u20131217. https:\/\/doi.org\/10.1016\/s0140-6736(96)90734-5","journal-title":"Lancet"},{"issue":"6","key":"3281_CR15","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1097\/00000658-199706000-00009","volume":"225","author":"RM Pokorny","year":"1997","unstructured":"Pokorny RM, Hofmeister A, Galandiuk S, Dietz AB, Cohen ND, Neibergs HL (1997) Crohn\u2019s disease and ulcerative colitis are associated with the DNA repair gene MLH1. Ann Surg 225(6):718\u2013725. https:\/\/doi.org\/10.1097\/00000658-199706000-00009","journal-title":"Ann Surg"},{"issue":"1","key":"3281_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.advms.2016.09.001","volume":"62","author":"Z Kmie\u0107","year":"2017","unstructured":"Kmie\u0107 Z, Cyman M, \u015alebioda TJ (2017) Cells of the innate and adaptive immunity and their interactions in inflammatory bowel disease. Adv Med Sci 62(1):1\u201316. https:\/\/doi.org\/10.1016\/j.advms.2016.09.001","journal-title":"Adv Med Sci"},{"issue":"4","key":"3281_CR17","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1136\/gut.42.4.477","volume":"42","author":"S Schreiber","year":"1998","unstructured":"Schreiber S, Nikolaus S, Hampe J (1998) Activation of nuclear factor kappa B inflammatory bowel disease. Gut 42(4):477\u2013484. https:\/\/doi.org\/10.1136\/gut.42.4.477","journal-title":"Gut"},{"issue":"8","key":"3281_CR18","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1136\/gut.2008.163667","volume":"58","author":"S Brand","year":"2009","unstructured":"Brand S (2009) Crohn\u2019s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn\u2019s disease. Gut 58(8):1152\u20131167. https:\/\/doi.org\/10.1136\/gut.2008.163667","journal-title":"Gut"},{"key":"3281_CR19","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.intimp.2018.01.026","volume":"56","author":"K Ma","year":"2018","unstructured":"Ma K, Yang L, Shen R et al (2018) Th17 cells regulate the production of CXCL1 in breast cancer. Int Immunopharmacol 56:320\u2013329. https:\/\/doi.org\/10.1016\/j.intimp.2018.01.026","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"3281_CR20","doi-asserted-by":"publisher","first-page":"e0125742","DOI":"10.1371\/journal.pone.0125742","volume":"10","author":"H Kim","year":"2015","unstructured":"Kim H, Kim Y, Bae S et al (2015) Direct interaction of CD40 on tumor cells with CD40L on T cells increases the proliferation of tumor cells by enhancing TGF-\u03b2 production and Th17 differentiation. PLoS\u00a0One 10(5):e0125742. https:\/\/doi.org\/10.1371\/journal.pone.0125742. (Published 2015 May 18)","journal-title":"PLoS\u00a0One"},{"key":"3281_CR21","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.biopha.2017.01.120","volume":"88","author":"V Alinejad","year":"2017","unstructured":"Alinejad V, Dolati S, Motallebnezhad M, Yousefi M (2017) The role of IL17B-IL17RB signaling pathway in breast cancer. Biomed Pharmacother 88:795\u2013803. https:\/\/doi.org\/10.1016\/j.biopha.2017.01.120","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"3281_CR22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3892\/ol.2020.11981","volume":"20","author":"J Zhou","year":"2020","unstructured":"Zhou J, Yang R (2020) Identification of key pathways and genes shared between Crohn\u2019s disease and breast cancer using bioinformatics analysis. Oncol Lett 20(4):119. https:\/\/doi.org\/10.3892\/ol.2020.11981","journal-title":"Oncol Lett"},{"issue":"11","key":"3281_CR23","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/ncb3041","volume":"16","author":"H Lu","year":"2014","unstructured":"Lu H, Clauser KR, Tam WL et al (2014) A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol 16(11):1105\u20131117. https:\/\/doi.org\/10.1038\/ncb3041. (Published correction appears in Nat Cell Biol. 2015 Dec;17(12):1607)","journal-title":"Nat Cell Biol"},{"key":"3281_CR24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cbi.2017.08.014","volume":"277","author":"B Li","year":"2017","unstructured":"Li B, Lu Y, Yu L et al (2017) miR-221, 222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt, NF-\u03baB, COX-2 activation. Chem Biol Interact 277:33\u201342. https:\/\/doi.org\/10.1016\/j.cbi.2017.08.014. (Published correction appears in Chem Biol Interact. 2021 Aug 25;345:109556)","journal-title":"Chem Biol Interact"},{"issue":"1","key":"3281_CR25","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1158\/1541-7786.MCR-17-0221","volume":"16","author":"A Nomura","year":"2018","unstructured":"Nomura A, Gupta VK, Dauer P et al (2018) NF\u03baB-mediated invasiveness in CD133+ pancreatic tics is regulated by autocrine and paracrine activation of IL1 signaling. Mol Cancer Res 16(1):162\u2013172. https:\/\/doi.org\/10.1158\/1541-7786.MCR-17-0221","journal-title":"Mol Cancer Res"},{"issue":"6","key":"3281_CR26","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.7150\/thno.15625","volume":"7","author":"H Ha","year":"2017","unstructured":"Ha H, Debnath B, Neamati N (2017) Role of the CXCL8-CXCR1\/2 axis in cancer and inflammatory diseases. Theranostics 7(6):1543\u20131588. https:\/\/doi.org\/10.7150\/thno.15625. (Published 2017 Apr 7)","journal-title":"Theranostics"},{"key":"3281_CR27","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.cytogfr.2016.08.002","volume":"31","author":"Q Liu","year":"2016","unstructured":"Liu Q, Li A, Tian Y et al (2016) The CXCL8-CXCR1\/2 pathways in cancer. Cytokine Growth Factor Rev 31:61\u201371. https:\/\/doi.org\/10.1016\/j.cytogfr.2016.08.002","journal-title":"Cytokine Growth Factor Rev"},{"issue":"18","key":"3281_CR28","doi-asserted-by":"publisher","first-page":"5200","DOI":"10.1158\/0008-5472.CAN-18-2225","volume":"78","author":"CA Dinarello","year":"2018","unstructured":"Dinarello CA (2018) An interleukin-1 signature in breast cancer treated with interleukin-1 receptor blockade: implications for treating cytokine release syndrome of checkpoint inhibitors. Cancer Res 78(18):5200\u20135202. https:\/\/doi.org\/10.1158\/0008-5472.CAN-18-2225","journal-title":"Cancer Res"},{"issue":"1","key":"3281_CR29","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.canlet.2014.08.015","volume":"354","author":"EA Perez-Yepez","year":"2014","unstructured":"Perez-Yepez EA, Ayala-Sumuano JT, Lezama R, Meza I (2014) A novel \u03b2-catenin signaling pathway activated by IL-1\u03b2 leads to the onset of epithelial-mesenchymal transition in breast cancer cells. Cancer Lett 354(1):164\u2013171. https:\/\/doi.org\/10.1016\/j.canlet.2014.08.015","journal-title":"Cancer Lett"},{"issue":"3\u20134","key":"3281_CR30","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s10555-011-9303-2","volume":"30","author":"J Reader","year":"2011","unstructured":"Reader J, Holt D, Fulton A (2011) Prostaglandin E2 EP receptors as therapeutic targets in breast cancer. Cancer Metastasis Rev 30(3\u20134):449\u2013463. https:\/\/doi.org\/10.1007\/s10555-011-9303-2","journal-title":"Cancer Metastasis Rev"},{"issue":"21\u201323","key":"3281_CR31","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1007\/BF01645143","volume":"69","author":"V Gross","year":"1991","unstructured":"Gross V, Andus T, Leser HG, Roth M, Sch\u00f6lmerich J (1991) Inflammatory mediators in chronic inflammatory bowel diseases. Klin Wochenschr 69(21\u201323):981\u2013987. https:\/\/doi.org\/10.1007\/BF01645143","journal-title":"Klin Wochenschr"},{"issue":"1","key":"3281_CR32","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3748\/wjg.v24.i1.15","volume":"24","author":"N Li","year":"2018","unstructured":"Li N, Shi RH (2018) Updated review on immune factors in pathogenesis of Crohn\u2019s disease. World J Gastroenterol 24(1):15\u201322. https:\/\/doi.org\/10.3748\/wjg.v24.i1.15","journal-title":"World J Gastroenterol"},{"issue":"4","key":"3281_CR33","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/ibd.20341","volume":"14","author":"KK S\u00f8gaard","year":"2008","unstructured":"S\u00f8gaard KK, Cronin-Fenton DP, Pedersen L, S\u00f8rensen HT, Lash TL (2008) Survival in Danish patients with breast cancer and inflammatory bowel disease: a nationwide cohort study. Inflamm Bowel Dis 14(4):519\u2013525. https:\/\/doi.org\/10.1002\/ibd.20341","journal-title":"Inflamm Bowel Dis"},{"issue":"13","key":"3281_CR34","doi-asserted-by":"publisher","first-page":"4707","DOI":"10.1158\/0008-5472.CAN-10-4554","volume":"71","author":"MK Asiedu","year":"2011","unstructured":"Asiedu MK, Ingle JN, Behrens MD, Radisky DC, Knutson KL (2011) TGFbeta\/TNF(alpha)-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype. Cancer Res 71(13):4707\u20134719. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-4554. (Published correction appears in Cancer Res. 2011 Sep 1;71(17):5942)","journal-title":"Cancer Res"},{"key":"3281_CR35","doi-asserted-by":"publisher","first-page":"32747","DOI":"10.1038\/srep32747","volume":"6","author":"KA van Schie","year":"2016","unstructured":"van Schie KA, Ooijevaar-de Heer P, Dijk L, Kruithof S, Wolbink G, Rispens T (2016) Therapeutic TNF inhibitors can differentially stabilize trimeric tnf by inhibiting monomer exchange. Sci Rep 6:32747. https:\/\/doi.org\/10.1038\/srep32747. (Published 2016 Sep 8)","journal-title":"Sci Rep"},{"issue":"21","key":"3281_CR36","first-page":"4940","volume":"58","author":"ME Burow","year":"1998","unstructured":"Burow ME, Weldon CB, Tang Y et al (1998) Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants. Cancer Res 58(21):4940\u20134946","journal-title":"Cancer Res"},{"issue":"5","key":"3281_CR37","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1158\/0008-5472.CAN-11-3123","volume":"72","author":"CW Li","year":"2012","unstructured":"Li CW, Xia W, Huo L et al (2012) Epithelial-mesenchymal transition induced by TNF-\u03b1 requires NF-\u03baB-mediated transcriptional upregulation of Twist1. Cancer Res 72(5):1290\u20131300. https:\/\/doi.org\/10.1158\/0008-5472.CAN-11-3123","journal-title":"Cancer Res"},{"issue":"7","key":"3281_CR38","doi-asserted-by":"publisher","first-page":"e0132710","DOI":"10.1371\/journal.pone.0132710","volume":"10","author":"EN Cohen","year":"2015","unstructured":"Cohen EN, Gao H, Anfossi S et al (2015) Inflammation mediated metastasis: immune induced epithelial-to-mesenchymal transition in inflammatory breast cancer cells. PLoS\u00a0One 10(7):e0132710. https:\/\/doi.org\/10.1371\/journal.pone.0132710. (Published 2015 Jul 24)","journal-title":"PLoS\u00a0One"},{"issue":"26","key":"3281_CR39","doi-asserted-by":"publisher","first-page":"12672","DOI":"10.1073\/pnas.1904099116","volume":"116","author":"MT Henke","year":"2019","unstructured":"Henke MT, Kenny DJ, Cassilly CD, Vlamakis H, Xavier RJ, Clardy J (2019) Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn\u2019s disease, produces an inflammatory polysaccharide. Proc Natl Acad Sci USA 116(26):12672\u201312677. https:\/\/doi.org\/10.1073\/pnas.1904099116","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"3281_CR40","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40168-020-0792-5","volume":"8","author":"H Sokol","year":"2020","unstructured":"Sokol H, Landman C, Seksik P et al (2020) Fecal microbiota transplantation to maintain remission in Crohn\u2019s disease: a pilot randomized controlled study. Microbiome 8(1):12. https:\/\/doi.org\/10.1186\/s40168-020-0792-5. (Published 2020 Feb 3)","journal-title":"Microbiome"},{"issue":"10","key":"3281_CR41","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1016\/j.chom.2022.08.002","volume":"30","author":"J Gao","year":"2022","unstructured":"Gao J, Zhao X, Hu S et al (2022) Gut microbial DL-endopeptidase alleviates Crohn\u2019s disease via the NOD2 pathway. Cell Host Microbe 30(10):1435-1449.e9. https:\/\/doi.org\/10.1016\/j.chom.2022.08.002","journal-title":"Cell Host Microbe"},{"issue":"14","key":"3281_CR42","doi-asserted-by":"publisher","first-page":"3662","DOI":"10.1158\/0008-5472.CAN-18-3464","volume":"79","author":"C Buchta Rosean","year":"2019","unstructured":"Buchta Rosean C, Bostic RR, Ferey JCM et al (2019) Preexisting commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor-positive breast cancer. Cancer Res 79(14):3662\u20133675. https:\/\/doi.org\/10.1158\/0008-5472.CAN-18-3464","journal-title":"Cancer Res"},{"issue":"8","key":"3281_CR43","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1158\/0008-5472.CAN-20-1659","volume":"81","author":"M Di Modica","year":"2021","unstructured":"Di Modica M, Gargari G, Regondi V et al (2021) Gut microbiota condition the therapeutic efficacy of trastuzumab in HER2-positive breast cancer. Cancer Res 81(8):2195\u20132206. https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-1659","journal-title":"Cancer Res"},{"issue":"5","key":"3281_CR44","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1158\/2159-8290.CD-20-0537","volume":"11","author":"S Parida","year":"2021","unstructured":"Parida S, Wu S, Siddharth S et al (2021) A procarcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates notch and \u03b2-catenin axes. Cancer Discov 11(5):1138\u20131157. https:\/\/doi.org\/10.1158\/2159-8290.CD-20-0537","journal-title":"Cancer Discov"},{"issue":"10","key":"3281_CR45","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1136\/gut.2005.064261","volume":"54","author":"JE Mawdsley","year":"2005","unstructured":"Mawdsley JE, Rampton DS (2005) Psychological stress in IBD: new insights into pathogenic and therapeutic implications. Gut 54(10):1481\u20131491. https:\/\/doi.org\/10.1136\/gut.2005.064261","journal-title":"Gut"},{"issue":"2","key":"3281_CR46","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1002\/ibd.21346","volume":"17","author":"W H\u00e4user","year":"2011","unstructured":"H\u00e4user W, Janke KH, Klump B, Hinz A (2011) Anxiety and depression in patients with inflammatory bowel disease: comparisons with chronic liver disease patients and the general population. Inflamm Bowel Dis 17(2):621\u2013632. https:\/\/doi.org\/10.1002\/ibd.21346","journal-title":"Inflamm Bowel Dis"},{"key":"3281_CR47","doi-asserted-by":"publisher","first-page":"175628482211274","DOI":"10.1177\/17562848221127474","volume":"15","author":"J Chen","year":"2022","unstructured":"Chen J, Geng J, Wang J et al (2022) Associations between inflammatory bowel disease, social isolation, and mortality: evidence from a longitudinal cohort study. Therap Adv Gastroenterol 15:17562848221127474. https:\/\/doi.org\/10.1177\/17562848221127474. (Published 2022 Sep 30)","journal-title":"Therap Adv Gastroenterol"},{"issue":"4","key":"3281_CR48","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1093\/ecco-jcc\/jjab191","volume":"16","author":"J Luo","year":"2022","unstructured":"Luo J, Xu Z, Noordam R, van Heemst D, Li-Gao R (2022) Depression and inflammatory bowel disease: a bidirectional two-sample mendelian randomization study. J Crohns Colitis 16(4):633\u2013642. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjab191","journal-title":"J Crohns Colitis"},{"issue":"4","key":"3281_CR49","first-page":"RA55","volume":"10","author":"A Mulak","year":"2004","unstructured":"Mulak A, Bonaz B (2004) Irritable bowel syndrome: a model of the brain-gut interactions. Med Sci Monit 10(4):RA55\u2013RA62","journal-title":"Med Sci Monit"},{"key":"3281_CR50","doi-asserted-by":"publisher","first-page":"6689443","DOI":"10.1155\/2021\/6689443","volume":"2021","author":"AM Sidebottom","year":"2021","unstructured":"Sidebottom AM, Rodriguez TG, Karpin JE, Rubin DT (2021) Clinical and translational considerations for understanding depression and anxiety in patients with inflammatory bowel disease. Gastroenterol Res Pract 2021:6689443. https:\/\/doi.org\/10.1155\/2021\/6689443. (Published 2021 Mar 5)","journal-title":"Gastroenterol Res Pract"},{"issue":"6","key":"3281_CR51","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.12998\/wjcc.v8.i6.1013","volume":"8","author":"E Sinagra","year":"2020","unstructured":"Sinagra E, Utzeri E, Morreale GC, Fabbri C, Pace F, Anderloni A (2020) Microbiota-gut-brain axis and its affect inflammatory bowel disease: pathophysiological concepts and insights for clinicians. World J Clin Cases 8(6):1013\u20131025. https:\/\/doi.org\/10.12998\/wjcc.v8.i6.1013","journal-title":"World J Clin Cases"},{"issue":"3","key":"3281_CR52","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/cei.13276","volume":"197","author":"CD Moulton","year":"2019","unstructured":"Moulton CD, Pavlidis P, Norton C et al (2019) Depressive symptoms in inflammatory bowel disease: an extraintestinal manifestation of inflammation? Clin Exp Immunol 197(3):308\u2013318. https:\/\/doi.org\/10.1111\/cei.13276","journal-title":"Clin Exp Immunol"},{"issue":"8","key":"3281_CR53","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1111\/cns.13401","volume":"26","author":"XJ Li","year":"2020","unstructured":"Li XJ, You XY, Wang CY et al (2020) Bidirectional brain-gut-microbiota axis in increased intestinal permeability induced by central nervous system injury. CNS Neurosci Ther 26(8):783\u2013790. https:\/\/doi.org\/10.1111\/cns.13401","journal-title":"CNS Neurosci Ther"},{"issue":"5","key":"3281_CR54","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1017\/neu.2017.3","volume":"30","author":"\u00c1 Abautret-Daly","year":"2018","unstructured":"Abautret-Daly \u00c1, Dempsey E, Parra-Blanco A, Medina C, Harkin A (2018) Gut-brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease. Acta Neuropsychiatr 30(5):275\u2013296. https:\/\/doi.org\/10.1017\/neu.2017.3","journal-title":"Acta Neuropsychiatr"},{"issue":"9","key":"3281_CR55","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1111\/nmo.12844","volume":"28","author":"A Rubio","year":"2016","unstructured":"Rubio A, Pellissier S, Van Oudenhove L et al (2016) Brain responses to uncertainty about upcoming rectal discomfort in quiescent Crohn\u2019s disease\u2014a fMRI study. Neurogastroenterol Motil 28(9):1419\u20131432. https:\/\/doi.org\/10.1111\/nmo.12844","journal-title":"Neurogastroenterol Motil"},{"key":"3281_CR56","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.bbi.2016.04.017","volume":"57","author":"Q Deng","year":"2016","unstructured":"Deng Q, Chen H, Liu Y et al (2016) Psychological stress promotes neutrophil infiltration in colon tissue through adrenergic signaling in DSS-induced colitis model. Brain Behav Immun 57:243\u2013254. https:\/\/doi.org\/10.1016\/j.bbi.2016.04.017","journal-title":"Brain Behav Immun"},{"issue":"12","key":"3281_CR57","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1136\/gutjnl-2013-306083","volume":"63","author":"W Wu","year":"2014","unstructured":"Wu W, Sun M, Zhang HP et al (2014) Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation. Gut 63(12):1883\u20131892. https:\/\/doi.org\/10.1136\/gutjnl-2013-306083. (Published correction appears in Gut. 2020 Oct;69(10):e7)","journal-title":"Gut"},{"issue":"1","key":"3281_CR58","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1186\/s12885-021-08409-z","volume":"21","author":"M Foster","year":"2021","unstructured":"Foster M, Niedzwiedz CL (2021) Associations between multimorbidity and depression among breast cancer survivors within the UK Biobank cohort: a cross-sectional study. BMC Cancer 21(1):650. https:\/\/doi.org\/10.1186\/s12885-021-08409-z. (Published 2021 May 31)","journal-title":"BMC Cancer"},{"issue":"1","key":"3281_CR59","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/wps.20821","volume":"20","author":"K Kroenke","year":"2021","unstructured":"Kroenke K (2021) PHQ-9: global uptake of a depression scale. World Psychiatry 20(1):135\u2013136. https:\/\/doi.org\/10.1002\/wps.20821","journal-title":"World Psychiatry"},{"issue":"9","key":"3281_CR60","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1136\/gutjnl-2018-317182","volume":"68","author":"AD Frolkis","year":"2019","unstructured":"Frolkis AD, Vallerand IA, Shaheen AA et al (2019) Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression. Gut 68(9):1606\u20131612. https:\/\/doi.org\/10.1136\/gutjnl-2018-317182","journal-title":"Gut"},{"key":"3281_CR61","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jpsychores.2016.06.001","volume":"87","author":"R Neuendorf","year":"2016","unstructured":"Neuendorf R, Harding A, Stello N, Hanes D, Wahbeh H (2016) Depression and anxiety in patients with inflammatory bowel disease: a systematic review. J Psychosom Res 87:70\u201380. https:\/\/doi.org\/10.1016\/j.jpsychores.2016.06.001","journal-title":"J Psychosom Res"},{"issue":"5","key":"3281_CR62","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S2468-1253(21)00014-5","volume":"6","author":"B Barberio","year":"2021","unstructured":"Barberio B, Zamani M, Black CJ, Savarino EV, Ford AC (2021) Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 6(5):359\u2013370. https:\/\/doi.org\/10.1016\/S2468-1253(21)00014-5","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"8","key":"3281_CR63","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1093\/ibd\/izaa349","volume":"27","author":"RA Marrie","year":"2021","unstructured":"Marrie RA, Graff LA, Fisk JD, Patten SB, Bernstein CN (2021) The relationship between symptoms of depression and anxiety and disease activity in IBD over time. Inflamm Bowel Dis 27(8):1285\u20131293. https:\/\/doi.org\/10.1093\/ibd\/izaa349","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"3281_CR64","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/bmb\/ldab010","volume":"138","author":"MP Eugenicos","year":"2021","unstructured":"Eugenicos MP, Ferreira NB (2021) Psychological factors associated with inflammatory bowel disease. Br Med Bull 138(1):16\u201328. https:\/\/doi.org\/10.1093\/bmb\/ldab010","journal-title":"Br Med Bull"},{"issue":"1","key":"3281_CR65","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.cgh.2012.08.032","volume":"11","author":"AN Ananthakrishnan","year":"2013","unstructured":"Ananthakrishnan AN, Khalili H, Pan A et al (2013) Association between depressive symptoms and incidence of Crohn\u2019s disease and ulcerative colitis: results from the Nurses\u2019 Health Study. Clin Gastroenterol Hepatol 11(1):57\u201362. https:\/\/doi.org\/10.1016\/j.cgh.2012.08.032","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"12","key":"3281_CR66","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1038\/s41380-020-00865-6","volume":"25","author":"X Wang","year":"2020","unstructured":"Wang X, Wang N, Zhong L et al (2020) Prognostic value of depression and anxiety on breast cancer recurrence and mortality: a systematic review and meta-analysis of 282,203 patients. Mol Psychiatry 25(12):3186\u20133197. https:\/\/doi.org\/10.1038\/s41380-020-00865-6","journal-title":"Mol Psychiatry"},{"key":"3281_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jad.2014.10.064","volume":"173","author":"HY Chang","year":"2015","unstructured":"Chang HY, Keyes KM, Mok Y, Jung KJ, Shin YJ, Jee SH (2015) Depression as a risk factor for overall and hormone-related cancer: the Korean cancer prevention study. J Affect Disord 173:1\u20138. https:\/\/doi.org\/10.1016\/j.jad.2014.10.064","journal-title":"J Affect Disord"},{"issue":"5","key":"3281_CR68","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1053\/j.seminoncol.2020.08.003","volume":"47","author":"S Casavilca-Zambrano","year":"2020","unstructured":"Casavilca-Zambrano S, Custodio N, Liendo-Picoaga R et al (2020) Depression in women with a diagnosis of breast cancer. Prevalence of symptoms of depression in Peruvian women with early breast cancer and related sociodemographic factors. Semin Oncol 47(5):293\u2013301. https:\/\/doi.org\/10.1053\/j.seminoncol.2020.08.003","journal-title":"Semin Oncol"},{"issue":"1","key":"3281_CR69","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.crohns.2009.12.002","volume":"4","author":"A Dignass","year":"2010","unstructured":"Dignass A, Van Assche G, Lindsay JO et al (2010) The second European evidence-based Consensus on the diagnosis and management of Crohn\u2019s disease: current management. J Crohns Colitis 4(1):28\u201362. https:\/\/doi.org\/10.1016\/j.crohns.2009.12.002. (Published correction appears in J Crohns Colitis. 2010 Sep;4(3):353. Dosage error in article text)","journal-title":"J Crohns Colitis"},{"issue":"19","key":"3281_CR70","doi-asserted-by":"publisher","first-page":"6528","DOI":"10.1158\/1078-0432.CCR-04-0730","volume":"10","author":"S Madhusudan","year":"2004","unstructured":"Madhusudan S, Foster M, Muthuramalingam SR et al (2004) A phase II study of etanercept (Enbrel), a tumor necrosis factor alpha inhibitor in patients with metastatic breast cancer. Clin Cancer Res 10(19):6528\u20136534. https:\/\/doi.org\/10.1158\/1078-0432.CCR-04-0730","journal-title":"Clin Cancer Res"},{"issue":"4","key":"3281_CR71","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1093\/ecco-jcc\/jjv032","volume":"9","author":"A Algaba","year":"2015","unstructured":"Algaba A, Guerra I, Mar\u00edn-Jim\u00e9nez I et al (2015) Incidence, management, and course of cancer in patients with inflammatory bowel disease. J Crohns Colitis 9(4):326\u2013333. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjv032","journal-title":"J Crohns Colitis"},{"issue":"12","key":"3281_CR72","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1136\/annrheumdis-2014-205745","volume":"74","author":"P Raaschou","year":"2015","unstructured":"Raaschou P, Frisell T, Askling J, ARTIS Study Group (2015) TNF inhibitor therapy and risk of breast cancer recurrence in patients with rheumatoid arthritis: a nationwide cohort study. Ann Rheum Dis 74(12):2137\u20132143. https:\/\/doi.org\/10.1136\/annrheumdis-2014-205745","journal-title":"Ann Rheum Dis"},{"key":"3281_CR73","doi-asserted-by":"publisher","first-page":"584","DOI":"10.3389\/fonc.2020.00584","volume":"10","author":"MF Mercogliano","year":"2020","unstructured":"Mercogliano MF, Bruni S, Elizalde PV, Schillaci R (2020) Tumor necrosis factor \u03b1 blockade: an opportunity to tackle breast cancer. Front Oncol 10:584. https:\/\/doi.org\/10.3389\/fonc.2020.00584. (Published 2020 Apr 22)","journal-title":"Front Oncol"},{"issue":"3","key":"3281_CR74","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11894-020-0747-9","volume":"22","author":"J Kimmel","year":"2020","unstructured":"Kimmel J, Axelrad J (2020) The complex interplay between inflammatory bowel disease and malignancy. Curr Gastroenterol Rep 22(3):13. https:\/\/doi.org\/10.1007\/s11894-020-0747-9. (Published 2020 Feb 13)","journal-title":"Curr Gastroenterol Rep"},{"issue":"5","key":"3281_CR75","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1093\/ibd\/izy313","volume":"25","author":"B Click","year":"2019","unstructured":"Click B, Regueiro M (2019) A practical guide to the safety and monitoring of new IBD therapies. Inflamm Bowel Dis 25(5):831\u2013842. https:\/\/doi.org\/10.1093\/ibd\/izy313","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"3281_CR76","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/apt.15538","volume":"51","author":"T Card","year":"2020","unstructured":"Card T, Ungaro R, Bhayat F, Blake A, Hantsbarger G, Travis S (2020) Vedolizumab use is not associated with increased malignancy incidence: GEMINI LTS study results and post-marketing data. Aliment Pharmacol Ther 51(1):149\u2013157. https:\/\/doi.org\/10.1111\/apt.15538","journal-title":"Aliment Pharmacol Ther"},{"issue":"10","key":"3281_CR77","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1093\/ecco-jcc\/jjac061","volume":"16","author":"F Poullenot","year":"2022","unstructured":"Poullenot F, Amiot A, Nachury M et al (2022) Comparative risk of incident cancer in patients with inflammatory bowel disease with prior non-digestive malignancy according to immunomodulator: a multicentre cohort study. J Crohns Colitis 16(10):1523\u20131530. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjac061","journal-title":"J Crohns Colitis"},{"issue":"1","key":"3281_CR78","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.cgh.2020.10.007","volume":"20","author":"A Vedamurthy","year":"2022","unstructured":"Vedamurthy A, Gangasani N, Ananthakrishnan AN (2022) Vedolizumab or tumor necrosis factor antagonist use and risk of new or recurrent cancer in patients with inflammatory bowel disease with prior malignancy: a retrospective cohort study. Clin Gastroenterol Hepatol 20(1):88\u201395. https:\/\/doi.org\/10.1016\/j.cgh.2020.10.007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3281_CR79","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac035","author":"SJ Hong","year":"2022","unstructured":"Hong SJ, Zenger C, Pecoriello J et al (2022) Ustekinumab and vedolizumab are not associated with subsequent cancer in IBD patients with prior malignancy. Inflamm Bowel Dis. https:\/\/doi.org\/10.1093\/ibd\/izac035. (Published online ahead of print, 2022 Mar 9)","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"3281_CR80","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1093\/ibd\/izy376","volume":"25","author":"SC Lin","year":"2019","unstructured":"Lin SC, Goldowsky A, Papamichael K, Cheifetz AS (2019) The treatment of inflammatory bowel disease in patients with a history of malignancy. Inflamm Bowel Dis 25(6):998\u20131005. https:\/\/doi.org\/10.1093\/ibd\/izy376","journal-title":"Inflamm Bowel Dis"},{"issue":"2","key":"3281_CR81","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3390\/cells11020259","volume":"11","author":"M Kundu","year":"2022","unstructured":"Kundu M, Raha S, Roy A, Pahan K (2022) Regression of triple-negative breast cancer in a patient-derived xenograft mouse model by monoclonal antibodies against IL-12 p40 monomer. Cells 11(2):259. https:\/\/doi.org\/10.3390\/cells11020259. (Published 2022 Jan 13)","journal-title":"Cells"},{"issue":"43","key":"3281_CR82","doi-asserted-by":"publisher","first-page":"11482","DOI":"10.1073\/pnas.1705536114","volume":"114","author":"M Kundu","year":"2017","unstructured":"Kundu M, Roy A, Pahan K (2017) Selective neutralization of IL-12 p40 monomer induces death in prostate cancer cells via IL-12-IFN-\u03b3. Proc Natl Acad Sci USA 114(43):11482\u201311487. https:\/\/doi.org\/10.1073\/pnas.1705536114","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"3281_CR83","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/nm.3895","volume":"21","author":"MW Teng","year":"2015","unstructured":"Teng MW, Bowman EP, McElwee JJ et al (2015) IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med 21(7):719\u2013729. https:\/\/doi.org\/10.1038\/nm.3895","journal-title":"Nat Med"},{"issue":"1","key":"3281_CR84","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/ecco-jcc\/jjz110","volume":"14","author":"SB Hanauer","year":"2020","unstructured":"Hanauer SB, Sandborn WJ, Feagan BG et al (2020) IM-UNITI: three-year efficacy, safety, and immunogenicity of ustekinumab treatment of Crohn\u2019s disease. J Crohns Colitis 14(1):23\u201332. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjz110","journal-title":"J Crohns Colitis"},{"issue":"6","key":"3281_CR85","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/j.cgh.2020.02.009","volume":"18","author":"L Beaugerie","year":"2020","unstructured":"Beaugerie L, Rahier JF, Kirchgesner J (2020) Predicting, preventing, and managing treatment-related complications in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol 18(6):1324-1335.e2. https:\/\/doi.org\/10.1016\/j.cgh.2020.02.009","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"3281_CR86","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/14712598.2020.1707800","volume":"20","author":"FS Macaluso","year":"2020","unstructured":"Macaluso FS, Maida M, Ventimiglia M, Cottone M, Orlando A (2020) Effectiveness and safety of Ustekinumab for the treatment of Crohn\u2019s disease in real-life experiences: a meta-analysis of observational studies. Expert Opin Biol Ther 20(2):193\u2013203. https:\/\/doi.org\/10.1080\/14712598.2020.1707800","journal-title":"Expert Opin Biol Ther"},{"issue":"2","key":"3281_CR87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11894-019-0669-6","volume":"21","author":"B Click","year":"2019","unstructured":"Click B, Regueiro M (2019) Managing risks with biologics. Curr Gastroenterol Rep 21(2):1. https:\/\/doi.org\/10.1007\/s11894-019-0669-6. (Published 2019 Jan 11)","journal-title":"Curr Gastroenterol Rep"},{"issue":"9","key":"3281_CR88","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.cgh.2012.06.016","volume":"10","author":"JE Axelrad","year":"2012","unstructured":"Axelrad JE, Fowler SA, Friedman S, Ananthakrishnan AN, Yajnik V (2012) Effects of cancer treatment on inflammatory bowel disease remission and reactivation. Clin Gastroenterol Hepatol 10(9):1021\u20137.e1. https:\/\/doi.org\/10.1016\/j.cgh.2012.06.016","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"3281_CR89","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.it.2020.12.005","volume":"42","author":"AC McPherson","year":"2021","unstructured":"McPherson AC, Pandey SP, Bender MJ, Meisel M (2021) Systemic immunoregulatory consequences of gut commensal translocation. Trends Immunol 42(2):137\u2013150. https:\/\/doi.org\/10.1016\/j.it.2020.12.005","journal-title":"Trends Immunol"},{"issue":"1","key":"3281_CR90","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13073-016-0331-y","volume":"8","author":"KA Shaw","year":"2016","unstructured":"Shaw KA, Bertha M, Hofmekler T et al (2016) Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease. Genome Med 8(1):75. https:\/\/doi.org\/10.1186\/s13073-016-0331-y. (Published 2016 Jul 13)","journal-title":"Genome Med"},{"issue":"1","key":"3281_CR91","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40168-020-0792-5","volume":"8","author":"H Sokol","year":"2020","unstructured":"Sokol H, Landman C, Seksik P et al (2020) Fecal microbiota transplantation to maintain remission in Crohn\u2019s disease: a pilot randomized controlled study. Microbiome 8(1):12. https:\/\/doi.org\/10.1186\/s40168-020-0792-5. (Published 2020 Feb 3)","journal-title":"Microbiome"},{"issue":"1","key":"3281_CR92","doi-asserted-by":"publisher","first-page":"4077","DOI":"10.1038\/s41467-021-24331-1","volume":"12","author":"M Luu","year":"2021","unstructured":"Luu M, Riester Z, Baldrich A et al (2021) Microbial short-chain fatty acids modulate CD8+\u00a0T cell responses and improve adoptive immunotherapy for cancer. Nat Commun 12(1):4077. https:\/\/doi.org\/10.1038\/s41467-021-24331-1. (Published 2021 Jul 1)","journal-title":"Nat Commun"},{"issue":"6529","key":"3281_CR93","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1126\/science.abb5920","volume":"371","author":"EN Baruch","year":"2021","unstructured":"Baruch EN, Youngster I, Ben-Betzalel G et al (2021) Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients. Science 371(6529):602\u2013609. https:\/\/doi.org\/10.1126\/science.abb5920","journal-title":"Science"},{"issue":"44","key":"3281_CR94","doi-asserted-by":"publisher","first-page":"27509","DOI":"10.1073\/pnas.1921223117","volume":"117","author":"S Sun","year":"2020","unstructured":"Sun S, Luo L, Liang W et al (2020) Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade. Proc Natl Acad Sci USA 117(44):27509\u201327515. https:\/\/doi.org\/10.1073\/pnas.1921223117","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"3281_CR95","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.3390\/nu13072125","volume":"13","author":"E Starz","year":"2021","unstructured":"Starz E, Wzorek K, Folwarski M et al (2021) The modification of the gut microbiota via selected specific diets in patients with Crohn\u2019s disease. Nutrients 13(7):2125. https:\/\/doi.org\/10.3390\/nu13072125. (Published 2021 Jun 22)","journal-title":"Nutrients"},{"issue":"6","key":"3281_CR96","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1007\/s00394-017-1489-9","volume":"57","author":"M Skouroliakou","year":"2018","unstructured":"Skouroliakou M, Grosomanidis D, Massara P et al (2018) Serum antioxidant capacity, biochemical profile and body composition of breast cancer survivors in a randomized mediterranean dietary intervention study. Eur J Nutr 57(6):2133\u20132145. https:\/\/doi.org\/10.1007\/s00394-017-1489-9","journal-title":"Eur J Nutr"},{"key":"3281_CR97","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjac105","author":"CM Verburgt","year":"2022","unstructured":"Verburgt CM, Dunn KA, Ghiboub M et al (2022) Successful dietary therapy in paediatric Crohn\u2019s disease is associated with shifts in bacterial dysbiosis and inflammatory metabotype towards healthy controls. J Crohns Colitis. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjac105. (Published online ahead of print, 2022 Sep 15)","journal-title":"J Crohns Colitis"},{"issue":"7","key":"3281_CR98","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.3390\/nu11071514","volume":"11","author":"P De Cicco","year":"2019","unstructured":"De Cicco P, Catani MV, Gasperi V, Sibilano M, Quaglietta M, Savini I (2019) Nutrition and breast cancer: a literature review on prevention, treatment and recurrence. Nutrients 11(7):1514. https:\/\/doi.org\/10.3390\/nu11071514. (Published 2019 Jul 3)","journal-title":"Nutrients"},{"issue":"3","key":"3281_CR99","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1093\/annonc\/mdq014","volume":"21","author":"WJ K\u00f6stler","year":"2010","unstructured":"K\u00f6stler WJ, Zielinski CC, Central European Cooperative Oncology Group (2010) Reply to Third consensus on medical treatment of metastatic breast cancer. Ann Oncol 21(3):665\u2013666. https:\/\/doi.org\/10.1093\/annonc\/mdq014","journal-title":"Ann Oncol"},{"issue":"7","key":"3281_CR100","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1093\/ibd\/izaa252","volume":"27","author":"M Alkhayyat","year":"2021","unstructured":"Alkhayyat M, Abureesh M, Gill A et al (2021) Lower rates of colorectal cancer in patients with inflammatory bowel disease using anti-TNF therapy. Inflamm Bowel Dis 27(7):1052\u20131060. https:\/\/doi.org\/10.1093\/ibd\/izaa252","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"3281_CR101","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1111\/jgh.15806","volume":"37","author":"B Hasan","year":"2022","unstructured":"Hasan B, Tandon KS, Miret R et al (2022) Ustekinumab does not increase risk of new or recurrent cancer in inflammatory bowel disease patients with prior malignancy. J Gastroenterol Hepatol 37(6):1016\u20131021. https:\/\/doi.org\/10.1111\/jgh.15806","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-023-03281-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-023-03281-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-023-03281-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T13:23:58Z","timestamp":1691587438000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11739-023-03281-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,3]]},"references-count":101,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["3281"],"URL":"https:\/\/doi.org\/10.1007\/s11739-023-03281-0","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,3]]},"assertion":[{"value":"20 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This review was not designed to involve experiments on humans and animals, and therefore requires no declaration of  humans and animals rights statement or informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights statement and Informed consent"}}]}}