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AG has received consultancy fees from Mylan and Jansen, and non-financial educational support and a research grant from Gilead sciences and ViiV Healthcare. GR has received grants and fees for speaker bureaus, advisory boards, and CME activities from BMS, ViiV, MSD, AbbVie, Gilead, Janssen, and Roche. SA has received support for research activities from Pfizer and Merck Sharp & Dome. The other authors have nothing to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by our Ethics Committee (Comitato Etico Interaziendale Area 1, Milan, Italy: Protocol No. 0037058).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval statement"}},{"value":"Informed consent was obtained directly from the patients capable of making informed decisions about their medical care and participation in the study; otherwise, informed\u00a0consent was obtained from his\/her legal guardian or representative.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent statement"}}]}}