{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:39:29Z","timestamp":1785148769530,"version":"3.55.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010607","name":"Universit\u00e0 degli Studi di Perugia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010607","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of awake prone positioning (aPP) in patients with acute hypoxemic respiratory failure is debated. We performed a systematic review and meta-analysis to evaluate the role of aPP in acute respiratory failure related to COronaVIrus Disease-19 (COVID-19). Studies reporting on the clinical course of patients with acute respiratory failure related to COVID-19 treated or not treated by aPP were included in the systematic review and meta-analysis (ProsperoID: CRD42022333211). The primary study outcome was the composite of in-hospital death or orotracheal intubation; the individual components of the primary outcome were secondary study outcomes. The composite of in-hospital death or orotracheal intubation was available for 6 studies (1884 patients), five randomized and one prospective; a significant reduction in the risk of this outcome was observed in patients treated vs. not treated by aPP (33.5% vs. 39.8%; OR 0.73, 95% CI 0.60\u20130.89;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>0%). In-hospital death was reported in 34 studies (6808 patients) and occurred in 17.4% vs. 23.5% of patients treated or not treated with aPP (random effect OR 0.60, 95% CI 0.46\u20130.79;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>59%); orotracheal intubation was observed in 25.8% vs. 32.7% of patients treated or not treated with aPP (27 studies, 5369 patients; random effect OR 0.85, 95% CI 0.56\u20131.27;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>84%). aPP reduces the risk for death or orotracheal intubation in patients with acute respiratory failure related to COVID-19. Further studies should be conducted to confirm the clinical benefit of aPP outside the ICU.<\/jats:p><jats:p><jats:italic>Registration<\/jats:italic>Prospero ID: CRD42022333211.<\/jats:p>","DOI":"10.1007\/s11739-023-03434-1","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T08:01:38Z","timestamp":1696492898000},"page":"147-158","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Awake prone positioning for patients with COVID-19-related respiratory failure: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9665-912X","authenticated-orcid":false,"given":"Mara","family":"Graziani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Galeazzo","family":"Rigutini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diletta","family":"Bartolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Traballi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Luzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana","family":"Regina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Caponi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Becattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"issue":"20","key":"3434_CR1","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1001\/jama.2021.19499","volume":"326","author":"MW Tenforde","year":"2021","unstructured":"Tenforde MW, Self WH, Adams K, Influenza and Other Viruses in the Acutely Ill (IVY) Network et al (2021) Association between mRNA vaccination and COVID-19 hospitalization and disease severity. JAMA 326(20):2043\u20132054","journal-title":"JAMA"},{"issue":"12","key":"3434_CR2","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1007\/s00134-020-06306-w","volume":"46","author":"C Gu\u00e9rin","year":"2020","unstructured":"Gu\u00e9rin C, Albert RK, Beitler J, Gattinoni L, Jaber S, Marini JJ, Munshi L, Papazian L, Pesenti A, Vieillard-Baron A, Mancebo J (2020) Prone position in ARDS patients: why, when, how and for whom. Intensive Care Med 46(12):2385\u20132396","journal-title":"Intensive Care Med"},{"issue":"23","key":"3434_CR3","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1056\/NEJMoa1214103","volume":"368","author":"C Gu\u00e9rin","year":"2013","unstructured":"Gu\u00e9rin C, Reignier J, Richard JC et al (2013) Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 368(23):2159\u20132168","journal-title":"N Engl J Med"},{"key":"3434_CR4","doi-asserted-by":"publisher","first-page":"S280","DOI":"10.1513\/AnnalsATS.201704-343OT","volume":"14","author":"L Munshi","year":"2017","unstructured":"Munshi L, Del Sorbo L, Adhikari NKJ et al (2017) Prone position for acute respiratory distress syndrome. A systematic review and meta-analysis. Ann Am Thorac Soc 14:S280\u2013S288","journal-title":"Ann Am Thorac Soc"},{"issue":"6 Pt 2","key":"3434_CR5","first-page":"143","volume":"110","author":"AC Bryan","year":"1974","unstructured":"Bryan AC (1974) Conference on the scientific basis of respiratory therapy. Pulmonary physiotherapy in the pediatric age group. Comments of a devil\u2019s advocate. Am Rev Respir Dis 110(6 Pt 2):143\u2013144","journal-title":"Am Rev Respir Dis"},{"issue":"2","key":"3434_CR6","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1177\/0885066620980399","volume":"36","author":"MC Shelhamer","year":"2021","unstructured":"Shelhamer MC, Wesson PD, Solari IL, Jensen DL, Steele WA, Dimitrov VG, Kelly JD, Aziz S, Gutierrez VP, Vittinghoff E, Chung KK, Menon VP, Ambris HA, Baxi SM (2021) Prone positioning in moderate to severe acute respiratory distress syndrome due to COVID-19: a cohort study and analysis of physiology. J Intensive Care Med 36(2):241\u2013252","journal-title":"J Intensive Care Med"},{"issue":"21","key":"3434_CR7","doi-asserted-by":"publisher","first-page":"10263","DOI":"10.3390\/app112110263","volume":"11","author":"\u00c1 Astasio-Picado","year":"2021","unstructured":"Astasio-Picado \u00c1, del Roc\u00edo S\u00e1nchez-S\u00e1nchez M (2021) Effectiveness of prone positioning in patients with COVID-19-related acute respiratory distress syndrome undergoing invasive mechanical ventilation. Appl Sci 11(21):10263","journal-title":"Appl Sci"},{"key":"3434_CR8","unstructured":"World Health Organization (2020) Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance. https:\/\/apps.who.int\/iris\/handle\/10665\/330893. Accessed Oct 2020"},{"issue":"12","key":"3434_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00437-9","volume":"9","author":"WC McGuire","year":"2021","unstructured":"McGuire WC, Pearce AK, Malhotra A (2021) Prone positioning might reduce the need for intubation in people with severe COVID-19. Lancet Respir Med 9(12):e110","journal-title":"Lancet Respir Med"},{"issue":"2","key":"3434_CR10","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.bja.2021.09.031","volume":"128","author":"B Fazzini","year":"2022","unstructured":"Fazzini B, Page A, Pearse R, Puthucheary Z (2022) Prone positioning for non-intubated spontaneously breathing patients with acute hypoxaemic respiratory failure: a systematic review and meta-analysis. Br J Anaesth 128(2):352\u2013362","journal-title":"Br J Anaesth"},{"issue":"160","key":"3434_CR11","doi-asserted-by":"publisher","first-page":"210022","DOI":"10.1183\/16000617.0022-2021","volume":"30","author":"F Touchon","year":"2021","unstructured":"Touchon F, Trigui Y, Prud\u2019homme E et al (2021) Awake prone positioning for hypoxaemic respiratory failure: past, COVID-19 and perspectives. Eur Respir Rev 30(160):210022","journal-title":"Eur Respir Rev"},{"issue":"11","key":"3434_CR12","doi-asserted-by":"publisher","first-page":"777","DOI":"10.7326\/M14-2385","volume":"162","author":"B Hutton","year":"2015","unstructured":"Hutton B, Salanti G, Caldwell DM et al (2015) The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med 162(11):777\u2013784","journal-title":"Ann Intern Med"},{"key":"3434_CR13","unstructured":"Cochrane Scientific Committee (2017) Recommendation statement\/report"},{"issue":"11","key":"3434_CR14","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/sim.1186","volume":"21","author":"JP Higgins","year":"2002","unstructured":"Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539\u20131558","journal-title":"Stat Med"},{"issue":"10","key":"3434_CR15","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.jclinepi.2012.03.006","volume":"65","author":"MM Leeflang","year":"2012","unstructured":"Leeflang MM, Deeks JJ, Rutjes AW, Reitsma JB, Bossuyt PM (2012) Bivariate meta-analysis of predictive values of diagnostic tests can be an alternative to bivariate meta-analysis of sensitivity and specificity. J Clin Epidemiol 65(10):1088\u20131097","journal-title":"J Clin Epidemiol"},{"key":"3434_CR16","volume-title":"Systematic reviews in health care: meta-analysis in context","author":"DG Altman","year":"2001","unstructured":"Altman DG, Chalmers I, Egger M, Smith GD (2001) Systematic reviews in health care: meta-analysis in context, 2nd edn. Blackwell BMJ Books, London","edition":"2"},{"issue":"21","key":"3434_CR17","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1001\/jama.2022.7993","volume":"327","author":"W Alhazzani","year":"2022","unstructured":"Alhazzani W, Parhar KKS, Weatherald J, COVI-PRONE Trial Investigators and the Saudi Critical Care Trials Group et al (2022) Effect of awake prone positioning on endotracheal intubation in patients with COVID-19 and acute respiratory failure: a randomized clinical trial. JAMA 327(21):2104\u20132113","journal-title":"JAMA"},{"issue":"2","key":"3434_CR18","first-page":"194","volume":"72","author":"M Altinay","year":"2022","unstructured":"Altinay M, Sayan I, Turk HS, Cinar AS, Say\u0131n P, Yucel T, Islamoglu S, Ozkan MT, Cetiner I (2022) Effect of early awake prone positioning application on prognosis in patients with acute respiratory failure due to COVID-19 pneumonia: a retrospective observational study. Braz J Anesthesiol 72(2):194\u2013199","journal-title":"Braz J Anesthesiol"},{"issue":"11","key":"3434_CR19","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14673","volume":"75","author":"\u0130 Ate\u015f","year":"2021","unstructured":"Ate\u015f \u0130, Erden A, G\u00fcrler EK et al (2021) Compliance to not only prone but also lateral and supine positioning improves outcome in hospitalised COVID-19 patients. Int J Clin Pract 75(11):e14673","journal-title":"Int J Clin Pract"},{"issue":"3","key":"3434_CR20","doi-asserted-by":"publisher","first-page":"208","DOI":"10.4266\/acc.2021.00500","volume":"36","author":"M Bahloul","year":"2021","unstructured":"Bahloul M, Kharrat S, Hafdhi M et al (2021) Impact of prone position on outcomes of COVID-19 patients with spontaneous breathing. Acute Crit Care 36(3):208\u2013214","journal-title":"Acute Crit Care"},{"key":"3434_CR21","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1136\/postgradmedj-2020-139631","volume":"98","author":"J Barker","year":"2021","unstructured":"Barker J, Pan D, Koeckerling D et al (2021) Effect of serial awake prone positioning on oxygenation in patients admitted to intensive care with COVID-19. Postgrad Med J 98:360\u2013364","journal-title":"Postgrad Med J"},{"key":"3434_CR22","doi-asserted-by":"publisher","first-page":"859","DOI":"10.12688\/f1000research.25384.1","volume":"9","author":"HC Burton-Papp","year":"2020","unstructured":"Burton-Papp HC, Jackson AIR, Beecham R, University Hospital Southampton Critical Care Team; REACT COVID Investigators et al (2020) Conscious prone positioning during non-invasive ventilation in COVID-19 patients: experience from a single centre. F1000Res 9:859","journal-title":"F1000Res"},{"issue":"8","key":"3434_CR23","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/S2213-2600(20)30268-X","volume":"8","author":"A Coppo","year":"2020","unstructured":"Coppo A, Bellani G, Winterton D, Di Pierro M et al (2020) Feasibility and physiological effects of prone positioning in non-intubated patients with acute respiratory failure due to COVID-19 (PRON-COVID): a prospective cohort study. Lancet Respir Med 8(8):765\u2013774","journal-title":"Lancet Respir Med"},{"issue":"12","key":"3434_CR24","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/S2213-2600(21)00356-8","volume":"9","author":"S Ehrmann","year":"2021","unstructured":"Ehrmann S, Li J, Ibarra-Estrada, Awake Prone Positioning Meta-Trial Group et al (2021) Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial. Lancet Respir Med 9(12):1387\u20131395","journal-title":"Lancet Respir Med"},{"issue":"1","key":"3434_CR25","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1186\/s13054-020-03314-6","volume":"24","author":"C Ferrando","year":"2020","unstructured":"Ferrando C, Mellado-Artigas R, Gea A et al (2020) Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study. Crit Care 24(1):597","journal-title":"Crit Care"},{"key":"3434_CR26","doi-asserted-by":"publisher","first-page":"e068585","DOI":"10.1136\/bmj-2021-068585","volume":"376","author":"M Fralick","year":"2022","unstructured":"Fralick M, Colacci M, Munshi L, COVID Prone Study Investigators et al (2022) Prone positioning of patients with moderate hypoxaemia due to covid-19: multicentre pragmatic randomised trial (COVID-PRONE). BMJ 376:e068585","journal-title":"BMJ"},{"key":"3434_CR27","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1080\/11101849.2021.1889944","volume":"37","author":"S Gad","year":"2021","unstructured":"Gad S (2021) Awake prone positioning versus non invasive ventilation for COVID-19 patients with acute hypoxemic respiratory failure. Egypt J Anaesth 37:85\u201390","journal-title":"Egypt J Anaesth"},{"key":"3434_CR28","doi-asserted-by":"publisher","first-page":"175346662311645","DOI":"10.1177\/17534666231164536","volume":"17","author":"M Graziani","year":"2023","unstructured":"Graziani M, Barbieri G, Maraziti G et al (2023) The role of prone positioning in patients with SARS-CoV-2-related respiratory failure in non-intensive care unit. Ther Adv Respir Dis 17:17534666231164536","journal-title":"Ther Adv Respir Dis"},{"issue":"1","key":"3434_CR29","doi-asserted-by":"publisher","first-page":"e000678","DOI":"10.1136\/bmjresp-2020-000678","volume":"7","author":"RJ Hallifax","year":"2020","unstructured":"Hallifax RJ, Porter BM, Elder PJ, Oxford Respiratory Group et al (2020) Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience. BMJ Open Respir Res 7(1):e000678","journal-title":"BMJ Open Respir Res"},{"issue":"2","key":"3434_CR30","first-page":"82","volume":"20","author":"SM Hashemian","year":"2021","unstructured":"Hashemian SM, Jamaati H, Malekmohammad M et al (2021) Efficacy of early prone positioning combined with noninvasive ventilation in COVID-19. Tanaffos 20(2):82\u201385","journal-title":"Tanaffos"},{"issue":"6","key":"3434_CR31","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.53350\/pjmhs211561256","volume":"15","author":"HT Hussain","year":"2021","unstructured":"Hussain HT (2021) Impact of proning in COVID-19 patients admitted in allama iqbal memorial teaching hospital Sialkot. Pak J Med Health Sci 15(6):1256\u20131258","journal-title":"Pak J Med Health Sci"},{"issue":"7","key":"3434_CR32","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.53350\/pjmhs211571864","volume":"15","author":"M Imran","year":"2021","unstructured":"Imran M (2021) Determine the impact of prone positioning in covid-19 patients. Pak J Med Health Sci 15(7):1864\u20131867","journal-title":"Pak J Med Health Sci"},{"issue":"10","key":"3434_CR33","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000229","volume":"2","author":"N Jagan","year":"2020","unstructured":"Jagan N, Morrow LE, Walters RW, Klein LP, Wallen TJ, Chung J, Plambeck RW (2020) The POSITIONED Study: prone positioning in nonventilated coronavirus disease 2019 patients\u2014a retrospective analysis. Crit Care Explor 2(10):e0229","journal-title":"Crit Care Explor"},{"issue":"8","key":"3434_CR34","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1177\/08850666211014480","volume":"36","author":"D Jayakumar","year":"2021","unstructured":"Jayakumar D, Ramachandran P, Rabindrarajan DNM et al (2021) Standard care versus awake prone position in adult nonintubated patients with acute hypoxemic respiratory failure secondary to COVID-19 infection\u2014a multicenter feasibility randomized controlled trial. J Intensive Care Med 36(8):918\u2013924","journal-title":"J Intensive Care Med"},{"issue":"8","key":"3434_CR35","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1513\/AnnalsATS.202011-1466RL","volume":"18","author":"SA Johnson","year":"2021","unstructured":"Johnson SA, Horton DJ, Fuller MJ et al (2021) Patient-directed prone positioning in awake patients with COVID-19 requiring hospitalization (PAPR). Ann Am Thorac Soc 18(8):1424\u20131426","journal-title":"Ann Am Thorac Soc"},{"key":"3434_CR36","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.jcrc.2021.04.014","volume":"64","author":"R Jouffroy","year":"2021","unstructured":"Jouffroy R, Darmon M, Isnard F et al (2021) Impact of prone position in non-intubated spontaneously breathing patients admitted to the ICU for severe acute respiratory failure due to COVID-19. J Crit Care 64:199\u2013204","journal-title":"J Crit Care"},{"issue":"8","key":"3434_CR37","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.medcli.2020.11.036","volume":"156","author":"X Liu","year":"2021","unstructured":"Liu X, Liu H, Lan Q, Zheng X et al (2021) Early prone positioning therapy for patients with mild COVID-19 disease. Med Clin (Barc) 156(8):386\u2013389","journal-title":"Med Clin (Barc)"},{"issue":"1","key":"3434_CR38","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13054-022-03937-x","volume":"26","author":"G Musso","year":"2022","unstructured":"Musso G, Taliano C, Molinaro F et al (2022) Early prolonged prone position in noninvasively ventilated patients with SARS-CoV-2-related moderate-to-severe hypoxemic respiratory failure: clinical outcomes and mechanisms for treatment response in the PRO-NIV study. Crit Care 26(1):118","journal-title":"Crit Care"},{"issue":"12","key":"3434_CR39","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1111\/acem.14160","volume":"27","author":"EMH Padr\u00e3o","year":"2020","unstructured":"Padr\u00e3o EMH, Valente FS, Besen BAMP, COVIDTEAM et al (2020) Awake prone positioning in COVID-19 hypoxemic respiratory failure: exploratory findings in a single-center retrospective cohort study. Acad Emerg Med 27(12):1249\u20131259","journal-title":"Acad Emerg Med"},{"key":"3434_CR40","doi-asserted-by":"publisher","first-page":"2100265","DOI":"10.1183\/13993003.00265-2021","volume":"59","author":"OR Perez-Nieto","year":"2021","unstructured":"Perez-Nieto OR, Escarraman-Martinez D, Guerrero-Gutierrez MA et al (2021) Awake prone positioning and oxygen therapy in patients with COVID-19: the APRONOX study. Eur Respir J 59:2100265","journal-title":"Eur Respir J"},{"issue":"1","key":"3434_CR41","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.chest.2021.01.048","volume":"160","author":"E Prud'homme","year":"2021","unstructured":"Prud\u2019homme E, Trigui Y, Elharrar X et al (2021) Effect of prone positioning on the respiratory support of nonintubated patients with COVID-19 and acute hypoxemic respiratory failure: a retrospective matching cohort study. Chest 160(1):85\u201388","journal-title":"Chest"},{"issue":"6","key":"3434_CR42","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1001\/jamainternmed.2022.1070","volume":"182","author":"ET Qian","year":"2022","unstructured":"Qian ET, Gatto CL, Amusina O, Vanderbilt Learning Healthcare System Platform Investigators et al (2022) Assessment of awake prone positioning in hospitalized adults with COVID-19: a nonrandomized controlled trial. JAMA Intern Med 182(6):612\u2013621","journal-title":"JAMA Intern Med"},{"issue":"1","key":"3434_CR43","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s13054-021-03602-9","volume":"25","author":"J Ros\u00e9n","year":"2021","unstructured":"Ros\u00e9n J, von Oelreich E, Fors D, Jonsson Fagerlund M, Taxbro K, Skorup P, Eby L, Campoccia Jalde F, Johansson N, Bergstr\u00f6m G, Frykholm P, PROFLO Study Group (2021) Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial. Crit Care 25(1):209","journal-title":"Crit Care"},{"issue":"1","key":"3434_CR44","doi-asserted-by":"publisher","first-page":"57","DOI":"10.5152\/TurkThoracJ.2021.20158","volume":"22","author":"F Simioli","year":"2021","unstructured":"Simioli F, Annunziata A, Langella G, Martino M, Musella S, Fiorentino G (2021) Early prone positioning and non-invasive ventilation in a critical COVID-19 subset. A single centre experience in Southern Italy. Turk Thorac J. 22(1):57\u201361","journal-title":"Turk Thorac J."},{"issue":"Supplement","key":"3434_CR45","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.4103\/lungindia.lungindia_794_20","volume":"38","author":"PB Sryma","year":"2021","unstructured":"Sryma PB, Mittal S, Mohan A, Madan K et al (2021) Effect of proning in patients with COVID-19 acute hypoxemic respiratory failure receiving noninvasive oxygen therapy. Lung India 38(Supplement):S6\u2013S10","journal-title":"Lung India"},{"issue":"20","key":"3434_CR46","doi-asserted-by":"publisher","first-page":"4783","DOI":"10.3390\/jcm10204783","volume":"10","author":"W Stilma","year":"2021","unstructured":"Stilma W, van Meenen DMP, Valk CMA, On Behalf Of The PRoVENT-Covid Collaborative Group et al (2021) Incidence and practice of early prone positioning in invasively ventilated COVID-19 patients-insights from the PRoVENT-COVID observational study. J Clin Med 10(20):4783","journal-title":"J Clin Med"},{"issue":"11","key":"3434_CR47","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1001\/jamainternmed.2020.3030","volume":"180","author":"AE Thompson","year":"2020","unstructured":"Thompson AE, Ranard BL, Wei Y, Jelic S (2020) Prone positioning in awake, nonintubated patients with COVID-19 hypoxemic respiratory failure. JAMA Intern Med 180(11):1537\u20131539. https:\/\/doi.org\/10.1001\/jamainternmed.2020.3030","journal-title":"JAMA Intern Med"},{"issue":"3","key":"3434_CR48","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.pulmoe.2021.03.002","volume":"28","author":"R Tonelli","year":"2022","unstructured":"Tonelli R, Pisani L, Tabb\u00ec L, Comellini V et al (2022) Early awake proning in critical and severe COVID-19 patients undergoing noninvasive respiratory support: a retrospective multicenter cohort study. Pulmonology 28(3):181\u2013192","journal-title":"Pulmonology"},{"issue":"15","key":"3434_CR49","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.3390\/jcm10153404","volume":"10","author":"A Vianello","year":"2021","unstructured":"Vianello A, Turrin M, Guarnieri G, Molena B et al (2021) Prone positioning is safe and may reduce the rate of intubation in selected COVID-19 patients receiving high-flow nasal oxygen therapy. J Clin Med 10(15):3404","journal-title":"J Clin Med"},{"issue":"10","key":"3434_CR50","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1007\/s00134-020-06182-4","volume":"46","author":"X Zang","year":"2020","unstructured":"Zang X, Wang Q, Zhou H, COVID-19 Early Prone Position Study Group et al (2020) Efficacy of early prone position for COVID-19 patients with severe hypoxia: a single-center prospective cohort study. Intensive Care Med 46(10):1927\u20131929","journal-title":"Intensive Care Med"},{"issue":"1","key":"3434_CR51","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1055\/s-0039-1685180","volume":"40","author":"L Gattinoni","year":"2019","unstructured":"Gattinoni L, Busana M, Giosa L et al (2019) Prone positioning in acute respiratory distress syndrome. Semin Respir Crit Care Med 40(1):94\u2013100","journal-title":"Semin Respir Crit Care Med"},{"issue":"23","key":"3434_CR52","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1056\/NEJMoa1214103","volume":"368","author":"C Gu\u00e9rin","year":"2013","unstructured":"Gu\u00e9rin C, Reignier J, Richard JC, PROSEVA Study Group et al (2013) Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 368(23):2159\u20132168","journal-title":"N Engl J Med"},{"issue":"19","key":"3434_CR53","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1056\/NEJMoa2007764","volume":"383","author":"JH Beigel","year":"2020","unstructured":"Beigel JH, Tomashek KM, Dodd LE, Study Group Members et al (2020) Remdesivir for the treatment of covid-19\u2014final report. N Engl J Med 383(19):1813\u20131826","journal-title":"N Engl J Med"},{"issue":"8","key":"3434_CR54","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1056\/NEJMoa2021436","volume":"384","author":"P Horby","year":"2021","unstructured":"Horby P, Lim WS, Emberson JR et al (2021) Dexamethasone in hospitalized patients with covid-19. N Engl J Med 384(8):693\u2013704","journal-title":"N Engl J Med"},{"issue":"4","key":"3434_CR55","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s00068-020-01542-7","volume":"47","author":"P Petrone","year":"2021","unstructured":"Petrone P, Brathwaite CEM, Joseph DK (2021) Prone ventilation as treatment of acute respiratory distress syndrome related to COVID-19. Eur J Trauma Emerg Surg 47(4):1017\u20131022","journal-title":"Eur J Trauma Emerg Surg"},{"issue":"9","key":"3434_CR56","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/S2213-2600(21)00229-0","volume":"9","author":"E Estenssoro","year":"2021","unstructured":"Estenssoro E, Loudet CI, R\u00edos FG, SATI-COVID-19 Study Group et al (2021) Clinical characteristics and outcomes of invasively ventilated patients with COVID-19 in Argentina (SATICOVID): a prospective, multicentre cohort study. Lancet Respir Med 9(9):989\u2013998","journal-title":"Lancet Respir Med"},{"issue":"22","key":"3434_CR57","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1001\/jama.2020.7861","volume":"323","author":"C Sartini","year":"2020","unstructured":"Sartini C, Tresoldi M, Scarpellini P et al (2020) Respiratory parameters in patients with COVID-19 after using noninvasive ventilation in the prone position outside the intensive care unit. JAMA 323(22):2338\u20132340","journal-title":"JAMA"},{"key":"3434_CR58","doi-asserted-by":"publisher","first-page":"175346662110094","DOI":"10.1177\/17534666211009407","volume":"15","author":"W Tan","year":"2021","unstructured":"Tan W, Xu DY, Xu MJ et al (2021) The efficacy and tolerance of prone positioning in non-intubation patients with acute hypoxemic respiratory failure and ARDS: a meta-analysis. Ther Adv Respir Dis 15:17534666211009408","journal-title":"Ther Adv Respir Dis"},{"issue":"4","key":"3434_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2022.101092","volume":"41","author":"C Le Terrier","year":"2022","unstructured":"Le Terrier C, Suh N, Wozniak H et al (2022) Delayed intubation is associated with mortality in patients with severe COVID-19: a single-centre observational study in Switzerland. Anaesth Crit Care Pain Med 41(4):101092","journal-title":"Anaesth Crit Care Pain Med"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-023-03434-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-023-03434-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-023-03434-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T02:18:21Z","timestamp":1730254701000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11739-023-03434-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,5]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["3434"],"URL":"https:\/\/doi.org\/10.1007\/s11739-023-03434-1","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,5]]},"assertion":[{"value":"7 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"There are no human and animal rights issues to declare since this study did not involve any human or animal.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}