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We aimed to evaluate the epicardial adipose tissue thickness in rheumatoid arthritis (RA) patients and its association with disease activity scores. A total of 81 rheumatoid arthritis patients and 70 age- and sex-matched healthy individuals were recruited for this cross-sectional study. Epicardial adipose tissue thickness (EATT) was measured by transthoracic two-dimensional echocardiography. Tender and swollen joint counts were recorded at the time of inclusion. The laboratory tests included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor, anti-citrullinated protein antibodies, and serum lipid levels. Disease activity was calculated based on Disease Activity Scores for 28 joints (DAS-28) ESR and CRP, the Simple Disease Activity Index (SDAI), and the Clinical Disease Activity Index (CDAI). Epicardial adipose tissue thickness was significantly higher in the RA patients compared to the healthy controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). We found statistically significant correlations of EATT with all disease activity indices (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and CRP (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). According to a cut-off value of 6.4\u00a0mm determined for epicardial adipose tissue thickness, the RA patients with thickness\u2009\u2265\u20096.4\u00a0mm had higher disease activity scores and CRP levels. In the multivariable regression analysis, only SDAI score was found as an independent risk factor for increased EATT (OR, (95%CI), 13.70 (3.88\u201348.43),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Epicardial adipose tissue thickness measurement by echocardiography is a reliable method for assessing subclinical atherosclerosis in rheumatoid arthritis patients, and a higher disease activity score is an independent risk factor for coronary artery disease.\n                  <\/jats:p>","DOI":"10.1007\/s11739-024-03542-6","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T10:01:34Z","timestamp":1712311294000},"page":"1015-1024","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Increased epicardial adipose tissue thickness as a sign of subclinical atherosclerosis in patients with rheumatoid arthritis and \u0131ts relationship with disease activity \u0131ndices"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8810-2869","authenticated-orcid":false,"given":"Ay\u015fe Bahar","family":"Kele\u015fo\u011flu Din\u00e7er","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1815-6567","authenticated-orcid":false,"given":"Haluk Furkan","family":"\u015eahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"3542_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12891-017-1563-8","volume":"18","author":"FR Spinelli","year":"2017","unstructured":"Spinelli FR, Pecani A, Ciciarello F, Colasanti T, Di Franco M, Miranda F et al (2017) Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients. 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