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This monocentric prospective registry study included 238 consecutive patients with cardiogenic shock (CS). The study aimed to assess the prognostic impact of partial arterial carbon dioxide (PaCO<jats:sub>2<\/jats:sub>) and oxygen pressure (PaO<jats:sub>2<\/jats:sub>) on 30-day all-cause mortality. Statistical analyses included t-tests, Spearman\u00b4s correlation, Kaplan\u2013Meier and Cox regression analyses. No difference was found between quartiles of PaCO<jats:sub>2<\/jats:sub> (log-rank p\u2009=\u20090.416) and PaO<jats:sub>2<\/jats:sub> (log-rank p\u2009=\u20090.946) in the entire cohort. In the subgroup of patients with ventilation on admission, patients with PaCO<jats:sub>2<\/jats:sub>\u2009\u2264\u200933\u00a0mmHg showed the highest 30-day all-cause mortality compared to the other quartiles (82.6% vs. 46.9% vs. 54.0% vs. 59.6% log-rank p\u2009=\u20090.026). No differences were found between levels of PaO<jats:sub>2<\/jats:sub>, when stratified by quartiles (log-rank p\u2009=\u20090.895). After differentiation between patients with PaCO<jats:sub>2<\/jats:sub>\u2009\u2264\u200933\u00a0mmHg and PaCO<jats:sub>2<\/jats:sub>\u2009&gt;\u200933\u00a0mmHg the association with 30-day all-cause mortality remained significant (82.6% vs. 54.5% log-rank p\u2009=\u20090.006) in ventilated patients, whereas still no difference could be seen in the entire cohort (log-rank p\u2009=\u20090.264). Even after multivariable adjustment PaCO<jats:sub>2<\/jats:sub>\u2009\u2264\u200933\u00a0mmHg remained an independent risk factor for 30-day all-cause mortality (HR 1.936; 95% CI 1.131\u20133.316; p\u2009=\u20090.016) in ventilated CS-patients. In conclusion, no association was found between different levels of PaCO<jats:sub>2<\/jats:sub> and PaO<jats:sub>2<\/jats:sub> with 30-day all-cause mortality\u00a0in patients with CS. However, in the subgroup of CS-patients requiring ventilation, PaCO<jats:sub>2<\/jats:sub>\u2009\u2264\u200933\u00a0mmHg was associated with an increased 30-day all-cause mortality.<\/jats:p>","DOI":"10.1007\/s11739-025-03926-2","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T16:07:50Z","timestamp":1746806870000},"page":"1077-1086","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Partial arterial carbon dioxide and oxygen pressure in patients with cardiogenic shock"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6617-2732","authenticated-orcid":false,"given":"Jonas","family":"Rusnak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Schupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Weidner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinela","family":"Ruka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Egner-Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muharrem","family":"Akin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kambis","family":"Mashayekhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Ayoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Behnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"3926_CR1","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.cjca.2019.11.038","volume":"36","author":"CL Alviar","year":"2020","unstructured":"Alviar CL, Rico-Mesa JS, Morrow DA, Thiele H, Miller PE, Maselli DJ et al (2020) Positive pressure ventilation in cardiogenic shock: review of the evidence and practical advice for patients with mechanical circulatory support. 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