{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:09:35Z","timestamp":1788894575734,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s11739-025-04104-0","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T06:43:56Z","timestamp":1756622636000},"page":"1999-2004","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Why internists should care about Helicobacter pylori: recapitulating gastric cancer prevention"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5476-7376","authenticated-orcid":false,"given":"Agostino","family":"Di Ciaula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Fiorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dino","family":"Vaira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Portincasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"issue":"3","key":"4104_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229\u2013263. https:\/\/doi.org\/10.3322\/caac.21834","journal-title":"CA Cancer J Clin"},{"issue":"8336","key":"4104_CR2","first-page":"1273","volume":"1","author":"JR Warren","year":"1983","unstructured":"Warren JR, Marshall B (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1(8336):1273\u20131275","journal-title":"Lancet"},{"issue":"12","key":"4104_CR3","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1056\/NEJMe1800147","volume":"378","author":"P Malfertheiner","year":"2018","unstructured":"Malfertheiner P (2018) Helicobacter pylori treatment for gastric cancer prevention. N Engl J Med 378(12):1154\u20131156. https:\/\/doi.org\/10.1056\/NEJMe1800147","journal-title":"N Engl J Med"},{"issue":"2","key":"4104_CR4","doi-asserted-by":"publisher","first-page":"276","DOI":"10.4251\/wjgo.v15.i2.276","volume":"15","author":"XY Wang","year":"2023","unstructured":"Wang XY, Wang LL, Xu L, Liang SZ, Yu MC, Zhang QY, Dong QJ (2023) Evaluation of polygenic risk score for risk prediction of gastric cancer. World J Gastrointest Oncol 15(2):276\u2013285. https:\/\/doi.org\/10.4251\/wjgo.v15.i2.276","journal-title":"World J Gastrointest Oncol"},{"key":"4104_CR5","unstructured":"Park JY (2025) Population-based helicobacter pylori screen-and-treat strategies for gastric cancer prevention: guidance on implementation. Lyon (FR): International Agency for Research on Cancer. (PMID: 40601795)"},{"issue":"13","key":"4104_CR6","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1056\/NEJMoa2211807","volume":"388","author":"Y Usui","year":"2023","unstructured":"Usui Y, Taniyama Y, Endo M et al (2023) Helicobacter pylori, Homologous-recombination genes, and gastric cancer. N Engl J Med 388(13):1181\u20131190. https:\/\/doi.org\/10.1056\/NEJMoa2211807","journal-title":"N Engl J Med"},{"issue":"1","key":"4104_CR7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41572-023-00431-8","volume":"9","author":"P Malfertheiner","year":"2023","unstructured":"Malfertheiner P, Camargo MC, El-Omar E, Liou JM, Peek R, Schulz C, Smith SI, Suerbaum S (2023) Helicobacter pylori infection. Nat Rev Dis Primers 9(1):19. https:\/\/doi.org\/10.1038\/s41572-023-00431-8","journal-title":"Nat Rev Dis Primers"},{"issue":"11","key":"4104_CR8","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.cmi.2015.06.004","volume":"21","author":"F Megraud","year":"2015","unstructured":"Megraud F, Bessede E, Varon C (2015) Helicobacter pylori infection and gastric carcinoma. Clin Microbiol Infect 21(11):984\u2013990. https:\/\/doi.org\/10.1016\/j.cmi.2015.06.004","journal-title":"Clin Microbiol Infect"},{"issue":"2","key":"4104_CR9","doi-asserted-by":"publisher","first-page":"e180","DOI":"10.1016\/S2214-109X(19)30488-7","volume":"8","author":"C de Martel","year":"2020","unstructured":"de Martel C, Georges D, Bray F, Ferlay J, Clifford GM (2020) Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis. Lancet Glob Health 8(2):e180\u2013e190. https:\/\/doi.org\/10.1016\/S2214-109X(19)30488-7","journal-title":"Lancet Glob Health"},{"issue":"2","key":"4104_CR10","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jcmgh.2016.12.001","volume":"3","author":"SF Moss","year":"2017","unstructured":"Moss SF (2017) The clinical evidence linking Helicobacter pylori to gastric cancer. Cell Mol Gastroenterol Hepatol 3(2):183\u2013191. https:\/\/doi.org\/10.1016\/j.jcmgh.2016.12.001","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"12","key":"4104_CR11","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1136\/gutjnl-2020-320839","volume":"69","author":"AC Ford","year":"2020","unstructured":"Ford AC, Yuan Y, Moayyedi P (2020) Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis. Gut 69(12):2113\u20132121. https:\/\/doi.org\/10.1136\/gutjnl-2020-320839","journal-title":"Gut"},{"key":"4104_CR12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.12.033","author":"AC Ford","year":"2025","unstructured":"Ford AC, Yuan Y, Park JY, Forman D, Moayyedi P (2025) Eradication therapy to prevent gastric cancer in Helicobacterpylori-positive individuals: systematic review and meta-analysis of randomized controlled trials and observational studies. Gastroenterology. https:\/\/doi.org\/10.1053\/j.gastro.2024.12.033","journal-title":"Gastroenterology"},{"issue":"4","key":"4104_CR13","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1053\/j.gastro.2023.12.022","volume":"166","author":"YC Chen","year":"2024","unstructured":"Chen YC, Malfertheiner P, Yu HT et al (2024) Global prevalence of Helicobacter pylori infection and incidence of gastric cancer between 1980 and 2022. Gastroenterology 166(4):605\u2013619. https:\/\/doi.org\/10.1053\/j.gastro.2023.12.022","journal-title":"Gastroenterology"},{"key":"4104_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03793-6","author":"JY Park","year":"2025","unstructured":"Park JY, Georges D, Alberts CJ, Bray F, Clifford G, Baussano I (2025) Global lifetime estimates of expected and preventable gastric cancers across 185 countries. Nat Med. https:\/\/doi.org\/10.1038\/s41591-025-03793-6","journal-title":"Nat Med"},{"key":"4104_CR15","doi-asserted-by":"publisher","first-page":"101527","DOI":"10.1016\/j.pmedr.2021.101527","volume":"24","author":"G Collatuzzo","year":"2021","unstructured":"Collatuzzo G, Fiorini G, Vaira B, Violante FS, Farioli A, Boffetta P (2021) The role of the occupational physician in controlling gastric cancer attributable to Helicobacter pylori infection: a review. Prev Med Rep 24:101527. https:\/\/doi.org\/10.1016\/j.pmedr.2021.101527","journal-title":"Prev Med Rep"},{"issue":"2","key":"4104_CR16","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1053\/j.gastro.2023.09.047","volume":"166","author":"SF Moss","year":"2024","unstructured":"Moss SF, Shah SC, Tan MC, El-Serag HB (2024) Evolving concepts in Helicobacter pylori management. Gastroenterology 166(2):267\u2013283. https:\/\/doi.org\/10.1053\/j.gastro.2023.09.047","journal-title":"Gastroenterology"},{"issue":"3","key":"4104_CR17","doi-asserted-by":"publisher","first-page":"e70039","DOI":"10.1111\/hel.70039","volume":"30","author":"DT Mulder","year":"2025","unstructured":"Mulder DT, O\u2019Mahony JF, Sun D et al (2025) The optimal age of Helicobacter pylori screen-and-treat for gastric cancer prevention in the United States. Helicobacter 30(3):e70039. https:\/\/doi.org\/10.1111\/hel.70039","journal-title":"Helicobacter"},{"issue":"4","key":"4104_CR18","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/00365521.2025.2473020","volume":"60","author":"Y Li","year":"2025","unstructured":"Li Y, Zhu S, Liu Y, He D, Liu Y, Li H (2025) Economic evaluation of preventing gastric cancer by eliminating Helicobacter pylori infection in China. Scand J Gastroenterol 60(4):327\u2013335. https:\/\/doi.org\/10.1080\/00365521.2025.2473020","journal-title":"Scand J Gastroenterol"},{"key":"4104_CR19","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327745","author":"P Malfertheiner","year":"2022","unstructured":"Malfertheiner P, Megraud F, Rokkas T et al (2022) Management of Helicobacter pylori infection: the Maastricht VI\/Florence consensus report. Gut. https:\/\/doi.org\/10.1136\/gutjnl-2022-327745","journal-title":"Gut"},{"issue":"2","key":"4104_CR20","doi-asserted-by":"publisher","first-page":"129","DOI":"10.15403\/jgld.2014.1121.262.itl","volume":"26","author":"A Di Ciaula","year":"2017","unstructured":"Di Ciaula A, Scaccianoce G, Venerito M, Zullo A, Bonfrate L, Rokkas T, Portincasa P (2017) Eradication rates in Italian subjects heterogeneously managed for Helicobacter pylori infection. Time to abandon empiric treatments in Southern Europe. J Gastrointest Liver Dis 26(2):129\u2013137. https:\/\/doi.org\/10.15403\/jgld.2014.1121.262.itl","journal-title":"J Gastrointest Liver Dis"},{"issue":"1","key":"4104_CR21","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1038\/s41598-023-28200-3","volume":"13","author":"S Shah","year":"2023","unstructured":"Shah S, Cappell K, Sedgley R, Pelletier C, Jacob R, Bonafede M, Yadlapati R (2023) Diagnosis and treatment patterns among patients with newly diagnosed Helicobacter pylori infection in the United States 2016\u20132019. Sci Rep 13(1):1375. https:\/\/doi.org\/10.1038\/s41598-023-28200-3","journal-title":"Sci Rep"},{"issue":"2","key":"4104_CR22","doi-asserted-by":"publisher","first-page":"e70025","DOI":"10.1111\/hel.70025","volume":"30","author":"M Zhu","year":"2025","unstructured":"Zhu M, Xu X, Cai P et al (2025) Global population structure, virulence factors and antibiotic resistance of Helicobacter pylori: a pooled analysis of 4067 isolates from 76 countries. Helicobacter 30(2):e70025. https:\/\/doi.org\/10.1111\/hel.70025","journal-title":"Helicobacter"},{"key":"4104_CR23","doi-asserted-by":"publisher","first-page":"151622","DOI":"10.1016\/j.ijmm.2024.151622","volume":"315","author":"C Li","year":"2024","unstructured":"Li C, He L, Wang A, Chen S, Fu P, Wang C (2024) Antibiotic resistance and virulence genes in Helicobacter pylori strains isolated from children in Shanghai, China (2019\u20132022). Int J Med Microbiol 315:151622. https:\/\/doi.org\/10.1016\/j.ijmm.2024.151622","journal-title":"Int J Med Microbiol"},{"key":"4104_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.70123","author":"G Botija","year":"2025","unstructured":"Botija G, Barrio J, Martinez-Escribano B et al (2025) Evolution of antibiotic resistance pattern of Helicobacter pylori in Spanish children: a 10-year multicenter study. J Pediatr Gastroenterol Nutr. https:\/\/doi.org\/10.1002\/jpn3.70123","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"4104_CR25","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12879-023-07993-8","volume":"23","author":"A Kamal","year":"2023","unstructured":"Kamal A, Ghazy RM, Sherief D, Ismail A, Ellakany WI (2023) Helicobacter pylori eradication rates using clarithromycin and levofloxacin-based regimens in patients with previous COVID-19 treatment: a randomized clinical trial. BMC Infect Dis 23(1):36. https:\/\/doi.org\/10.1186\/s12879-023-07993-8","journal-title":"BMC Infect Dis"},{"issue":"3","key":"4104_CR26","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1136\/gutjnl-2020-322179","volume":"70","author":"MD Rutter","year":"2021","unstructured":"Rutter MD, Brookes M, Lee TJ, Rogers P, Sharp L (2021) Impact of the COVID-19 pandemic on UK endoscopic activity and cancer detection: a national endoscopy database analysis. Gut 70(3):537\u2013543. https:\/\/doi.org\/10.1136\/gutjnl-2020-322179","journal-title":"Gut"},{"issue":"4","key":"4104_CR27","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1053\/j.gastro.2020.05.068","volume":"159","author":"W Ruan","year":"2020","unstructured":"Ruan W, Fishman DS, Lerner DG, Engevik MA, Elmunzer BJ, Walsh CM, International Pediatric Endoscopy C-A (2020) Changes in pediatric endoscopic practice during the coronavirus disease 2019 pandemic: results from an international survey. Gastroenterology 159(4):1547\u20131550. https:\/\/doi.org\/10.1053\/j.gastro.2020.05.068","journal-title":"Gastroenterology"},{"issue":"1","key":"4104_CR28","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1136\/gutjnl-2024-332804","volume":"74","author":"L Olmedo","year":"2024","unstructured":"Olmedo L, Calvet X, Gene E et al (2024) Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-EuReg). Gut 74(1):15\u201325. https:\/\/doi.org\/10.1136\/gutjnl-2024-332804","journal-title":"Gut"},{"key":"4104_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/nu17010142","author":"A Zaramella","year":"2024","unstructured":"Zaramella A, Arcidiacono D, Duci M et al (2024) Predictive value of a gastric microbiota dysbiosis test for stratifying cancer risk in atrophic gastritis patients. Nutrients. https:\/\/doi.org\/10.3390\/nu17010142","journal-title":"Nutrients"},{"issue":"2","key":"4104_CR30","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1136\/gutjnl-2017-314205","volume":"67","author":"RM Ferreira","year":"2018","unstructured":"Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C (2018) Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota. Gut 67(2):226\u2013236. https:\/\/doi.org\/10.1136\/gutjnl-2017-314205","journal-title":"Gut"},{"issue":"7","key":"4104_CR31","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1136\/gutjnl-2021-324489","volume":"71","author":"SK Kwon","year":"2022","unstructured":"Kwon SK, Park JC, Kim KH et al (2022) Human gastric microbiota transplantation recapitulates premalignant lesions in germ-free mice. Gut 71(7):1266\u20131276. https:\/\/doi.org\/10.1136\/gutjnl-2021-324489","journal-title":"Gut"},{"issue":"9","key":"4104_CR32","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1136\/gutjnl-2019-319696","volume":"69","author":"Y Guo","year":"2020","unstructured":"Guo Y, Zhang Y, Gerhard M et al (2020) Effect of Helicobacter pylori on gastrointestinal microbiota: a population-based study in Linqu, a high-risk area of gastric cancer. Gut 69(9):1598\u20131607. https:\/\/doi.org\/10.1136\/gutjnl-2019-319696","journal-title":"Gut"},{"issue":"1","key":"4104_CR33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s12672-025-01771-5","volume":"16","author":"P He","year":"2025","unstructured":"He P, Li X, Zou D, Tang F, Chen H, Li Y (2025) Environmental factors inducing gastric cancer: insights into risk and prevention strategies. Discov Oncol 16(1):25. https:\/\/doi.org\/10.1007\/s12672-025-01771-5","journal-title":"Discov Oncol"},{"issue":"5","key":"4104_CR34","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.clinre.2018.10.002","volume":"43","author":"R Monno","year":"2019","unstructured":"Monno R, De Laurentiis V, Trerotoli P, Roselli AM, Ierardi E, Portincasa P (2019) Helicobacter pylori infection: association with dietary habits and socioeconomic conditions. Clin Res Hepatol Gastroenterol 43(5):603\u2013607. https:\/\/doi.org\/10.1016\/j.clinre.2018.10.002","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"4104_CR35","doi-asserted-by":"publisher","first-page":"04083","DOI":"10.7189\/jogh.15.04083","volume":"15","author":"L Zhao","year":"2025","unstructured":"Zhao L, Huang H, Zhang C et al (2025) Temporospatial variation in environmental risk factors and related gastric cancer incidence: a registry-based study in an area with the largest gastric cancer burden in China. J Glob Health 15:04083. https:\/\/doi.org\/10.7189\/jogh.15.04083","journal-title":"J Glob Health"},{"key":"4104_CR36","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.envint.2018.07.030","volume":"120","author":"G Weinmayr","year":"2018","unstructured":"Weinmayr G, Pedersen M, Stafoggia M et al (2018) Particulate matter air pollution components and incidence of cancers of the stomach and the upper aerodigestive tract in the European study of cohorts of air pollution effects (ESCAPE). Environ Int 120:163\u2013171. https:\/\/doi.org\/10.1016\/j.envint.2018.07.030","journal-title":"Environ Int"},{"issue":"5","key":"4104_CR37","doi-asserted-by":"publisher","first-page":"57014","DOI":"10.1289\/EHP15039","volume":"133","author":"C Donat-Vargas","year":"2025","unstructured":"Donat-Vargas C, Kogevinas M, Castano-Vinyals G et al (2025) Long-term exposure to nitrate and trihalomethanes in drinking water and gastric cancer: a multicase-control study in Spain (MCC-Spain). Environ Health Perspect 133(5):57014. https:\/\/doi.org\/10.1289\/EHP15039","journal-title":"Environ Health Perspect"},{"issue":"5","key":"4104_CR38","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1080\/17474124.2017.1300528","volume":"11","author":"A Di Ciaula","year":"2017","unstructured":"Di Ciaula A (2017) Asbestos ingestion and gastrointestinal cancer: a possible underestimated hazard. Expert Rev Gastroenterol Hepatol 11(5):419\u2013425. https:\/\/doi.org\/10.1080\/17474124.2017.1300528","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"4104_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.19191\/EP19.2-3.S1.032","volume":"43","author":"A Zona","year":"2019","unstructured":"Zona A, Iavarone I, Buzzoni C et al (2019) SENTIERI: epidemiological study of residents in National Priority Contaminated Sites. Fifth Report. Epidemiol Prev 43:1\u2013208. https:\/\/doi.org\/10.19191\/EP19.2-3.S1.032","journal-title":"Epidemiol Prev"},{"issue":"3","key":"4104_CR40","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1080\/09603123.2015.1109069","volume":"26","author":"A Di Ciaula","year":"2016","unstructured":"Di Ciaula A (2016) Increased deaths from gastric cancer in communities living close to waste landfills. Int J Environ Res Public Health 26(3):281\u2013290. https:\/\/doi.org\/10.1080\/09603123.2015.1109069","journal-title":"Int J Environ Res Public Health"},{"key":"4104_CR41","unstructured":"Park JY (2025) Population-based helicobacter pylori screen-and-treat strategies for gastric cancer prevention: guidance on implementation"},{"issue":"34","key":"4104_CR42","doi-asserted-by":"publisher","first-page":"11950","DOI":"10.3748\/wjg.v20.i34.11950","volume":"20","author":"F Wong","year":"2014","unstructured":"Wong F, Rayner-Hartley E, Byrne MF (2014) Extraintestinal manifestations of Helicobacter pylori: a concise review. World J Gastroenterol WJG 20(34):11950\u201311961. https:\/\/doi.org\/10.3748\/wjg.v20.i34.11950","journal-title":"World J Gastroenterol WJG"},{"key":"4104_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11164822","author":"H Takeuchi","year":"2022","unstructured":"Takeuchi H, Okamoto A (2022) Helicobacter pylori infection and chronic immune thrombocytopenia. J Clin Med. https:\/\/doi.org\/10.3390\/jcm11164822","journal-title":"J Clin Med"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-025-04104-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-025-04104-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-025-04104-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T15:43:06Z","timestamp":1760715786000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11739-025-04104-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,31]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["4104"],"URL":"https:\/\/doi.org\/10.1007\/s11739-025-04104-0","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,31]]},"assertion":[{"value":"15 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors hereby affirm that there are no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain anystudies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights and Informed consent"}}]}}