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This study verified the possible correlation between COVID-19 infection and blood pressure control. In the multicenter study presented here, we enrolled 185 hypertensive patients with a positive nasopharyngeal swab for SARS-CoV-2 in the 6\u00a0months prior to the follow-up visit (Group 1, 90F, age 63.38\u2009\u00b1\u200910.29\u00a0years) and 97 hypertensive patients consistently negative for SARS-CoV-2 (Group 2, 49F, age 64.20\u2009\u00b1\u200910.79\u00a0years), overlapping in terms of age, sex, weight, and Body Mass Index (BMI). We evaluated the follow-up visit within 12\u00a0months (T1) and the one prior to the infection (T0). Group 2 had a higher percentage of patients with dyslipidemia and a significantly lower percentage of patients with hypertensive cardiomyopathy (HTN-CM) compared to Group 1. In Group 1, we observed a significant decrease in the number of smokers and an increase in the diagnosis of HTN-CM at T1, with a significant increase in systolic values (134.30\u2009\u00b1\u200914.93\u00a0mmHg vs 132.40\u2009\u00b1\u200916.19\u00a0mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and a decrease in diastolic values (78.30\u2009\u00b1\u20098.77\u00a0mmHg vs 79.63\u2009\u00b1\u20098.41\u00a0mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) compared to T0. Moreover, there was a significant increase in the number of antihypertensive drugs taken at T1 in Group 1, particularly angiotensin-receptor blockers, compared to T0. Finally, at T1 in Group 1, we observed a significant increase in pulse wave velocity (PWV) compared to T0. These findings were absent in Group 2. Patients who contracted the COVID-19 infection showed increased vascular stiffness, hence higher blood pressure values, and needed a greater number of medications for blood pressure control.\n                  <\/jats:p>","DOI":"10.1007\/s11739-025-04138-4","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:50:13Z","timestamp":1762350613000},"page":"2421-2432","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["COVID-19 induces greater difficulty in blood pressure control due to increased arterial stiffness"],"prefix":"10.1007","volume":"20","author":[{"given":"Marialuisa S.","family":"Marozzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Fucile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immacolata","family":"Panettieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pagani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Curcio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Corvasce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe S.","family":"Falcone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Mancusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Izzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Vacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1980-5728","authenticated-orcid":false,"given":"Sebastiano","family":"Cicco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"4138_CR1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585","volume":"323","author":"D Wang","year":"2020","unstructured":"Wang D, Hu B, Hu C et al (2020) Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. 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