{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:11:19Z","timestamp":1777961479232,"version":"3.51.4"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s11739-025-04152-6","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T09:46:45Z","timestamp":1761040005000},"page":"1131-1132","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bridging innovation and clinical impact: advances and challenges in beta cell replacement therapies"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9071-1505","authenticated-orcid":false,"given":"Muhammad","family":"Naveed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3734-5709","authenticated-orcid":false,"given":"Uzair Ahmad","family":"Mahar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3534-4141","authenticated-orcid":false,"given":"Muhammad","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6715-6805","authenticated-orcid":false,"given":"Wajiha","family":"Asim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"4152_CR1","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1016\/S0140-6736(22)01655-5","volume":"400","author":"E Ahmad","year":"2022","unstructured":"Ahmad E, Lim S, Lamptey R et al (2022) Type 2 diabetes. Lancet 400:1803\u20131820. https:\/\/doi.org\/10.1016\/S0140-6736(22)01655-5","journal-title":"Lancet"},{"key":"4152_CR2","doi-asserted-by":"publisher","first-page":"1524518","DOI":"10.3389\/FBIOM.2025.1524518","volume":"4","author":"J S\u00e1","year":"2025","unstructured":"S\u00e1 J, S\u00e1 S, Lem\u00e9nager H et al (2025) Advancing diabetes treatment: from human beta cell technology to bioartificial pancreas development. Front Biomater Sci 4:1524518. https:\/\/doi.org\/10.3389\/FBIOM.2025.1524518","journal-title":"Front Biomater Sci"},{"key":"4152_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/BIOM12060810","author":"MV Karimova","year":"2022","unstructured":"Karimova MV, Gvazava IG, Vorotelyak EA (2022) Overcoming the limitations of stem cell-derived beta cells. Biomolecules. https:\/\/doi.org\/10.3390\/BIOM12060810","journal-title":"Biomolecules"},{"key":"4152_CR4","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3803\/ENM.2021.879","volume":"36","author":"MJ Kim","year":"2021","unstructured":"Kim MJ, Park HS, Kim JW et al (2021) Suppression of fibrotic reactions of chitosan-alginate microcapsules containing porcine islets by dexamethasone surface coating. Endocrinol Metab 36:146\u2013156. https:\/\/doi.org\/10.3803\/ENM.2021.879","journal-title":"Endocrinol Metab"},{"key":"4152_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/J.SCR.2023.103138","volume":"71","author":"N Thongsin","year":"2023","unstructured":"Thongsin N, Suwanpitak S, Wattanapanitch M (2023) CRISPR-Cas9-mediated disruption of B2M and CIITA genes eliminates HLA class I and II expression in human induced pluripotent stem cells (MUSIi001-A-2). Stem Cell Res 71:103138. https:\/\/doi.org\/10.1016\/J.SCR.2023.103138","journal-title":"Stem Cell Res"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-025-04152-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-025-04152-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-025-04152-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:28:42Z","timestamp":1777958922000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11739-025-04152-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,21]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["4152"],"URL":"https:\/\/doi.org\/10.1007\/s11739-025-04152-6","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,21]]},"assertion":[{"value":"20 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}