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Ivan Ferraz-Amaro has received grants\/research support from Abbott, MSD, Jansen and Roche, as well as consultation fees from company-sponsored speakers\u2019 bureaus associated with Abbott, Pfizer, Roche, Sanofi, Celgene and MSD. Santos Casta\u00f1eda has received research support from MSD, Pfizer and UCB, and had consultation fees\/participation in company-sponsored speaker\u2019s bureau from BMS, Eli-Lilly, MSD, Roche and UCB. Ricardo Blanco received grants\/research support from AbbVie, MSD, and Roche, and had consultation fees\/participation in a company-sponsored speaker\u2019s bureau from AbbVie, Pfizer, Roche, Bristol-Myers, Janssen, Lilly, UCB, and MSD. Carmen Secada-G\u00f3mez, Adri\u00e1n Mart\u00edn-Guti\u00e9rrez, Fernando L\u00f3pez-Guti\u00e9rrez and Isabel Mart\u00ednez Rodr\u00edguez do not declare any conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted in accordance with the principles outlined in the Declaration of Helsinki. No animals were involved in this\nresearch.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"According to the approval of our local Ethics Committee informed consent was not required, as this was a retrospective\nstudy and all data were analyzed anonymously.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}