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Troponin appears to be a suitable biomarker but has primarily been evaluated in the setting of infarct-related CS, not in heart failure-related CS (HF-CS), which accounts for almost 50% of cases.\n                    <jats:italic>Objectives:<\/jats:italic>\n                    To assess the association of Troponin T with shock severity and mortality in HF-CS patients.\n                    <jats:italic>Methods:<\/jats:italic>\n                    Heart failure-related CS patients treated in 15 tertiary care centres (5 European countries, 2016\u20132021) were retrospectively enrolled (NCT03313687). Association of baseline high-sensitive Troponin T and its 24-h kinetics with shock severity according to the SCAI classification and with in-hospital mortality was assessed by fitting multivariable adjusted regression models.\n                    <jats:italic>Results:<\/jats:italic>\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009477 patients (mean age 62\u00a0years, 30.2% women). High-sensitive Troponin T at baseline (median 164\u00a0ng\/l) was significantly associated with in-hospital mortality (HR\u00a01.008, 95%CI 1.002\u20131.013,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Increasing Troponin within 24\u00a0h from baseline indicated a 2.4-fold higher risk of death vs. decreasing Troponin levels (HR\u00a02.439, 95%\u00a0CI 1.070\u20135.558,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). In addition, higher Troponin T levels correlate with higher SCAI stages (e.g., baseline Troponin T per 250\u00a0ng\/l increase: OR 5.268, 95%CI: 1.637, 16.953,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01 for SCAI stage D vs. C).\n                    <jats:italic>Conclusions:<\/jats:italic>\n                    Troponin T, a marker of myocardial injury, associates with shock severity in patients with heart failure-related CS. It predicts mortality both with its baseline value as well as with its 24-h kinetics. Thus, Troponin may be a suitable marker to guide therapy or clinical trial enrolment in these patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>Central Illustration. Baseline Troponin and its 24-hour kinetics predict all-cause in-hospital mortality in patients with heart failure-related cardiogenic shock. In addition, Troponin associates with shock severity according to the SCAI classification. SCAI: Society for Cardiovascular Angiography and Interventions.<\/jats:p>","DOI":"10.1007\/s11739-025-04197-7","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T16:48:00Z","timestamp":1763484480000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Troponin predicts mortality in heart failure-related cardiogenic shock"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4315-2533","authenticated-orcid":false,"given":"Benedikt N.","family":"Beer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Sundermeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Besch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Dettling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin","family":"Kriz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulus","family":"Kirchhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Bertoldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Dauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Westenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Kelham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Luedike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Luesebrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Orban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Mangner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuccia","family":"Morici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Villanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Sramko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Pazdernik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair","family":"Proudfoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H. 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J Am Coll Cardiol 56:1071\u20131078. https:\/\/doi.org\/10.1016\/j.jacc.2010.06.016","journal-title":"J Am Coll Cardiol"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-025-04197-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-025-04197-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-025-04197-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T05:07:59Z","timestamp":1763528879000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11739-025-04197-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":29,"alternative-id":["4197"],"URL":"https:\/\/doi.org\/10.1007\/s11739-025-04197-7","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"assertion":[{"value":"23 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was performed in accordance with the Declaration of Helsinki and was approved by the local ethics committees at all participating centres.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The datasets used and\/or analysed during the current study are available from the corresponding author on reasonable request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data Availability"}},{"value":"BNB reports research funding from the German Research Foundation (grant number 535014557) and\u00a0from the German Center for Cardiovascular Research (grant number 81X4710101), both outside of the present project.\u00a0He reports travel grants by the German Center for Cardiovascular Research, the Swedish Hj\u00e4rt-Lungfonden, and the Korean Society of Heart Failure, all outside of this work. BS received speaker fees from Abbott, Abiomed and AstraZeneca, as well as research funding from the German Research Foundation and Abiomed; outside of the submitted work. JS received travel grants from Abiomed; outside of the submitted work. JD received speaker honoraria from AstraZeneca, Bayer, Boehringer Ingelheim and Novartis, as well as travel grants from AstraZeneca, Bayer and Daiichi-Sankyo; outside of the submitted work. CS received speaker honoraria from AstraZeneca; outside of the submitted work. AP received institutional funding for consulting for Abiomed and Getinge as well as research funding from the Medical Research Council and Barts Charity. RHGS received speaker honoraria from AstraZeneca, Daiichi-Sankyo, Edwards, Bristol Myers Squibb, Pfizer, Bayer Vital and Boehringer Ingelheim; outside of the submitted work. All other authors do not report any potential conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}