{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:11:16Z","timestamp":1777961476772,"version":"3.51.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s11739-025-04235-4","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:36:13Z","timestamp":1766475373000},"page":"869-875","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time in therapeutic range as predictor of early left-ventricular thrombosis resolution: a retrospective cohort study"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-7626","authenticated-orcid":false,"given":"Arianna","family":"Pannunzio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria Maria","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Paolo","family":"Donadini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Santagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Ageno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Dragoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Chistolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Becattini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Satula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Menichelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Pastori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Pignatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Valeriani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"issue":"15","key":"4235_CR1","doi-asserted-by":"publisher","first-page":"e205","DOI":"10.1161\/CIR.0000000000001092","volume":"146","author":"GN Levine","year":"2022","unstructured":"Levine GN et al (2022) Management of patients at risk for and with left ventricular thrombus: a scientific statement from the American Heart Association. Circulation 146(15):e205\u2013e223","journal-title":"Circulation"},{"issue":"2","key":"4235_CR2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","volume":"39","author":"B Ibanez","year":"2018","unstructured":"Ibanez B et al (2018) 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 39(2):119\u2013177","journal-title":"Eur Heart J"},{"issue":"2 Suppl","key":"4235_CR3","doi-asserted-by":"publisher","first-page":"e637S","DOI":"10.1378\/chest.11-2306","volume":"141","author":"PO Vandvik","year":"2012","unstructured":"Vandvik PO et al (2012) Primary and secondary prevention of cardiovascular disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141(2 Suppl):e637S-e668S","journal-title":"Chest"},{"key":"4235_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.hrtlng.2024.04.019","volume":"67","author":"M Mehrpooya","year":"2024","unstructured":"Mehrpooya M, Barakzehi MR, Nikoobakhsh M (2024) Evaluation of the safety and efficacy of direct oral anticoagulants compared with vitamin-k antagonists in the treatment of left-ventricular thrombosis. A systematic review and meta-analysis. Heart Lung 67:121\u2013136","journal-title":"Heart Lung"},{"issue":"1","key":"4235_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-61664-5","volume":"14","author":"P Kosum","year":"2024","unstructured":"Kosum P et al (2024) Utility of TTR-INR guided warfarin adjustment protocol to improve time in therapeutic range in patients with atrial fibrillation receiving warfarin. Sci Rep 14(1):11647","journal-title":"Sci Rep"},{"issue":"3","key":"4235_CR6","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1093\/eurheartj\/ehx551","volume":"39","author":"N Maniwa","year":"2018","unstructured":"Maniwa N et al (2018) Anticoagulation combined with antiplatelet therapy in patients with left-ventricular thrombus after first acute myocardial infarction. Eur Heart J 39(3):201\u2013208","journal-title":"Eur Heart J"},{"issue":"3","key":"4235_CR7","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/j.1538-7836.2007.02874.x","volume":"6","author":"Y van Leeuwen","year":"2008","unstructured":"van Leeuwen Y, Rosendaal FR, Cannegieter SC (2008) Prediction of hemorrhagic and thrombotic events in patients with mechanical heart valve prostheses treated with oral anticoagulants. J Thromb Haemost 6(3):451\u2013456","journal-title":"J Thromb Haemost"},{"issue":"2","key":"4235_CR8","doi-asserted-by":"publisher","first-page":"884","DOI":"10.21037\/jtd-23-1582","volume":"16","author":"Y Zhou","year":"2024","unstructured":"Zhou Y et al (2024) Direct oral anticoagulants compared with warfarin in patients with left-ventricular thrombus: a cohort study from China. J Thorac Dis 16(2):884\u2013892","journal-title":"J Thorac Dis"},{"key":"4235_CR9","doi-asserted-by":"publisher","unstructured":"Schmitt L, Speckman J, Ansell J. Quality assessment of anticoagulation dose management: comparative evaluation of measures of time-in-therapeutic range. J Thromb Thrombolysis. 2003 Jun;15(3):213-6. https:\/\/doi.org\/10.1023\/B:THRO.0000011377.78585.63. PMID: 14739631.","DOI":"10.1023\/B:THRO.0000011377.78585.63"},{"issue":"4","key":"4235_CR10","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","volume":"3","author":"S Schulman","year":"2005","unstructured":"Schulman S et al (2005) Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost 3(4):692\u2013694","journal-title":"J Thromb Haemost"},{"issue":"11","key":"4235_CR11","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1111\/jth.13140","volume":"13","author":"S Kaatz","year":"2015","unstructured":"Kaatz S et al (2015) Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH. J Thromb Haemost 13(11):2119\u20132126","journal-title":"J Thromb Haemost"},{"issue":"4","key":"4235_CR12","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1007\/s11739-025-03922-6","volume":"20","author":"E Valeriani","year":"2025","unstructured":"Valeriani E et al (2025) Long-term left-ventricular thrombosis resolution in patients receiving vitamin k antagonists: a multicenter observational study. Intern Emerg Med 20(4):1069\u20131076","journal-title":"Intern Emerg Med"},{"issue":"38","key":"4235_CR13","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","volume":"44","author":"RA Byrne","year":"2023","unstructured":"Byrne RA et al (2023) 2023 ESC guidelines for the management of acute coronary syndromes. Eur Heart J 44(38):3720\u20133826","journal-title":"Eur Heart J"},{"issue":"8","key":"4235_CR14","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1001\/jamacardio.2019.1880","volume":"4","author":"RD Lopes","year":"2019","unstructured":"Lopes RD et al (2019) Safety and Efficacy of antithrombotic strategies in patients with atrial fibrillation undergoing percutaneous coronary intervention: a network meta-analysis of randomized controlled trials. JAMA Cardiol 4(8):747\u2013755","journal-title":"JAMA Cardiol"},{"issue":"3","key":"4235_CR15","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s10557-022-07417-w","volume":"38","author":"LAF Di Odoardo","year":"2024","unstructured":"Di Odoardo LAF et al (2024) Left ventricular thrombus management after acute myocardial infarction in clinical practice: results from LEVITATION survey and narrative review. Cardiovasc Drugs Ther 38(3):483\u2013492","journal-title":"Cardiovasc Drugs Ther"},{"issue":"10","key":"4235_CR16","doi-asserted-by":"publisher","first-page":"298","DOI":"10.31083\/j.rcm2410298","volume":"24","author":"B Shi","year":"2023","unstructured":"Shi B et al (2023) Time trends of etiology, treatment, and long-term outcomes among patients with left ventricular thrombus. Rev Cardiovasc Med 24(10):298","journal-title":"Rev Cardiovasc Med"},{"issue":"12","key":"4235_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144314","volume":"10","author":"A Tosetto","year":"2015","unstructured":"Tosetto A et al (2015) Center-related determinants of VKA anticoagulation quality: a prospective, multicenter evaluation. PLoS ONE 10(12):e0144314","journal-title":"PLoS ONE"},{"issue":"1","key":"4235_CR18","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1538-7836.2009.03652.x","volume":"8","author":"YK Kim","year":"2010","unstructured":"Kim YK et al (2010) Effect of a simple two-step warfarin dosing algorithm on anticoagulant control as measured by time in therapeutic range: a pilot study. J Thromb Haemost 8(1):101\u2013106","journal-title":"J Thromb Haemost"},{"issue":"19","key":"4235_CR19","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1161\/CIRCULATIONAHA.112.101808","volume":"126","author":"HG Van Spall","year":"2012","unstructured":"Van Spall HG et al (2012) Variation in warfarin dose-adjustment practice is responsible for differences in the quality of anticoagulation control between centers and countries: an analysis of patients receiving warfarin in the randomized evaluation of long-term anticoagulation therapy (RE-LY) trial. Circulation 126(19):2309\u20132316","journal-title":"Circulation"},{"issue":"9","key":"4235_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042269","volume":"7","author":"PM Erkens","year":"2012","unstructured":"Erkens PM et al (2012) Benchmark for time in therapeutic range in venous thromboembolism: a systematic review and meta-analysis. PLoS ONE 7(9):e42269","journal-title":"PLoS ONE"},{"key":"4235_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2024.132329","volume":"411","author":"M Fujino","year":"2024","unstructured":"Fujino M et al (2024) Comparison of embolic risk in left-ventricular thrombus between nonischemic and ischemic cardiomyopathy: a nationwide database analysis. Int J Cardiol 411:132329","journal-title":"Int J Cardiol"},{"issue":"3","key":"4235_CR22","doi-asserted-by":"publisher","first-page":"168","DOI":"10.5543\/tkda.2022.21068","volume":"50","author":"H Salah Shabib Ahmed","year":"2022","unstructured":"Salah Shabib Ahmed H et al (2022) Surrogates of the left ventricular thrombus resolution: a retrospective data review. Arch Turk Soc Cardiol 50(3):168\u2013174","journal-title":"Arch Turk Soc Cardiol"},{"issue":"14","key":"4235_CR23","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1016\/j.jacc.2020.01.057","volume":"75","author":"B Lattuca","year":"2020","unstructured":"Lattuca B et al (2020) Antithrombotic therapy for patients with left ventricular mural thrombus. J Am Coll Cardiol 75(14):1676\u20131685","journal-title":"J Am Coll Cardiol"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-025-04235-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-025-04235-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-025-04235-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:28:38Z","timestamp":1777958918000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11739-025-04235-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["4235"],"URL":"https:\/\/doi.org\/10.1007\/s11739-025-04235-4","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,23]]},"assertion":[{"value":"5 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki. Ethical approval was obtained from the appropriate institutional review board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights statement and"}},{"value":"Written informed consent was obtained from all participants prior to their inclusion in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}