{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:24:49Z","timestamp":1792686289124,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100010724","name":"Health Systems Research Institute","doi-asserted-by":"crossref","award":["59-053"],"award-info":[{"award-number":["59-053"]}],"id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100032332","name":"Heart Association of Thailand","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100032332","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s11739-025-04243-4","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:18:37Z","timestamp":1768933117000},"page":"907-917","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optimal heart rate in patients with atrial fibrillation: insights from the COOL-AF registry"],"prefix":"10.1007","volume":"21","author":[{"given":"Rungroj","family":"Krittayaphong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arintaya","family":"Phrommintikul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulaluk","family":"Komoltri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahthit","family":"Yindeengam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"4243_CR1","doi-asserted-by":"publisher","first-page":"163","DOI":"10.26599\/1671-5411.2023.03.008","volume":"20","author":"R Krittayaphong","year":"2023","unstructured":"Krittayaphong R, Pumprueg S, Kaewkumdee P, Yindeengam A, Lip GY (2023) Three-year outcomes of patients with non-valvular atrial fibrillation: the COOL-AF registry. J Geriat Cardiol: JGC 20:163\u2013173. https:\/\/doi.org\/10.26599\/1671-5411.2023.03.008","journal-title":"J Geriat Cardiol: JGC"},{"key":"4243_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2217\/fca-2020-0014","volume":"17","author":"JP Bassand","year":"2021","unstructured":"Bassand JP, Apenteng PN, Atar D, Camm AJ, Cools F, Corbalan R, Fitzmaurice DA, Fox KA, Goto S, Haas S, Hacke W, Jerjes-Sanchez C, Koretsune Y, Heuzey JL, Sawhney JP, Oh S, Stepinska J, Cate VT, Verheugt FW, Kayani G, Pieper KS, Kakkar AK, Garfield-Af Investigators FT (2021) GARFIELD-AF: a worldwide prospective registry of patients with atrial fibrillation at risk of stroke. Future Cardiol 17:19\u201338. https:\/\/doi.org\/10.2217\/fca-2020-0014","journal-title":"Future Cardiol"},{"key":"4243_CR3","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","volume":"45","author":"IC Van Gelder","year":"2024","unstructured":"Van Gelder IC, Rienstra M, Bunting KV, Casado-Arroyo R, Caso V, Crijns H, De Potter TJR, Dwight J, Guasti L, Hanke T, Jaarsma T, Lettino M, Lochen ML, Lumbers RT, Maesen B, Molgaard I, Rosano GMC, Sanders P, Schnabel RB, Suwalski P, Svennberg E, Tamargo J, Tica O, Traykov V, Tzeis S, Kotecha D, Group ESCSD (2024) 2024 ESC guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 45:3314\u20133414. https:\/\/doi.org\/10.1093\/eurheartj\/ehae176","journal-title":"Eur Heart J"},{"key":"4243_CR4","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jacc.2023.08.017","volume":"83","author":"M Writing Committee","year":"2024","unstructured":"Writing Committee M, Joglar JA, Chung MK, Armbruster AL, Benjamin EJ, Chyou JY, Cronin EM, Deswal A, Eckhardt LL, Goldberger ZD, Gopinathannair R, Gorenek B, Hess PL, Hlatky M, Hogan G, Ibeh C, Indik JH, Kido K, Kusumoto F, Link MS, Linta KT, Marcus GM, McCarthy PM, Patel N, Patton KK, Perez MV, Piccini JP, Russo AM, Sanders P, Streur MM, Thomas KL, Times S, Tisdale JE, Valente AM, Van Wagoner DR (2024) 2023 ACC\/AHA\/ACCP\/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol 83:109\u2013279. https:\/\/doi.org\/10.1016\/j.jacc.2023.08.017","journal-title":"J Am Coll Cardiol"},{"key":"4243_CR5","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1055\/a-2325-5923","volume":"124","author":"Y Wang","year":"2024","unstructured":"Wang Y, Guo Y, Qin M, Fan J, Tang M, Zhang X, Wang H, Li X, Lip GYH, Expert R (2024) 2024 Chinese expert consensus guidelines on the diagnosis and treatment of atrial fibrillation in the elderly, endorsed by Geriatric Society of Chinese Medical Association (Cardiovascular Group) and Chinese Society of Geriatric Health Medicine (Cardiovascular Branch): executive summary. Thromb Haemost 124:897\u2013911. https:\/\/doi.org\/10.1055\/a-2325-5923","journal-title":"Thromb Haemost"},{"key":"4243_CR6","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nrcardio.2017.153","volume":"14","author":"GYH Lip","year":"2017","unstructured":"Lip GYH (2017) The ABC pathway: an integrated approach to improve AF management. Nat Rev Cardiol 14:627\u2013628. https:\/\/doi.org\/10.1038\/nrcardio.2017.153","journal-title":"Nat Rev Cardiol"},{"key":"4243_CR7","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae237","author":"R Krittayaphong","year":"2024","unstructured":"Krittayaphong R, Treewaree S, Lip GYH (2024) Components of the Atrial fibrillation Better Care pathway for holistic care of patients with atrial fibrillation: a win ratio analysis from the COOL-AF registry. Europace. https:\/\/doi.org\/10.1093\/europace\/euae237","journal-title":"Europace"},{"key":"4243_CR8","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1055\/s-0043-1772773","volume":"124","author":"S Treewaree","year":"2024","unstructured":"Treewaree S, Lip GYH, Krittayaphong R (2024) Non-vitamin K antagonist oral anticoagulant, warfarin, and ABC pathway adherence on hierarchical outcomes: win ratio analysis of the COOL-AF registry. Thromb Haemost 124:69\u201379. https:\/\/doi.org\/10.1055\/s-0043-1772773","journal-title":"Thromb Haemost"},{"key":"4243_CR9","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1055\/s-0043-1769612","volume":"123","author":"GF Romiti","year":"2023","unstructured":"Romiti GF, Guo Y, Corica B, Proietti M, Zhang H, Lip GYH, AFAIIti (2023) Mobile health-technology-integrated care for atrial fibrillation: a win ratio analysis from the mAFA-II randomized clinical trial. Thromb Haemost 123:1042\u20131048. https:\/\/doi.org\/10.1055\/s-0043-1769612","journal-title":"Thromb Haemost"},{"key":"4243_CR10","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1055\/s-0043-1768580","volume":"123","author":"R Krittayaphong","year":"2023","unstructured":"Krittayaphong R, Boonyapisit W, Sairat P, Lip GYH (2023) Visit-to-visit heart rate variability in the prediction of clinical outcomes of patients with atrial fibrillation. Thromb Haemost 123:920\u2013929. https:\/\/doi.org\/10.1055\/s-0043-1768580","journal-title":"Thromb Haemost"},{"key":"4243_CR11","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1056\/NEJMoa1001337","volume":"362","author":"IC Van Gelder","year":"2010","unstructured":"Van Gelder IC, Groenveld HF, Crijns HJ, Tuininga YS, Tijssen JG, Alings AM, Hillege HL, Bergsma-Kadijk JA, Cornel JH, Kamp O, Tukkie R, Bosker HA, Van Veldhuisen DJ, Van den Berg MP, Investigators RI (2010) Lenient versus strict rate control in patients with atrial fibrillation. N Engl J Med 362:1363\u20131373. https:\/\/doi.org\/10.1056\/NEJMoa1001337","journal-title":"N Engl J Med"},{"key":"4243_CR12","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.jchf.2023.11.016","volume":"12","author":"JA Keefe","year":"2024","unstructured":"Keefe JA, Garber R, McCauley MD, Wehrens XHT (2024) Tachycardia and atrial fibrillation-related cardiomyopathies: potential mechanisms and current therapies. JACC Heart Fail 12:605\u2013615. https:\/\/doi.org\/10.1016\/j.jchf.2023.11.016","journal-title":"JACC Heart Fail"},{"key":"4243_CR13","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1016\/j.jacc.2019.02.045","volume":"73","author":"JF Huizar","year":"2019","unstructured":"Huizar JF, Ellenbogen KA, Tan AY, Kaszala K (2019) Arrhythmia-induced cardiomyopathy: JACC state-of-the-art review. J Am Coll Cardiol 73:2328\u20132344. https:\/\/doi.org\/10.1016\/j.jacc.2019.02.045","journal-title":"J Am Coll Cardiol"},{"key":"4243_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.100967","volume":"43","author":"K Teppo","year":"2024","unstructured":"Teppo K, Lip GYH, Airaksinen KEJ, Halminen O, Haukka J, Putaala J, Mustonen P, Linna M, Hartikainen J, Lehto M (2024) Comparing CHA(2)DS(2)-VA and CHA(2)DS(2)-VASc scores for stroke risk stratification in patients with atrial fibrillation: a temporal trends analysis from the retrospective Finnish AntiCoagulation in Atrial Fibrillation (FinACAF) cohort. Lancet Reg Health Eur 43:100967. https:\/\/doi.org\/10.1016\/j.lanepe.2024.100967","journal-title":"Lancet Reg Health Eur"},{"key":"4243_CR15","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1378\/chest.10-0134","volume":"138","author":"R Pisters","year":"2010","unstructured":"Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJ, Lip GY (2010) A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest 138:1093\u20131100. https:\/\/doi.org\/10.1378\/chest.10-0134","journal-title":"Chest"},{"key":"4243_CR16","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1056\/NEJMoa2019422","volume":"383","author":"P Kirchhof","year":"2020","unstructured":"Kirchhof P, Camm AJ, Goette A, Brandes A, Eckardt L, Elvan A, Fetsch T, van Gelder IC, Haase D, Haegeli LM, Hamann F, Heidb\u00fcchel H, Hindricks G, Kautzner J, Kuck KH, Mont L, Ng GA, Rekosz J, Schoen N, Schotten U, Suling A, Taggeselle J, Themistoclakis S, Vettorazzi E, Vardas P, Wegscheider K, Willems S, Crijns H, Breithardt G (2020) Early rhythm-control therapy in patients with atrial fibrillation. N Engl J Med 383:1305\u20131316. https:\/\/doi.org\/10.1056\/NEJMoa2019422","journal-title":"N Engl J Med"},{"key":"4243_CR17","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad051","author":"S Gottschalk","year":"2023","unstructured":"Gottschalk S, Kany S, Konig HH, Crijns HJ, Vardas P, Camm AJ, Wegscheider K, Metzner A, Rillig A, Kirchhof P, Dams J (2023) Cost-effectiveness of early rhythm control vs. usual care in atrial fibrillation care: an analysis based on data from the EAST-AFNET 4 trial. Europace. https:\/\/doi.org\/10.1093\/europace\/euad051","journal-title":"Europace"},{"key":"4243_CR18","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1056\/NEJMoa1707855","volume":"378","author":"NF Marrouche","year":"2018","unstructured":"Marrouche NF, Brachmann J, Andresen D, Siebels J, Boersma L, Jordaens L, Merkely B, Pokushalov E, Sanders P, Proff J, Schunkert H, Christ H, Vogt J, Bansch D, Investigators C-A (2018) Catheter ablation for atrial fibrillation with heart failure. N Engl J Med 378:417\u2013427. https:\/\/doi.org\/10.1056\/NEJMoa1707855","journal-title":"N Engl J Med"},{"key":"4243_CR19","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1056\/NEJMoa2306037","volume":"389","author":"C Sohns","year":"2023","unstructured":"Sohns C, Fox H, Marrouche NF, Crijns H, Costard-Jaeckle A, Bergau L, Hindricks G, Dagres N, Sossalla S, Schramm R, Fink T, El Hamriti M, Moersdorf M, Sciacca V, Konietschke F, Rudolph V, Gummert J, Tijssen JGP, Sommer P, Investigators CH (2023) Catheter ablation in end-stage heart failure with atrial fibrillation. N Engl J Med 389:1380\u20131389. https:\/\/doi.org\/10.1056\/NEJMoa2306037","journal-title":"N Engl J Med"},{"key":"4243_CR20","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1093\/eurheartj\/ehw233","volume":"37","author":"JP Bassand","year":"2016","unstructured":"Bassand JP, Accetta G, Camm AJ, Cools F, Fitzmaurice DA, Fox KA, Goldhaber SZ, Goto S, Haas S, Hacke W, Kayani G, Mantovani LG, Misselwitz F, Ten Cate H, Turpie AG, Verheugt FW, Kakkar AK, Investigators G-A (2016) Two-year outcomes of patients with newly diagnosed atrial fibrillation: results from GARFIELD-AF. Eur Heart J 37:2882\u20132889. https:\/\/doi.org\/10.1093\/eurheartj\/ehw233","journal-title":"Eur Heart J"},{"key":"4243_CR21","doi-asserted-by":"publisher","first-page":"421","DOI":"10.5853\/jos.2023.01753","volume":"25","author":"SH Ha","year":"2023","unstructured":"Ha SH, Jeong S, Park JY, Yang SY, Cha MJ, Cho MS, Chang JY, Kang DW, Kwon SU, Kim BJ (2023) Association between slow ventricular response and severe stroke in atrial fibrillation-related cardioembolic stroke. J Stroke 25:421\u2013424. https:\/\/doi.org\/10.5853\/jos.2023.01753","journal-title":"J Stroke"},{"key":"4243_CR22","doi-asserted-by":"publisher","first-page":"2888","DOI":"10.1161\/CIRCULATIONAHA.105.578161","volume":"112","author":"WC Little","year":"2005","unstructured":"Little WC (2005) Diastolic dysfunction beyond distensibility: adverse effects of ventricular dilatation. Circulation 112:2888\u20132890. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.105.578161","journal-title":"Circulation"},{"key":"4243_CR23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s42444-023-00090-6","volume":"24","author":"H Park","year":"2023","unstructured":"Park H, Yu HT, Kim T-H, Park J, Park J-K, Kang K-W, Shim J, Kim J-B, Kim J, Choi E-K, Park H, Lee YS, Joung B (2023) Resting heart rate and cardiovascular outcomes in patients with non-paroxysmal atrial fibrillation: CODE-AF registry. Int J Arrhythm 24:15. https:\/\/doi.org\/10.1186\/s42444-023-00090-6","journal-title":"Int J Arrhythm"},{"key":"4243_CR24","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.hrthm.2015.08.028","volume":"13","author":"JG Andrade","year":"2016","unstructured":"Andrade JG, Roy D, Wyse DG, Tardif JC, Talajic M, Leduc H, Tourigny JC, Shohoudi A, Dubuc M, Rivard L, Guerra PG, Thibault B, Dyrda K, Macle L, Khairy P (2016) Heart rate and adverse outcomes in patients with atrial fibrillation: a combined AFFIRM and AF-CHF substudy. Heart Rhythm: The Off J Heart Rhythm Soc 13:54\u201361. https:\/\/doi.org\/10.1016\/j.hrthm.2015.08.028","journal-title":"Heart Rhythm: The Off J Heart Rhythm Soc"},{"key":"4243_CR25","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad088","author":"LM Westergaard","year":"2023","unstructured":"Westergaard LM, Alhakak A, Rorth R, Fosbol EL, Kristensen SL, Svendsen JH, Graff C, Nielsen JB, Gislason GH, Kober L, Torp-Pedersen C, Lee CJY, Weeke PE (2023) Ventricular rate in atrial fibrillation and the risk of heart failure and death. Europace. https:\/\/doi.org\/10.1093\/europace\/euad088","journal-title":"Europace"},{"key":"4243_CR26","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2021-001606","author":"G Moschovitis","year":"2021","unstructured":"Moschovitis G, Johnson LSB, Blum S, Aeschbacher S, De Perna ML, Pagnamenta A, Mayer Melchiorre PA, Benz AP, Kobza R, Di Valentino M, Zuern CS, Auricchio A, Conte G, Rodondi N, Blum MR, Beer JH, Kuhne M, Osswald S, Conen D, Beat AF, Swiss AFi (2021) Heart rate and adverse outcomes in patients with prevalent atrial fibrillation. Open Heart. https:\/\/doi.org\/10.1136\/openhrt-2021-001606","journal-title":"Open Heart"},{"key":"4243_CR27","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.038511","volume":"14","author":"B Lidgard","year":"2025","unstructured":"Lidgard B, Fan DX, Zelnick LR, An J, Harrison TN, Lee MS, Singer D, Tabada GH, Go AS, Bansal N (2025) Association of rate-control and antiarrhythmic medication use and risk of ischemic stroke and death in patients on dialysis with atrial fibrillation. J Am Heart Assoc 14:e038511. https:\/\/doi.org\/10.1161\/JAHA.124.038511","journal-title":"J Am Heart Assoc"},{"key":"4243_CR28","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1093\/europace\/euad010","volume":"25","author":"M Meyer","year":"2023","unstructured":"Meyer M, Lustgarten D (2023) Beta-blockers in atrial fibrillation-trying to make sense of unsettling results. Europace 25:260\u2013262. https:\/\/doi.org\/10.1093\/europace\/euad010","journal-title":"Europace"},{"key":"4243_CR29","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.ajem.2024.12.070","volume":"89","author":"TD Hintze","year":"2025","unstructured":"Hintze TD, Downing JV, Acquisto NM, Downton Mslis K, Yardi I, Moran M, Sharma A, Pourmand A, Tran QK (2025) Metoprolol vs diltiazem for atrial fibrillation with rapid ventricular rate: systematic review and meta-analysis of adverse events. Am J Emerg Med 89:230\u2013240. https:\/\/doi.org\/10.1016\/j.ajem.2024.12.070","journal-title":"Am J Emerg Med"},{"key":"4243_CR30","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1055\/a-2269-1123","volume":"124","author":"DS Kang","year":"2024","unstructured":"Kang DS, Yang PS, Kim D, Jang E, Yu HT, Kim TH, Sung JH, Pak HN, Lee MH, Lip GYH, Joung B (2024) Racial differences in bleeding risk: an ecological epidemiological study comparing Korea and United Kingdom subjects. Thromb Haemost 124:842\u2013851. https:\/\/doi.org\/10.1055\/a-2269-1123","journal-title":"Thromb Haemost"},{"key":"4243_CR31","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1055\/a-2278-8769","volume":"124","author":"DS Kang","year":"2024","unstructured":"Kang DS, Yang PS, Kim D, Jang E, Yu HT, Kim TH, Sung JH, Pak HN, Lee MH, Lip GYH, Joung B (2024) Racial differences in ischemic and hemorrhagic stroke: an ecological epidemiological study. Thromb Haemost 124:883\u2013892. https:\/\/doi.org\/10.1055\/a-2278-8769","journal-title":"Thromb Haemost"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-025-04243-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-025-04243-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-025-04243-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:28:38Z","timestamp":1777958918000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11739-025-04243-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["4243"],"URL":"https:\/\/doi.org\/10.1007\/s11739-025-04243-4","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]},"assertion":[{"value":"14 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"GYHL: consultant and speaker for BMS\/Pfizer, Boehringer Ingelheim, and Daiichi-Sankyo. No fees are directly received personally. Other authors hereby declare no personal or professional conflicts of interest relating to any aspect of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}