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Fiammetta Cosci, Giovanni Mansueto, Stefano Romagnoli, and Alberto Moggi Pignone reports a relationship with University of Florence that includes employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. All authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The research protocol was approved by the Ethical Committee of the Tuscan Region \u2013 Large Central Area (29546_spe).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All procedures contributing to this work complied with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2013.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights statement"}},{"value":"All participants signed an informed consent form.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}