{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:38:57Z","timestamp":1792733937058,"version":"4.5.0"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s11739-026-04431-w","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:54:30Z","timestamp":1785254070000},"page":"2759-2761","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepcidin dynamics predict outcomes in COVID-19 patients treated with interleukin inhibitors"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-7935","authenticated-orcid":false,"given":"Elena","family":"Buzzetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Bolondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Pietrangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Corradini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"4431_CR1","unstructured":"World Health Organization. WHO Coronavirus (COVID-19) Dashboard. https:\/\/data.who.int\/dashboards\/covid19\/deaths.\u00a0Accessed on 31 May 2026"},{"key":"4431_CR2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247275","volume":"16","author":"C Mussini","year":"2021","unstructured":"Mussini C, Cozzi-Lepri A, Menozzi M, Meschiari M, Franceschini E, Milic J, Brugioni L, Pietrangelo A, Girardis M, Cossarizza A, Tonelli R, Clini E, Massari M, Bartoletti M, Ferrari A, Cattelan AM, Zuccala P, Lichtner M, Rossotti R, Girardi E, Nicastri E, Puoti M, Antinori A, Viale P, Guaraldi G (2021) Development and validation of a prediction model for tocilizumab failure in hospitalized patients with SARS-CoV-2 infection. PLoS ONE 16:e0247275. https:\/\/doi.org\/10.1371\/journal.pone.0247275","journal-title":"PLoS ONE"},{"key":"4431_CR3","doi-asserted-by":"publisher","first-page":"E32","DOI":"10.1002\/ajh.26027","volume":"96","author":"A Nai","year":"2021","unstructured":"Nai A, Lore NI, Pagani A, De Lorenzo R, Di Modica S, Saliu F, Cirillo DM, Rovere-Querini P, Manfredi AA, Silvestri L (2021) Hepcidin levels predict Covid-19 severity and mortality in a cohort of hospitalized Italian patients. Am J Hematol 96:E32\u2013E35. https:\/\/doi.org\/10.1002\/ajh.26027","journal-title":"Am J Hematol"},{"key":"4431_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12112665","author":"M Ciotti","year":"2022","unstructured":"Ciotti M, Nuccetelli M, Pieri M, Petrangeli CM, Giovannelli A, Cosio T, Rosa L, Valenti P, Leonardis F, Legramante JM, Bernardini S, Campione E, Minieri M (2022) Evaluation of hepcidin level in COVID-19 patients admitted to the intensive care unit. Diagnostics. https:\/\/doi.org\/10.3390\/diagnostics12112665","journal-title":"Diagnostics"},{"key":"4431_CR5","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1126\/science.1104742","volume":"306","author":"E Nemeth","year":"2004","unstructured":"Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090\u20132093. https:\/\/doi.org\/10.1126\/science.1104742","journal-title":"Science"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-026-04431-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-026-04431-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-026-04431-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:02:15Z","timestamp":1792731735000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-026-04431-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["4431"],"URL":"https:\/\/doi.org\/10.1007\/s11739-026-04431-w","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"15 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The data were collected under a protocol approved by the Regional Ethics Committee of Emilia-Romagna. The study was conducted in accordance with the STROBE guidelines for observational research.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}