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Being naturally immunodeficient, the chick embryo accepts transplantation from various tissues and species. This article analyzes the literature data concerning the use of the CAM model to study melanoma and other skin pathological conditions, due to the lack of literature data summarizing this topic.<\/jats:p>","DOI":"10.1007\/s11739-026-04525-5","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:07:40Z","timestamp":1789632460000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The chick embryo chorioallantoic membrane as an in vivo assay to study the skin in melanoma and other skin pathological conditions"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4768-8431","authenticated-orcid":false,"given":"Domenico","family":"Ribatti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Tamma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"issue":"2","key":"4525_CR1","first-page":"361","volume":"30","author":"K Simkiss","year":"1990","unstructured":"Simkiss K (1990) Water and ionic fluxes inside the egg. 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