{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:50:26Z","timestamp":1792086626114,"version":"4.4.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"DOI":"10.1007\/s11739-026-04549-x","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:20:27Z","timestamp":1792066827000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of low volume versus high-volume polyethylene glycol-based bowel preparation for colonoscopy in people receiving haemodialysis: a randomized non-inferiority trial"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-9515","authenticated-orcid":false,"given":"Andrea","family":"Iannone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7038-3287","authenticated-orcid":false,"given":"Giuseppe","family":"Losurdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Di Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Iabichino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpiero","family":"Manes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Squeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Marotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Angelillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0545-5656","authenticated-orcid":false,"given":"Mariabeatrice","family":"Principi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicla","family":"Campobasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Simone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Di Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-0911","authenticated-orcid":false,"given":"Loreto","family":"Gesualdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6936-0616","authenticated-orcid":false,"given":"Giovanni F. M.","family":"Strippoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2026-1200","authenticated-orcid":false,"given":"Alfredo","family":"Di Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"6","key":"4549_CR1","doi-asserted-by":"publisher","first-page":"414","DOI":"10.2471\/BLT.17.206441","volume":"96","author":"VA Luyckx","year":"2018","unstructured":"Luyckx VA, Tonelli M, Stanifer JW (2018) The global burden of kidney disease and the sustainable development goals. Bull World Health Organ 96(6):414\u2013422","journal-title":"Bull World Health Organ"},{"key":"4549_CR2","unstructured":"Registro Italiano di Dialisi e Trapianto. Report 2016. [26th February 2019]; Available from: https:\/\/ridt.sinitaly.org\/2018\/10\/16\/report-2016\/. Accessed April 25th 2019"},{"issue":"16","key":"4549_CR3","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1001\/jama.2009.1488","volume":"302","author":"DJ de Jager","year":"2009","unstructured":"de Jager DJ, Grootendorst DC, Jager KJ et al (2009) Cardiovascular and noncardiovascular mortality among patients starting dialysis. JAMA 302(16):1782\u20131789","journal-title":"JAMA"},{"issue":"9","key":"4549_CR4","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1097\/MCG.0000000000000880","volume":"52","author":"Y Komaki","year":"2018","unstructured":"Komaki Y, Komaki F, Micic D et al (2018) Risk of colorectal cancer in chronic kidney disease: a systematic review and meta-analysis. J Clin Gastroenterol 52(9):796\u2013804","journal-title":"J Clin Gastroenterol"},{"issue":"6","key":"4549_CR5","doi-asserted-by":"publisher","first-page":"952","DOI":"10.3904\/kjim.2025.015","volume":"40","author":"Y Ahn","year":"2025","unstructured":"Ahn Y, Yu H, Bae Y, Kim M, Lee SB (2025) Risk of colorectal cancer in kidney transplant recipients and patients with end-stage renal disease undergoing hemodialysis. Korean J Intern Med 40(6):952\u2013960","journal-title":"Korean J Intern Med"},{"issue":"10","key":"4549_CR6","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.2215\/CJN.04970512","volume":"7","author":"AW Williams","year":"2012","unstructured":"Williams AW, Dwyer AC, Eddy AA et al (2012) Critical and honest conversations: the evidence behind the \u201cChoosing Wisely\u201d campaign recommendations by the American Society of Nephrology. Clin J Am Soc Nephrol 7(10):1664\u20131672","journal-title":"Clin J Am Soc Nephrol"},{"issue":"11","key":"4549_CR7","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1093\/ndt\/gfu216","volume":"30","author":"D Abramowicz","year":"2015","unstructured":"Abramowicz D, Cochat P, Claas FH et al (2015) European renal best practice guideline on kidney donor and recipient evaluation and perioperative care. Nephrol Dial Transplant 30(11):1790\u20131797","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"4549_CR8","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1067\/mge.2003.294","volume":"58","author":"GC Harewood","year":"2003","unstructured":"Harewood GC, Sharma VK, de Garmo P (2003) Impact of colonoscopy preparation quality on detection of suspected colonic neoplasia. Gastrointest Endosc 58(1):76\u201379","journal-title":"Gastrointest Endosc"},{"issue":"3","key":"4549_CR9","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/S0016-5107(04)02776-2","volume":"61","author":"F Froehlich","year":"2005","unstructured":"Froehlich F, Wietlisbach V, Gonvers JJ et al (2005) Impact of colonic cleansing on quality and diagnostic yield of colonoscopy: the European panel of appropriateness of gastrointestinal endoscopy European multicenter study. Gastrointest Endosc 61(3):378\u2013384","journal-title":"Gastrointest Endosc"},{"issue":"7","key":"4549_CR10","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1111\/j.1572-0241.2002.05827.x","volume":"97","author":"DK Rex","year":"2002","unstructured":"Rex DK, Imperiale TF, Latinovich DR et al (2002) Impact of bowel preparation on efficiency and cost of colonoscopy. Am J Gastroenterol 97(7):1696\u20131700","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"4549_CR11","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.gie.2014.09.048","volume":"81","author":"JR Saltzman","year":"2015","unstructured":"Saltzman JR, Cash BD, Pasha SF et al (2015) Bowel preparation before colonoscopy. Gastrointest Endosc 81(4):781\u2013794","journal-title":"Gastrointest Endosc"},{"issue":"2","key":"4549_CR12","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1055\/s-0032-1326186","volume":"45","author":"C Hassan","year":"2013","unstructured":"Hassan C, Bretthauer M, Kaminski MF et al (2013) Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) guideline. Endoscopy 45(2):142\u2013150","journal-title":"Endoscopy"},{"issue":"4","key":"4549_CR13","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1053\/j.gastro.2014.07.002","volume":"147","author":"DA Johnson","year":"2014","unstructured":"Johnson DA, Barkun AN, Cohen LB et al (2014) Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US multi-society task force on colorectal cancer. Gastroenterology 147(4):903\u2013924","journal-title":"Gastroenterology"},{"issue":"11","key":"4549_CR14","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1136\/gutjnl-2011-300861","volume":"61","author":"A Connor","year":"2012","unstructured":"Connor A, Tolan D, Hughes S et al (2012) Consensus guidelines for the safe prescription and administration of oral bowel-cleansing agents. Gut 61(11):1525\u20131532","journal-title":"Gut"},{"issue":"36","key":"4549_CR15","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004755","volume":"95","author":"JM Lee","year":"2016","unstructured":"Lee JM, Keum B, Yoo IK et al (2016) Polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease. Medicine (Baltimore) 95(36):e4755","journal-title":"Medicine (Baltimore)"},{"issue":"11","key":"4549_CR16","doi-asserted-by":"publisher","first-page":"3229","DOI":"10.1007\/s10620-016-4262-7","volume":"61","author":"N Yoshida","year":"2016","unstructured":"Yoshida N, Naito Y, Murakami T et al (2016) Safety and efficacy of a same-day low-volume 1 L PEG bowel preparation in colonoscopy for the elderly people and people with renal dysfunction. Dig Dis Sci 61(11):3229\u20133235","journal-title":"Dig Dis Sci"},{"issue":"3 Pt 2","key":"4549_CR17","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.gie.2008.05.057","volume":"69","author":"EJ Lai","year":"2009","unstructured":"Lai EJ, Calderwood AH, Doros G et al (2009) The Boston bowel preparation scale: a valid and reliable instrument for colonoscopy-oriented research. Gastrointest Endosc 69(3 Pt 2):620\u2013625","journal-title":"Gastrointest Endosc"},{"issue":"4","key":"4549_CR18","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/ajg.2018.25","volume":"113","author":"X Kang","year":"2018","unstructured":"Kang X, Zhao L, Zhu Z et al (2018) Same-day single dose of 2 liter polyethylene glycol is not inferior to the standard bowel preparation regimen in low-risk patients: a randomized, controlled trial. Am J Gastroenterol 113(4):601\u2013610","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"4549_CR19","doi-asserted-by":"publisher","first-page":"E907","DOI":"10.1055\/a-0624-2266","volume":"6","author":"P Kump","year":"2018","unstructured":"Kump P, Hassan C, Spada C et al (2018) Efficacy and safety of a new low-volume PEG with citrate and simethicone bowel preparation for colonoscopy (Clensia): a multicenter randomized observer-blind clinical trial vs a low-volume PEG with ascorbic acid (PEG-ASC). Endosc Int Open 6(8):E907\u2013E913","journal-title":"Endosc Int Open"},{"issue":"6","key":"4549_CR20","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.dld.2017.01.167","volume":"49","author":"C Spada","year":"2017","unstructured":"Spada C, Cesaro P, Bazzoli F et al (2017) Evaluation of Clensia ((R)), a new low-volume PEG bowel preparation in colonoscopy: multicentre randomized controlled trial versus 4L PEG. Dig Liver Dis 49(6):651\u2013656","journal-title":"Dig Liver Dis"},{"key":"4549_CR21","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5363827","author":"Z Haibin","year":"2020","unstructured":"Haibin Z, Xiaofeng Z, Jianfeng Y (2020) Correlation of cleanliness among different bowel segments during colonoscopy: a retrospective study. Gastroenterol Res Pract. https:\/\/doi.org\/10.1155\/2020\/5363827","journal-title":"Gastroenterol Res Pract"},{"key":"4549_CR22","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1001\/jamainternmed.2016.0960","volume":"176","author":"M Bretthauer","year":"2016","unstructured":"Bretthauer M et al (2016) Population-based colonoscopy screening for colorectal cancer: a randomized clinical trial. JAMA Intern Med 176:894\u2013902","journal-title":"JAMA Intern Med"},{"key":"4549_CR23","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.3748\/wjg.v29.i11.1685","volume":"29","author":"E Shahini","year":"2023","unstructured":"Shahini E, Sinagra E, Vitello A et al (2023) Factors affecting the quality of bowel preparation for colonoscopy in hard-to-prepare patients: evidence from the literature. World J Gastroenterol 29:1685\u20131707","journal-title":"World J Gastroenterol"},{"issue":"45","key":"4549_CR24","doi-asserted-by":"publisher","first-page":"7748","DOI":"10.3748\/wjg.v27.i45.7748","volume":"27","author":"M Di Leo","year":"2021","unstructured":"Di Leo M, Iannone A, Arena M et al (2021) Novel frontiers of agents for bowel cleansing for colonoscopy. World J Gastroenterol 27(45):7748\u20137770","journal-title":"World J Gastroenterol"},{"key":"4549_CR25","volume":"13","author":"S Kindt","year":"2025","unstructured":"Kindt S, Vanhooren M, Poortmans PJ, Fran\u00e7ois K (2025) Retrospective case-control study of the impact of dialysis on bowel preparation scores. Endosc Int Open 13:a25658022","journal-title":"Endosc Int Open"},{"issue":"7","key":"4549_CR26","doi-asserted-by":"publisher","first-page":"3158","DOI":"10.1007\/s10620-021-07137-5","volume":"67","author":"HJ Goong","year":"2022","unstructured":"Goong HJ, Ko BM, Lee MS (2022) Adverse events associated with routine colonoscopy in patients with end-stage renal disease. Dig Dis Sci 67(7):3158\u20133165","journal-title":"Dig Dis Sci"},{"key":"4549_CR27","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6696591","author":"N Ohmiya","year":"2021","unstructured":"Ohmiya N, Nakagawa Y, Horiguchi N et al (2021) Safety of polyethylene glycol solution plus ascorbic acid for bowel preparation for colonoscopy in patients with chronic kidney disease. Gastroenterol Res Pract. https:\/\/doi.org\/10.1155\/2021\/6696591","journal-title":"Gastroenterol Res Pract"},{"issue":"13","key":"4549_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12134377","volume":"12","author":"G Losurdo","year":"2023","unstructured":"Losurdo G, Martino ML, De Bellis M et al (2023) Effect of visual booklets to improve bowel preparation in colonoscopy: systematic review with meta-analysis. J Clin Med 12(13):4377","journal-title":"J Clin Med"},{"issue":"1","key":"4549_CR29","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1186\/s12876-023-02987-x","volume":"23","author":"G Rezamand","year":"2023","unstructured":"Rezamand G, Joukar F, Amini-Salehi E et al (2023) The effectiveness of walking exercise on the bowel preparation before colonoscopy: a single blind randomized clinical trial study. BMC Gastroenterol 23(1):351","journal-title":"BMC Gastroenterol"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-026-04549-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-026-04549-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-026-04549-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:32:57Z","timestamp":1792085577000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11739-026-04549-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":29,"alternative-id":["4549"],"URL":"https:\/\/doi.org\/10.1007\/s11739-026-04549-x","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]},"assertion":[{"value":"11 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"None to declare. The manufacturer provided only preparation, without influencing study design or analysis.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All patients gave written informed consent before enrollment.","order":2,"name":"Ethics","label":"Patient consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}