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The effect of peroxidative stimuli mediated by vitamin E deficiency, a diet high in polyunsaturated fatty acids (containing cod liver oil), and carbon tetrachloride administration on urinary excretion of a number of lipophilic aldehydes and related carbonyl compounds was examined in rats. These secondary lipid peroxidation products were measured as 2,4\u2010dinitrophenylhydrazine derivatives. All three treatments increased urinary excretion of secondary lipid peroxidation products, although the pattern of excretion of these products varied somewhat among the treatments. Significant increases were found in butanal, hexanal, octanal. butan\u20102\u2010one, pentan\u20102\u2010one, hex\u20102\u2010enal, hepta\u20102,4\u2010dienal, 4\u2010hydroxyhex\u20102\u2010enal, 4\u2010hydroxyoct\u20102\u2010enal, 4\u2010hydroxynon\u20102\u2010enal, and a number of unidentified carbonyl compounds. These results suggest that urinary excretion of these lipophilic secondary lipid peroxidation products is a useful and noninvasive marker of whole\u2010body lipid peroxidation.<\/jats:p>","DOI":"10.1007\/s11745-000-0594-y","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T12:31:58Z","timestamp":1163421118000},"page":"855-862","source":"Crossref","is-referenced-by-count":13,"title":["Response of urinary lipophilic aldehydes and related carbonyl compounds to factors that stimulate lipid peroxidation <i>in vivo<\/i>"],"prefix":"10.1002","volume":"35","author":[{"given":"A. Saari","family":"Csallany","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition University of Minnesota 1334 Eckles Ave St. Paul Minnesota 55108"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song\u2010Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition University of Minnesota 1334 Eckles Ave St. Paul Minnesota 55108"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel D.","family":"Gallaher","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition University of Minnesota 1334 Eckles Ave St. Paul Minnesota 55108"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2000,8]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"328","article-title":"Reactive Oxygen Species in Tissue Injury","volume":"41","author":"De Groot H.","year":"1994","journal-title":"Hepatogastroenterol"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1994.tb01453.x"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/53.4.1050S"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19940030"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(90)90515-M"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/53.1.201S"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02536650"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb14907.x"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02533996"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-642760-8.50013-2"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)34276-0"},{"key":"e_1_2_2_13_1","first-page":"L481","article-title":"Supplemental Fatty Acids Alter Lipid Peroxidation and Oxidant Injury in Endothelial Cells","volume":"260","author":"Hart C.M.","year":"1991","journal-title":"Am. 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