{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:54:06Z","timestamp":1786982046216,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diet and fatty acid metabolism interact in yet unknown ways to modulate membrane fatty acid composition and certain cellular functions. For example, dietary precursors or metabolic products of n\u20103 fatty acid metabolism differ in their ability to modify specific membrane components. In the present study, the effect of dietary 22\u22366n\u22123 or its metabolic precursor, 18\u22363n\u22123, on the selective accumulation of 22\u22366n\u22123 by heart was investigated. The mass and fatty acid compositions of individual phospholipids (PL) in heart and liver were quantified in mice fed either 22\u22366n\u22123 (from crocodile oil) or 18\u22363n\u22123 (from soybean oil) for 13 wk. This study was conducted to determine if the selective accumulation of 22\u22366n\u22123 in heart was due to the incorporation of 22\u22366n\u22123 into cardiolipin (CL), a PL most prevalent in heart and known to accumulate 22\u22366n\u22123. Although heart was significantly enriched with 22\u22366n\u22123 relative to liver, the accumulation of 22\u22366n\u22123 by CL in heart could not quantitatively account for this difference. CL from heart did accumulate 22\u22366n\u22123, but only in mice fed preformed 22\u22366n\u22123. Diets rich in non\u201022\u22366n\u22123 fatty acids result in a fatty acid composition of phosphatidylcholine (PC) in heart that is unusually enriched with 22\u22366n\u22123. In this study, the mass of PC in heart was positively correlated with the enrichment of 22\u22366n\u22123 into PC. The increased mass of PC was coincident with a decrease in the mass of phosphatidylethanolamine, suggesting that 22\u22366n\u22123 induced PC synthesis by increasing phosphatidylethanolamine\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methyltransferase activity in the heart.\n                  <\/jats:p>","DOI":"10.1007\/s11745-001-0714-8","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T15:28:23Z","timestamp":1163431703000},"page":"247-254","source":"Crossref","is-referenced-by-count":63,"title":["Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or \u03b1\u2010linolenic acids"],"prefix":"10.1002","volume":"36","author":[{"given":"S. M.","family":"Watkins","sequence":"first","affiliation":[{"name":"Department of Food Science and Technology University of California at Davis 1 Shields Ave. Davis CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology University of California at Davis 1 Shields Ave. Davis CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology University of California at Davis 1 Shields Ave. Davis CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Ching","sequence":"additional","affiliation":[{"name":"FAME Analytics, West Sacramento California 95691"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"DePeters","sequence":"additional","affiliation":[{"name":"Department of Animal Science University of California Davis California 05616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Halpern","sequence":"additional","affiliation":[{"name":"School of Medicine University of California Davis California 05616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. L.","family":"Walzem","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, Faculty of Nutrition Texas A&amp;M University, College Sation Texas 77843"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"German","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology University of California at Davis 1 Shields Ave. Davis CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,3]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(93)90524-D"},{"key":"e_1_2_2_3_1","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1093\/jn\/123.12.2067","article-title":"Dietary Fish Oil Supplementation Attenuates Myocardial Dysfunction and Injury Caused by Global Ischemia and Reperfusion in Isolated Rat Hearts","volume":"123","author":"Yang B.","year":"1993","journal-title":"J. Nutr."},{"key":"e_1_2_2_4_1","first-page":"H1518","article-title":"Influence of Dietary n\u20103 Fatty Acids on Myocardial Ischemia and Reperfusion","volume":"259","author":"Hock C.E.","year":"1990","journal-title":"Am. J. 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