{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:09:35Z","timestamp":1773248975642,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertension is a major risk factor for cardiovascular and cerebrovascular disease. Previous work in both animals and humans with high blood pressure has demonstrated the antihypertensive effects of n\u22123 polyunsaturated fatty acids (PUFA), although it is not known whether these nutrients are effective in preventing hypertension. The predominant n\u22123 PUFA in the mammalian nervous system, docosahexaenoic acid (DHA), is deposited into synaptic membranes at a high rate during the perinatal period, and recent observations indicate that the perinatal environment is important for the normal development of blood pressure control. This study investigated the importance of perinatal n\u22123 PUFA supply in the control of blood pressure in adult Sprague\u2010Dawley rats. Pregnant rat dams were fed semisynthetic diets that were either deficient in (DEF) or supplemented with (CON) n\u22123 PUFA. Offspring were fed the same diets as their mothers until 9 wk; then, half of the rats from each group were crossed over to the opposite diet, creating four groups, i.e., CON\u2010CON; CON\u2010DEF; DEF\u2010DEF, DEF\u2010CON. Mean arterial blood pressures (MAP) were measured directly, at 33 wk of age, by cannulation of the femoral artery. The phospholipid fatty acid profile of the hypothalamic region was determined by capillary gas\u2010liquid chromatography. The tissue phospholipid fatty acid profile reflected the diet that the rats were consuming at the time of testing. Both groups receiving DEF after 9 wk of age (i.e., DEF\u2010DEF and CON\u2010DEF) had similar profiles with a reduction in DHA levels of 30%, compared with rats receiving CON (i.e., CON\u2010CON and DEF\u2010CON). DEF\u2010DEF rats had significantly raised MAP compared with all other groups, with differences as great as 17 mm Hg. DEF\u2010CON rats had raised MAP compared with CON\u2010CON rats, and DEF\u2010DEF rats had higher MAP than CON\u2010DEF rats, despite the fact that their respective fatty acid profiles were not different. These findings indicate that inadequate levels of DHA in the perinatal period are associated with altered blood pressure control in later life. The way in which these long\u2010term effects are produced remains to be elucidated.<\/jats:p>","DOI":"10.1007\/s11745-003-1084-y","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T11:25:37Z","timestamp":1165404337000},"page":"459-464","source":"Crossref","is-referenced-by-count":73,"title":["Increased blood pressure later in life may be associated with perinatal n\u22123 fatty acid deficiency"],"prefix":"10.1002","volume":"38","author":[{"given":"James A.","family":"Armitage","sequence":"first","affiliation":[{"name":"Department of Optometry and Vision Sciences University of Melbourne Victoria 3010 Australia"},{"name":"Section of Neurobiology, Howard Florey Institute of Experimental Physiology and Medicine University of Melbourne Victoria 3010 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian D.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Section of Neurobiology, Howard Florey Institute of Experimental Physiology and Medicine University of Melbourne Victoria 3010 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Department of Food Science Royal Melbourne Institute of Technology University MelbournneVictoria 3000 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Algis J.","family":"Vingrys","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision Sciences University of Melbourne Victoria 3010 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard S.","family":"Weisinger","sequence":"additional","affiliation":[{"name":"Section of Neurobiology, Howard Florey Institute of Experimental Physiology and Medicine University of Melbourne Victoria 3010 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harrison S.","family":"Weisinger","sequence":"additional","affiliation":[{"name":"Section of Neurobiology, Howard Florey Institute of Experimental Physiology and Medicine University of Melbourne Victoria 3010 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,4]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"1","article-title":"Deaths: Final Data for 2000","volume":"50","author":"Minino A.M.","year":"2002","journal-title":"Natl. Vital Stat. Rep."},{"key":"e_1_2_2_3_1","first-page":"1","article-title":"Deaths: Preliminary Data for 2000","volume":"49","author":"Minino A.M.","year":"2001","journal-title":"Natl. Vital Stat. Rep."},{"key":"e_1_2_2_4_1","volume-title":"2002 Heart and Stroke Statistical Update","author":"American Heart Association","year":"2001"},{"key":"e_1_2_2_5_1","first-page":"184","volume-title":"Textbook of Medical Physiology","author":"Guyton A.C.","year":"2000"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1996.tb02823.x"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/85354"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19750051"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.10.1668"},{"key":"e_1_2_2_10_1","unstructured":"Bazan N.G. andScott B.L.(1990)Dietary Omega\u20103 Fatty Acids and Accumulation of Docosahexaenoic Acid in Rod Photoreceptor Cells of the Retina and at Synapses Upsala J. Med. Sci.(Suppl. 48) 97\u2013107."},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.182.4118.1253"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.11.4021"},{"key":"e_1_2_2_13_1","first-page":"327","article-title":"Effects of Dietary n\u20103 Fatty Acid Deficiency and Repletion in the Guinea Pig Retina","volume":"40","author":"Weisinger H.S.","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91035-2"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199011000-00014"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02562305"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(92)90167-Z"},{"key":"e_1_2_2_18_1","first-page":"258","article-title":"Perinatal Omega\u20103 Fatty Acid Deprivation Alters Thirst and Sodium Appetite in Adult Rats","volume":"37","author":"Armitage J.A.","year":"2001","journal-title":"Appetite"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1995.tb02931.x"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.2.253"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(85)90021-8"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6539.104"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198904203201603"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/66.4.1020S"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853899409148370"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-001-0694-8"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043798-199706000-00006"},{"key":"e_1_2_2_28_1","first-page":"1573","article-title":"Coronary Heart Disease Among Men of Japanese Ancestry in Hawaii. The Honolulu Heart Study","volume":"7","author":"Kagan A.","year":"1971","journal-title":"Isr. J. Med. Sci."},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6746.259"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/096374800100859"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.5.1344s"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.19.4195"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(96)00018-7"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02536307"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32552-9"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199003223221202"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.2.523"},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1993.00410120017003"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200208000-00010"},{"key":"e_1_2_2_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/77702"},{"key":"e_1_2_2_41_1","first-page":"R70","article-title":"Differences in Perinatal NaCl Exposure Alters Blood Pressure Levels of Adult Rats","volume":"256","author":"Contreras R.J.","year":"1989","journal-title":"Am. J. Physiol."},{"key":"e_1_2_2_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1095-1009"},{"key":"e_1_2_2_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.23.4.531"},{"key":"e_1_2_2_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.27.3.481"},{"key":"e_1_2_2_45_1","first-page":"417","article-title":"Renal Mechanisms of Angiotensin II\u2010Induced Hypertension","volume":"20","author":"Granger J.P.","year":"2000","journal-title":"Semin. Nephrol."},{"key":"e_1_2_2_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042698699"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s11745-003-1084-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:13:47Z","timestamp":1760969627000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/s11745-003-1084-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["10.1007\/s11745-003-1084-y"],"URL":"https:\/\/doi.org\/10.1007\/s11745-003-1084-y","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}