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This impairment, although latent, is potentially serious: About 3% of the general population in the United States is now suffering from nonalcoholic steatohepatitis associated with obesity and hyperlipidemia. Therefore, in the present study we tried to restore impaired hepatic FA \u03b2\u2010oxidation by administering a novel statin, pitavastatin, to aromatase\u2010deficient (Ar\u2212\/\u2212) mice defective in intrinsic estrogen synthesis. Northern blot analysis of Ar\u2212\/\u2212 mice liver revealed a significant restoration of mRNA expression of essential enzymes involved in FA \u03b2\u2010oxidation such as very long fatty acyl\u2010CoA synthetase in peroxisome, peroxisomal fatty acyl\u2010CoA oxidase, and medium\u2010chain acyl\u2010CoA dehydrogenase. Severe hepatic steatosis observed in Ar\u2212\/\u2212 mice substantially regressed. Consistent findings were obtained in the <jats:italic>in vitro<\/jats:italic> assays of FA \u03b2\u2010oxidation activity. These findings demonstrate that pitavastatin is capable of restoring impaired FA \u03b2\u2010oxidation <jats:italic>in vivo via<\/jats:italic> the peroxisome proliferator\u2010activated receptor\u2010\u03b1\u2010mediated signaling pathway and is potent enough to ameliorate severe hepatic steatosis in mice deficient in intrinsic estrogen.<\/jats:p>","DOI":"10.1007\/s11745-003-1093-x","type":"journal-article","created":{"date-parts":[[2006,11,15]],"date-time":"2006-11-15T04:46:33Z","timestamp":1163565993000},"page":"519-523","source":"Crossref","is-referenced-by-count":29,"title":["Pitavastatin ameliorates severe hepatic steatosis in aromatase\u2010deficient (Ar\u2212\/\u2212) mice"],"prefix":"10.1002","volume":"38","author":[{"given":"Tetsu","family":"Egawa","sequence":"first","affiliation":[{"name":"Department of Medicine Kochi Medical School Nankoku 783\u20108505 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