{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:46:45Z","timestamp":1761007605330,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two endogenous antioxidants that are speculated to be defense substances against preeclampsia, 2\u2010hydroxyestradiol (2\u2010OH\u2010E<jats:sub>2<\/jats:sub>) and its 17\u2010sulfate, 2\u2010hydroxyestradiol 17\u2010sulfate (2\u2010OH\u2010E<jats:sub>2<\/jats:sub>\u201017\u2010S), were administered to rats to compare their inhibitory effects on hepatic microsomal lipid peroxidation, and the lipid peroxides were determined in NADPH\u2010 and ascorbic acid\u2010dependent systems. The two catechols showed a strong inhibitory effect on lipid peroxidation in both systems, and the effect was dose dependent. However, a large difference was observed in their inhibition patterns. After administration of 2\u2010OH\u2010E<jats:sub>2<\/jats:sub>, the effect appeared immediately and decreased gradually with time. In contrast, the effect of 2\u2010OH\u2010E<jats:sub>2<\/jats:sub>\u201017\u2010S appeared some time after administration and persisted for a longer time. Both catechols also showed a striking difference in their dynamics. After administration, 2\u2010OH\u2010E<jats:sub>2<\/jats:sub> was detected in the blood together with its metabolites, 2\u2010methoxyestradiol and 2\u2010methoxyestrone, and they disappeared immediately. In contrast, 2\u2010OH\u2010E<jats:sub>2<\/jats:sub>\u201017\u2010S was present in the blood for a longer time together with its O\u2010methylated product, 2\u2010methoxyestradiol 17\u2010sulfate, but disappeared from liver microsomes within 2 h after administration. The results imply no occurrence of a direct inhibition effect of 2\u2010OH\u2010E<jats:sub>2<\/jats:sub>\u201017\u2010S.<\/jats:p>","DOI":"10.1007\/s11745-003-1135-4","type":"journal-article","created":{"date-parts":[[2006,11,15]],"date-time":"2006-11-15T19:34:32Z","timestamp":1163619272000},"page":"847-854","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of <i>ex vivo<\/i> inhibitory effect between 2\u2010hydroxyestradiol and its 17\u2010sulfate on rat hepatic microsomal lipid peroxidation"],"prefix":"10.1002","volume":"38","author":[{"given":"Kaori","family":"Takanashi","sequence":"first","affiliation":[{"name":"Hokkaido College of Pharmacy 7\u20101 Katsuraoka\u2010cho Otaru, Hokkaido 047\u20100264 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Osanai","sequence":"additional","affiliation":[{"name":"Hokkaido College of Pharmacy 7\u20101 Katsuraoka\u2010cho Otaru, Hokkaido 047\u20100264 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Kyo","sequence":"additional","affiliation":[{"name":"Hokkaido College of Pharmacy 7\u20101 Katsuraoka\u2010cho Otaru, Hokkaido 047\u20100264 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsuo","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Hokkaido College of Pharmacy 7\u20101 Katsuraoka\u2010cho Otaru, Hokkaido 047\u20100264 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,8]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90778-3"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrine1927.72.1_85"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb39081.x"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-54-1-150"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.16.217"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.18.1120"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.46.453"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.3.373"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.34.2231"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.2116\/bunsekikagaku.44.793"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(67)90032-0"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(89)90458-5"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-113-5-1781"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-51-2-404"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(83)90228-5"},{"issue":"232","key":"e_1_2_2_18_1","first-page":"1","article-title":"Catecholestrogens","volume":"93","author":"Ball P.","year":"1980","journal-title":"Acta En\u2010docrinol."},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-107-4-1192"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(77)90198-4"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s11745-003-1135-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:19:52Z","timestamp":1760969992000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/s11745-003-1135-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["10.1007\/s11745-003-1135-4"],"URL":"https:\/\/doi.org\/10.1007\/s11745-003-1135-4","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"type":"print","value":"0024-4201"},{"type":"electronic","value":"1558-9307"}],"subject":[],"published":{"date-parts":[[2003,8]]}}}