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To determine whether these dietary fat effects are similar in females and in another model of renal cystic disease, in this study we used both male and female <jats:italic>pcy<\/jats:italic> mice to examine the effects of fat level and type on disease progression. Adult <jats:italic>pcy<\/jats:italic> mice were fed 4, 10, or 20 g soybean oil\/100 g diet for 130 d in study 1. In study 2, weanling <jats:italic>pcy<\/jats:italic> mice were fed high or low levels of fat rich in 18\u22362n\u22126 (corn oil, CO) 18\u22363n\u22123 (flaxseed oil\/CO 4\u22361 g\/g, FO), or 22\u22366n\u22123 (algal oil\/CO 4\u22361 g\/g, DO) for 8 wk. In adult <jats:italic>pcy<\/jats:italic> mice, low\u2010compared with high\u2010fat diets lowered kidney weights (2.4\u00b10.2 vs. 3.1\u00b10.2 g\/100 g body weight, <jats:italic>P<\/jats:italic>=0.006) and serum urea nitrogen (SUN) (9.6\u00b10.6 vs. 11.9\u00b10.6 mmol\/L, <jats:italic>P<\/jats:italic>=0.009), whereas in young <jats:italic>pcy<\/jats:italic> mice it reduced renal fibrosis volumes (0.44\u00b10.04 vs. 0.62\u00b10.04 mL\/kg body weight, <jats:italic>P<\/jats:italic>&lt;0.0001). FO feeding in young <jats:italic>pcy<\/jats:italic> mice mitigated the detrimental effects of high fat on fibrosis while not altering kidney size, function, and oxidative damage when compared with the CO\u2010fed mice. In contrast, DO\u2010compared with CO\u2010fed mice had higher kidney weights (2.64\u00b10.07 vs. 2.24\u00b10.08 g\/100 g body weight, <jats:italic>P<\/jats:italic>=0.005), SUN (9.4\u00b10.57 vs. 7.0\u00b10.62 nmol\/L, <jats:italic>P<\/jats:italic>&lt;0.0001), and cyst volumes (7.9\u00b10.28 vs. 6.2\u00b10.30 mL\/kg body weight, <jats:italic>P<\/jats:italic>&lt;0.0001) and similar levels of oxidative damage and fibrosis. The FA compositions of the diets were reflected in the kidneys: 18\u22362n\u22126, 18\u22363n\u22123, and 22\u22366n\u22123 were the highest in the CO, FO, and DO diets, respectively. Dietary effects on kidney disease progression were similar in males and females. A low\u2010fat diet slows progression of renal injury in male and female <jats:italic>pcy<\/jats:italic> mice, consistent with findings in the male Han:SPRD\u2010<jats:italic>cy<\/jats:italic> rat. Dietary fat type also influenced renal injury, with flaxseed oil diets rich in 18\u22363n\u22123 slowing early fibrosis progression compared with diets rich in 18\u22362n\u22126 or in 22\u22366n\u22123.<\/jats:p>","DOI":"10.1007\/s11745-004-1221-7","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T19:53:58Z","timestamp":1163447638000},"page":"207-214","source":"Crossref","is-referenced-by-count":42,"title":["Modulation of renal injury in <i>pcy<\/i> mice by dietary fat containing n\u22123 fatty acids depends on the level and type of fat"],"prefix":"10.1002","volume":"39","author":[{"given":"Deepa","family":"Sankaran","sequence":"first","affiliation":[{"name":"University of Manitoba H506 Duff Roblin Winnipeg MB R3T 2N2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[{"name":"Texas Women's University Denton Texas 76383"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Bankovic\u2010Calic","sequence":"additional","affiliation":[{"name":"University of Manitoba H506 Duff Roblin Winnipeg MB R3T 2N2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm R.","family":"Ogborn","sequence":"additional","affiliation":[{"name":"University of Manitoba H506 Duff Roblin Winnipeg MB R3T 2N2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold M.","family":"Aukema","sequence":"additional","affiliation":[{"name":"University of Manitoba H506 Duff Roblin Winnipeg MB R3T 2N2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,3]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2003.13"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000028643.17901.42"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V102300"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80907-3"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V561355"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V551193"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1998.274.3.F541"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00287.x"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00869.x"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-002-1001-4"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.1.180"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.9.2356"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V17980"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.358"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(96)90081-5"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V121107"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00195.2003"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(05)80537-8"},{"key":"e_1_2_2_20_1","first-page":"335","article-title":"Effects of Dietary Supplementation with n\u20103 Fatty Acids on Kidney Morphology and the Fatty Acid Composition of Phospholipids and Triglycerides from Mice with Polycystic Kidney Disease","volume":"69","author":"Yamaguchi T.","year":"1990","journal-title":"Res. 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