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This exploratory study investigates (i) the level of affective dysregulation (AD) in IBS patients and healthy controls; (ii) PUFA and cholesterol profiles in IBS patients compared with controls; and (iii) associations between PUFA and cholesterol parameters with the level of AD. Blood samples were obtained for determination of the FA composition of plasma phospholipids and serum cholesterol in 23 diarrheapredominant IBS patients and 23 healthy matched controls. AD was scored using the Symptom Check List depression scale, the Hospital Anxiety and Depression Scale, and the Hamilton Depression Rating Scale. The level of AD was higher in IBS patients compared with controls. PUFA and cholesterol profiles did not differ significantly between groups. Total n\u22123 PUFA and cholesterol were significantly negatively associated and the ratio of n\u22126 to n\u22123 PUFA and the ratio of arachidonic acid to EPA were significantly positively associated with the level of AD. The findings of the present study reveal that AD was higher in IBS patients compared with healthy controls and that changes in PUFA and cholesterol profiles were significantly associated with the level of AD. These results warrant further studies regarding the role of PUFA and cholesterol status in the co\u2010occurrence of AD and functional gastrointestinal disorders.<\/jats:p>","DOI":"10.1007\/s11745-004-1247-x","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T14:21:27Z","timestamp":1163427687000},"page":"425-431","source":"Crossref","is-referenced-by-count":15,"title":["Fatty acid profile and affective dysregulation in irritable bowel syndrome"],"prefix":"10.1002","volume":"39","author":[{"given":"Tessa O. 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