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The author has studied aspects of the biochemistry and clinical chemistry of steroids and bile acids for more than 50 years, and this paper, which is an extended version of the Schroepfer Medal Award lecture, reviews and discusses part of this work. Development and application of analytical methods based on chromatography and mass spectrometry (MS) have been a central part of many projects, aiming at detailed characterization and quantification of metabolic profiles of steroids and bile acids under different conditions. In present terminology, much of the work may be termed steroidomics and cholanoidomics. Topics discussed are bile acids in human bile and feces, bile acid production, bacterial dehydroxylation of bile acids and steroids during the enterohepatic circulation, profiles of steroid sulfates in plasma of humans and other primates, development of neutral and ion\u2010exchanging lipophilic derivatives of Sephadex for sample preparation and group separation of steroid and bile acid conjugates, profiles of steroids and bile acids in human urine under different conditions, hydroxylation of bile acids in liver disease, effects of alcohol\u2010induced redox changes on steroid synthesis and metabolism, alcohol\u2010induced changes of bile acid biosynthesis, compartmentation of bile acid synthesis studied with <jats:sup>3<\/jats:sup>H\u2010labeled ethanol, formation and metabolism of sulfated metabolites of progesterone in human pregnancy, abnormal patterns of these in patients with intrahepatic cholestasis of pregnancy corrected by ursodeoxycholic acid, inherited and acquired defects of bile acid biosynthesis and their treatment, conjugation of bile acids and steroids with <jats:italic>N<\/jats:italic>\u2010acetylglucosamine, sulfate\u2010glucuronide double conjugates of hydroxycholesterols, extrahepatic 7\u03b1\u2010hydroxylation and 3\u2010dehydrogenation of hydroxycholesterols, and extrahepatic formation of C<jats:sub>27<\/jats:sub> bile acids. The final part discusses analysis of free and sulfated steroids in brain tissue by capillary liquid chromatography\u2010electrospray MS and suggests a need for reevaluation of the function of steroid sulfates in rat brain.<\/jats:p>","DOI":"10.1007\/s11745-004-1288-1","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T11:59:26Z","timestamp":1516622366000},"page":"703-722","source":"Crossref","is-referenced-by-count":77,"title":["Fifty years with bile acids and steroids in health and disease"],"prefix":"10.1002","volume":"39","author":[{"given":"Jan","family":"Sj\u00f6vall","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm SE\u2010171 77 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,8]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.11603"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37187-X"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)30045-6"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.1.361"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000013312.32196.49"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-002-1015-y"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.05-1267"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.14-1693"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.14-1701"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.08-0339"},{"key":"e_1_2_2_12_1","first-page":"317","article-title":"Quantitative Determination of Bile Acids on Paper Chromatograms. 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