{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:54:45Z","timestamp":1786982085849,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Long\u2010chain n\u20103 PUFA in fish oil have modulating effects on inflammatory responses. The aim of this open pilot study was to investigate whether duodenal seal oil administration would benefit patients with inflammatory bowel disease (IBD). Seal oil (10 mL) was administered three times a day directly into the distal part of the duodenum\n                    <jats:italic>via<\/jats:italic>\n                    a nasoduodenal feeding tube for 10 d in 10 patients, 5 of whom had Crohn's disease and 5 ulcerative colitis. Nine of the 10 patients suffered from IBD\u2010associated joint pain. Various parameters of disease activity and FA incorporation in tissues were analyzed before and after treatment. Following seal oil therapy, joint pain index, disease activity, and serum cholesterol level were significantly decreased, whereas the n\u20103 to n\u20106 ratio both in intestinal biopsies and blood was significantly increased. Measures of calprotectin concentration in gut lavage fluid, intestinal permeability, and lipid peroxidation were not significantly changed. The results suggest positive effects of seal oil in patients with IBD, especially on IBD\u2010associated joint pain. Further controlled studies are warranted.\n                  <\/jats:p>","DOI":"10.1007\/s11745-006-0983-2","type":"journal-article","created":{"date-parts":[[2006,11,15]],"date-time":"2006-11-15T19:35:49Z","timestamp":1163619349000},"page":"935-940","source":"Crossref","is-referenced-by-count":27,"title":["Effects of duodenal seal oil administration in patients with inflammatory bowel disease"],"prefix":"10.1002","volume":"37","author":[{"given":"G\u00fclen","family":"Arslan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Institute of Medicine Haukeland University Hospital Bergen N\u20105021 Norway"},{"name":"Institute of Nutrition Directorate of Fisheries Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn Anne","family":"Brunborg","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Directorate of Fisheries Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livar","family":"Fr\u00f8yland","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Directorate of Fisheries Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan G.","family":"Brun","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Insitute of Medicine Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete","family":"Valen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Insitute of Medicine Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Berstad","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Institute of Medicine Haukeland University Hospital Bergen N\u20105021 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,10]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"267","article-title":"Fish Oil in the Treatment of Ulcerative Colitis","volume":"31","author":"O'Morain C.","year":"1990","journal-title":"Scand. 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